HK1226062B - TOLL-like receptor modulator 4,6-diamino-pyridine [3,2-D] pyrimidine compound - Google Patents

TOLL-like receptor modulator 4,6-diamino-pyridine [3,2-D] pyrimidine compound Download PDF

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Publication number
HK1226062B
HK1226062B HK16114301.7A HK16114301A HK1226062B HK 1226062 B HK1226062 B HK 1226062B HK 16114301 A HK16114301 A HK 16114301A HK 1226062 B HK1226062 B HK 1226062B
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Hong Kong
Prior art keywords
inhibitors
compound
pharmaceutically acceptable
present disclosure
acceptable salt
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HK16114301.7A
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German (de)
English (en)
French (fr)
Chinese (zh)
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HK1226062A1 (en
Inventor
Evangelos Aktoudianakis
Gregory CHIN
Richard L. Mackman
Samuel E. Metobo
Michael R. Mish
Hyung-Jung Pyun
Jeff Zablocki
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Gilead Sciences, Inc.
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Publication of HK1226062A1 publication Critical patent/HK1226062A1/en
Publication of HK1226062B publication Critical patent/HK1226062B/en

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16114301.7A 2015-03-04 2016-03-02 TOLL-like receptor modulator 4,6-diamino-pyridine [3,2-D] pyrimidine compound HK1226062B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562128397P 2015-03-04 2015-03-04
US62/128,397 2015-03-04
US201562250403P 2015-11-03 2015-11-03
US62/250,403 2015-11-03

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HK1226062A1 HK1226062A1 (en) 2017-09-22
HK1226062B true HK1226062B (en) 2017-09-22

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