ES2140524T3 - Derivados de metotrexato. - Google Patents
Derivados de metotrexato.Info
- Publication number
- ES2140524T3 ES2140524T3 ES94903046T ES94903046T ES2140524T3 ES 2140524 T3 ES2140524 T3 ES 2140524T3 ES 94903046 T ES94903046 T ES 94903046T ES 94903046 T ES94903046 T ES 94903046T ES 2140524 T3 ES2140524 T3 ES 2140524T3
- Authority
- ES
- Spain
- Prior art keywords
- metotrexate
- derivatives
- antirheumatic
- chem
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE PRESENTA UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (A), UNA SAL DEL MISMO, Y UN ANTIRREUMATICO QUE CONTIENE AL MENOS UNO DE ELLOS COMO INGREDIENTE ACTIVO, EN DONDE R1 Y R2 PUDEN SER IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO O ALQUIL C1C4.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP36202792 | 1992-12-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2140524T3 true ES2140524T3 (es) | 2000-03-01 |
Family
ID=18475662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94903046T Expired - Lifetime ES2140524T3 (es) | 1992-12-25 | 1993-12-24 | Derivados de metotrexato. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5728692A (es) |
EP (1) | EP0676399B1 (es) |
KR (1) | KR100259742B1 (es) |
CN (1) | CN1037771C (es) |
AT (1) | ATE184605T1 (es) |
AU (1) | AU5715894A (es) |
CA (1) | CA2152485A1 (es) |
DE (1) | DE69326479T2 (es) |
DK (1) | DK0676399T3 (es) |
ES (1) | ES2140524T3 (es) |
GR (1) | GR3031864T3 (es) |
SG (1) | SG52733A1 (es) |
WO (1) | WO1994014810A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100400509B1 (ko) * | 1995-03-27 | 2004-04-03 | 쥬가이 세이야쿠 가부시키가이샤 | 메토트렉세이트유도체를함유하는약제 |
EP0897724A4 (en) * | 1996-03-19 | 2003-05-07 | Chugai Pharmaceutical Co Ltd | MEDICINE AGAINST UVEITY |
US6383520B1 (en) * | 1998-06-26 | 2002-05-07 | Chugai Seiyaku Kabushiki Kaisha | Fine powder of L-α-aminoadipic acid derivative, oral solid preparations containing the same, and method for treatment of bulk powders |
AU6594000A (en) * | 1999-08-17 | 2001-03-13 | Chugai Seiyaku Kabushiki Kaisha | Remedies for myocardial infarction |
US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
US7741317B2 (en) * | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
AU2009223453B2 (en) | 2008-03-03 | 2014-05-01 | Tosk, Inc. | Methotrexate adjuvants to reduce toxicity and methods for using the same |
EP2527322A1 (en) | 2011-05-24 | 2012-11-28 | Noscira, S.A. | Carbamyl alkylphenyl disulfide derivatives and their therapeutic uses |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2784670B2 (ja) * | 1989-08-09 | 1998-08-06 | 株式会社シーエスケイ | パチンコ景品交換システム |
JPH04368385A (ja) * | 1991-06-12 | 1992-12-21 | Chugai Pharmaceut Co Ltd | 新規メトトレキセート誘導体 |
AU8333291A (en) * | 1990-08-14 | 1992-03-17 | Chugai Seiyaku Kabushiki Kaisha | Novel methotrexate derivative |
CA2128205C (en) * | 1992-01-27 | 2004-03-30 | Hiroharu Matsuoka | Methotrexate derivatives |
JP3281099B2 (ja) * | 1992-02-13 | 2002-05-13 | 中外製薬株式会社 | 抗リウマチ剤 |
-
1993
- 1993-12-24 KR KR1019950702631A patent/KR100259742B1/ko not_active IP Right Cessation
- 1993-12-24 DE DE69326479T patent/DE69326479T2/de not_active Expired - Fee Related
- 1993-12-24 CA CA002152485A patent/CA2152485A1/en not_active Abandoned
- 1993-12-24 WO PCT/JP1993/001867 patent/WO1994014810A1/ja active IP Right Grant
- 1993-12-24 ES ES94903046T patent/ES2140524T3/es not_active Expired - Lifetime
- 1993-12-24 EP EP94903046A patent/EP0676399B1/en not_active Expired - Lifetime
- 1993-12-24 SG SG1996008496A patent/SG52733A1/en unknown
- 1993-12-24 DK DK94903046T patent/DK0676399T3/da active
- 1993-12-24 AT AT94903046T patent/ATE184605T1/de not_active IP Right Cessation
- 1993-12-24 AU AU57158/94A patent/AU5715894A/en not_active Abandoned
- 1993-12-24 CN CN93121089A patent/CN1037771C/zh not_active Expired - Fee Related
-
1995
- 1995-12-24 US US08/454,290 patent/US5728692A/en not_active Expired - Fee Related
-
1999
- 1999-11-17 GR GR990402959T patent/GR3031864T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69326479T2 (de) | 2000-03-02 |
SG52733A1 (en) | 1998-09-28 |
EP0676399A1 (en) | 1995-10-11 |
CA2152485A1 (en) | 1994-07-07 |
CN1093365A (zh) | 1994-10-12 |
CN1037771C (zh) | 1998-03-18 |
ATE184605T1 (de) | 1999-10-15 |
US5728692A (en) | 1998-03-17 |
KR960700245A (ko) | 1996-01-19 |
GR3031864T3 (en) | 2000-02-29 |
DK0676399T3 (da) | 2000-03-20 |
AU5715894A (en) | 1994-07-19 |
WO1994014810A1 (en) | 1994-07-07 |
EP0676399A4 (en) | 1996-04-17 |
KR100259742B1 (ko) | 2000-07-01 |
EP0676399B1 (en) | 1999-09-15 |
DE69326479D1 (de) | 1999-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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