KR840007438A - 안트라시클리논 글루코시드의 정제방법 - Google Patents

안트라시클리논 글루코시드의 정제방법 Download PDF

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Publication number
KR840007438A
KR840007438A KR1019830006090A KR830006090A KR840007438A KR 840007438 A KR840007438 A KR 840007438A KR 1019830006090 A KR1019830006090 A KR 1019830006090A KR 830006090 A KR830006090 A KR 830006090A KR 840007438 A KR840007438 A KR 840007438A
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KR
South Korea
Prior art keywords
resin
glucoside
purifying
crude product
purified
Prior art date
Application number
KR1019830006090A
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English (en)
Other versions
KR900008743B1 (ko
Inventor
오피치 에르네스토 (외 2)
Original Assignee
기오르기오 오란도
파미탈리아 카를로 에바 에스피에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 기오르기오 오란도, 파미탈리아 카를로 에바 에스피에이 filed Critical 기오르기오 오란도
Publication of KR840007438A publication Critical patent/KR840007438A/ko
Application granted granted Critical
Publication of KR900008743B1 publication Critical patent/KR900008743B1/ko
Priority to KR1019910014922A priority Critical patent/KR920000102B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Abstract

내용 없음.

Description

안트라시클리논 글루코시드의 정제방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 조생성물 수용액의 수지상의 선택흡수에 의해 정제를 수행하는 것을 특징으로 한 안트라시클리는 글루코시드의 정제방법.
  2. 제1항에 있어서, 정제할 조생성물을 함유하는 용액을 수지상에 흡수시키기 전에 pH3 내지 5로 조절하는 것을 특징으로 한 방법.
  3. 제1항에 있어서, 흡수를 위해 사용되는 수지를 폴리머/이온교환 흡수성수지 또는 카르복시메틸셀루로오즈로 이루어진 군에서 선택하는 것을 특징으로 한 방법.
  4. 제1항에 있어서, 단지 한종류의 수지를 사용하거나 또는 불순물의 특성에 따라서는 적합하게 선택된 순서로 사용된 여러 형태의 수지를 사용하고, 정제할 조생성물을 함유하는 용액을 수지상에 흡수시키는 것을 특징으로 한 방법.
  5. 제1항에 있어서, 정제물질이 수지로부터 탈습되는 것을 특징으로 한 방법.
  6. 제5항에 있어서, 수지로부터 정제물질의 탈습을 약산성수 또는 물과 극성용매와의 혼합물에 의해 용출시켜 행하는 것을 특징으로 한 방법.
  7. 제1항에 있어서, 수지상의 선택흡수에 의한 정제가 발효법에 의해 수득된 안트라시클리논글루코시드와 이와 유사한 합성화합물을 둘 다 사용되어도 좋은 것을 특징으로 한 방법.
  8. ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019830006090A 1982-12-23 1983-12-22 안트라시클리논 글리코시드의 정제방법 KR900008743B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910014922A KR920000102B1 (ko) 1982-12-23 1991-08-23 안트라시클리논 글리코시드의 정제방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT24939A/82 1982-12-23
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019910014922A Division KR920000102B1 (ko) 1982-12-23 1991-08-23 안트라시클리논 글리코시드의 정제방법

Publications (2)

Publication Number Publication Date
KR840007438A true KR840007438A (ko) 1984-12-07
KR900008743B1 KR900008743B1 (ko) 1990-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006090A KR900008743B1 (ko) 1982-12-23 1983-12-22 안트라시클리논 글리코시드의 정제방법

Country Status (30)

Country Link
US (1) US4861870A (ko)
JP (2) JPS59118797A (ko)
KR (1) KR900008743B1 (ko)
AT (1) AT383601B (ko)
AU (1) AU570935B2 (ko)
BE (1) BE898506A (ko)
CA (1) CA1204738A (ko)
CH (1) CH657623A5 (ko)
CS (1) CS258114B2 (ko)
DE (1) DE3345445C2 (ko)
DK (1) DK594083A (ko)
ES (1) ES528226A0 (ko)
FI (1) FI834650A (ko)
FR (1) FR2538394B1 (ko)
GB (1) GB2133005B (ko)
GR (1) GR79135B (ko)
HK (1) HK74887A (ko)
HU (1) HU197917B (ko)
IE (1) IE56678B1 (ko)
IL (1) IL70500A (ko)
IT (1) IT1155446B (ko)
NL (1) NL193108C (ko)
NO (1) NO834765L (ko)
NZ (1) NZ206605A (ko)
PT (1) PT77883B (ko)
SE (1) SE8307134L (ko)
SG (1) SG34587G (ko)
SU (6) SU1440350A3 (ko)
YU (1) YU247183A (ko)
ZA (1) ZA839564B (ko)

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KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
DE04777189T1 (de) * 2003-07-02 2011-04-07 Solux Corporation, San Diego Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
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CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
CA2748034A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
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Also Published As

Publication number Publication date
HU197917B (en) 1989-06-28
SE8307134D0 (sv) 1983-12-22
GR79135B (ko) 1984-10-02
FI834650A (fi) 1984-06-24
ES8504758A1 (es) 1985-05-01
US4861870A (en) 1989-08-29
DK594083D0 (da) 1983-12-22
IL70500A (en) 1990-07-12
DK594083A (da) 1984-06-24
ES528226A0 (es) 1985-05-01
CH657623A5 (it) 1986-09-15
NZ206605A (en) 1987-02-20
NO834765L (no) 1984-06-25
GB8333511D0 (en) 1984-01-25
NL8304327A (nl) 1984-07-16
CA1204738A (en) 1986-05-20
DE3345445A1 (de) 1984-06-28
SU1575943A3 (ru) 1990-06-30
SG34587G (en) 1988-03-04
CS980283A2 (en) 1987-12-17
JPH0439476B2 (ko) 1992-06-29
HK74887A (en) 1987-10-23
FI834650A0 (fi) 1983-12-16
JPH07252291A (ja) 1995-10-03
ZA839564B (en) 1984-08-29
AU2245583A (en) 1984-06-28
IT1155446B (it) 1987-01-28
NL193108B (nl) 1998-07-01
IL70500A0 (en) 1984-03-30
KR900008743B1 (ko) 1990-11-29
JP2749272B2 (ja) 1998-05-13
BE898506A (fr) 1984-04-16
GB2133005A (en) 1984-07-18
DE3345445C2 (de) 1995-09-21
CS258114B2 (en) 1988-07-15
SU1440350A3 (ru) 1988-11-23
ATA440083A (de) 1986-12-15
SU1470197A3 (ru) 1989-03-30
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
SU1450747A3 (ru) 1989-01-07
NL193108C (nl) 1998-11-03
FR2538394A1 (fr) 1984-06-29
FR2538394B1 (fr) 1986-03-28
SE8307134L (sv) 1984-06-24
IE56678B1 (en) 1991-11-06
PT77883B (en) 1986-04-09
IT8224939A0 (it) 1982-12-23
AU570935B2 (en) 1988-03-31
SU1447287A3 (ru) 1988-12-23
GB2133005B (en) 1986-04-30
HUT35270A (en) 1985-06-28
IE833060L (en) 1984-06-23
SU1450748A3 (ru) 1989-01-07
AT383601B (de) 1987-07-27
YU247183A (en) 1985-10-31

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