MA39601A - Composés 4,6-diamino-pyrido[3,2-d]pyrimidine modulateurs du récepteur de type toll - Google Patents

Composés 4,6-diamino-pyrido[3,2-d]pyrimidine modulateurs du récepteur de type toll

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Publication number
MA39601A
MA39601A MA039601A MA39601A MA39601A MA 39601 A MA39601 A MA 39601A MA 039601 A MA039601 A MA 039601A MA 39601 A MA39601 A MA 39601A MA 39601 A MA39601 A MA 39601A
Authority
MA
Morocco
Prior art keywords
toll
pyrido
diamino
pyrimidine compounds
type receiver
Prior art date
Application number
MA039601A
Other languages
English (en)
Inventor
Evangelos Aktoudianakis
Gregory Chin
Richard L Mackman
Samuel E Metobo
Michael R Mish
Hyung-Jung Pyun
Jeff Zablocki
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA39601A publication Critical patent/MA39601A/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de manière générale des composés modulateurs du récepteur de type toll, par exemple des composés diamino-pyrido [3,2d] pyrimidine, et des compositions pharmaceutiques qui, entre autres choses, modulent les récepteurs de type toll (par exemple tlr-8). L'invention porte également sur leurs procédés de fabrication et d'utilisation.
MA039601A 2015-03-04 2016-03-02 Composés 4,6-diamino-pyrido[3,2-d]pyrimidine modulateurs du récepteur de type toll MA39601A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562128397P 2015-03-04 2015-03-04
US201562250403P 2015-11-03 2015-11-03

Publications (1)

Publication Number Publication Date
MA39601A true MA39601A (fr) 2016-11-30

Family

ID=55590135

Family Applications (2)

Application Number Title Priority Date Filing Date
MA039601A MA39601A (fr) 2015-03-04 2016-03-02 Composés 4,6-diamino-pyrido[3,2-d]pyrimidine modulateurs du récepteur de type toll
MA051081A MA51081A (fr) 2015-03-04 2016-03-02 Composés modulateurs de récepteurs de type toll

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MA051081A MA51081A (fr) 2015-03-04 2016-03-02 Composés modulateurs de récepteurs de type toll

Country Status (43)

Country Link
US (4) US9670205B2 (fr)
EP (3) EP3722297A1 (fr)
JP (4) JP6182278B2 (fr)
KR (3) KR101756050B1 (fr)
CN (2) CN107108615B (fr)
AU (4) AU2016216673B2 (fr)
BR (1) BR102016004764B1 (fr)
CA (1) CA2978188C (fr)
CL (1) CL2017002225A1 (fr)
CO (1) CO2017009032A2 (fr)
CR (1) CR20170395A (fr)
CU (2) CU20170115A7 (fr)
CY (2) CY1120143T1 (fr)
DK (2) DK3321265T3 (fr)
DO (1) DOP2017000203A (fr)
EA (1) EA035093B1 (fr)
EC (1) ECSP17058129A (fr)
ES (2) ES2656225T3 (fr)
HR (2) HRP20172003T1 (fr)
HU (2) HUE050029T2 (fr)
IL (1) IL254164B (fr)
LT (2) LT3321265T (fr)
MA (2) MA39601A (fr)
MD (2) MD20170081A2 (fr)
ME (1) ME02893B (fr)
MX (2) MX2020012049A (fr)
MY (3) MY188211A (fr)
NZ (1) NZ735176A (fr)
PE (1) PE20180031A1 (fr)
PH (2) PH12021551982A1 (fr)
PL (2) PL3321265T3 (fr)
PT (2) PT3321265T (fr)
RS (1) RS56787B1 (fr)
SA (1) SA517382248B1 (fr)
SG (1) SG11201606876RA (fr)
SI (2) SI3097102T1 (fr)
SM (1) SMT201800023T1 (fr)
SV (1) SV2017005528A (fr)
TW (1) TWI705964B (fr)
UA (1) UA123090C2 (fr)
UY (1) UY36577A (fr)
WO (1) WO2016141092A1 (fr)
ZA (3) ZA201705958B (fr)

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AU2020286178A1 (en) 2021-01-07
ME02893B (fr) 2018-04-20
EP3097102B1 (fr) 2017-10-18
UY36577A (es) 2016-09-30
HK1254205A1 (en) 2019-07-12
MY199989A (en) 2023-12-02
SV2017005528A (es) 2018-11-29
JP2017203033A (ja) 2017-11-16
BR102016004764A2 (pt) 2016-09-06
PE20180031A1 (es) 2018-01-09
SMT201800023T1 (it) 2018-03-08
AU2018282291B2 (en) 2020-09-10
AU2017202755C1 (en) 2019-01-17
ES2801380T3 (es) 2021-01-11
HK1226062B (en) 2017-09-22
TWI705964B (zh) 2020-10-01
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AU2017202755A1 (en) 2017-05-18
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JP2023083474A (ja) 2023-06-15
ECSP17058129A (es) 2017-10-31
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PT3321265T (pt) 2020-07-07
CL2017002225A1 (es) 2018-04-13
PH12017501590B1 (en) 2024-05-15
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SA517382248B1 (ar) 2022-10-30
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US20160289229A1 (en) 2016-10-06
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EA035093B1 (ru) 2020-04-27
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MA51081A (fr) 2020-10-14
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IL254164A0 (en) 2017-10-31
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US20170281627A1 (en) 2017-10-05
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JP6182278B2 (ja) 2017-08-16
US10285990B2 (en) 2019-05-14
MD3097102T2 (ro) 2018-02-28
AU2016216673A1 (en) 2016-09-22
JP7268064B2 (ja) 2023-05-02
EA201791782A1 (ru) 2018-05-31
CA2978188C (fr) 2020-05-12
AU2018282291A1 (en) 2019-01-17
PH12017501590A1 (en) 2018-02-05
JP2021046456A (ja) 2021-03-25
HUE038059T2 (hu) 2018-10-29
US12377100B2 (en) 2025-08-05
WO2016141092A1 (fr) 2016-09-09
KR20160113243A (ko) 2016-09-28
US9670205B2 (en) 2017-06-06
KR101756050B1 (ko) 2017-07-07
HRP20172003T1 (hr) 2018-02-23
SI3097102T1 (en) 2018-02-28
AU2016216673B2 (en) 2017-02-02
ZA202106538B (en) 2024-12-18
AU2020286178B2 (en) 2022-11-17
US20220218709A1 (en) 2022-07-14
CU20170115A7 (es) 2018-03-13
KR102394917B1 (ko) 2022-05-09
LT3321265T (lt) 2020-07-27
ES2656225T3 (es) 2018-02-26
ZA201806702B (en) 2022-10-26
MY199988A (en) 2023-12-02

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