JPS57109799A - Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same - Google Patents
Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the sameInfo
- Publication number
- JPS57109799A JPS57109799A JP18408880A JP18408880A JPS57109799A JP S57109799 A JPS57109799 A JP S57109799A JP 18408880 A JP18408880 A JP 18408880A JP 18408880 A JP18408880 A JP 18408880A JP S57109799 A JPS57109799 A JP S57109799A
- Authority
- JP
- Japan
- Prior art keywords
- adenosine
- triphosphate
- halogeno
- antitumor agent
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound (acid addition salt) of formulaI(X is halogen; R is straight chain alkyl).
EXAMPLE: 2-Chloro-adenosine-3',5'-cyclic n-heptyl triphosphate.
USE: An antitumor agent with low toxicity having improved carcinostatic action on leukemia, ascitic cancer, adenocarcinoma, etc.
PROCESS: One mole 2-halogeno-adenosine-3',5'-cyclic triphosphate of formula II is reacted with preferably 3W10mol alkyl halide of the formula R-X, e.g. n- heptyl bromide, in the presence of a base, preferably a tertiary amine, e.g. triethylamine, and if desired the reaction product is then converted into an acid addition salt thereof to give the compound of formulaI. The reaction is preferably carried out in a substantially anhydrous solvent, e.g. DMF, at 70W120°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18408880A JPS57109799A (en) | 1980-12-26 | 1980-12-26 | Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18408880A JPS57109799A (en) | 1980-12-26 | 1980-12-26 | Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57109799A true JPS57109799A (en) | 1982-07-08 |
JPS634840B2 JPS634840B2 (en) | 1988-02-01 |
Family
ID=16147181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18408880A Granted JPS57109799A (en) | 1980-12-26 | 1980-12-26 | Novel 2-halogeno-adenosine-3',5'-cyclic alkyl triphosphate, its preparation and antitumor agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57109799A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015180655A (en) * | 2008-06-11 | 2015-10-15 | ギリアド ファーマセット エルエルシー | Nucleoside cyclic phosphates |
-
1980
- 1980-12-26 JP JP18408880A patent/JPS57109799A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015180655A (en) * | 2008-06-11 | 2015-10-15 | ギリアド ファーマセット エルエルシー | Nucleoside cyclic phosphates |
Also Published As
Publication number | Publication date |
---|---|
JPS634840B2 (en) | 1988-02-01 |
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