ES2140524T3 - Derivados de metotrexato. - Google Patents

Derivados de metotrexato.

Info

Publication number
ES2140524T3
ES2140524T3 ES94903046T ES94903046T ES2140524T3 ES 2140524 T3 ES2140524 T3 ES 2140524T3 ES 94903046 T ES94903046 T ES 94903046T ES 94903046 T ES94903046 T ES 94903046T ES 2140524 T3 ES2140524 T3 ES 2140524T3
Authority
ES
Spain
Prior art keywords
metotrexate
derivatives
antirheumatic
chem
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903046T
Other languages
English (en)
Inventor
Nobuhiro Ohi
Hiroshi Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2140524T3 publication Critical patent/ES2140524T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTA UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (A), UNA SAL DEL MISMO, Y UN ANTIRREUMATICO QUE CONTIENE AL MENOS UNO DE ELLOS COMO INGREDIENTE ACTIVO, EN DONDE R1 Y R2 PUDEN SER IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO O ALQUIL C1C4.
ES94903046T 1992-12-25 1993-12-24 Derivados de metotrexato. Expired - Lifetime ES2140524T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP36202792 1992-12-25

Publications (1)

Publication Number Publication Date
ES2140524T3 true ES2140524T3 (es) 2000-03-01

Family

ID=18475662

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903046T Expired - Lifetime ES2140524T3 (es) 1992-12-25 1993-12-24 Derivados de metotrexato.

Country Status (13)

Country Link
US (1) US5728692A (es)
EP (1) EP0676399B1 (es)
KR (1) KR100259742B1 (es)
CN (1) CN1037771C (es)
AT (1) ATE184605T1 (es)
AU (1) AU5715894A (es)
CA (1) CA2152485A1 (es)
DE (1) DE69326479T2 (es)
DK (1) DK0676399T3 (es)
ES (1) ES2140524T3 (es)
GR (1) GR3031864T3 (es)
SG (1) SG52733A1 (es)
WO (1) WO1994014810A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100400509B1 (ko) * 1995-03-27 2004-04-03 쥬가이 세이야쿠 가부시키가이샤 메토트렉세이트유도체를함유하는약제
EP0897724A4 (en) * 1996-03-19 2003-05-07 Chugai Pharmaceutical Co Ltd MEDICINE AGAINST UVEITY
US6383520B1 (en) * 1998-06-26 2002-05-07 Chugai Seiyaku Kabushiki Kaisha Fine powder of L-α-aminoadipic acid derivative, oral solid preparations containing the same, and method for treatment of bulk powders
AU6594000A (en) * 1999-08-17 2001-03-13 Chugai Seiyaku Kabushiki Kaisha Remedies for myocardial infarction
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7741317B2 (en) * 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AU2009223453B2 (en) 2008-03-03 2014-05-01 Tosk, Inc. Methotrexate adjuvants to reduce toxicity and methods for using the same
EP2527322A1 (en) 2011-05-24 2012-11-28 Noscira, S.A. Carbamyl alkylphenyl disulfide derivatives and their therapeutic uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2784670B2 (ja) * 1989-08-09 1998-08-06 株式会社シーエスケイ パチンコ景品交換システム
JPH04368385A (ja) * 1991-06-12 1992-12-21 Chugai Pharmaceut Co Ltd 新規メトトレキセート誘導体
AU8333291A (en) * 1990-08-14 1992-03-17 Chugai Seiyaku Kabushiki Kaisha Novel methotrexate derivative
CA2128205C (en) * 1992-01-27 2004-03-30 Hiroharu Matsuoka Methotrexate derivatives
JP3281099B2 (ja) * 1992-02-13 2002-05-13 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
DE69326479T2 (de) 2000-03-02
SG52733A1 (en) 1998-09-28
EP0676399A1 (en) 1995-10-11
CA2152485A1 (en) 1994-07-07
CN1093365A (zh) 1994-10-12
CN1037771C (zh) 1998-03-18
ATE184605T1 (de) 1999-10-15
US5728692A (en) 1998-03-17
KR960700245A (ko) 1996-01-19
GR3031864T3 (en) 2000-02-29
DK0676399T3 (da) 2000-03-20
AU5715894A (en) 1994-07-19
WO1994014810A1 (en) 1994-07-07
EP0676399A4 (en) 1996-04-17
KR100259742B1 (ko) 2000-07-01
EP0676399B1 (en) 1999-09-15
DE69326479D1 (de) 1999-10-21

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