JPS57109799A - Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same - Google Patents

Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same

Info

Publication number
JPS57109799A
JPS57109799A JP18408880A JP18408880A JPS57109799A JP S57109799 A JPS57109799 A JP S57109799A JP 18408880 A JP18408880 A JP 18408880A JP 18408880 A JP18408880 A JP 18408880A JP S57109799 A JPS57109799 A JP S57109799A
Authority
JP
Japan
Prior art keywords
adenosine
triphosphate
halogeno
antitumor agent
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18408880A
Other languages
Japanese (ja)
Other versions
JPS634840B2 (en
Inventor
Ayako Nasu
Nobuyuki Yamatsugu
Motohiko Kato
Kenkichi Tomita
Atsushi Ichikawa
Mariko Watanabe
Yasuhiko Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kikkoman Corp
Original Assignee
Kikkoman Corp
Kikkoman Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kikkoman Corp, Kikkoman Shoyu KK filed Critical Kikkoman Corp
Priority to JP18408880A priority Critical patent/JPS57109799A/en
Publication of JPS57109799A publication Critical patent/JPS57109799A/en
Publication of JPS634840B2 publication Critical patent/JPS634840B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound (acid addition salt) of formulaI(X is halogen; R is straight chain alkyl).
EXAMPLE: 2-Chloro-adenosine-3',5'-cyclic n-heptyl triphosphate.
USE: An antitumor agent with low toxicity having improved carcinostatic action on leukemia, ascitic cancer, adenocarcinoma, etc.
PROCESS: One mole 2-halogeno-adenosine-3',5'-cyclic triphosphate of formula II is reacted with preferably 3W10mol alkyl halide of the formula R-X, e.g. n- heptyl bromide, in the presence of a base, preferably a tertiary amine, e.g. triethylamine, and if desired the reaction product is then converted into an acid addition salt thereof to give the compound of formulaI. The reaction is preferably carried out in a substantially anhydrous solvent, e.g. DMF, at 70W120°C.
COPYRIGHT: (C)1982,JPO&Japio
JP18408880A 1980-12-26 1980-12-26 Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same Granted JPS57109799A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18408880A JPS57109799A (en) 1980-12-26 1980-12-26 Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18408880A JPS57109799A (en) 1980-12-26 1980-12-26 Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same

Publications (2)

Publication Number Publication Date
JPS57109799A true JPS57109799A (en) 1982-07-08
JPS634840B2 JPS634840B2 (en) 1988-02-01

Family

ID=16147181

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18408880A Granted JPS57109799A (en) 1980-12-26 1980-12-26 Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same

Country Status (1)

Country Link
JP (1) JPS57109799A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015180655A (en) * 2008-06-11 2015-10-15 ギリアド ファーマセット エルエルシー Nucleoside cyclic phosphates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015180655A (en) * 2008-06-11 2015-10-15 ギリアド ファーマセット エルエルシー Nucleoside cyclic phosphates

Also Published As

Publication number Publication date
JPS634840B2 (en) 1988-02-01

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