AR072104A1 - Fosfatos ciclicos de nucleosidos, composiciones farmaceuticas, su uso en el tratamiento de enfermedades virales y procedimiento de preparacion de los mismos - Google Patents

Fosfatos ciclicos de nucleosidos, composiciones farmaceuticas, su uso en el tratamiento de enfermedades virales y procedimiento de preparacion de los mismos

Info

Publication number
AR072104A1
AR072104A1 ARP090102112A ARP090102112A AR072104A1 AR 072104 A1 AR072104 A1 AR 072104A1 AR P090102112 A ARP090102112 A AR P090102112A AR P090102112 A ARP090102112 A AR P090102112A AR 072104 A1 AR072104 A1 AR 072104A1
Authority
AR
Argentina
Prior art keywords
halogenated
alkyl
optionally substituted
nhr
alkynyl
Prior art date
Application number
ARP090102112A
Other languages
English (en)
Spanish (es)
Inventor
Bruce Ross
Ganapati Reddy Pamulapati
Jinfa Du
Dhanapalan Nagarathnam
Michael Joseph Sofia
Original Assignee
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Inc filed Critical Pharmasset Inc
Publication of AR072104A1 publication Critical patent/AR072104A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ARP090102112A 2008-06-11 2009-06-11 Fosfatos ciclicos de nucleosidos, composiciones farmaceuticas, su uso en el tratamiento de enfermedades virales y procedimiento de preparacion de los mismos AR072104A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6068308P 2008-06-11 2008-06-11
US14036908P 2008-12-23 2008-12-23
US12/479,075 US8173621B2 (en) 2008-06-11 2009-06-05 Nucleoside cyclicphosphates

Publications (1)

Publication Number Publication Date
AR072104A1 true AR072104A1 (es) 2010-08-04

Family

ID=40974681

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102112A AR072104A1 (es) 2008-06-11 2009-06-11 Fosfatos ciclicos de nucleosidos, composiciones farmaceuticas, su uso en el tratamiento de enfermedades virales y procedimiento de preparacion de los mismos

Country Status (19)

Country Link
US (2) US8173621B2 (OSRAM)
EP (1) EP2313422B1 (OSRAM)
JP (2) JP5749160B2 (OSRAM)
KR (2) KR101682494B1 (OSRAM)
CN (1) CN102119167A (OSRAM)
AR (1) AR072104A1 (OSRAM)
AU (1) AU2009257647C1 (OSRAM)
BR (1) BRPI0915484A2 (OSRAM)
CA (1) CA2727495C (OSRAM)
CL (1) CL2010001407A1 (OSRAM)
CO (1) CO6321272A2 (OSRAM)
ES (1) ES2536727T3 (OSRAM)
IL (1) IL209916A (OSRAM)
MX (1) MX2010013768A (OSRAM)
PT (1) PT2313422E (OSRAM)
TW (1) TW201002733A (OSRAM)
UY (1) UY31892A (OSRAM)
WO (1) WO2009152095A2 (OSRAM)
ZA (1) ZA201008829B (OSRAM)

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