ZA201705958B - Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds - Google Patents

Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds

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Publication number
ZA201705958B
ZA201705958B ZA2017/05958A ZA201705958A ZA201705958B ZA 201705958 B ZA201705958 B ZA 201705958B ZA 2017/05958 A ZA2017/05958 A ZA 2017/05958A ZA 201705958 A ZA201705958 A ZA 201705958A ZA 201705958 B ZA201705958 B ZA 201705958B
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ZA
South Africa
Prior art keywords
pyrido
toll
diamino
pyrimidine compounds
receptor modulating
Prior art date
Application number
ZA2017/05958A
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English (en)
Inventor
Evangelos Aktoudianakis
Gregory Chin
Richard L Mackman
Samuel E Metobo
Michael R Mish
Hyung-Jung Pyun
Jeff Zablocki
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Gilead Sciences In
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Publication date
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Publication of ZA201705958B publication Critical patent/ZA201705958B/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA2017/05958A 2015-03-04 2017-09-01 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds ZA201705958B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562128397P 2015-03-04 2015-03-04
US201562250403P 2015-11-03 2015-11-03
PCT/US2016/020499 WO2016141092A1 (en) 2015-03-04 2016-03-02 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds

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ZA201705958B true ZA201705958B (en) 2022-10-26

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ZA2017/05958A ZA201705958B (en) 2015-03-04 2017-09-01 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
ZA2018/06702A ZA201806702B (en) 2015-03-04 2018-10-08 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
ZA2021/06538A ZA202106538B (en) 2015-03-04 2021-08-24 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds

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ZA2018/06702A ZA201806702B (en) 2015-03-04 2018-10-08 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
ZA2021/06538A ZA202106538B (en) 2015-03-04 2021-08-24 Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds

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