IT1155446B - Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine - Google Patents

Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Info

Publication number
IT1155446B
IT1155446B IT24939/82A IT2493982A IT1155446B IT 1155446 B IT1155446 B IT 1155446B IT 24939/82 A IT24939/82 A IT 24939/82A IT 2493982 A IT2493982 A IT 2493982A IT 1155446 B IT1155446 B IT 1155446B
Authority
IT
Italy
Prior art keywords
anthracyclinonic
adsobment
glucosides
resins
selective
Prior art date
Application number
IT24939/82A
Other languages
English (en)
Other versions
IT8224939A0 (it
Inventor
Ernesto Oppici
Carlo Varesio
Onorino Giacomarosa
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of IT8224939A0 publication Critical patent/IT8224939A0/it
Priority to IT24939/82A priority Critical patent/IT1155446B/it
Priority to DE3345445A priority patent/DE3345445C2/de
Priority to AU22455/83A priority patent/AU570935B2/en
Priority to NL8304327A priority patent/NL193108C/nl
Priority to SU833674607A priority patent/SU1440350A3/ru
Priority to GB08333511A priority patent/GB2133005B/en
Priority to AT0440083A priority patent/AT383601B/de
Priority to CA000443557A priority patent/CA1204738A/en
Priority to NZ206605A priority patent/NZ206605A/en
Priority to FI834650A priority patent/FI834650A/fi
Priority to YU02471/83A priority patent/YU247183A/xx
Priority to ES528226A priority patent/ES528226A0/es
Priority to FR8320378A priority patent/FR2538394B1/fr
Priority to IL70500A priority patent/IL70500A/xx
Priority to BE0/212079A priority patent/BE898506A/fr
Priority to GR73292A priority patent/GR79135B/el
Priority to CH6767/83A priority patent/CH657623A5/it
Priority to HU834427A priority patent/HU197917B/hu
Priority to ZA839564A priority patent/ZA839564B/xx
Priority to SE8307134A priority patent/SE8307134L/xx
Priority to NO834765A priority patent/NO834765L/no
Priority to KR1019830006090A priority patent/KR900008743B1/ko
Priority to PT77883A priority patent/PT77883B/pt
Priority to DK594083A priority patent/DK594083A/da
Priority to CS839802A priority patent/CS258114B2/cs
Priority to JP58241118A priority patent/JPS59118797A/ja
Priority to IE3060/83A priority patent/IE56678B1/en
Priority to SU874028799A priority patent/SU1450747A3/ru
Priority to SU874028798A priority patent/SU1447287A3/ru
Priority to SU874028832A priority patent/SU1470197A3/ru
Priority to SU874028823A priority patent/SU1450748A3/ru
Priority to SU874028858A priority patent/SU1575943A3/ru
Application granted granted Critical
Publication of IT1155446B publication Critical patent/IT1155446B/it
Priority to US07/009,550 priority patent/US4861870A/en
Priority to SG345/87A priority patent/SG34587G/en
Priority to HK748/87A priority patent/HK74887A/xx
Priority to KR1019910014922A priority patent/KR920000102B1/ko
Priority to JP6296499A priority patent/JP2749272B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
IT24939/82A 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine IT1155446B (it)

Priority Applications (37)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
DE3345445A DE3345445C2 (de) 1982-12-23 1983-12-15 Verfahren zur Reinigung von 4-Demethoxy-daunorubicin und 4-Demethoxy-doxorubicin durch selektive Adsorption an Harzen
AU22455/83A AU570935B2 (en) 1982-12-23 1983-12-15 Purification of anthracyclinonic gylcosides by selective adsorption on resins
NL8304327A NL193108C (nl) 1982-12-23 1983-12-15 Werkwijze voor het zuiveren van een anthracyclinon-glycoside.
SU833674607A SU1440350A3 (ru) 1982-12-23 1983-12-16 Способ очистки 4Ъ-эпидоксорубицина
GB08333511A GB2133005B (en) 1982-12-23 1983-12-16 Purification of anthracycline glycosides
AT0440083A AT383601B (de) 1982-12-23 1983-12-16 Verfahren zur reinigung von rohem daunorubicin, doxorubicin und deren analoga
CA000443557A CA1204738A (en) 1982-12-23 1983-12-16 Process for purifying anthracyclinonic glycosides by selective adsorption on resins
NZ206605A NZ206605A (en) 1982-12-23 1983-12-16 Purifying anthracyclinonic glycosides
FI834650A FI834650A (fi) 1982-12-23 1983-12-16 Foerfarande foer renande av antracyklinoniska glykosider medelst selektiv adsorption vid hartser.
YU02471/83A YU247183A (en) 1982-12-23 1983-12-20 Process for the purification of anthracyclone glycosides by means of selective adsorption on resins
ES528226A ES528226A0 (es) 1982-12-23 1983-12-20 Un procedimiento de purificacion de glicosidos antraciclinonicos
FR8320378A FR2538394B1 (fr) 1982-12-23 1983-12-20 Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines
IL70500A IL70500A (en) 1982-12-23 1983-12-20 Process for purifying anthracycline glycosides by selective adsorption on resins
BE0/212079A BE898506A (fr) 1982-12-23 1983-12-20 Procédé pour la purification de glycosides anthracyclinoniques par adsorption sélective sur des résines.
GR73292A GR79135B (it) 1982-12-23 1983-12-20
CH6767/83A CH657623A5 (it) 1982-12-23 1983-12-20 Procedimento per purificare glucosidi antraciclinonici.
ZA839564A ZA839564B (en) 1982-12-23 1983-12-22 A process for purifying anthracyclinonic glycosides by selective adsorption on resins
HU834427A HU197917B (en) 1982-12-23 1983-12-22 Process for cleaning glycosides with anthracyclinone skeleton by selective adsorption on resins
SE8307134A SE8307134L (sv) 1982-12-23 1983-12-22 Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser
NO834765A NO834765L (no) 1982-12-23 1983-12-22 Fremgangsmaate for rensing av antra-cyclinon-glukosider ved adsorpsjon paa harpikser
KR1019830006090A KR900008743B1 (ko) 1982-12-23 1983-12-22 안트라시클리논 글리코시드의 정제방법
PT77883A PT77883B (en) 1982-12-23 1983-12-22 Process for purifying anthracyclinonic glycosides by selective adsorption on resins
DK594083A DK594083A (da) 1982-12-23 1983-12-22 Fremgangsmaade til rensning af anthracyclinone glycosider ved selektiv adsorption paa harpikser
CS839802A CS258114B2 (en) 1982-12-23 1983-12-22 Method of raw anthracycline glycosides purification
JP58241118A JPS59118797A (ja) 1982-12-23 1983-12-22 アントラサイクリノングリコシドの精製法
IE3060/83A IE56678B1 (en) 1982-12-23 1983-12-23 Purification of anthracycline glycosides
SU874028798A SU1447287A3 (ru) 1982-12-23 1987-01-14 Способ очистки даунорубицина гидрохлорида
SU874028799A SU1450747A3 (ru) 1982-12-23 1987-01-14 Способ очистки сырого 4-деметоксидоксорубицина
SU874028832A SU1470197A3 (ru) 1982-12-23 1987-01-20 Способ очистки сырого доксорубицина
SU874028823A SU1450748A3 (ru) 1982-12-23 1987-01-20 Способ очистки сырого 4-деметоксидаунорубицина
SU874028858A SU1575943A3 (ru) 1982-12-23 1987-01-23 Способ очистки 4 @ -дезоксидоксорубицина
US07/009,550 US4861870A (en) 1982-12-23 1987-02-02 Process for purifying anthracyclinone glycosides by selective adsorption on resins
SG345/87A SG34587G (en) 1982-12-23 1987-04-14 Purification of anthracycline glycosides
HK748/87A HK74887A (en) 1982-12-23 1987-10-15 Purification of anthracycline glycosides
KR1019910014922A KR920000102B1 (ko) 1982-12-23 1991-08-23 안트라시클리논 글리코시드의 정제방법
JP6296499A JP2749272B2 (ja) 1982-12-23 1994-11-30 アントラサイクリノングリコシドの精製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (2)

Publication Number Publication Date
IT8224939A0 IT8224939A0 (it) 1982-12-23
IT1155446B true IT1155446B (it) 1987-01-28

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Country Status (30)

Country Link
US (1) US4861870A (it)
JP (2) JPS59118797A (it)
KR (1) KR900008743B1 (it)
AT (1) AT383601B (it)
AU (1) AU570935B2 (it)
BE (1) BE898506A (it)
CA (1) CA1204738A (it)
CH (1) CH657623A5 (it)
CS (1) CS258114B2 (it)
DE (1) DE3345445C2 (it)
DK (1) DK594083A (it)
ES (1) ES528226A0 (it)
FI (1) FI834650A (it)
FR (1) FR2538394B1 (it)
GB (1) GB2133005B (it)
GR (1) GR79135B (it)
HK (1) HK74887A (it)
HU (1) HU197917B (it)
IE (1) IE56678B1 (it)
IL (1) IL70500A (it)
IT (1) IT1155446B (it)
NL (1) NL193108C (it)
NO (1) NO834765L (it)
NZ (1) NZ206605A (it)
PT (1) PT77883B (it)
SE (1) SE8307134L (it)
SG (1) SG34587G (it)
SU (6) SU1440350A3 (it)
YU (1) YU247183A (it)
ZA (1) ZA839564B (it)

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US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
CA2301654C (en) 1997-08-28 2008-02-26 Mercian Corporation Method of purifying daunomycin
ES2356284T3 (es) 1997-12-05 2011-04-06 Mercian Corporation Antibiótico de antraciclina cristalino y procedimiento para su producción.
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
EP1122260B1 (en) * 1998-10-16 2004-12-15 Mercian Corporation Crystallization of doxorubicin hydrochloride
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US20050059156A1 (en) * 2003-08-06 2005-03-17 Pharmacia Italia S.P.A. Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
EP1976858B1 (en) * 2005-12-13 2016-01-06 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
PL2301943T3 (pl) 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
CN108350015A (zh) * 2015-11-05 2018-07-31 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

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Also Published As

Publication number Publication date
DK594083D0 (da) 1983-12-22
DE3345445C2 (de) 1995-09-21
NL8304327A (nl) 1984-07-16
FI834650A0 (fi) 1983-12-16
CA1204738A (en) 1986-05-20
ATA440083A (de) 1986-12-15
NO834765L (no) 1984-06-25
IL70500A0 (en) 1984-03-30
SU1450748A3 (ru) 1989-01-07
JPH07252291A (ja) 1995-10-03
ES8504758A1 (es) 1985-05-01
NL193108B (nl) 1998-07-01
NL193108C (nl) 1998-11-03
US4861870A (en) 1989-08-29
FI834650A (fi) 1984-06-24
AU2245583A (en) 1984-06-28
HUT35270A (en) 1985-06-28
SU1470197A3 (ru) 1989-03-30
SE8307134L (sv) 1984-06-24
JP2749272B2 (ja) 1998-05-13
JPH0439476B2 (it) 1992-06-29
IE56678B1 (en) 1991-11-06
CS980283A2 (en) 1987-12-17
SG34587G (en) 1988-03-04
IE833060L (en) 1984-06-23
AU570935B2 (en) 1988-03-31
GR79135B (it) 1984-10-02
GB8333511D0 (en) 1984-01-25
GB2133005A (en) 1984-07-18
FR2538394B1 (fr) 1986-03-28
NZ206605A (en) 1987-02-20
KR900008743B1 (ko) 1990-11-29
SE8307134D0 (sv) 1983-12-22
SU1447287A3 (ru) 1988-12-23
IL70500A (en) 1990-07-12
PT77883B (en) 1986-04-09
CS258114B2 (en) 1988-07-15
FR2538394A1 (fr) 1984-06-29
DK594083A (da) 1984-06-24
SU1575943A3 (ru) 1990-06-30
ES528226A0 (es) 1985-05-01
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
HK74887A (en) 1987-10-23
BE898506A (fr) 1984-04-16
HU197917B (en) 1989-06-28
AT383601B (de) 1987-07-27
SU1440350A3 (ru) 1988-11-23
ZA839564B (en) 1984-08-29
CH657623A5 (it) 1986-09-15
GB2133005B (en) 1986-04-30
IT8224939A0 (it) 1982-12-23
KR840007438A (ko) 1984-12-07
SU1450747A3 (ru) 1989-01-07
YU247183A (en) 1985-10-31
DE3345445A1 (de) 1984-06-28

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