FR2538394B1 - Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines - Google Patents

Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines

Info

Publication number
FR2538394B1
FR2538394B1 FR8320378A FR8320378A FR2538394B1 FR 2538394 B1 FR2538394 B1 FR 2538394B1 FR 8320378 A FR8320378 A FR 8320378A FR 8320378 A FR8320378 A FR 8320378A FR 2538394 B1 FR2538394 B1 FR 2538394B1
Authority
FR
France
Prior art keywords
anthracyclinonic
glycosides
resins
purification
selective adsorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8320378A
Other languages
English (en)
Other versions
FR2538394A1 (fr
Inventor
Ernesto Oppici
Carlo Varesio
Onorino Giacoma Rosa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2538394A1 publication Critical patent/FR2538394A1/fr
Application granted granted Critical
Publication of FR2538394B1 publication Critical patent/FR2538394B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
FR8320378A 1982-12-23 1983-12-20 Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines Expired FR2538394B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (2)

Publication Number Publication Date
FR2538394A1 FR2538394A1 (fr) 1984-06-29
FR2538394B1 true FR2538394B1 (fr) 1986-03-28

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8320378A Expired FR2538394B1 (fr) 1982-12-23 1983-12-20 Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines

Country Status (30)

Country Link
US (1) US4861870A (fr)
JP (2) JPS59118797A (fr)
KR (1) KR900008743B1 (fr)
AT (1) AT383601B (fr)
AU (1) AU570935B2 (fr)
BE (1) BE898506A (fr)
CA (1) CA1204738A (fr)
CH (1) CH657623A5 (fr)
CS (1) CS258114B2 (fr)
DE (1) DE3345445C2 (fr)
DK (1) DK594083A (fr)
ES (1) ES528226A0 (fr)
FI (1) FI834650A (fr)
FR (1) FR2538394B1 (fr)
GB (1) GB2133005B (fr)
GR (1) GR79135B (fr)
HK (1) HK74887A (fr)
HU (1) HU197917B (fr)
IE (1) IE56678B1 (fr)
IL (1) IL70500A (fr)
IT (1) IT1155446B (fr)
NL (1) NL193108C (fr)
NO (1) NO834765L (fr)
NZ (1) NZ206605A (fr)
PT (1) PT77883B (fr)
SE (1) SE8307134L (fr)
SG (1) SG34587G (fr)
SU (6) SU1440350A3 (fr)
YU (1) YU247183A (fr)
ZA (1) ZA839564B (fr)

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US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
CA2301654C (fr) 1997-08-28 2008-02-26 Mercian Corporation Procede de purification de daunomycine
EP1036797B1 (fr) 1997-12-05 2010-11-17 Mercian Corporation Anthracycline cristalline antibiotique et son procede de production
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
ES2235518T3 (es) * 1998-10-16 2005-07-01 Mercian Corporation Cristalizacion de hidrocloruro de doxorubicina.
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
DE04777189T1 (de) * 2003-07-02 2011-04-07 Solux Corporation, San Diego Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
CA2748034A1 (fr) 2008-12-23 2010-07-01 Pharmasset, Inc. Promedicaments de 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate purifie destines au traitement d'infections virales
EP2636676A3 (fr) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Cristallisation dýépidaunorubicine x HCI
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (fr) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Monohydrate cristallin d'hydrochlorure d'épirubicine
WO2017075994A1 (fr) * 2015-11-05 2017-05-11 浙江海正药业股份有限公司 Procédé de séparation et de purification d'épirubicine ou son chlorhydrate

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (fr) *
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (fr) * 1968-11-18 1970-05-25
JPS4944347A (fr) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (fr) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
HU197917B (en) 1989-06-28
SE8307134D0 (sv) 1983-12-22
GR79135B (fr) 1984-10-02
FI834650A (fi) 1984-06-24
KR840007438A (ko) 1984-12-07
ES8504758A1 (es) 1985-05-01
US4861870A (en) 1989-08-29
DK594083D0 (da) 1983-12-22
IL70500A (en) 1990-07-12
DK594083A (da) 1984-06-24
ES528226A0 (es) 1985-05-01
CH657623A5 (it) 1986-09-15
NZ206605A (en) 1987-02-20
NO834765L (no) 1984-06-25
GB8333511D0 (en) 1984-01-25
NL8304327A (nl) 1984-07-16
CA1204738A (fr) 1986-05-20
DE3345445A1 (de) 1984-06-28
SU1575943A3 (ru) 1990-06-30
SG34587G (en) 1988-03-04
CS980283A2 (en) 1987-12-17
JPH0439476B2 (fr) 1992-06-29
HK74887A (en) 1987-10-23
FI834650A0 (fi) 1983-12-16
JPH07252291A (ja) 1995-10-03
ZA839564B (en) 1984-08-29
AU2245583A (en) 1984-06-28
IT1155446B (it) 1987-01-28
NL193108B (nl) 1998-07-01
IL70500A0 (en) 1984-03-30
KR900008743B1 (ko) 1990-11-29
JP2749272B2 (ja) 1998-05-13
BE898506A (fr) 1984-04-16
GB2133005A (en) 1984-07-18
DE3345445C2 (de) 1995-09-21
CS258114B2 (en) 1988-07-15
SU1440350A3 (ru) 1988-11-23
ATA440083A (de) 1986-12-15
SU1470197A3 (ru) 1989-03-30
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
SU1450747A3 (ru) 1989-01-07
NL193108C (nl) 1998-11-03
FR2538394A1 (fr) 1984-06-29
SE8307134L (sv) 1984-06-24
IE56678B1 (en) 1991-11-06
PT77883B (en) 1986-04-09
IT8224939A0 (it) 1982-12-23
AU570935B2 (en) 1988-03-31
SU1447287A3 (ru) 1988-12-23
GB2133005B (en) 1986-04-30
HUT35270A (en) 1985-06-28
IE833060L (en) 1984-06-23
SU1450748A3 (ru) 1989-01-07
AT383601B (de) 1987-07-27
YU247183A (en) 1985-10-31

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