SI2736909T1 - Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli - Google Patents

Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli

Info

Publication number
SI2736909T1
SI2736909T1 SI201230989T SI201230989T SI2736909T1 SI 2736909 T1 SI2736909 T1 SI 2736909T1 SI 201230989 T SI201230989 T SI 201230989T SI 201230989 T SI201230989 T SI 201230989T SI 2736909 T1 SI2736909 T1 SI 2736909T1
Authority
SI
Slovenia
Prior art keywords
sitagliptin
preparation
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
SI201230989T
Other languages
English (en)
Inventor
Silvo Zupancic
Rok Zupet
Original Assignee
Farma Grs, D.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farma Grs, D.O.O. filed Critical Farma Grs, D.O.O.
Publication of SI2736909T1 publication Critical patent/SI2736909T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201230989T 2011-07-27 2012-07-27 Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli SI2736909T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI201100277 2011-07-27
EP12740505.8A EP2736909B1 (en) 2011-07-27 2012-07-27 Process for the preparation of sitagliptin and its pharmaceutically acceptable salts
PCT/EP2012/003214 WO2013013833A1 (en) 2011-07-27 2012-07-27 Process for the preparation of sitagliptin and its pharmaceutically acceptable salts

Publications (1)

Publication Number Publication Date
SI2736909T1 true SI2736909T1 (sl) 2017-08-31

Family

ID=46583953

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201230989T SI2736909T1 (sl) 2011-07-27 2012-07-27 Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli

Country Status (4)

Country Link
EP (1) EP2736909B1 (sl)
EA (1) EA024688B1 (sl)
SI (1) SI2736909T1 (sl)
WO (1) WO2013013833A1 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2013MU00916A (sl) 2013-03-20 2015-06-26 Cadila Healthcare Ltd
WO2015001568A2 (en) * 2013-07-01 2015-01-08 Laurus Labs Private Limited Sitagliptin lipoate salt, process for the preparation and pharmaceutical composition thereof
WO2015145333A1 (en) 2014-03-26 2015-10-01 Sun Pharmaceutical Industries Limited Process for the preparation of sitagliptin and its intermediate
CN106124667B (zh) * 2016-08-29 2018-07-31 上海应用技术学院 一种分离测定西格列汀有关物质的方法
CN112209931A (zh) * 2019-07-10 2021-01-12 浙江昌海制药有限公司 一种提高西格列汀收率和纯度的工艺方法
CN113149991A (zh) * 2020-12-31 2021-07-23 浙江美诺华药物化学有限公司 西他列汀游离碱及西他列汀磷酸盐一水合物的合成方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
DE60316416T2 (de) 2002-03-25 2008-06-26 Merck & Co., Inc. Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes
JP4530852B2 (ja) 2002-07-15 2010-08-25 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病治療のためのピペリジノピリミジンジペプチジルペプチダーゼ阻害剤
CA2508947A1 (en) 2002-12-20 2004-07-15 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AR043515A1 (es) 2003-03-19 2005-08-03 Merck & Co Inc Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica
WO2004085661A2 (en) 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salts of dipeptidyl betidase inhibitor 4
CA2536251C (en) 2003-09-02 2009-08-04 Merck & Co., Inc. Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
US20070021430A1 (en) 2003-09-23 2007-01-25 Chen Alex M Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
WO2005072530A1 (en) 2004-01-16 2005-08-11 Merck & Co., Inc. Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
TW200602293A (en) 2004-04-05 2006-01-16 Merck & Co Inc Process for the preparation of enantiomerically enriched beta amino acid derivatives
JP4963671B2 (ja) 2004-06-21 2012-06-27 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療または予防のためのジペプチジルペプチダーゼ−ｉｖ阻害剤としてのアミノシクロヘキサン
EP1784188B1 (en) 2004-08-23 2010-07-14 Merck Sharp & Dohme Corp. Fused triazole derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2006033848A1 (en) 2004-09-15 2006-03-30 Merck & Co., Inc. Amorphous form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
AR052879A1 (es) 2005-01-24 2007-04-11 Merck & Co Inc Procedimiento para preparar derivados de beta aminoacidos quirales por hidrogenacion asimetrica
US20090124601A1 (en) 2005-03-29 2009-05-14 Song Zhiguo J Tartaric Acid Salts of a Dipeptidyl Peptidase-IV Inhibitor
JP2008540426A (ja) 2005-05-02 2008-11-20 メルク エンド カムパニー インコーポレーテッド 糖尿病及び肥満の治療のためのジペプチジルペプチダーゼｉｖ阻害薬及びカンナビノイドｃｂ１受容体拮抗薬の組み合わせ
US20090221592A1 (en) 2005-07-25 2009-09-03 Ellison Martha E Dodecylsulfate Salt Of A Dipeptidyl Peptidase-Iv Inhibitor
WO2007050485A2 (en) 2005-10-25 2007-05-03 Merck & Co., Inc. Combination of a dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension
KR20070111099A (ko) 2006-05-16 2007-11-21 영진약품공업주식회사 시타글립틴 염산염의 신규 결정형, 이의 제조 방법과 이를포함하는 약학적 조성물
US7820666B2 (en) 2007-05-08 2010-10-26 Concert Pharmaceuticals, Inc. Tetrahydrotriazolopyrazine derivatives and uses thereof
WO2009084024A2 (en) 2007-11-02 2009-07-09 Glenmark Generics Limited A process for the preparation of r-sit agliptin and its pharmaceutically acceptable salts thereof
WO2009064476A1 (en) 2007-11-13 2009-05-22 Teva Pharmaceutical Industries Ltd. Preparation of sitagliptin intermediate
US20090221595A1 (en) 2007-11-26 2009-09-03 Nurit Perlman Crystalline form of sitagliptin
CN101903390A (zh) 2007-12-20 2010-12-01 雷迪博士实验室有限公司 制备西他列汀及其药学上可接受的盐的方法
CN101468988A (zh) 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
US20100041885A1 (en) 2008-03-25 2010-02-18 Nurit Perlman Crystalline forms of sitagliptin phosphate
US20090247532A1 (en) 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation
EP2318411A2 (en) 2008-07-03 2011-05-11 Ratiopharm GmbH Crystalline salts of sitagliptin
CN101633625B (zh) 2008-07-23 2013-02-13 江苏恒瑞医药股份有限公司 R-β-氨基苯丁酸衍生物的制备方法
DE202008010396U1 (de) 2008-07-29 2009-12-10 Krauss, Gunter Strömungsenergieanlage
US20100069637A1 (en) 2008-07-29 2010-03-18 Medichem S.A. CRYSTALLINE SALT FORMS OF A 5,6,7,8-TETRAHYDRO-1,2,4-TRIAZOLO[4,3-a]PYRAZINE DERIVATIVE
EP2331545B1 (en) 2008-08-27 2013-10-02 Cadila Healthcare Limited Improved process for preparation of (2r)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin- 7(8h)-yl]-l-(2,4,5-trifluorophenyl)butan-2-amine&new impurities in preparation thereof
ES2603215T3 (es) 2008-12-31 2017-02-24 Chiral Quest, Inc. Procedimiento y productos intermedios para la preparación de derivados de beta-aminoácidos N-acilados-4-arilo
EP2218721A1 (en) 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
CA2757241A1 (en) 2009-03-30 2010-10-14 Teva Pharmaceutical Industries Ltd. Solid state forms of sitagliptin salts
WO2010122578A2 (en) 2009-04-20 2010-10-28 Msn Laboratories Limited Process for the preparation of sitagliptin and its intermediates
CA2759196A1 (en) 2009-05-11 2010-11-18 Generics [Uk] Limited Novel crystalline polymorph of sitagliptin dihydrogen phosphate
AU2010247193B2 (en) * 2009-05-11 2016-05-19 Generics [Uk] Limited Sitagliptin synthesis
IT1395596B1 (it) 2009-06-30 2012-10-16 Dipharma Francis Srl Procedimento per la preparazione di sitagliptin
WO2011018494A1 (de) 2009-08-13 2011-02-17 Sandoz Ag Kristalline verbindung von 7-[(3r)-3-amino-1-oxo-4- (2, 4, 5-trifluorphenyl) butyl]-5, 6, 7, 8-tetrahydro-3-(tri fluormethyl)-1, 2, 4-triazolo[4,3-a]pyrazin

Also Published As

Publication number Publication date
EP2736909B1 (en) 2017-03-29
EA201490383A1 (ru) 2014-06-30
WO2013013833A1 (en) 2013-01-31
EA024688B1 (ru) 2016-10-31
EP2736909A1 (en) 2014-06-04

Similar Documents

Publication Publication Date Title
ZA201206095B (en) Process for the preparation of isoxazoline derivatives
LT2734536T (lt) Estetrolio gamybos būdas
ZA201305972B (en) Method for the preparation of biphephos
PL2785701T3 (pl) Krystaliczna postać kabazytakselu i sposób jej otrzymywania
SI2691083T1 (sl) Farmacevtski sestavek sitagliptina
SG11201400939YA (en) Process for the preparation of methoxymelonal
EP2736905A4 (en) INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF LURASIDONE AND SALTS THEREOF
HK1194733A1 (zh) 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體
ZA201403736B (en) Process for the preparation of sterol derivatives
SI2736909T1 (sl) Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli
IL227711A0 (en) Phenyl-isoxazole history and their preparation process
IL232652A (en) A method for the preparation and isolation of Vardenafil salts with acids
EP2780348A4 (en) PROCESS FOR THE PRODUCTION OF TENOFOVIR
IL231645A (en) Process for making isoxazolyl - methoxy - nicotinic acids
ZA201309713B (en) Process for the preparation of paliperidone
IL226436A0 (en) Methods for the preparation of bendamustine
ZA201500865B (en) Process for the preparation of sitagliptin and intermediate compounds
HU1000565D0 (en) Process for the preparation of pharmaceutically active compound and intermediers
PL396708A1 (pl) Epoksydowe pochodne alkaloidów drzewa chinowego i sposób wytwarzania epoksydowych pochodnych alkaloidów drzewa chinowego
EP2766369A4 (en) NOVEL SALT OF SITAGLIPTIN, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF
ZA201403104B (en) Process for the preparation of higher alcohols
IL218764A0 (en) Crystalline levofolinic acid and process for its preparation
ZA201309732B (en) Process for the preparation of dexlansoprazole
EP2699560A4 (en) 5-CARBAMOYL-ADAMANTAN-2-YL AMID DERIVATIVES, PHARMACEUTICALLY ALLOWED SALTS AND METHOD FOR THE PRODUCTION THEREOF
PL395425A1 (pl) Sposób wytwarzania chlorowodorku 2-amino-N-tert-butylo-2- cyjanoacetamidu