US20090155256A1 - Immunotherapy Regimes Dependent On APOE Status - Google Patents
Immunotherapy Regimes Dependent On APOE Status Download PDFInfo
- Publication number
- US20090155256A1 US20090155256A1 US12/253,929 US25392908A US2009155256A1 US 20090155256 A1 US20090155256 A1 US 20090155256A1 US 25392908 A US25392908 A US 25392908A US 2009155256 A1 US2009155256 A1 US 2009155256A1
- Authority
- US
- United States
- Prior art keywords
- antibody
- ser
- patients
- patient
- apoe4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Business, Economics & Management (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- General Business, Economics & Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/253,929 US20090155256A1 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy Regimes Dependent On APOE Status |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99942307P | 2007-10-17 | 2007-10-17 | |
US8382708P | 2008-07-25 | 2008-07-25 | |
US12/253,929 US20090155256A1 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy Regimes Dependent On APOE Status |
Publications (1)
Publication Number | Publication Date |
---|---|
US20090155256A1 true US20090155256A1 (en) | 2009-06-18 |
Family
ID=40568093
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/253,929 Abandoned US20090155256A1 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy Regimes Dependent On APOE Status |
US12/738,396 Active 2031-02-26 US9644025B2 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy regimes dependent on ApoE status |
US13/231,903 Abandoned US20120070379A1 (en) | 2007-10-17 | 2011-09-13 | Immunotherapy regimes dependent on apoe status |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/738,396 Active 2031-02-26 US9644025B2 (en) | 2007-10-17 | 2008-10-17 | Immunotherapy regimes dependent on ApoE status |
US13/231,903 Abandoned US20120070379A1 (en) | 2007-10-17 | 2011-09-13 | Immunotherapy regimes dependent on apoe status |
Country Status (32)
Country | Link |
---|---|
US (3) | US20090155256A1 (fr) |
EP (2) | EP2952524A1 (fr) |
JP (2) | JP5745853B2 (fr) |
KR (1) | KR101197839B1 (fr) |
CN (2) | CN101969988A (fr) |
AR (1) | AR071732A1 (fr) |
AU (1) | AU2008311823A1 (fr) |
BR (1) | BRPI0818000A2 (fr) |
CA (2) | CA2940337A1 (fr) |
CL (1) | CL2008003089A1 (fr) |
CO (1) | CO6331295A2 (fr) |
CY (1) | CY1116552T1 (fr) |
DK (1) | DK2207565T3 (fr) |
EA (2) | EA201590833A1 (fr) |
ES (1) | ES2547230T3 (fr) |
HK (2) | HK1146234A1 (fr) |
HR (1) | HRP20150790T1 (fr) |
HU (1) | HUE025684T2 (fr) |
IL (1) | IL205127A (fr) |
JO (1) | JO3076B1 (fr) |
MX (1) | MX2010004250A (fr) |
MY (1) | MY156454A (fr) |
PA (1) | PA8800801A1 (fr) |
PE (1) | PE20090971A1 (fr) |
PL (1) | PL2207565T3 (fr) |
PT (1) | PT2207565E (fr) |
RS (1) | RS54130B1 (fr) |
SG (2) | SG10201607589XA (fr) |
SI (1) | SI2207565T1 (fr) |
TW (2) | TWI581803B (fr) |
WO (1) | WO2009052439A2 (fr) |
ZA (1) | ZA201002544B (fr) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040081657A1 (en) * | 1997-12-02 | 2004-04-29 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US20060188512A1 (en) * | 2003-02-01 | 2006-08-24 | Ted Yednock | Active immunization to generate antibodies to solble a-beta |
US20060193850A1 (en) * | 2005-01-28 | 2006-08-31 | Warne Nicholas W | Anti a beta antibody formulation |
US20070072307A1 (en) * | 2005-06-17 | 2007-03-29 | Ranganathan Godavarti | Methods of purifying Fc region containing proteins |
US20080227718A1 (en) * | 1997-12-02 | 2008-09-18 | Elan Pharma International Limited | Prevention and treatment of amyloidogenic disease |
US20090285806A1 (en) * | 2004-10-05 | 2009-11-19 | Martin Sinacore | Methods and compositions for improving recombinant protein production |
US20100221187A1 (en) * | 2007-07-27 | 2010-09-02 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US20100291097A1 (en) * | 2007-10-05 | 2010-11-18 | Andrea Pfeifer | Monoclonal antibody |
US20100297013A1 (en) * | 2007-10-05 | 2010-11-25 | Andrea Pfeifer | Humanized antibody |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
WO2011106732A1 (fr) * | 2010-02-25 | 2011-09-01 | Wyeth Llc | Surveillance pet d'une immunothérapie dirigée contre l'aβ |
WO2011130355A1 (fr) * | 2010-04-13 | 2011-10-20 | Baxter International Inc. | Utilisation du taux d'agrandissement ventriculaire dans le traitement par immunoglobuline par voie intraveineuse de la maladie d'alzheimer |
WO2011133919A1 (fr) * | 2010-04-22 | 2011-10-27 | Janssen Alzheimer Immunotherapy | Utilisation de tau pour un suivi d'immunothérapie |
US8128928B2 (en) | 2002-03-12 | 2012-03-06 | Wyeth Llc | Humanized antibodies that recognize beta amyloid peptide |
US20120064065A1 (en) * | 2010-07-30 | 2012-03-15 | Andrea Pfeifer | Safe and functional humanized antibodies |
WO2012080926A2 (fr) | 2010-12-15 | 2012-06-21 | Wyeth Llc | Anticorps anti-notch1 |
US20130132110A1 (en) * | 2011-11-22 | 2013-05-23 | Sharp Kabushiki Kaisha | Dementia care support method, dementia information output apparatus, and dementia care support system |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8796439B2 (en) | 2006-07-14 | 2014-08-05 | Ac Immune S.A. | Nucleic acid molecules encoding a humanized antibody |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
US9051363B2 (en) | 1997-12-02 | 2015-06-09 | Janssen Sciences Ireland Uc | Humanized antibodies that recognize beta amyloid peptide |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US9090690B2 (en) | 2009-06-18 | 2015-07-28 | Pfizer Inc. | Anti Notch-1 antibodies |
US20150246963A1 (en) * | 2014-02-08 | 2015-09-03 | Genentech, Inc. | Methods of treating alzheimer's disease |
US9146244B2 (en) | 2007-06-12 | 2015-09-29 | Ac Immune S.A. | Polynucleotides encoding an anti-beta-amyloid monoclonal antibody |
US20160158165A1 (en) * | 2012-10-25 | 2016-06-09 | The General Hospital Corporation | Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders |
US9644025B2 (en) | 2007-10-17 | 2017-05-09 | Wyeth Llc | Immunotherapy regimes dependent on ApoE status |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
US20180251551A1 (en) * | 2013-09-13 | 2018-09-06 | Beigene, Ltd. | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
US10188757B2 (en) | 2013-10-22 | 2019-01-29 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
US10428146B2 (en) | 2014-07-22 | 2019-10-01 | Cb Therapeutics, Inc. | Anti PD-1 antibodies |
US10435470B2 (en) | 2014-08-05 | 2019-10-08 | Cb Therapeutics, Inc. | Anti-PD-L1 antibodies |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
US10561612B2 (en) | 2017-07-20 | 2020-02-18 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ibuprofen |
WO2020051333A1 (fr) | 2018-09-07 | 2020-03-12 | Pfizer Inc. | Anticorps anti-avb8, compositions et utilisations associées |
US10864203B2 (en) | 2016-07-05 | 2020-12-15 | Beigene, Ltd. | Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer |
WO2021113748A1 (fr) * | 2019-12-05 | 2021-06-10 | Arbele Corp. | Composition d'anticorps triaxiaux et son procédé de production et d'utilisation |
US11291648B2 (en) | 2018-07-02 | 2022-04-05 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and alpha-lactose |
US11555038B2 (en) | 2017-01-25 | 2023-01-17 | Beigene, Ltd. | Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
US11597768B2 (en) | 2017-06-26 | 2023-03-07 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
US11679095B2 (en) | 2016-08-31 | 2023-06-20 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
US11701357B2 (en) | 2016-08-19 | 2023-07-18 | Beigene Switzerland Gmbh | Treatment of B cell cancers using a combination comprising Btk inhibitors |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006106905A1 (fr) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Procede pour la production de polypeptide au moyen de la regulation d’un ensemble |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
EP3689912A1 (fr) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Procédé de modification d'un anticorps par point isoélectrique par substitution d'acide aminé dans cdr |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
RU2531521C2 (ru) | 2007-12-05 | 2014-10-20 | Чугаи Сейяку Кабусики Кайся | Антитело против nr10 и его применение |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2010131733A1 (fr) | 2009-05-15 | 2010-11-18 | 中外製薬株式会社 | Anticorps anti-axl |
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EP2481752B1 (fr) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Régions constantes modifiées d'un anticorps |
US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
PT2506871T (pt) | 2009-11-30 | 2016-11-07 | Janssen Biotech Inc | Mutantes de fc de anticorpos com funções efetoras inutilizadas |
US9102717B2 (en) | 2010-03-01 | 2015-08-11 | The J. David Gladstone Institutes | Antibody specific for apolipoprotein and methods of use thereof |
PE20130527A1 (es) | 2010-03-03 | 2013-05-09 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta biparatopicos |
JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2012142301A2 (fr) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Procédé de détermination d'un protocole de traitement et/ou d'un pronostic de rétablissement d'un patient à la suite d'un traumatisme cérébral |
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PE20190920A1 (es) | 2013-04-29 | 2019-06-26 | Hoffmann La Roche | Anticuerpos modificados de union a fcrn humano y metodos de utilizacion |
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EP3374379A4 (fr) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | Épitopes n-terminaux dans la bêta-amyloïde et anticorps conformationnellement sélectifs associés |
US10774120B2 (en) | 2015-11-09 | 2020-09-15 | The University Of British Columbia | Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide |
WO2017079834A1 (fr) * | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Épitopes dans la bêta-amyloïde et anticorps conformationnels sélectifs associés |
DK3380522T3 (da) | 2015-11-25 | 2024-01-22 | Visterra Inc | Antistofmolekyler til april og anvendelser deraf |
AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
KR20180104635A (ko) * | 2015-12-30 | 2018-09-21 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
US10611842B2 (en) | 2016-08-03 | 2020-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Disrupting FC receptor engagement on macrophages enhances efficacy of anti-SIRPα antibody therapy |
SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
AU2018250695A1 (en) | 2017-04-14 | 2019-11-07 | Kodiak Sciences Inc. | Complement factor D antagonist antibodies and conjugates thereof |
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