JP6076737B2 - 高血圧症の防止及び治療のための組成物並びに方法 - Google Patents

高血圧症の防止及び治療のための組成物並びに方法 Download PDF

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JP6076737B2
JP6076737B2 JP2012514549A JP2012514549A JP6076737B2 JP 6076737 B2 JP6076737 B2 JP 6076737B2 JP 2012514549 A JP2012514549 A JP 2012514549A JP 2012514549 A JP2012514549 A JP 2012514549A JP 6076737 B2 JP6076737 B2 JP 6076737B2
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hypertension
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blood pressure
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JP2012529484A5 (ja
JP2012529484A (ja
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リ ミン
ミン リ
ペン ペン
ペン ペン
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ジェネレックス ファーマシューティカルズ インコーポレイテッド
ジェネレックス ファーマシューティカルズ インコーポレイテッド
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61P9/12Antihypertensives
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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JP2012514549A 2009-06-12 2010-06-11 高血圧症の防止及び治療のための組成物並びに方法 Expired - Fee Related JP6076737B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18670909P 2009-06-12 2009-06-12
US61/186,709 2009-06-12
US18790509P 2009-06-17 2009-06-17
US61/187,905 2009-06-17
PCT/IB2010/001412 WO2010143059A1 (en) 2009-06-12 2010-06-11 Compositioins and preparation methods of compositions for prevention and treatment of hypertension

Related Child Applications (1)

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JP2015126332A Division JP2015164966A (ja) 2009-06-12 2015-06-24 高血圧症の防止及び治療のための組成物並びに方法

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JP2012529484A JP2012529484A (ja) 2012-11-22
JP2012529484A5 JP2012529484A5 (ja) 2013-07-18
JP6076737B2 true JP6076737B2 (ja) 2017-02-08

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Application Number Title Priority Date Filing Date
JP2012514549A Expired - Fee Related JP6076737B2 (ja) 2009-06-12 2010-06-11 高血圧症の防止及び治療のための組成物並びに方法
JP2012514550A Expired - Fee Related JP5892928B2 (ja) 2009-06-12 2010-06-11 赤血球凝固の予防及び治療のための組成物並びに方法
JP2012514548A Expired - Fee Related JP5689117B2 (ja) 2009-06-12 2010-06-11 心不全を防止及び治療するための組成物及び方法
JP2012514554A Expired - Fee Related JP5892929B2 (ja) 2009-06-12 2010-06-11 生存期間及び健康寿命を増加させるための組成物及び方法
JP2012514552A Expired - Fee Related JP5712207B2 (ja) 2009-06-12 2010-06-11 脳疾患及び状態の予防及び治療のための組成物及び方法
JP2012514551A Expired - Fee Related JP5827618B2 (ja) 2009-06-12 2010-06-11 冠動脈性心疾患の予防及び治療のための組成物及び方法
JP2015111092A Pending JP2015155468A (ja) 2009-06-12 2015-06-01 赤血球凝固の予防及び治療のための組成物並びに方法
JP2015124801A Pending JP2015164963A (ja) 2009-06-12 2015-06-22 冠動脈性心疾患の予防及び治療のための組成物及び方法
JP2015126506A Expired - Fee Related JP6187831B2 (ja) 2009-06-12 2015-06-24 生存期間及び健康寿命を増加させるための組成物及び方法
JP2015126332A Pending JP2015164966A (ja) 2009-06-12 2015-06-24 高血圧症の防止及び治療のための組成物並びに方法
JP2017090148A Withdrawn JP2017128608A (ja) 2009-06-12 2017-04-28 生存期間及び健康寿命を増加させるための組成物及び方法

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JP2012514550A Expired - Fee Related JP5892928B2 (ja) 2009-06-12 2010-06-11 赤血球凝固の予防及び治療のための組成物並びに方法
JP2012514548A Expired - Fee Related JP5689117B2 (ja) 2009-06-12 2010-06-11 心不全を防止及び治療するための組成物及び方法
JP2012514554A Expired - Fee Related JP5892929B2 (ja) 2009-06-12 2010-06-11 生存期間及び健康寿命を増加させるための組成物及び方法
JP2012514552A Expired - Fee Related JP5712207B2 (ja) 2009-06-12 2010-06-11 脳疾患及び状態の予防及び治療のための組成物及び方法
JP2012514551A Expired - Fee Related JP5827618B2 (ja) 2009-06-12 2010-06-11 冠動脈性心疾患の予防及び治療のための組成物及び方法
JP2015111092A Pending JP2015155468A (ja) 2009-06-12 2015-06-01 赤血球凝固の予防及び治療のための組成物並びに方法
JP2015124801A Pending JP2015164963A (ja) 2009-06-12 2015-06-22 冠動脈性心疾患の予防及び治療のための組成物及び方法
JP2015126506A Expired - Fee Related JP6187831B2 (ja) 2009-06-12 2015-06-24 生存期間及び健康寿命を増加させるための組成物及び方法
JP2015126332A Pending JP2015164966A (ja) 2009-06-12 2015-06-24 高血圧症の防止及び治療のための組成物並びに方法
JP2017090148A Withdrawn JP2017128608A (ja) 2009-06-12 2017-04-28 生存期間及び健康寿命を増加させるための組成物及び方法

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US (7) US9629884B2 (enExample)
EP (6) EP2440222A4 (enExample)
JP (11) JP6076737B2 (enExample)
CN (6) CN102573865B (enExample)
AU (11) AU2010258356B2 (enExample)
WO (6) WO2010143059A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12397008B2 (en) * 2006-04-13 2025-08-26 Lead Billion Limited Pharmaceutical composition and method for regenerating myofibers in the treatment of muscle injuries
CN102573865B (zh) 2009-06-12 2016-08-24 基因雷克斯制药有限公司 用于预防和治疗红细胞聚集的组合物
EP2655390B1 (en) * 2010-12-23 2019-03-27 Huya Bioscience International LLC Purified cardiogenin isomer and related methods
JP6000521B2 (ja) * 2011-08-10 2016-09-28 株式会社ブルボン 血圧上昇抑制剤
US10047034B2 (en) * 2012-05-16 2018-08-14 Prairie Berry Europe Gmbh Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors
US20140044813A1 (en) * 2012-08-09 2014-02-13 Kemin Industries, Inc. Plant Extracts for Improving Cognitive Health and Function
CN103623753B (zh) * 2013-11-27 2016-03-23 大兴安岭嘉迪欧营养原料有限公司 大兴安岭野生金老梅总三萜提取物的制备方法
CN106074560A (zh) * 2013-11-29 2016-11-09 江西中医药大学 覆盆子提取物的应用
US20150174057A1 (en) * 2013-12-24 2015-06-25 Generex Pharamaceutics Inc. Compositions and methods for the prevention and treatment of oral diseases
KR20160113277A (ko) * 2014-01-30 2016-09-28 케민 인더스트리즈, 인코포레이티드 인지 기능을 개선시키기 위한 식물 추출물
CN105311030B (zh) * 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN104971091B (zh) * 2015-06-03 2019-08-13 兴明生物医药技术(上海)有限公司 一种用于制备促进心肌再生药物的提取物的制备方法及其应用
US12121339B2 (en) 2015-07-24 2024-10-22 Northeastern University Quantitative magnetic resonance imaging of the vasculature
MX390131B (es) * 2015-09-04 2025-03-19 Reto Asmis Método para el tratamiento de la disfunción de monocitos y enfermedades microvasculares y macrovasculares inflamatorias crónicas.
CN105106222B (zh) * 2015-09-14 2020-05-08 新乡医学院 吐曼酸在制备治疗或预防雌激素缺乏引起的阿尔茨海默病药物中的应用
CN106581006B (zh) * 2015-10-16 2019-11-29 香港理工大学深圳研究院 三萜类化合物在制备治疗帕金森药物中的应用
CN106153761B (zh) * 2016-06-07 2018-08-14 贵州师范大学 同时检测无籽刺梨果实中3种黄酮类成分的方法
EP3471623B1 (en) * 2016-06-20 2023-01-25 Butterfly Network, Inc. Automated image acquisition for assisting a user to operate an ultrasound device
WO2018085330A1 (en) 2016-11-02 2018-05-11 Temple University Of The Commonwealth System Of Higher Education Systems and methods for reducing the viscosity of blood, suppressing turbulence in blood circulation, and curing rouleaux
KR20250067961A (ko) * 2017-04-25 2025-05-15 버크 인스티튜트 포 리서치 온 에이징 수명 및 건강수명을 연장시키기 위한 제제
CN106946971A (zh) * 2017-04-28 2017-07-14 南宁馨艺荣生物科技有限公司 一种从积雪草中提取积雪草酸的工艺
CN107445855B (zh) * 2017-08-07 2018-12-14 绍兴市逸晨医疗科技有限公司 一种盐酸多西环素杂质c的制备方法
WO2019172174A1 (ja) * 2018-03-05 2019-09-12 日本新薬株式会社 Rageシグナル阻害作用をもつ食品素材
MX2020009237A (es) * 2018-03-06 2021-04-28 Epibone Inc Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso.
US20210298662A1 (en) * 2018-07-27 2021-09-30 Northeastern University Diagnosis of Dementia by Vascular Magnetic Resonance Imaging
KR102152182B1 (ko) * 2018-09-05 2020-09-04 한국식품연구원 큰뱀무 추출물을 유효성분으로 함유하는 우울 증상 또는 스트레스의 개선, 예방 또는 치료용 조성물
CN112955139B (zh) 2018-09-25 2025-04-18 庞塞迪利昂健康特定活动公司 用于制备α-酮戊二酸钙的方法
CA3122590A1 (en) 2018-12-21 2020-06-25 Arlanxeo Singapore Pte. Ltd. Continuous process for producing halogenated isoolefin copolymer
CN109884222B (zh) * 2019-01-17 2021-07-13 贵州中医药大学 一种小花清风藤的hplc指纹图谱建立方法
KR102152174B1 (ko) * 2020-03-30 2020-09-04 한국식품연구원 큰뱀무 추출물을 유효성분으로 함유하는 인지기능 장애의 개선, 예방 또는 치료용 조성물
CN111643556A (zh) * 2020-07-16 2020-09-11 杭州科倍安生物制药有限公司 一种用于预防和治疗痔疮的药物及其应用
WO2022043407A1 (fr) 2020-08-25 2022-03-03 Laouarem Yousra Compositions destinées au traitement des troubles neurologiques
KR102574207B1 (ko) * 2020-12-03 2023-09-04 경북대학교 산학협력단 뱀무 추출물을 유효성분으로 하는 혈전성 질환 치료 또는 예방용 조성물
CN112587599A (zh) * 2021-01-11 2021-04-02 贵州中医药大学 一种预防急性高原反应的中药组合物
CN112755079A (zh) * 2021-01-18 2021-05-07 杭州科倍安生物制药有限公司 一种预防血栓形成或溶解已形成血栓的药物及其制备方法
CN113367166B (zh) * 2021-05-13 2022-07-26 海南大学 一种褐背蒲桃提取物杀菌剂及其制备方法和应用
CN114028459A (zh) * 2021-11-11 2022-02-11 杭州科贝生物制药有限公司 预防和治疗哺乳动物缺血性心脏病的药物和制备方法及应用
CN114722066B (zh) * 2022-03-23 2023-04-07 电子科技大学 一种预测材料自旋霍尔电导及反常霍尔电导的方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JP2871763B2 (ja) * 1989-12-15 1999-03-17 株式会社資生堂 テストステロン―5α―レダクターゼ阻害剤
CN1069629A (zh) 1991-08-27 1993-03-10 段民生 一种康复面的制备方法
CN1047089C (zh) * 1992-12-03 1999-12-08 张斌 治疗近视眼的药物及制备工艺
JPH07179347A (ja) * 1993-12-21 1995-07-18 Showa Shell Sekiyu Kk 抗ウイルス組成物
CN1102993A (zh) 1993-12-21 1995-05-31 吴文才 多酶体系加工中草药的制剂方法
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
CA2289531C (en) * 1997-05-15 2009-09-29 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
CN1176814A (zh) 1997-06-26 1998-03-25 李静 预防和治疗脑血管病的口服液
CN1102399C (zh) * 2000-06-09 2003-03-05 张庆玉 降脂通脉胶囊
AU2001278341A1 (en) * 2000-07-26 2002-02-05 Vitaplant Ag Piper methysticum plant extract
AU2001283038A1 (en) 2000-07-31 2002-02-13 University Of Virginia Patent Foundation Inhibitors of dna polymerase sigma
US6629835B2 (en) 2000-08-01 2003-10-07 Metaproteomics, Llc Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2
JP2002255804A (ja) 2001-03-02 2002-09-11 Suntory Ltd インシュリン様作用を有するヘキサオキシジフェン酸誘導体を含んでなる組成物
JPWO2002078468A1 (ja) 2001-03-30 2004-08-19 日清オイリオ株式会社 血管障害疾患用飲食物
KR100453569B1 (ko) * 2001-09-11 2004-10-20 대한민국 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는항산화제
JP2003201229A (ja) 2001-10-23 2003-07-18 Shiseido Co Ltd マトリックスメタロプロテアーゼ活性阻害剤および抗老化用化粧料
DE60143132D1 (de) 2001-11-21 2010-11-04 Univ Hong Kong Chinese Zusammensetzungen aus organischen extrakten von geum japonicum thunb var. und ihre verwendung
JP4393777B2 (ja) 2002-03-19 2010-01-06 株式会社ファンケル 抗ヘリコバクター・ピロリ用組成物
AU2002350380B2 (en) * 2002-12-10 2006-11-16 Lead Billion Limited An organic extract of Geum Japonicum thumb variant and use thereof
CN1239155C (zh) 2003-01-23 2006-02-01 北京中医药大学 一种治疗缺血性脑中风的药物组合物及其制备方法
US20040247698A1 (en) 2003-06-04 2004-12-09 Valenzuela Cortes Carmen Maria Erectile Dysfunction Treatment
WO2005034958A1 (en) 2003-10-10 2005-04-21 Sk Chemicals, Co., Ltd. Triterpene compounds which are effective on improvement of brain function
CN1185007C (zh) 2003-12-08 2005-01-19 张小朋 降脂溶栓药物
CN100509008C (zh) * 2004-04-12 2009-07-08 赵晓昂 舒痛方及其制剂和用途
WO2006054370A1 (en) 2004-11-16 2006-05-26 Use-Techno Corporation Gluconeogenesis inhibiting agent
KR100704003B1 (ko) * 2005-06-10 2007-04-06 안동대학교 산학협력단 2-알파-하이드록시-올레아놀산을 함유하는 트롬빈 저해혈전증 예방 및 치료용 조성물
JP2006347967A (ja) 2005-06-16 2006-12-28 Yuusu Techno Corporation:Kk 血糖値上昇抑制剤
EP1848445B1 (en) 2005-10-27 2015-04-01 Lead Billion Limited Pharmaceutical composition and method for neoangiogenesis/revascularization useful in treating ischemic heart diseases
WO2007049089A1 (en) 2005-10-27 2007-05-03 Lead Billion Limited Method of stimulating growth of functional blood vessels and/or regeneration of myocardium in damaged tissues
WO2007049088A1 (en) 2005-10-27 2007-05-03 Lead Billion Limited Method of stimulating growth of functional blood vessels and/or regeneration of myocardium in damaged tissues
KR100718602B1 (ko) 2005-12-29 2007-06-21 대한민국 항비만 및 항염증 효과를 가지는 뱀무 추출물, 이를포함하는 식품 조성물 및 이들의 제조 방법
JP2007204447A (ja) 2006-02-03 2007-08-16 Yoshihiro Futamura 中性脂肪減少作用を呈するカルニチン誘導体、それからなる抗肥満薬、食品製剤及びセルライト減少作用を呈する化粧品
JP4731350B2 (ja) 2006-02-17 2011-07-20 丸善製薬株式会社 抗老化剤、皮膚化粧料及び美容用飲食品
MY162067A (en) * 2006-03-16 2017-05-31 Moleac Pte Ltd Combination therapy for treatment of patients with neurological disorders and cerebral infarction
CN1857627B (zh) * 2006-04-12 2010-05-19 贵阳利多药物技术开发有限公司 治疗中风的中药制剂及其制备方法
US8821947B2 (en) 2006-06-01 2014-09-02 Howard W. Selby, III Cholesterol-reducing diet
CN101091751A (zh) 2006-06-22 2007-12-26 北京中医药大学 一种治疗高血压的中药组合物及其制备方法
JP5281234B2 (ja) 2006-06-27 2013-09-04 ポーラ化成工業株式会社 毛様体過緊張による疲れ目の改善・予防のための経口投与組成物
CN100528195C (zh) * 2006-06-28 2009-08-19 海南晨菲药业有限公司 一种大青根注射剂制备工艺
CN101099770A (zh) 2006-07-04 2008-01-09 北京中医药大学 一种具有咪唑啉受体激动活性的药物组合物及制备方法和应用
JP2008074801A (ja) * 2006-09-25 2008-04-03 Oriza Yuka Kk 肝保護剤
JP5366358B2 (ja) * 2006-09-29 2013-12-11 株式会社コーセー 皮膚の老化機構に作用する剤、抗老化用皮膚外用剤、及び抗老化方法
CN101040901A (zh) 2007-04-12 2007-09-26 云南龙润药业有限公司 迷迭香提取物及其制备方法和应用
US9205112B2 (en) * 2007-04-23 2015-12-08 Creative Medical Health, Inc. Combination treatment of cardiovascular disease
US20100189830A1 (en) 2007-05-21 2010-07-29 Zhijun Liu Sweet Gum Fruit Extract as a Therapeutic Agent
US20090022827A1 (en) 2007-07-19 2009-01-22 Ming Li Agent and method for eliminating malignance of cancer cells without harmful effect to normal cells
CN101125171B (zh) * 2007-08-20 2010-05-26 刘凤元 一种男、女补强中药
KR100891881B1 (ko) * 2007-08-23 2009-04-07 대한민국 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는고지혈증 및 mmp 과다활성으로 인한 혈관질환 예방 및치료용 조성물
CN101406537B (zh) 2007-10-11 2013-05-15 首都医科大学 柔毛水杨梅提取物用于制备治疗肥胖的药物的用途
CN101274012B (zh) 2008-01-23 2011-12-28 上海海天医药科技开发有限公司 夏枯草属植物提取物的组合物、制备方法及其药物用途
CN102573865B (zh) 2009-06-12 2016-08-24 基因雷克斯制药有限公司 用于预防和治疗红细胞聚集的组合物

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