BG108493A - БЕТА-АМИНО ТЕТРАХИДРОИМИДАЗО (1,2-а) ПИРАЗИНИ И ТЕТРАХИДРОТРИАЗОЛО (4,3-а) ПИРАЗИНИ КАТО ИНХИБИТОРИ НА ДИПЕПТИДИЛ ПЕПТИДАЗА ЗА ЛЕЧЕНИЕ ИЛИ ПРЕВЕНЦИЯ НА ДИАБЕТ - Google Patents

БЕТА-АМИНО ТЕТРАХИДРОИМИДАЗО (1,2-а) ПИРАЗИНИ И ТЕТРАХИДРОТРИАЗОЛО (4,3-а) ПИРАЗИНИ КАТО ИНХИБИТОРИ НА ДИПЕПТИДИЛ ПЕПТИДАЗА ЗА ЛЕЧЕНИЕ ИЛИ ПРЕВЕНЦИЯ НА ДИАБЕТ

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Publication number
BG108493A
BG108493A BG108493A BG10849303A BG108493A BG 108493 A BG108493 A BG 108493A BG 108493 A BG108493 A BG 108493A BG 10849303 A BG10849303 A BG 10849303A BG 108493 A BG108493 A BG 108493A
Authority
BG
Bulgaria
Prior art keywords
pyrazines
diabetes
prevention
dipeptidyl peptidase
treatment
Prior art date
Application number
BG108493A
Other languages
English (en)
Inventor
Scott Edmondson
Michael Fisher
Dooseop Kim
Malcolm Maccoss
Emma Parmee
Ann Weber
Jinyou Xu
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG108493(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of BG108493A publication Critical patent/BG108493A/bg

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Изобретението се отнася до съединения, които са инхибитори на ензима дипептидил пептидаза-ІV (DР-IV инхибитори) и се използват при лечението или превенцията на заболявания, в които участва ензимът дипептидил пептидаза-ІV, например диабет и особено диабет тип II. Изобретението се отнася също до фармацевтични състави, съдържащи тези съединения, и до тяхното използване за лечение или превенция на заболявания, при които участва ензимът дипептидил пептидаза-ІV. а
BG108493A 2001-07-06 2003-12-22 БЕТА-АМИНО ТЕТРАХИДРОИМИДАЗО (1,2-а) ПИРАЗИНИ И ТЕТРАХИДРОТРИАЗОЛО (4,3-а) ПИРАЗИНИ КАТО ИНХИБИТОРИ НА ДИПЕПТИДИЛ ПЕПТИДАЗА ЗА ЛЕЧЕНИЕ ИЛИ ПРЕВЕНЦИЯ НА ДИАБЕТ BG108493A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06

Publications (1)

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BG108493A true BG108493A (bg) 2005-04-30

Family

ID=23172273

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108493A BG108493A (bg) 2001-07-06 2003-12-22 БЕТА-АМИНО ТЕТРАХИДРОИМИДАЗО (1,2-а) ПИРАЗИНИ И ТЕТРАХИДРОТРИАЗОЛО (4,3-а) ПИРАЗИНИ КАТО ИНХИБИТОРИ НА ДИПЕПТИДИЛ ПЕПТИДАЗА ЗА ЛЕЧЕНИЕ ИЛИ ПРЕВЕНЦИЯ НА ДИАБЕТ

Country Status (46)

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US (9) US7125873B2 (bg)
EP (4) EP1412357B1 (bg)
JP (1) JP3762407B2 (bg)
KR (1) KR100606871B1 (bg)
CN (2) CN1861077A (bg)
AR (1) AR036114A1 (bg)
AT (2) ATE471148T1 (bg)
AU (1) AU2002320303B2 (bg)
BE (1) BE2007C047I2 (bg)
BG (1) BG108493A (bg)
BR (1) BRPI0210866B8 (bg)
CA (1) CA2450740C (bg)
CR (1) CR7235A (bg)
CY (3) CY2007019I2 (bg)
DE (4) DE60236767D1 (bg)
DK (2) DK1625847T3 (bg)
DO (1) DOP2002000438A (bg)
EA (2) EA006845B1 (bg)
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ES (2) ES2259713T3 (bg)
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HU (2) HU225695B1 (bg)
IL (3) IL159109A0 (bg)
IS (2) IS2218B (bg)
JO (1) JO2230B1 (bg)
LT (1) LTC1412357I2 (bg)
LU (2) LUC91360I2 (bg)
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SI (1) SI1412357T1 (bg)
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UA (1) UA74912C2 (bg)
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KR20040010842A (ko) 2004-01-31

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