DE69330639T2 - Methotrexat-derivate - Google Patents

Methotrexat-derivate

Info

Publication number
DE69330639T2
DE69330639T2 DE69330639T DE69330639T DE69330639T2 DE 69330639 T2 DE69330639 T2 DE 69330639T2 DE 69330639 T DE69330639 T DE 69330639T DE 69330639 T DE69330639 T DE 69330639T DE 69330639 T2 DE69330639 T2 DE 69330639T2
Authority
DE
Germany
Prior art keywords
methotrexate derivatives
antirheumatic
chem
iii
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69330639T
Other languages
English (en)
Other versions
DE69330639D1 (de
Inventor
Hiroharu Matsuoka
Hiroshi Suzuki
Nobuaki Kato
Keiichiro Tsuji
Toshio Kuroki
Noriaki Maruyama
Kazuya Nakagomi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE69330639D1 publication Critical patent/DE69330639D1/de
Application granted granted Critical
Publication of DE69330639T2 publication Critical patent/DE69330639T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69330639T 1992-01-27 1993-01-27 Methotrexat-derivate Expired - Fee Related DE69330639T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24
PCT/JP1993/000096 WO1993015077A1 (en) 1992-01-27 1993-01-27 Methotrexate derivative

Publications (2)

Publication Number Publication Date
DE69330639D1 DE69330639D1 (de) 2001-09-27
DE69330639T2 true DE69330639T2 (de) 2002-07-04

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330639T Expired - Fee Related DE69330639T2 (de) 1992-01-27 1993-01-27 Methotrexat-derivate

Country Status (10)

Country Link
US (2) US6559149B1 (de)
EP (1) EP0632038B1 (de)
KR (1) KR100248324B1 (de)
AT (1) ATE204576T1 (de)
AU (1) AU3367693A (de)
CA (1) CA2128205C (de)
DE (1) DE69330639T2 (de)
ES (1) ES2161713T3 (de)
TW (1) TW223637B (de)
WO (1) WO1993015077A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632038B1 (de) * 1992-01-27 2001-08-22 Chugai Seiyaku Kabushiki Kaisha Methotrexat-derivate
ES2140524T3 (es) * 1992-12-25 2000-03-01 Chugai Pharmaceutical Co Ltd Derivados de metotrexato.
EP0818199A4 (de) * 1995-03-27 2002-08-14 Chugai Pharmaceutical Co Ltd Ein methotrexatderivat enthaltendes medikament
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
WO2001087834A1 (fr) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
WO2007062403A2 (en) 2005-11-28 2007-05-31 Vernon D Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
US10144736B2 (en) * 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
CN101646670A (zh) 2007-04-11 2010-02-10 默克阿泼洛发股份公司 18f-标记的叶酸酯
ES2781401T3 (es) 2008-11-19 2020-09-01 Pola Chem Ind Inc Agentes antiarrugas
CU20180011A7 (es) 2015-03-04 2018-06-05 Gilead Sciences Inc Composiciones farmacéuticas que comprenden compuestos derivados de diaminopirido (3,2-d) como moduladores de receptor de tipo toll
CA3035346A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
DK0543997T3 (da) * 1990-08-14 2000-04-10 Chugai Pharmaceutical Co Ltd Methotrexatderivat med antirheumatisk aktivitet
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
EP0632038B1 (de) * 1992-01-27 2001-08-22 Chugai Seiyaku Kabushiki Kaisha Methotrexat-derivate
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
EP0632038A4 (de) 1995-02-22
AU3367693A (en) 1993-09-01
KR100248324B1 (ko) 2000-04-01
CA2128205C (en) 2004-03-30
CA2128205A1 (en) 1993-08-05
WO1993015077A1 (en) 1993-08-05
US6559149B1 (en) 2003-05-06
TW223637B (de) 1994-05-11
ES2161713T3 (es) 2001-12-16
EP0632038B1 (de) 2001-08-22
EP0632038A1 (de) 1995-01-04
US20030171376A1 (en) 2003-09-11
ATE204576T1 (de) 2001-09-15
DE69330639D1 (de) 2001-09-27

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee