SE460792B - Metod foer framstaellning av tvaerbunden hyaluronsyragel, tvaerbunden gel framstaelld enligt denna metod, blandning av tvaerbunden hyaluronsyra gel med annan hydrofil polymer samt kompositioner som innehaaller denna gel - Google Patents
Metod foer framstaellning av tvaerbunden hyaluronsyragel, tvaerbunden gel framstaelld enligt denna metod, blandning av tvaerbunden hyaluronsyra gel med annan hydrofil polymer samt kompositioner som innehaaller denna gelInfo
- Publication number
- SE460792B SE460792B SE8503486A SE8503486A SE460792B SE 460792 B SE460792 B SE 460792B SE 8503486 A SE8503486 A SE 8503486A SE 8503486 A SE8503486 A SE 8503486A SE 460792 B SE460792 B SE 460792B
- Authority
- SE
- Sweden
- Prior art keywords
- weight
- sodium hyaluronate
- gel
- hyaluronic acid
- hydrophilic polymer
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/678,895 US4582865A (en) | 1984-12-06 | 1984-12-06 | Cross-linked gels of hyaluronic acid and products containing such gels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8503486D0 SE8503486D0 (sv) | 1985-07-15 |
| SE8503486L SE8503486L (sv) | 1986-06-07 |
| SE460792B true SE460792B (sv) | 1989-11-20 |
Family
ID=24724742
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8503486A SE460792B (sv) | 1984-12-06 | 1985-07-15 | Metod foer framstaellning av tvaerbunden hyaluronsyragel, tvaerbunden gel framstaelld enligt denna metod, blandning av tvaerbunden hyaluronsyra gel med annan hydrofil polymer samt kompositioner som innehaaller denna gel |
| SE8901672A SE501828C2 (sv) | 1984-12-06 | 1989-05-10 | Matris bestående av en tvärbunden gel av hyaluronsyra för avgivning av en i matrisen innesluten substans med biologisk eller farmakologisk verkan |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8901672A SE501828C2 (sv) | 1984-12-06 | 1989-05-10 | Matris bestående av en tvärbunden gel av hyaluronsyra för avgivning av en i matrisen innesluten substans med biologisk eller farmakologisk verkan |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4582865A (pm) |
| JP (2) | JPS61138601A (pm) |
| AU (2) | AU569157B2 (pm) |
| CA (1) | CA1230186A (pm) |
| DE (2) | DE3546811C2 (pm) |
| FR (1) | FR2574414B1 (pm) |
| GB (4) | GB2168067B (pm) |
| IT (1) | IT1187737B (pm) |
| SE (2) | SE460792B (pm) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
| US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
Families Citing this family (296)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0611694B2 (ja) * | 1985-01-29 | 1994-02-16 | 生化学工業株式会社 | 皮膚化粧料 |
| US4863907A (en) * | 1984-06-29 | 1989-09-05 | Seikagaku Kogyo Co., Ltd. | Crosslinked glycosaminoglycans and their use |
| US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US4713448A (en) * | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
| US5099013A (en) * | 1985-03-12 | 1992-03-24 | Biomatrix, Inc, | Hylan preparation and method of recovery thereof from animal tissues |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
| EP0224987B1 (en) * | 1985-11-29 | 1992-04-15 | Biomatrix, Inc. | Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same |
| IT1198449B (it) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| AU610512B2 (en) * | 1986-12-11 | 1991-05-23 | Biomatrix Incorporated | Improved hyaluronate-poly (ethylene oxide) mixtures |
| ATE129254T1 (de) * | 1987-03-19 | 1995-11-15 | Arthropharm Pty Ltd | Antientzündungsmittel und zusammensetzungen. |
| US4795741A (en) * | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
| GB8713662D0 (en) * | 1987-06-11 | 1987-07-15 | Skandigen Ab | Hyaluronic acid derivatives |
| US6610669B1 (en) | 1987-09-18 | 2003-08-26 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| US5017229A (en) * | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5527893A (en) * | 1987-09-18 | 1996-06-18 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| US6174999B1 (en) * | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| US4937270A (en) * | 1987-09-18 | 1990-06-26 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| AU619760B2 (en) * | 1987-12-10 | 1992-02-06 | Genzyme Biosurgery Corporation | Hylan preparation and method of recovery thereof from animal tissues |
| US4888016A (en) * | 1988-02-10 | 1989-12-19 | Langerman David W | "Spare parts" for use in ophthalmic surgical procedures |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| JPH0662678B2 (ja) * | 1988-11-28 | 1994-08-17 | 電気化学工業株式会社 | ヒアルロン酸固定化蛋白質及びその製造方法 |
| US4973473A (en) * | 1989-06-23 | 1990-11-27 | Revlon, Inc. | Skin care preparation |
| US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| US5153174A (en) * | 1989-10-30 | 1992-10-06 | Union Carbide Chemicals & Plastics Inc. | Polymer mixtures useful in skin care |
| CA2086014A1 (en) * | 1990-07-03 | 1992-01-04 | CHARLES D. kELMAN | Collagen-based viscoelastic solution for visco-surgery |
| US5246698A (en) * | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5639738A (en) * | 1992-02-20 | 1997-06-17 | Hyal Pharmaceutical Corporation | Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs |
| US5219360A (en) * | 1991-05-10 | 1993-06-15 | Fortis Research Corporation | Mammary prosthesis fill and method of making same |
| EP0516026A1 (en) * | 1991-05-28 | 1992-12-02 | Takeda Chemical Industries, Ltd. | Hydrogel and method of producing same |
| US5234914A (en) * | 1991-06-11 | 1993-08-10 | Patent Biopharmaceutics, Inc. | Methods of treating hemorrhoids and anorecial disease |
| US5817644A (en) * | 1991-07-03 | 1998-10-06 | Hyal Pharmaceutical Corporation | Targeting of dosages of medicine and therapeutic agents |
| US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6103704A (en) * | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| US5990095A (en) * | 1991-07-03 | 1999-11-23 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US6022866A (en) * | 1991-07-03 | 2000-02-08 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
| WO1994007505A1 (en) * | 1991-07-03 | 1994-04-14 | Norpharmco Inc. | Use of hyaluronic acid and forms to prevent arterial restenosis |
| JPH0539480U (ja) * | 1991-10-31 | 1993-05-28 | ジユーキ株式会社 | ミシンの針棒 |
| AU636544B1 (en) * | 1991-11-27 | 1993-04-29 | Lignyte Co., Ltd. | Water insoluble biocompatible hyaluronic acid polyion complex and method of making the same |
| DE4200080A1 (de) * | 1992-01-03 | 1993-09-30 | Reinmueller Johannes | Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung |
| CA2072918A1 (en) * | 1992-02-14 | 1993-08-15 | Jian Qin | Modified polysaccharides having improved absorbent properties and process for the preparation thereof |
| US6147059A (en) * | 1992-02-20 | 2000-11-14 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| CA2061567C (en) * | 1992-02-20 | 1998-02-03 | Rudolf E. Falk | Use of hyaluronic acid to repair ischemia reperfusion damage |
| US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6114314A (en) * | 1992-02-21 | 2000-09-05 | Hyal Pharmaceutical Corp. | Formulations containing hyaluronic acid |
| US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
| DE69321285T2 (de) * | 1992-05-15 | 1999-03-04 | Shiseido Co. Ltd., Tokio/Tokyo | Äusserliches Hautpräparat |
| IT1260154B (it) * | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| US5437867A (en) * | 1993-03-19 | 1995-08-01 | Collaborative Laboratories | Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same |
| US5531716A (en) * | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
| US5616568A (en) * | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| US5585361A (en) | 1994-06-07 | 1996-12-17 | Genzyme Corporation | Methods for the inhibition of platelet adherence and aggregation |
| US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| US5690961A (en) * | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| US5498705A (en) * | 1995-02-22 | 1996-03-12 | Kimberly-Clark Corporation | Modified polysaccharides having improved absorbent properties and process for the preparation thereof |
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| WO1997017023A1 (en) | 1995-11-07 | 1997-05-15 | Fusion Medical Technologies, Inc. | Methods and articles for fusing polysaccharide-containing matrix layers to tissue |
| US6132462A (en) * | 1995-12-22 | 2000-10-17 | Santen Pharmaceutical Co., Ltd. | Copolymers formed from three components and intraocular lenses made thereof |
| SE9601368D0 (sv) * | 1996-04-11 | 1996-04-11 | Pharmacia Biotech Ab | Process for the production of a porous cross-linked polysaccharide gel |
| US6060534A (en) | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
| US6368356B1 (en) | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
| ATE406176T1 (de) | 1996-12-06 | 2008-09-15 | Amgen Inc | Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| GB2322864A (en) * | 1997-03-07 | 1998-09-09 | Polybiomed Ltd | Gel for application to the human or animal body |
| US6709873B1 (en) * | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
| EP1004597A4 (en) * | 1997-05-28 | 2002-06-05 | Tapic Int Co Ltd | COLLAGEN GEL |
| US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
| US5897988A (en) * | 1998-01-21 | 1999-04-27 | Yale University | Process and system for selection of mature sperm by surface membrane determinants for assisted reproduction |
| ATE261454T1 (de) * | 1998-02-27 | 2004-03-15 | Stichting Hippomedics | Verfahren zur herstellung von vernetzter hyaluronsäure |
| US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
| IT1303738B1 (it) * | 1998-11-11 | 2001-02-23 | Aquisitio S P A | Processo di reticolazione di polisaccaridi carbossilati. |
| US7375096B1 (en) * | 1998-12-04 | 2008-05-20 | California Institute Of Technology | Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network |
| ATE483480T1 (de) * | 1998-12-16 | 2010-10-15 | Tno | Saure superabsorbierende polysaccharide |
| GB9902412D0 (en) * | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
| GB9902652D0 (en) | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
| US6638538B1 (en) * | 1999-02-19 | 2003-10-28 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel composition, process for producing the same, and medical material containing the same |
| JP2002539157A (ja) | 1999-03-15 | 2002-11-19 | トラスティーズ オブ ボストン ユニバーシティ | 血管新生阻害 |
| US20040048021A1 (en) * | 1999-03-19 | 2004-03-11 | Wan Barbara Y. F. | Surface modification of substrates |
| CA2366897C (en) * | 1999-04-06 | 2009-11-17 | Andrew B. Onderdonk | Immunomodulatory compositions and methods of use thereof |
| US6288043B1 (en) | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
| WO2001006973A1 (en) | 1999-07-28 | 2001-02-01 | United States Surgical Corporation | Hyaluronic acid anti-adhesion barrier |
| KR100721752B1 (ko) | 2000-01-24 | 2007-05-25 | 쿠라레 메디카루 가부시키가이샤 | 수팽윤성 고분자 겔 및 그 제조법 |
| US6521223B1 (en) * | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
| US6749865B2 (en) * | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| KR100375299B1 (ko) | 2000-10-10 | 2003-03-10 | 주식회사 엘지생명과학 | 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법 |
| EP1339349A4 (en) * | 2000-11-14 | 2007-07-04 | R Labs Inc Nv | LAMININ GELS AND RETICULATED HYALURONIC ACID AND THEIR USE IN CELL CULTURE AND MEDICAL IMPLANTS |
| ATE312076T1 (de) * | 2001-02-22 | 2005-12-15 | Anika Therapeutics Inc | Thiol-modifizierte hyaluronan-derivate |
| US20020172712A1 (en) * | 2001-03-19 | 2002-11-21 | Alan Drizen | Antiemetic, anti-motion sustained release drug delivery system |
| US6913765B2 (en) * | 2001-03-21 | 2005-07-05 | Scimed Life Systems, Inc. | Controlling resorption of bioresorbable medical implant material |
| US8580290B2 (en) * | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
| US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
| AU2003221078A1 (en) * | 2002-04-08 | 2003-10-20 | Denki Kagaku Kogyo Kabushiki Kaisha | Therapeutic composition for bone infectious disease |
| DE10223310A1 (de) * | 2002-05-24 | 2003-12-11 | Biotronik Mess & Therapieg | Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage |
| EP2075014B9 (en) * | 2002-05-24 | 2012-02-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| US8313760B2 (en) * | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| CA2489712C (en) * | 2002-06-21 | 2016-07-12 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
| US7034127B2 (en) * | 2002-07-02 | 2006-04-25 | Genzyme Corporation | Hydrophilic biopolymer-drug conjugates, their preparation and use |
| US7338433B2 (en) * | 2002-08-13 | 2008-03-04 | Allergan, Inc. | Remotely adjustable gastric banding method |
| US20060135469A1 (en) * | 2002-08-16 | 2006-06-22 | Denki Kagaku Kogyo Kabushiki Kaisha | Separate type medical material |
| DK1553878T3 (da) * | 2002-08-28 | 2010-05-31 | Allergan Inc | Træthedsbestandig gastrisk båndanordning |
| KR101476067B1 (ko) * | 2002-09-06 | 2014-12-23 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
| DE10252816B4 (de) * | 2002-11-13 | 2008-02-14 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Kosmetische Zubereitung, sowie ein Verfahren zu ihrer Herstellung und ihre Verwendung |
| EP1564220A4 (en) * | 2002-11-21 | 2010-03-17 | Chugai Pharmaceutical Co Ltd | EXCIPIENT FOR DELAYED RELEASE MEDICINE |
| TWI251596B (en) * | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
| LT5098B (lt) | 2003-03-28 | 2004-01-26 | Alvyda GUDELEVI�I�T� | Kremų kompozicijos senstančiai odai |
| FR2861734B1 (fr) * | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| AU2003901834A0 (en) | 2003-04-17 | 2003-05-01 | Clearcoll Pty Ltd | Cross-linked polysaccharide compositions |
| JP2004323454A (ja) * | 2003-04-25 | 2004-11-18 | Chisso Corp | 薬剤 |
| CN101137388A (zh) * | 2003-05-15 | 2008-03-05 | 犹他卅大学研究基金会 | 抗粘连复合材料及其应用方法 |
| ES2226567B1 (es) * | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
| DE10328815A1 (de) * | 2003-06-21 | 2005-01-05 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit |
| DE10328816A1 (de) | 2003-06-21 | 2005-01-05 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit |
| ES2232287B1 (es) * | 2003-07-04 | 2006-11-01 | Advanced In Vitro Cell Technologies, S.L. | Nanoparticulas de derivados polioxietilenados. |
| US20060246137A1 (en) * | 2003-07-30 | 2006-11-02 | Laurence Hermitte | Complex matrix for biomedical use |
| ES2406555T3 (es) * | 2003-10-29 | 2013-06-07 | Teijin Limited | Compuesto de ácido hialurónico, hidrogel del mismo y material para tratar articulaciones |
| AU2004293075A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| WO2005056763A2 (en) * | 2003-12-04 | 2005-06-23 | University Of Utah Research Foundation | Process and formulation to improve viability of stored cells and tissue |
| CN100537606C (zh) * | 2003-12-30 | 2009-09-09 | 建新公司 | 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 |
| US8524213B2 (en) * | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
| JP2007527279A (ja) | 2004-01-23 | 2007-09-27 | アラーガン、インコーポレイテッド | 取り外し可能に固定できるワンピース調整可能な胃バンド |
| CA2559056A1 (en) * | 2004-03-08 | 2005-09-22 | Endoart S.A. | Closure system for tubular organs |
| AU2005223678B2 (en) * | 2004-03-17 | 2010-08-26 | Genzyme Corporation | Anti-adhesion spraying |
| EP1732635B1 (en) * | 2004-03-18 | 2011-07-27 | Allergan, Inc. | Apparatus for volume adjustment of intragastric balloons |
| BRPI0510477B1 (pt) | 2004-04-28 | 2023-01-17 | Angiotech Biomaterials Corporation | Método para formar um gel e dispositivo para uso em aplicações médicas |
| ES2246695B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
| ES2246694B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
| EP1753787B1 (en) * | 2004-05-20 | 2016-10-19 | Mentor Worldwide LLC | Method of covalently linking hyaluronan and chitosan |
| CA2567532C (en) * | 2004-05-20 | 2013-10-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
| ITMI20041373A1 (it) | 2004-07-09 | 2004-10-09 | Lima Lto S P A | N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido |
| JP5060131B2 (ja) | 2004-09-07 | 2012-10-31 | 中外製薬株式会社 | 水溶性ヒアルロン酸修飾物の製造方法 |
| JP4875988B2 (ja) * | 2004-11-15 | 2012-02-15 | 株式会社 資生堂 | 架橋ヒアルロン酸ゲルの製造方法 |
| WO2006056204A1 (en) * | 2004-11-24 | 2006-06-01 | Novozymes Biopolymer A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
| PL1835923T3 (pl) * | 2004-12-30 | 2014-03-31 | Genzyme Corp | Schematy wiskosuplementacji dostawowej |
| AU2005100176A4 (en) * | 2005-03-01 | 2005-04-07 | Gym Tv Pty Ltd | Garbage bin clip |
| US8251888B2 (en) | 2005-04-13 | 2012-08-28 | Mitchell Steven Roslin | Artificial gastric valve |
| DE102005030614B4 (de) * | 2005-06-30 | 2014-05-08 | Biotissue Ag | Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel |
| US8378091B2 (en) * | 2005-08-04 | 2013-02-19 | Teijin Limited | Cellulose derivative |
| CA2620663A1 (en) * | 2005-09-02 | 2007-03-08 | Colbar Lifescience Ltd. | Cross-linked polysaccharide and protein matrices and methods for their preparation |
| AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| CA2633957A1 (en) * | 2005-12-14 | 2007-06-21 | Anika Therapeutics, Inc. | Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid |
| WO2007070617A1 (en) | 2005-12-14 | 2007-06-21 | Anika Therapeutics, Inc. | Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects |
| US7798954B2 (en) | 2006-01-04 | 2010-09-21 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
| US8043206B2 (en) | 2006-01-04 | 2011-10-25 | Allergan, Inc. | Self-regulating gastric band with pressure data processing |
| ES2428376T3 (es) | 2006-03-07 | 2013-11-07 | Prochon Biotech Ltd. | Derivados hidrazido de ácido hialurónico |
| US7674781B2 (en) * | 2006-04-28 | 2010-03-09 | Heather Sheardown | Hyaluronic acid-retaining polymers |
| ITMI20061726A1 (it) * | 2006-09-11 | 2008-03-12 | Fidia Farmaceutici | Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry |
| CN101522164B (zh) * | 2006-09-13 | 2014-03-26 | 提升肤质产品公司 | 用于治疗皮肤的化妆品组合物及其方法 |
| JP5030219B2 (ja) * | 2007-07-19 | 2012-09-19 | 眞知子 瀧上 | カルボキシメチルセルロースアルカリ塩のゲルの製造方法及びそれによって得られたカルボキシメチルセルロースアルカリ塩のゲル |
| DE102006047346A1 (de) * | 2006-10-06 | 2008-04-10 | Transtissue Technologies Gmbh | Matrix-Gel-Transplantat ohne Zellen |
| US8329870B2 (en) * | 2007-01-04 | 2012-12-11 | Hepacore Ltd. | Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| US8529951B1 (en) | 2007-02-21 | 2013-09-10 | Anand Ramamurthi | Elastogenic cues and methods for using same |
| EP2143446B1 (en) * | 2007-05-01 | 2019-07-24 | National University Corporation Tokyo Medical and Dental University | Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same |
| AU2008256819A1 (en) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Cross-linked collagen and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| FR2918377B1 (fr) | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
| US20110077737A1 (en) * | 2007-07-30 | 2011-03-31 | Allergan, Inc. | Tunably Crosslinked Polysaccharide Compositions |
| US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
| EP3498299A1 (en) | 2007-11-16 | 2019-06-19 | Aclaris Therapeutics, Inc. | Compositions and methods for treating purpura |
| US8394782B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8394784B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
| US20090143348A1 (en) * | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
| FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| WO2009077399A1 (en) * | 2007-12-19 | 2009-06-25 | Evonik Goldschmidt Gmbh | Crosslinked hyaluronic acid in emulsion |
| RU2366666C1 (ru) * | 2007-12-20 | 2009-09-10 | Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН | Способ получения сшитых солей гиалуроновой кислоты в водной среде |
| US7763268B2 (en) * | 2008-01-18 | 2010-07-27 | The Research Foundation Of State University Of New York | Load bearing hydrogel implants |
| RU2386640C2 (ru) * | 2008-06-25 | 2010-04-20 | Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН | Способ получения модифицированной рибофлавином сшитой соли гиалуроновой кислоты |
| RU2386641C2 (ru) * | 2008-07-09 | 2010-04-20 | Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН | Способ получения модифицированной ретинолом сшитой соли гиалуроновой кислоты |
| RU2387671C1 (ru) * | 2008-07-30 | 2010-04-27 | Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН | Способ получения модифицированной витаминами сшитой соли гиалуроновой кислоты |
| RU2387670C1 (ru) * | 2008-07-30 | 2010-04-27 | Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН | Способ получения модифицированной фолиевой кислотой сшитой соли гиалуроновой кислоты |
| US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| ES2829971T3 (es) | 2008-09-02 | 2021-06-02 | Tautona Group Lp | Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos y usos de los mismos |
| TWI387620B (zh) * | 2008-09-23 | 2013-03-01 | Scivision Biotech Inc | 交聯透明質酸之製造方法 |
| EP2337536B1 (en) | 2008-10-02 | 2020-08-12 | L.R. R & D Ltd. | Interface layer wound dressing |
| US20100305397A1 (en) * | 2008-10-06 | 2010-12-02 | Allergan Medical Sarl | Hydraulic-mechanical gastric band |
| WO2010042493A1 (en) * | 2008-10-06 | 2010-04-15 | Allergan, Inc. | Mechanical gastric band with cushions |
| CN101721349B (zh) | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| US20100185049A1 (en) | 2008-10-22 | 2010-07-22 | Allergan, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
| CZ301555B6 (cs) | 2008-11-06 | 2010-04-14 | Cpn S. R. O. | Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace |
| US8679470B2 (en) | 2008-11-28 | 2014-03-25 | Luromed Llc | Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications |
| JP2010202522A (ja) * | 2009-02-27 | 2010-09-16 | Shiseido Co Ltd | 耐塩性増粘剤及びそれを配合した化粧料 |
| ES2621380T3 (es) * | 2009-04-02 | 2017-07-03 | Allergan, Inc. | Hidrogeles con forma de cabello para aumento de tejidos blandos |
| US9371402B2 (en) | 2009-04-09 | 2016-06-21 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
| US20110184229A1 (en) * | 2009-05-01 | 2011-07-28 | Allergan, Inc. | Laparoscopic gastric band with active agents |
| EP2424583A2 (en) * | 2009-05-01 | 2012-03-07 | Allergan, Inc. | Laparoscopic gastric band with active agents |
| IT1399351B1 (it) | 2009-06-16 | 2013-04-16 | Fidia Farmaceutici | Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi |
| WO2011014432A1 (en) | 2009-07-30 | 2011-02-03 | Carbylan Biosurgery, Inc. | Modified hyaluronic acid polymer compositions and related methods |
| WO2011031400A2 (en) * | 2009-08-28 | 2011-03-17 | Allergan, Inc. | Gastric band with electric stimulation |
| US20110137112A1 (en) * | 2009-08-28 | 2011-06-09 | Allergan, Inc. | Gastric band with electric stimulation |
| US8273725B2 (en) | 2009-09-10 | 2012-09-25 | Genzyme Corporation | Stable hyaluronan/steroid formulation |
| US8247390B2 (en) * | 2009-09-28 | 2012-08-21 | Luromed Llc | Modified hydrophilic polymers containing hydrophobic groups |
| CN102781237A (zh) * | 2009-11-23 | 2012-11-14 | 天蓝制药公司 | 用于传递治疗剂的基于环糊精的聚合物 |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| US20110171286A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan, Inc. | Hyaluronic acid compositions for dermatological use |
| US20110171311A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
| US8758221B2 (en) * | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
| US8840541B2 (en) * | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
| EP2544652A2 (en) | 2010-03-12 | 2013-01-16 | Allergan Industrie SAS | A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition. |
| PL2550027T5 (pl) | 2010-03-22 | 2019-07-31 | Allergan, Inc. | Polisacharydowe i białkowo-polisacharydowe usieciowane hydrożele do powiększania tkanek miękkich |
| US9028394B2 (en) | 2010-04-29 | 2015-05-12 | Apollo Endosurgery, Inc. | Self-adjusting mechanical gastric band |
| US9044298B2 (en) | 2010-04-29 | 2015-06-02 | Apollo Endosurgery, Inc. | Self-adjusting gastric band |
| US20110270024A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
| US20110270025A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Remotely powered remotely adjustable gastric band system |
| US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US9017712B2 (en) | 2010-07-12 | 2015-04-28 | Shin Poong Pharmaceutical Co., Ltd. | Filler composition for tissue reinforcement |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US20120059216A1 (en) | 2010-09-07 | 2012-03-08 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
| CZ303548B6 (cs) | 2011-01-05 | 2012-11-28 | Contipro Pharma A.S. | Zdravotní prípravek tvorící jód, zpusob jeho prípravy a bandáž, která jej obsahuje |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US9381269B2 (en) | 2011-04-13 | 2016-07-05 | Avent, Inc. | Biosorbable wound treatment device, process for making, and method of using the same |
| WO2012145439A1 (en) | 2011-04-20 | 2012-10-26 | Carbylan Biosurgery, Inc. | In-situ gel forming compositions |
| ITTO20110428A1 (it) | 2011-05-13 | 2012-11-14 | Rottapharm Spa | Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia |
| KR102154944B1 (ko) | 2011-06-03 | 2020-09-11 | 알러간 인더스트리 에스에이에스 | 항산화제를 포함하는 피부 충전제 조성물 |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| CN103687622A (zh) | 2011-06-16 | 2014-03-26 | 香港科技大学 | 含有多个乙烯砜的分子 |
| WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
| PL2742070T3 (pl) | 2011-08-10 | 2022-01-31 | Glycores 2000 Srl | Odporny na rozkład usieciowany hialuronian o niskiej masie cząsteczkowej |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US20140256695A1 (en) * | 2011-11-11 | 2014-09-11 | Phi Nguyen | Injectable filler |
| FR2983483B1 (fr) | 2011-12-02 | 2014-11-14 | Vivacy Lab | Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles |
| US8876694B2 (en) | 2011-12-07 | 2014-11-04 | Apollo Endosurgery, Inc. | Tube connector with a guiding tip |
| JP6316537B2 (ja) * | 2011-12-20 | 2018-04-25 | 三洋化成工業株式会社 | 分岐ヒアルロン酸及びその製造方法 |
| US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
| WO2013109959A1 (en) * | 2012-01-18 | 2013-07-25 | University Of Kansas | Hyaluronic acid particles and their use in biomedical applications |
| DK2831237T3 (en) | 2012-03-30 | 2018-03-05 | Univ Oklahoma | HIGH-MOLECULAR HEPAROSAN POLYMERS AND METHODS OF PRODUCING AND USING THEREOF |
| CZ2012282A3 (cs) | 2012-04-25 | 2013-11-06 | Contipro Biotech S.R.O. | Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi |
| ITPD20120173A1 (it) | 2012-05-31 | 2013-12-01 | Fidia Farmaceutici | "nuovo sistema di rilascio di proteine idrofobiche" |
| WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| US20160228603A1 (en) * | 2013-04-12 | 2016-08-11 | Miba Medical Inc. | Body augmentation device |
| KR102048395B1 (ko) * | 2013-06-28 | 2019-11-25 | 갈데르마 소시에떼아노님 | 성형된 가교 히알루론산 생성물의 제조 방법 |
| CN103333349A (zh) * | 2013-06-28 | 2013-10-02 | 陕西巨子生物技术有限公司 | 一种注射用透明质酸-胶原蛋白复合水凝胶及其制备方法 |
| EP2832378A2 (en) | 2013-08-01 | 2015-02-04 | Ivis Technologies S R L | Adhesive biopolymer for use as a temporary replacement of the epithelium |
| TWI482634B (zh) * | 2013-10-24 | 2015-05-01 | Ind Tech Res Inst | 生醫組合物 |
| KR101459070B1 (ko) | 2013-12-09 | 2014-11-17 | (주) 뉴메딕 | 지속성을 갖는 히알루론산 겔 조성물 |
| AR099900A1 (es) | 2014-04-01 | 2016-08-24 | Merz Pharma Gmbh & Co Kgaa | Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso |
| KR20230048175A (ko) | 2014-08-15 | 2023-04-10 | 더 존스 홉킨스 유니버시티 | 조직 복원용 복합 재료 |
| EP3620184A1 (en) | 2014-09-30 | 2020-03-11 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
| KR101694121B1 (ko) | 2014-10-28 | 2017-01-10 | (주)헵틸와이 | 이중 가교구조의 생체친화형 다공성 시트 및 그 제조방법 |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| KR101521058B1 (ko) * | 2014-12-08 | 2015-05-15 | 이노팜 주식회사 | 생체적합성 조성물 및 이의 제조방법 |
| CN104530460A (zh) * | 2014-12-19 | 2015-04-22 | 大连理工大学 | 糖基化高分子材料及其制备方法 |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| AU2016217792B2 (en) | 2015-02-13 | 2020-07-02 | Allergan Industrie, Sas | Implants for sculpting, augmenting or correcting facial features such as the chin |
| CN107921237A (zh) | 2015-04-27 | 2018-04-17 | 反射医学公司 | 交感神经心肺神经调节系统和方法 |
| EP3316921B1 (en) * | 2015-06-30 | 2021-05-05 | Merz Pharma GmbH & Co. KGaA | Method for producing crosslinked hyaluronic acid |
| KR101818705B1 (ko) | 2015-07-20 | 2018-01-16 | 포항공과대학교 산학협력단 | 약물이 충전된 히알루론산 가교물 하이드로겔 및 이의 이용 |
| KR20170025778A (ko) | 2015-08-31 | 2017-03-08 | 대화제약 주식회사 | 항산화제를 포함하는 생체 적합성 고분자 히알루론산 유도체 및 그 히알루론산의 가교결합물 |
| CA3005438A1 (en) * | 2015-11-18 | 2017-05-26 | Lifecell Corporation | Hydrogel coated mesh |
| US11246879B2 (en) | 2016-02-09 | 2022-02-15 | Tulai Therapeutics, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| KR101866310B1 (ko) | 2016-05-31 | 2018-06-11 | 주식회사 글랜젠 | 생체 내 지속성 및 항산화 작용이 향상된 진피 충전재 조성물 및 이의 제조방법 |
| EP3478287A4 (en) | 2016-06-29 | 2020-04-08 | Tulavi Therapeutics, Inc. | TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM |
| EP3512561A4 (en) * | 2016-09-16 | 2020-10-07 | Glycologix, LLC | SULFATED GLYCOSAMINOGLYCAN BIOMATERIALS AS PROTEOGLYCAN MIMETICS |
| CZ2016826A3 (cs) | 2016-12-22 | 2018-07-04 | Contipro A.S. | Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití |
| US20200230288A1 (en) | 2017-02-02 | 2020-07-23 | Amtixbio Co., Ltd | Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof |
| US20190240335A1 (en) | 2018-02-07 | 2019-08-08 | Promedon S.A. | Biocompatible Hydrogel Compositions |
| EP3773732A4 (en) * | 2018-03-29 | 2022-07-27 | Ramesh S. Ayyala | METHODS AND COMPOSITIONS FOR THE ADMINISTRATION OF A THERAPEUTIC AGENT |
| JP2021522938A (ja) | 2018-05-09 | 2021-09-02 | ザ ジョンズ ホプキンス ユニバーシティ | 細胞及び組織の送達のためのナノファイバー−ハイドロゲル複合体 |
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| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
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| KR102162724B1 (ko) | 2020-03-24 | 2020-10-07 | 바이오플러스 주식회사 | 가교 히알루론산 겔 및 이의 제조 방법 |
| EP4129349A4 (en) * | 2020-03-31 | 2024-03-27 | Kureha Corporation | BIOABSORBABLE MEDICAL MATERIAL |
| BR112022023209A2 (pt) * | 2020-05-14 | 2023-02-07 | Allergan Pharmaceuticals Int Ltd | Composições compreendendo tropoelastina reticulada ao ácido hialurônico e métodos de uso das mesmas |
| KR102366394B1 (ko) * | 2021-01-05 | 2022-02-23 | 조광용 | 고팽윤성 히알루론산 비드 겔 |
| KR20220106283A (ko) | 2021-01-22 | 2022-07-29 | (주)앰틱스바이오 | 자가 가교형 히알루론산 유도체 기반 창상피복재 |
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| US20250090719A1 (en) * | 2021-07-30 | 2025-03-20 | Regents Of The University Of Minnesota | Biomaterials for embolization and drug delivery |
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| WO2024172910A1 (en) * | 2023-02-15 | 2024-08-22 | Lifesprout, Inc. | Modified crosslinked polymers |
| WO2025091137A1 (en) | 2023-11-02 | 2025-05-08 | Volumina Medical Sa | Implantable device compositions including ester bonds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1047380B (de) * | 1954-08-18 | 1958-12-24 | American Home Prod | Verfahren zur Herstellung einer hyaluronidasefreien, teilweise depolymerisierte Hyaluronsaeure enthaltenden waessrigen Traegerloesung fuer Arzneimittel |
| DE1043589B (de) * | 1956-01-02 | 1958-11-13 | Kisaku Ibe | Haut- und Haarpflegemittel und Verfahren zu ihrer Herstellung |
| US3357784A (en) * | 1964-09-30 | 1967-12-12 | Kendall & Co | Exposure to intense ultraviolet light to improve characteristics of cellulosic fabrics in divinyl sulfone and glyoxal cross-linking processes |
| SE361320B (pm) * | 1972-03-14 | 1973-10-29 | Exploaterings Ab Tbf | |
| US4152170A (en) * | 1975-06-18 | 1979-05-01 | Sumitomo Chemical Company, Ltd. | Cross-linked pullulan |
| GB1515963A (en) * | 1975-07-15 | 1978-06-28 | Massachusetts Inst Technology | Crosslinked collagen-mucopolysaccharide composite materials |
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4303676A (en) * | 1980-03-21 | 1981-12-01 | Balazs Endre A | Hyaluronate based compositions and cosmetic formulations containing same |
| JPS59162779A (ja) * | 1983-03-04 | 1984-09-13 | Toshiba Corp | 周波数変換装置の制御方法 |
| US4448718A (en) * | 1983-09-13 | 1984-05-15 | Massachusetts Institute Of Technology | Method for the preparation of collagen-glycosaminoglycan composite materials |
| US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
| CA1238043A (en) * | 1983-12-15 | 1988-06-14 | Endre A. Balazs | Water insoluble preparations of hyaluronic acid and processes therefor |
| US4500676A (en) * | 1983-12-15 | 1985-02-19 | Biomatrix, Inc. | Hyaluronate modified polymeric articles |
| US4713448A (en) * | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
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1984
- 1984-12-06 US US06/678,895 patent/US4582865A/en not_active Expired - Lifetime
-
1985
- 1985-05-08 CA CA000481055A patent/CA1230186A/en not_active Expired
- 1985-05-13 GB GB8512072A patent/GB2168067B/en not_active Expired
- 1985-05-28 AU AU43045/85A patent/AU569157B2/en not_active Expired
- 1985-05-28 FR FR8507941A patent/FR2574414B1/fr not_active Expired
- 1985-06-04 DE DE3546811A patent/DE3546811C2/de not_active Expired - Lifetime
- 1985-06-04 DE DE19853520008 patent/DE3520008A1/de active Granted
- 1985-07-04 JP JP60147612A patent/JPS61138601A/ja active Granted
- 1985-07-15 SE SE8503486A patent/SE460792B/sv not_active IP Right Cessation
- 1985-09-09 IT IT22089/85A patent/IT1187737B/it active
-
1986
- 1986-07-31 GB GB8618719A patent/GB2181147B/en not_active Expired
- 1986-07-31 GB GB8618720A patent/GB2181148B/en not_active Expired
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1987
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1988
- 1988-07-26 GB GB8817772A patent/GB2205848B/en not_active Expired
-
1989
- 1989-05-10 SE SE8901672A patent/SE501828C2/sv not_active IP Right Cessation
- 1989-09-06 JP JP1232667A patent/JPH0637575B2/ja not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
| US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2574414B1 (fr) | 1987-07-03 |
| AU569157B2 (en) | 1988-01-21 |
| IT1187737B (it) | 1987-12-23 |
| AU7217387A (en) | 1987-08-27 |
| CA1230186A (en) | 1987-12-08 |
| JPH0637575B2 (ja) | 1994-05-18 |
| GB8817772D0 (en) | 1988-09-01 |
| JPH0430961B2 (pm) | 1992-05-25 |
| AU4304585A (en) | 1986-06-12 |
| SE501828C2 (sv) | 1995-05-22 |
| US4582865A (en) | 1986-04-15 |
| GB8618720D0 (en) | 1986-09-10 |
| DE3546811C2 (pm) | 1993-09-02 |
| SE8901672D0 (sv) | 1989-05-10 |
| GB2181148B (en) | 1989-06-07 |
| GB2168067A (en) | 1986-06-11 |
| SE8901672L (sv) | 1989-05-10 |
| JPH02138346A (ja) | 1990-05-28 |
| AU572419B2 (en) | 1988-05-05 |
| GB2181147A (en) | 1987-04-15 |
| GB2181147B (en) | 1989-06-07 |
| IT8522089A0 (it) | 1985-09-09 |
| SE8503486D0 (sv) | 1985-07-15 |
| DE3520008A1 (de) | 1986-06-19 |
| DE3520008C2 (pm) | 1991-10-10 |
| FR2574414A1 (fr) | 1986-06-13 |
| GB8512072D0 (en) | 1985-06-19 |
| SE8503486L (sv) | 1986-06-07 |
| JPS61138601A (ja) | 1986-06-26 |
| GB2168067B (en) | 1989-06-07 |
| GB2181148A (en) | 1987-04-15 |
| GB2205848A (en) | 1988-12-21 |
| GB8618719D0 (en) | 1986-09-10 |
| GB2205848B (en) | 1989-05-24 |
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