TWI716362B - 針對ｐｄ－ｌ１之抗體分子及其用途 - Google Patents

針對ｐｄ－ｌ１之抗體分子及其用途 Download PDF

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TWI716362B
TWI716362B TW104133578A TW104133578A TWI716362B TW I716362 B TWI716362 B TW I716362B TW 104133578 A TW104133578 A TW 104133578A TW 104133578 A TW104133578 A TW 104133578A TW I716362 B TWI716362 B TW I716362B
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seq
amino acid
bap058
acid sequence
cancer
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TW104133578A
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TW201620940A (zh
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高登 詹姆士 費里曼
阿爾玲 海倫 夏培
喬哈德 喬翰 弗萊
懷文 張
珍妮佛 瑪莉 瑪塔拉薩
葛蘭 德蘭歐夫
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瑞士商諾華公司
美商達納 法伯癌症協會
哈佛大學校長及研究員協會
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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TW104133578A 2014-10-14 2015-10-13 針對ｐｄ－ｌ１之抗體分子及其用途 TWI716362B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462063852P 2014-10-14 2014-10-14
US62/063,852 2014-10-14
US201462094847P 2014-12-19 2014-12-19
US62/094,847 2014-12-19
US201562198545P 2015-07-29 2015-07-29
US62/198,545 2015-07-29
US201562213076P 2015-09-01 2015-09-01
US62/213,076 2015-09-01

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TW201620940A TW201620940A (zh) 2016-06-16
TWI716362B true TWI716362B (zh) 2021-01-21

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US (4) US9988452B2 (enExample)
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KR (1) KR102513870B1 (enExample)
CN (2) CN107001478B (enExample)
AU (1) AU2015333687B2 (enExample)
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