SE8307134L - Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser - Google Patents

Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser

Info

Publication number
SE8307134L
SE8307134L SE8307134A SE8307134A SE8307134L SE 8307134 L SE8307134 L SE 8307134L SE 8307134 A SE8307134 A SE 8307134A SE 8307134 A SE8307134 A SE 8307134A SE 8307134 L SE8307134 L SE 8307134L
Authority
SE
Sweden
Prior art keywords
resin
selective adsorption
antracyclinon
glycosides
purification
Prior art date
Application number
SE8307134A
Other languages
English (en)
Swedish (sv)
Other versions
SE8307134D0 (sv
Inventor
E Oppici
C Varesio
O G Rosa
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8307134D0 publication Critical patent/SE8307134D0/xx
Publication of SE8307134L publication Critical patent/SE8307134L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SE8307134A 1982-12-23 1983-12-22 Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser SE8307134L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (2)

Publication Number Publication Date
SE8307134D0 SE8307134D0 (sv) 1983-12-22
SE8307134L true SE8307134L (sv) 1984-06-24

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8307134A SE8307134L (sv) 1982-12-23 1983-12-22 Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser

Country Status (30)

Country Link
US (1) US4861870A (fr)
JP (2) JPS59118797A (fr)
KR (1) KR900008743B1 (fr)
AT (1) AT383601B (fr)
AU (1) AU570935B2 (fr)
BE (1) BE898506A (fr)
CA (1) CA1204738A (fr)
CH (1) CH657623A5 (fr)
CS (1) CS258114B2 (fr)
DE (1) DE3345445C2 (fr)
DK (1) DK594083A (fr)
ES (1) ES8504758A1 (fr)
FI (1) FI834650A (fr)
FR (1) FR2538394B1 (fr)
GB (1) GB2133005B (fr)
GR (1) GR79135B (fr)
HK (1) HK74887A (fr)
HU (1) HU197917B (fr)
IE (1) IE56678B1 (fr)
IL (1) IL70500A (fr)
IT (1) IT1155446B (fr)
NL (1) NL193108C (fr)
NO (1) NO834765L (fr)
NZ (1) NZ206605A (fr)
PT (1) PT77883B (fr)
SE (1) SE8307134L (fr)
SG (1) SG34587G (fr)
SU (6) SU1440350A3 (fr)
YU (1) YU247183A (fr)
ZA (1) ZA839564B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
DE69810796T2 (de) * 1997-08-28 2003-05-22 Mercian Corp., Tokio/Tokyo Verfahren zur reinigung von daunomycin
ES2356284T3 (es) * 1997-12-05 2011-04-06 Mercian Corporation Antibiótico de antraciclina cristalino y procedimiento para su producción.
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
ATE284893T1 (de) 1998-10-16 2005-01-15 Mercian Corp Kristallisation von doxorubicin-hydrochlorid
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
WO2005004805A2 (fr) 2003-07-02 2005-01-20 Solux Corporation Hydrochlorure d'epirubicine cristalline thermiquement stable et procede de fabrication correspondant
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
EP2376514A2 (fr) 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2301943B1 (fr) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Cristallisation d'épidaunorubicine x HCI
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (fr) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Monohydrate cristallin d'hydrochlorure d'épirubicine
CN108350015A (zh) * 2015-11-05 2018-07-31 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003383A (fr) *
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (fr) * 1968-11-18 1970-05-25
JPS4944347A (fr) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (fr) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
GR79135B (fr) 1984-10-02
YU247183A (en) 1985-10-31
GB8333511D0 (en) 1984-01-25
AU570935B2 (en) 1988-03-31
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
CH657623A5 (it) 1986-09-15
ATA440083A (de) 1986-12-15
HU197917B (en) 1989-06-28
BE898506A (fr) 1984-04-16
FR2538394B1 (fr) 1986-03-28
GB2133005B (en) 1986-04-30
PT77883B (en) 1986-04-09
SU1470197A3 (ru) 1989-03-30
NL193108C (nl) 1998-11-03
IL70500A0 (en) 1984-03-30
HK74887A (en) 1987-10-23
FI834650A0 (fi) 1983-12-16
SU1447287A3 (ru) 1988-12-23
SU1575943A3 (ru) 1990-06-30
NO834765L (no) 1984-06-25
DE3345445A1 (de) 1984-06-28
SU1440350A3 (ru) 1988-11-23
SU1450748A3 (ru) 1989-01-07
FR2538394A1 (fr) 1984-06-29
ZA839564B (en) 1984-08-29
KR900008743B1 (ko) 1990-11-29
IT1155446B (it) 1987-01-28
FI834650A (fi) 1984-06-24
NL8304327A (nl) 1984-07-16
SE8307134D0 (sv) 1983-12-22
IT8224939A0 (it) 1982-12-23
US4861870A (en) 1989-08-29
CS258114B2 (en) 1988-07-15
KR840007438A (ko) 1984-12-07
JP2749272B2 (ja) 1998-05-13
NL193108B (nl) 1998-07-01
SG34587G (en) 1988-03-04
GB2133005A (en) 1984-07-18
AU2245583A (en) 1984-06-28
IL70500A (en) 1990-07-12
DK594083D0 (da) 1983-12-22
ES528226A0 (es) 1985-05-01
ES8504758A1 (es) 1985-05-01
NZ206605A (en) 1987-02-20
HUT35270A (en) 1985-06-28
IE833060L (en) 1984-06-23
AT383601B (de) 1987-07-27
CA1204738A (fr) 1986-05-20
DE3345445C2 (de) 1995-09-21
DK594083A (da) 1984-06-24
SU1450747A3 (ru) 1989-01-07
IE56678B1 (en) 1991-11-06
JPH07252291A (ja) 1995-10-03
CS980283A2 (en) 1987-12-17
JPH0439476B2 (fr) 1992-06-29

Similar Documents

Publication Publication Date Title
SE8307134L (sv) Forfarande for rening av antracyklinonglykosider genom selektiv adsorption pa hartser
JPS525800A (en) Method of purifying stevioside
FI832890A0 (fi) Foerfarande foer separation av sakkaros fraon en vattenloesning
DE3064133D1 (en) Purification of human growth hormone
GB2004908B (en) Process for separating polymeric contaminants from aqueous absorbent solutions used to treat organic gas-containing gas streams
PT88975A (pt) Processo para o isolamento e purificacao de hirudina
SE8505451D0 (sv) Purification of l-phenylalanine
SE8401664D0 (sv) Forfarande for rening av tylosin
GB1068639A (en) A purified form of the antibiotic moenomycin and a process for its manufacture
ES526195A0 (es) Procedimiento de purificacion de soluciones acuosas uraniferas que contienen impurezas
EP0102256A3 (fr) Procédé de purification d'une solution d'édulcorant
BR8500657A (pt) Processo de purificacao de dolucoes aquosas de hidrato de hidrazina
JPS5251305A (en) Proces for purification of isoprene
JPS6475487A (en) Purification of pyrroloquinolinequinonoes
JPS5239652A (en) Process for isolating kanamycin b derivatives with high purity
JPS57203015A (en) Purifying method of human urinary callicrein
JPS5262207A (en) Purification process for chloroform
HUT37378A (en) Selectiv adsorbic process for production of highly clean, straight- and bifurcated chained, saturated and unsaturated hydrocarbons and their derivatives
JPS5398989A (en) Purification of cephalosporin compounds
JPS51141463A (en) Facility for purifying polluted water
GB934462A (en) Improved hydroxocobalamin purification process
JPS5265289A (en) Purification of cephalothin sodium
ES436092A1 (es) Un procedimiento para la purificacion de un antibiotico.
HUT38650A (en) Process for the concentration and purification of peptide type ergot alkaloids
JPS51143684A (en) Process for separating isopropylidenated nucleosides

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8307134-0

Effective date: 19880825