ES2161713T3 - Derivado de metotrexato. - Google Patents

Derivado de metotrexato.

Info

Publication number
ES2161713T3
ES2161713T3 ES93902536T ES93902536T ES2161713T3 ES 2161713 T3 ES2161713 T3 ES 2161713T3 ES 93902536 T ES93902536 T ES 93902536T ES 93902536 T ES93902536 T ES 93902536T ES 2161713 T3 ES2161713 T3 ES 2161713T3
Authority
ES
Spain
Prior art keywords
metotrexate
derivative
antirheumatic
chem
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902536T
Other languages
English (en)
Inventor
Hiroharu Matsuoka
Hiroshi Suzuki
Nobuaki Kato
Keiichiro Tsuji
Toshio Kuroki
Noriaki Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2161713T3 publication Critical patent/ES2161713T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (II) Y UN ANTIRREUMATICO QUE LO CONTIENE COMO INGREDIENTE ACTIVO, EN LA QUE W REPRESENTA UN GRUPO REPRESENTADO POR CUALQUIERA DE LAS FORMULAS GENERALES (III), (IV), (V), (VI).
ES93902536T 1992-01-27 1993-01-27 Derivado de metotrexato. Expired - Lifetime ES2161713T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24

Publications (1)

Publication Number Publication Date
ES2161713T3 true ES2161713T3 (es) 2001-12-16

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902536T Expired - Lifetime ES2161713T3 (es) 1992-01-27 1993-01-27 Derivado de metotrexato.

Country Status (10)

Country Link
US (2) US6559149B1 (es)
EP (1) EP0632038B1 (es)
KR (1) KR100248324B1 (es)
AT (1) ATE204576T1 (es)
AU (1) AU3367693A (es)
CA (1) CA2128205C (es)
DE (1) DE69330639T2 (es)
ES (1) ES2161713T3 (es)
TW (1) TW223637B (es)
WO (1) WO1993015077A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559149B1 (en) * 1992-01-27 2003-05-06 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivatives
EP0676399B1 (en) * 1992-12-25 1999-09-15 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivatives
EP0818199A4 (en) * 1995-03-27 2002-08-14 Chugai Pharmaceutical Co Ltd MEDICINE CONTAINING METHOTREXATE DERIVATIVE
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
WO2001087834A1 (fr) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
CA2631014C (en) 2005-11-28 2015-04-28 Vernon D. Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
US10144736B2 (en) * 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
ES2707574T3 (es) 2007-04-11 2019-04-04 Merck & Cie Folatos marcados con 18F
AU2009318483B2 (en) 2008-11-19 2015-03-19 Pola Chemical Industries Inc. Anti-wrinkle agents
UA123090C2 (uk) 2015-03-04 2021-02-17 Гіліад Сайєнсіз, Інк. 4,6-ДІАМІНОПІРИДО[3,2-d]ПІРИМІДИНОВІ СПОЛУКИ, ЯКІ МОДУЛЮЮТЬ TOLL-ПОДІБНІ РЕЦЕПТОРИ
EP3507276B1 (en) 2016-09-02 2021-11-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
EP0543997B1 (en) * 1990-08-14 1999-12-08 Chugai Seiyaku Kabushiki Kaisha Derivatives of methotrexate with antirheumatic activity
US6559149B1 (en) * 1992-01-27 2003-05-06 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivatives
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
ATE204576T1 (de) 2001-09-15
CA2128205C (en) 2004-03-30
US6559149B1 (en) 2003-05-06
US20030171376A1 (en) 2003-09-11
EP0632038A1 (en) 1995-01-04
EP0632038B1 (en) 2001-08-22
CA2128205A1 (en) 1993-08-05
AU3367693A (en) 1993-09-01
WO1993015077A1 (en) 1993-08-05
DE69330639D1 (de) 2001-09-27
EP0632038A4 (en) 1995-02-22
TW223637B (es) 1994-05-11
KR100248324B1 (ko) 2000-04-01
DE69330639T2 (de) 2002-07-04

Similar Documents

Publication Publication Date Title
ES2161713T3 (es) Derivado de metotrexato.
AU628138B2 (en) Triazine derivative and herbicide containing the same as active ingredient
DE69533277D1 (de) Dc-89 derivat
IL96882A0 (en) Uracil derivatives and pesticides containing the same as active ingredient
MX9300222A (es) Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion.
ZA916268B (en) Tricyclic compound or salts thereof,method for producing the same and antimicrobial agent containing the same
ES2093037T3 (es) Derivados de beta-lactama y su preparacion.
AU7415387A (en) Imidazolesulfonamide derivatives and herbicides
DE69312776D1 (de) Fungizide 3,4-Diaryl-(5H)-Furan-2-Onederivate
ES2140524T3 (es) Derivados de metotrexato.
FI955728A (fi) Ahdistusta lievittävä aine
ATE159253T1 (de) 2-thiazolylpyrroleakrylate mit fungizider wirkung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 632038

Country of ref document: ES