ATE284893T1 - Kristallisation von doxorubicin-hydrochlorid - Google Patents

Kristallisation von doxorubicin-hydrochlorid

Info

Publication number
ATE284893T1
ATE284893T1 AT99947917T AT99947917T ATE284893T1 AT E284893 T1 ATE284893 T1 AT E284893T1 AT 99947917 T AT99947917 T AT 99947917T AT 99947917 T AT99947917 T AT 99947917T AT E284893 T1 ATE284893 T1 AT E284893T1
Authority
AT
Austria
Prior art keywords
doxorubicin hydrochloride
crystallization
doxorubicin
carrying
condition
Prior art date
Application number
AT99947917T
Other languages
English (en)
Inventor
Osamu Johdo
Takuma Nakao
Takeo Yoshioka
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Application granted granted Critical
Publication of ATE284893T1 publication Critical patent/ATE284893T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99947917T 1998-10-16 1999-10-15 Kristallisation von doxorubicin-hydrochlorid ATE284893T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30954298 1998-10-16
PCT/JP1999/005699 WO2000023453A1 (fr) 1998-10-16 1999-10-15 Cristallisation de chlorhydrate de doxorubicine

Publications (1)

Publication Number Publication Date
ATE284893T1 true ATE284893T1 (de) 2005-01-15

Family

ID=17994281

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99947917T ATE284893T1 (de) 1998-10-16 1999-10-15 Kristallisation von doxorubicin-hydrochlorid

Country Status (11)

Country Link
US (1) US6653455B1 (de)
EP (1) EP1122260B1 (de)
JP (1) JP4533537B2 (de)
CN (1) CN1188424C (de)
AT (1) ATE284893T1 (de)
AU (1) AU750738B2 (de)
CA (1) CA2347515C (de)
DE (1) DE69922681T2 (de)
ES (1) ES2235518T3 (de)
NZ (1) NZ511093A (de)
WO (1) WO2000023453A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
JP5075130B2 (ja) * 2006-01-24 2012-11-14 バイオコンパティブルズ ユーケー リミテッド ポリマー粒子を薬物で負荷する方法
US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2376515A1 (de) 2008-12-23 2011-10-19 Pharmasset, Inc. Synthese von purinnukleosiden
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
PL2301943T3 (pl) * 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
UY33312A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidato de nucleosido de purina
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
CL2011000718A1 (es) 2010-03-31 2012-04-09 Gilead Pharmasset Llc Proceso para la preparacion de compuestos fosforados enantiomericos.
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
IT1155446B (it) * 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
HU204570B (en) * 1989-09-04 1992-01-28 Gyogyszerkutato Intezet Process for purifying adriamycin-hydrochloride
JP3980101B2 (ja) * 1996-11-25 2007-09-26 財団法人微生物化学研究会 結晶質アントラサイクリン抗生物質およびその製造方法
JP2975018B2 (ja) * 1997-11-28 1999-11-10 住友製薬株式会社 結晶性塩酸アムルビシン

Also Published As

Publication number Publication date
JP4533537B2 (ja) 2010-09-01
CA2347515A1 (en) 2000-04-27
DE69922681T2 (de) 2005-05-25
US6653455B1 (en) 2003-11-25
EP1122260A1 (de) 2001-08-08
EP1122260B1 (de) 2004-12-15
ES2235518T3 (es) 2005-07-01
EP1122260A4 (de) 2001-12-19
CN1188424C (zh) 2005-02-09
DE69922681D1 (de) 2005-01-20
CN1323312A (zh) 2001-11-21
AU750738B2 (en) 2002-07-25
WO2000023453A1 (fr) 2000-04-27
NZ511093A (en) 2003-04-29
AU6123499A (en) 2000-05-08
CA2347515C (en) 2009-10-13

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