AU2010258355B2 - Compositions and methods for prevention and treatment of coronary heart diseases - Google Patents

Compositions and methods for prevention and treatment of coronary heart diseases Download PDF

Info

Publication number
AU2010258355B2
AU2010258355B2 AU2010258355A AU2010258355A AU2010258355B2 AU 2010258355 B2 AU2010258355 B2 AU 2010258355B2 AU 2010258355 A AU2010258355 A AU 2010258355A AU 2010258355 A AU2010258355 A AU 2010258355A AU 2010258355 B2 AU2010258355 B2 AU 2010258355B2
Authority
AU
Australia
Prior art keywords
formula
compound
groups
substituted
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010258355A
Other languages
English (en)
Other versions
AU2010258355A1 (en
Inventor
Ming Li
Hongwey Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generex Pharmaceuticals Inc
Original Assignee
Generex Pharmaceuticals Inc
GENEREX PHARM Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generex Pharmaceuticals Inc, GENEREX PHARM Inc filed Critical Generex Pharmaceuticals Inc
Publication of AU2010258355A1 publication Critical patent/AU2010258355A1/en
Application granted granted Critical
Publication of AU2010258355B2 publication Critical patent/AU2010258355B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
AU2010258355A 2009-06-12 2010-06-11 Compositions and methods for prevention and treatment of coronary heart diseases Ceased AU2010258355B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18670909P 2009-06-12 2009-06-12
US61/186,709 2009-06-12
US18790509P 2009-06-17 2009-06-17
US61/187,905 2009-06-17
PCT/IB2010/001416 WO2010143062A1 (en) 2009-06-12 2010-06-11 Compositions and methods for prevention and treatment of coronary heart diseases

Publications (2)

Publication Number Publication Date
AU2010258355A1 AU2010258355A1 (en) 2012-02-02
AU2010258355B2 true AU2010258355B2 (en) 2016-04-28

Family

ID=43308481

Family Applications (11)

Application Number Title Priority Date Filing Date
AU2010258355A Ceased AU2010258355B2 (en) 2009-06-12 2010-06-11 Compositions and methods for prevention and treatment of coronary heart diseases
AU2010258352A Ceased AU2010258352B2 (en) 2009-06-12 2010-06-11 Compositions and methods for the prevention and treatment of hypertension
AU2010258354A Ceased AU2010258354B2 (en) 2009-06-12 2010-06-11 Composition used to prevent and treat red blood cell coagulation
AU2010258358A Ceased AU2010258358B2 (en) 2009-06-12 2010-06-11 Compositions and methods for increasing lifespan and health span
AU2010258351A Ceased AU2010258351B2 (en) 2009-06-12 2010-06-11 Compositions and methods for the prevention and treatment of heart failure
AU2010258356A Ceased AU2010258356B2 (en) 2009-06-12 2010-06-11 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2016201525A Abandoned AU2016201525A1 (en) 2009-06-12 2016-03-09 Compositions and methods for increasing lifespan and health span
AU2016202674A Abandoned AU2016202674A1 (en) 2009-06-12 2016-04-27 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2017202573A Expired - Fee Related AU2017202573B2 (en) 2009-06-12 2017-04-19 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2017202572A Expired - Fee Related AU2017202572B2 (en) 2009-06-12 2017-04-19 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2018202291A Abandoned AU2018202291A1 (en) 2009-06-12 2018-03-29 Compositions and methods for increasing lifespan and health span

Family Applications After (10)

Application Number Title Priority Date Filing Date
AU2010258352A Ceased AU2010258352B2 (en) 2009-06-12 2010-06-11 Compositions and methods for the prevention and treatment of hypertension
AU2010258354A Ceased AU2010258354B2 (en) 2009-06-12 2010-06-11 Composition used to prevent and treat red blood cell coagulation
AU2010258358A Ceased AU2010258358B2 (en) 2009-06-12 2010-06-11 Compositions and methods for increasing lifespan and health span
AU2010258351A Ceased AU2010258351B2 (en) 2009-06-12 2010-06-11 Compositions and methods for the prevention and treatment of heart failure
AU2010258356A Ceased AU2010258356B2 (en) 2009-06-12 2010-06-11 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2016201525A Abandoned AU2016201525A1 (en) 2009-06-12 2016-03-09 Compositions and methods for increasing lifespan and health span
AU2016202674A Abandoned AU2016202674A1 (en) 2009-06-12 2016-04-27 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2017202573A Expired - Fee Related AU2017202573B2 (en) 2009-06-12 2017-04-19 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2017202572A Expired - Fee Related AU2017202572B2 (en) 2009-06-12 2017-04-19 Compositions and methods for prevention and treatment of brain diseases and conditions
AU2018202291A Abandoned AU2018202291A1 (en) 2009-06-12 2018-03-29 Compositions and methods for increasing lifespan and health span

Country Status (6)

Country Link
US (7) US9050277B2 (enExample)
EP (6) EP2440221A4 (enExample)
JP (11) JP6076737B2 (enExample)
CN (6) CN102711768B (enExample)
AU (11) AU2010258355B2 (enExample)
WO (6) WO2010143062A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12397008B2 (en) * 2006-04-13 2025-08-26 Lead Billion Limited Pharmaceutical composition and method for regenerating myofibers in the treatment of muscle injuries
WO2010143062A1 (en) * 2009-06-12 2010-12-16 Generex Pharmaceuticals, Inc. Compositions and methods for prevention and treatment of coronary heart diseases
KR20140010936A (ko) * 2010-12-23 2014-01-27 후야 바이오사이언스 인터내셔널 엘엘씨 정제된 카디오게닌 이성질체 및 관련된 방법
JP6000521B2 (ja) * 2011-08-10 2016-09-28 株式会社ブルボン 血圧上昇抑制剤
EP2812005B8 (en) * 2012-05-16 2018-10-31 Prairie Berry Europe GmbH Polyhydroxylated pentacyclic triterpene acids as hmg-coa reductase inhibitors
US20140044813A1 (en) * 2012-08-09 2014-02-13 Kemin Industries, Inc. Plant Extracts for Improving Cognitive Health and Function
CN103623753B (zh) * 2013-11-27 2016-03-23 大兴安岭嘉迪欧营养原料有限公司 大兴安岭野生金老梅总三萜提取物的制备方法
CN103623082B (zh) * 2013-11-29 2016-08-17 江西中医药大学 覆盆子提取物及其应用
US20150174057A1 (en) * 2013-12-24 2015-06-25 Generex Pharamaceutics Inc. Compositions and methods for the prevention and treatment of oral diseases
KR20160113277A (ko) * 2014-01-30 2016-09-28 케민 인더스트리즈, 인코포레이티드 인지 기능을 개선시키기 위한 식물 추출물
CN105311030B (zh) * 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN104971091B (zh) * 2015-06-03 2019-08-13 兴明生物医药技术(上海)有限公司 一种用于制备促进心肌再生药物的提取物的制备方法及其应用
WO2017019182A1 (en) 2015-07-24 2017-02-02 Northeastern University Quantitative magnetic resonance imaging of the vasculature
CA2997659C (en) * 2015-09-04 2023-08-01 Reto ASMIS Methods for treatment of monocyte dysfunction and chronic inflammatory micro- and macro-vascular diseases
CN105106222B (zh) * 2015-09-14 2020-05-08 新乡医学院 吐曼酸在制备治疗或预防雌激素缺乏引起的阿尔茨海默病药物中的应用
CN106581006B (zh) * 2015-10-16 2019-11-29 香港理工大学深圳研究院 三萜类化合物在制备治疗帕金森药物中的应用
CN106153761B (zh) * 2016-06-07 2018-08-14 贵州师范大学 同时检测无籽刺梨果实中3种黄酮类成分的方法
JP7361470B2 (ja) 2016-06-20 2023-10-16 バタフライ ネットワーク,インコーポレイテッド ユーザによる超音波装置の操作を援助するための自動画像取得
CN109562217A (zh) 2016-11-02 2019-04-02 天普大学-联邦高等教育体系 用于降低血液粘稠度、抑制血液循环中的乱流及治愈缗线状形成的系统及方法
EP4559523A3 (en) * 2017-04-25 2026-01-07 Buck Institute for Research on Aging Formulations for extending lifespan and healthspan
CN106946971A (zh) * 2017-04-28 2017-07-14 南宁馨艺荣生物科技有限公司 一种从积雪草中提取积雪草酸的工艺
CN107445855B (zh) * 2017-08-07 2018-12-14 绍兴市逸晨医疗科技有限公司 一种盐酸多西环素杂质c的制备方法
WO2019172174A1 (ja) * 2018-03-05 2019-09-12 日本新薬株式会社 Rageシグナル阻害作用をもつ食品素材
WO2019173435A1 (en) * 2018-03-06 2019-09-12 Epibone, Inc. Injectable off-the- shelf cartilage, tendon, and ligament repair compositions and methods of use
JP7365068B2 (ja) * 2018-07-27 2023-10-19 ノースイースタン ユニバーシティ 血管磁気共鳴画像法による認知症の診断
KR102152182B1 (ko) * 2018-09-05 2020-09-04 한국식품연구원 큰뱀무 추출물을 유효성분으로 함유하는 우울 증상 또는 스트레스의 개선, 예방 또는 치료용 조성물
CN112955139B (zh) 2018-09-25 2025-04-18 庞塞迪利昂健康特定活动公司 用于制备α-酮戊二酸钙的方法
WO2020124221A1 (en) 2018-12-21 2020-06-25 ARLANXEO Canada Inc. Continuous process for producing halogenated isoolefin copolymer
CN109884222B (zh) * 2019-01-17 2021-07-13 贵州中医药大学 一种小花清风藤的hplc指纹图谱建立方法
KR102152174B1 (ko) * 2020-03-30 2020-09-04 한국식품연구원 큰뱀무 추출물을 유효성분으로 함유하는 인지기능 장애의 개선, 예방 또는 치료용 조성물
CN111643556A (zh) * 2020-07-16 2020-09-11 杭州科倍安生物制药有限公司 一种用于预防和治疗痔疮的药物及其应用
WO2022043407A1 (fr) 2020-08-25 2022-03-03 Laouarem Yousra Compositions destinées au traitement des troubles neurologiques
KR102574207B1 (ko) * 2020-12-03 2023-09-04 경북대학교 산학협력단 뱀무 추출물을 유효성분으로 하는 혈전성 질환 치료 또는 예방용 조성물
CN112587599A (zh) * 2021-01-11 2021-04-02 贵州中医药大学 一种预防急性高原反应的中药组合物
CN112755079A (zh) * 2021-01-18 2021-05-07 杭州科倍安生物制药有限公司 一种预防血栓形成或溶解已形成血栓的药物及其制备方法
CN113367166B (zh) * 2021-05-13 2022-07-26 海南大学 一种褐背蒲桃提取物杀菌剂及其制备方法和应用
CN114028459A (zh) * 2021-11-11 2022-02-11 杭州科贝生物制药有限公司 预防和治疗哺乳动物缺血性心脏病的药物和制备方法及应用
CN114722066B (zh) * 2022-03-23 2023-04-07 电子科技大学 一种预测材料自旋霍尔电导及反常霍尔电导的方法
CN117257781A (zh) * 2022-06-13 2023-12-22 上海市东方医院(同济大学附属东方医院) 美金刚通过靶向心房心肌细胞谷氨酸受体有效干预房颤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069629A (zh) * 1991-08-27 1993-03-10 段民生 一种康复面的制备方法
CN1279970A (zh) * 2000-06-09 2001-01-17 张庆玉 血络赋降脂通脉胶囊
CN1682788A (zh) * 2004-04-12 2005-10-19 赵晓昂 舒痛方及其制剂和用途
CN101125171A (zh) * 2007-08-20 2008-02-20 刘凤元 一种男、女补强中药
JP2008074801A (ja) * 2006-09-25 2008-04-03 Oriza Yuka Kk 肝保護剤

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JP2871763B2 (ja) * 1989-12-15 1999-03-17 株式会社資生堂 テストステロン―5α―レダクターゼ阻害剤
CN1047089C (zh) * 1992-12-03 1999-12-08 张斌 治疗近视眼的药物及制备工艺
CN1102993A (zh) 1993-12-21 1995-05-31 吴文才 多酶体系加工中草药的制剂方法
JPH07179347A (ja) * 1993-12-21 1995-07-18 Showa Shell Sekiyu Kk 抗ウイルス組成物
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
CA2289531C (en) 1997-05-15 2009-09-29 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
CN1176814A (zh) 1997-06-26 1998-03-25 李静 预防和治疗脑血管病的口服液
AU2001278341A1 (en) * 2000-07-26 2002-02-05 Vitaplant Ag Piper methysticum plant extract
WO2002009720A1 (en) * 2000-07-31 2002-02-07 University Of Virginia Patent Foundation Inhibitors of dna polymerase sigma
US6629835B2 (en) 2000-08-01 2003-10-07 Metaproteomics, Llc Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2
JP2002255804A (ja) * 2001-03-02 2002-09-11 Suntory Ltd インシュリン様作用を有するヘキサオキシジフェン酸誘導体を含んでなる組成物
WO2002078685A1 (en) 2001-03-30 2002-10-10 The Nisshin_Oillio, Ltd. Drugs for vascular lesion
KR100453569B1 (ko) * 2001-09-11 2004-10-20 대한민국 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는항산화제
JP2003201229A (ja) 2001-10-23 2003-07-18 Shiseido Co Ltd マトリックスメタロプロテアーゼ活性阻害剤および抗老化用化粧料
US7572467B2 (en) 2001-11-21 2009-08-11 The Chinese University Of Hong Kong Compositions comprising organic extracts of Geum japonicum thunb var. and the use thereof
JP4393777B2 (ja) 2002-03-19 2010-01-06 株式会社ファンケル 抗ヘリコバクター・ピロリ用組成物
US7387801B2 (en) * 2002-12-10 2008-06-17 The Chinese University Of Hong Kong Organic extract of Geum japonicum Thunb variant and use thereof
CN1239155C (zh) * 2003-01-23 2006-02-01 北京中医药大学 一种治疗缺血性脑中风的药物组合物及其制备方法
US20040247698A1 (en) * 2003-06-04 2004-12-09 Valenzuela Cortes Carmen Maria Erectile Dysfunction Treatment
US20070249711A1 (en) * 2003-10-10 2007-10-25 Wonrack Choi Triterpene Compounds which are Effective on Improvement of Brain Function
CN1185007C (zh) 2003-12-08 2005-01-19 张小朋 降脂溶栓药物
WO2006054370A1 (en) * 2004-11-16 2006-05-26 Use-Techno Corporation Gluconeogenesis inhibiting agent
KR100704003B1 (ko) * 2005-06-10 2007-04-06 안동대학교 산학협력단 2-알파-하이드록시-올레아놀산을 함유하는 트롬빈 저해혈전증 예방 및 치료용 조성물
JP2006347967A (ja) * 2005-06-16 2006-12-28 Yuusu Techno Corporation:Kk 血糖値上昇抑制剤
WO2007049089A1 (en) * 2005-10-27 2007-05-03 Lead Billion Limited Method of stimulating growth of functional blood vessels and/or regeneration of myocardium in damaged tissues
WO2007049088A1 (en) 2005-10-27 2007-05-03 Lead Billion Limited Method of stimulating growth of functional blood vessels and/or regeneration of myocardium in damaged tissues
AU2006308338B2 (en) 2005-10-27 2009-11-05 Lead Billion Limited Pharmaceutical composition and method for neoangiogenesis/revascularization useful in treating ischemic heart diseases
KR100718602B1 (ko) * 2005-12-29 2007-06-21 대한민국 항비만 및 항염증 효과를 가지는 뱀무 추출물, 이를포함하는 식품 조성물 및 이들의 제조 방법
JP2007204447A (ja) * 2006-02-03 2007-08-16 Yoshihiro Futamura 中性脂肪減少作用を呈するカルニチン誘導体、それからなる抗肥満薬、食品製剤及びセルライト減少作用を呈する化粧品
JP4731350B2 (ja) 2006-02-17 2011-07-20 丸善製薬株式会社 抗老化剤、皮膚化粧料及び美容用飲食品
CA2646240A1 (en) * 2006-03-16 2007-09-20 Xuemin Shi Combination therapy for treatment of patients with neurological disorders and cerebral infarction
CN1857627B (zh) * 2006-04-12 2010-05-19 贵阳利多药物技术开发有限公司 治疗中风的中药制剂及其制备方法
US8821947B2 (en) 2006-06-01 2014-09-02 Howard W. Selby, III Cholesterol-reducing diet
CN101091751A (zh) * 2006-06-22 2007-12-26 北京中医药大学 一种治疗高血压的中药组合物及其制备方法
JP5281234B2 (ja) * 2006-06-27 2013-09-04 ポーラ化成工業株式会社 毛様体過緊張による疲れ目の改善・予防のための経口投与組成物
CN100528195C (zh) * 2006-06-28 2009-08-19 海南晨菲药业有限公司 一种大青根注射剂制备工艺
CN101099770A (zh) 2006-07-04 2008-01-09 北京中医药大学 一种具有咪唑啉受体激动活性的药物组合物及制备方法和应用
JP5366358B2 (ja) * 2006-09-29 2013-12-11 株式会社コーセー 皮膚の老化機構に作用する剤、抗老化用皮膚外用剤、及び抗老化方法
CN101040901A (zh) 2007-04-12 2007-09-26 云南龙润药业有限公司 迷迭香提取物及其制备方法和应用
US9205112B2 (en) 2007-04-23 2015-12-08 Creative Medical Health, Inc. Combination treatment of cardiovascular disease
US20100189830A1 (en) 2007-05-21 2010-07-29 Zhijun Liu Sweet Gum Fruit Extract as a Therapeutic Agent
US20090022827A1 (en) * 2007-07-19 2009-01-22 Ming Li Agent and method for eliminating malignance of cancer cells without harmful effect to normal cells
KR100891881B1 (ko) 2007-08-23 2009-04-07 대한민국 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는고지혈증 및 mmp 과다활성으로 인한 혈관질환 예방 및치료용 조성물
CN101406537B (zh) * 2007-10-11 2013-05-15 首都医科大学 柔毛水杨梅提取物用于制备治疗肥胖的药物的用途
CN101274012B (zh) 2008-01-23 2011-12-28 上海海天医药科技开发有限公司 夏枯草属植物提取物的组合物、制备方法及其药物用途
WO2010143062A1 (en) 2009-06-12 2010-12-16 Generex Pharmaceuticals, Inc. Compositions and methods for prevention and treatment of coronary heart diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069629A (zh) * 1991-08-27 1993-03-10 段民生 一种康复面的制备方法
CN1279970A (zh) * 2000-06-09 2001-01-17 张庆玉 血络赋降脂通脉胶囊
CN1682788A (zh) * 2004-04-12 2005-10-19 赵晓昂 舒痛方及其制剂和用途
JP2008074801A (ja) * 2006-09-25 2008-04-03 Oriza Yuka Kk 肝保護剤
CN101125171A (zh) * 2007-08-20 2008-02-20 刘凤元 一种男、女补强中药

Also Published As

Publication number Publication date
JP2017128608A (ja) 2017-07-27
AU2010258351B2 (en) 2015-05-21
AU2010258355A1 (en) 2012-02-02
JP2015155468A (ja) 2015-08-27
AU2018202291A1 (en) 2018-04-26
WO2010143061A1 (en) 2010-12-16
AU2010258358B2 (en) 2015-12-10
CN102548560B (zh) 2016-01-20
US9050277B2 (en) 2015-06-09
EP2440221A1 (en) 2012-04-18
EP2440222A1 (en) 2012-04-18
WO2010143065A1 (en) 2010-12-16
EP2440223A1 (en) 2012-04-18
CN102740870B (zh) 2016-06-29
JP2012529485A (ja) 2012-11-22
JP5689117B2 (ja) 2015-03-25
AU2016201525A1 (en) 2016-03-24
JP2012529484A (ja) 2012-11-22
CN102548571A (zh) 2012-07-04
US20120177759A1 (en) 2012-07-12
EP2440212A1 (en) 2012-04-18
AU2010258352A1 (en) 2012-02-02
WO2010143063A1 (en) 2010-12-16
WO2010143059A1 (en) 2010-12-16
CN102740870A (zh) 2012-10-17
AU2010258356A1 (en) 2012-02-02
CN102548571B (zh) 2014-08-27
AU2010258356B2 (en) 2017-01-19
AU2017202572B2 (en) 2019-02-21
AU2017202573A1 (en) 2017-05-11
US9950019B2 (en) 2018-04-24
AU2010258358A1 (en) 2012-02-02
EP2440220A4 (en) 2012-12-12
CN102497873A (zh) 2012-06-13
CN102497873B (zh) 2016-04-13
US20120082741A1 (en) 2012-04-05
CN102711768A (zh) 2012-10-03
US9283255B2 (en) 2016-03-15
AU2016202674A1 (en) 2016-05-19
EP2440209A4 (en) 2013-03-20
JP2012529488A (ja) 2012-11-22
EP2440221A4 (en) 2012-12-12
JP2015164963A (ja) 2015-09-17
WO2010143062A1 (en) 2010-12-16
JP6076737B2 (ja) 2017-02-08
JP5712207B2 (ja) 2015-05-07
US20120148691A1 (en) 2012-06-14
EP2440222A4 (en) 2012-12-12
AU2010258352B2 (en) 2016-04-28
US20120076878A1 (en) 2012-03-29
JP5827618B2 (ja) 2015-12-02
AU2010258351A1 (en) 2012-02-02
AU2017202572A1 (en) 2017-05-11
EP2440220A1 (en) 2012-04-18
EP2440223A4 (en) 2012-12-12
JP6187831B2 (ja) 2017-08-30
JP2012529483A (ja) 2012-11-22
JP2012529487A (ja) 2012-11-22
WO2010143058A1 (en) 2010-12-16
JP5892929B2 (ja) 2016-03-23
CN102573865A (zh) 2012-07-11
US20180055896A1 (en) 2018-03-01
AU2010258354B2 (en) 2015-08-13
US9629884B2 (en) 2017-04-25
CN102548560A (zh) 2012-07-04
US20120077761A1 (en) 2012-03-29
AU2010258354A1 (en) 2012-02-02
AU2017202573B2 (en) 2019-02-21
CN102573865B (zh) 2016-08-24
JP2012529486A (ja) 2012-11-22
JP2015164967A (ja) 2015-09-17
CN102711768B (zh) 2014-04-09
EP2440212A4 (en) 2013-03-20
JP2015164966A (ja) 2015-09-17
EP2440209A1 (en) 2012-04-18
JP5892928B2 (ja) 2016-03-23
US20120077762A1 (en) 2012-03-29

Similar Documents

Publication Publication Date Title
AU2010258355B2 (en) Compositions and methods for prevention and treatment of coronary heart diseases
JP5755633B2 (ja) 新規サルビアノール酸化合物l、その調製方法及び使用
ES2383599T3 (es) Composición farmacéutica para tratamiento de enfermedades cardiovasculares y cerebrovasculares
CN100999470A (zh) 一种丹参丹酚酸a及制剂的制备方法和用途
KR20010081188A (ko) 신경보호작용을 갖는 황금추출물 및 이를 함유하는 약학적제제
CN109846896A (zh) 常春藤皂苷在制备抗血管内皮细胞炎性损伤药物中的应用
CN115304653A (zh) 从山茱萸中提取的四个环烯醚萜苷化合物及其制备方法与应用
JP2021514951A (ja) 14−デオキシ−11,12−デヒドロ−8,12−エポキシまたは7,8−エン−アンドログラフォライドおよびその15位置換誘導体と用途
CN112716986A (zh) 白桦茸在制备抗心室重构的药物中的应用
JP2000154151A (ja) 免疫抑制剤
CN1283462A (zh) 黄芪甲苷在制备药物组合物中的应用
KR102414649B1 (ko) 에리스로포이에틴-유래된 펩타이드, 이의 제조 방법 및 이의 용도
CN101292987B (zh) 药物组合物
KR100458131B1 (ko) 신경보호작용을 갖는 가시오가피 추출물 및 이를 함유하는약학적 제제
CN109771416B (zh) 14-脱氧-11,12-脱氢-7,8-烯-穿心莲内酯及15-亚基取代衍生物的用途
CN102085206A (zh) 药物组合物
CN100422189C (zh) 塔斯品碱的制备方法以及在制备治疗肿瘤药物中的应用
CN100393704C (zh) 红毛新碱b化合物及其用于制备抗心肌缺血药物的用途
CN115192587B (zh) 一种枸杞子寡糖的新用途
CN115624560B (zh) 一种治疗慢性肾功能衰竭的中药有效成分复方及其应用
CN100453113C (zh) 一种治疗皮肤癌的中药外用透皮制剂
CN102973564A (zh) 治疗乙型肝炎的药物及其组合物
CN101584702B (zh) 白背叶提取物制备方法以及抗乙肝病毒的用途
CN101732605A (zh) 一种白茅根提取物的用途及制备方法
CN107334765B (zh) 一种治疗癌症的药物组合物及其用途

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired