PT1454907E - Derivados de quinazolina e piridopirimidina - Google Patents
Derivados de quinazolina e piridopirimidina Download PDFInfo
- Publication number
- PT1454907E PT1454907E PT04076762T PT04076762T PT1454907E PT 1454907 E PT1454907 E PT 1454907E PT 04076762 T PT04076762 T PT 04076762T PT 04076762 T PT04076762 T PT 04076762T PT 1454907 E PT1454907 E PT 1454907E
- Authority
- PT
- Portugal
- Prior art keywords
- fluoro
- benzyloxy
- chloro
- fluorobenzyloxy
- formula
- Prior art date
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- 150000008518 pyridopyrimidines Chemical class 0.000 title description 3
- -1 pyridylmethoxy Chemical group 0.000 claims abstract description 60
- 150000001875 compounds Chemical class 0.000 claims abstract description 53
- 238000000034 method Methods 0.000 claims abstract description 23
- 125000005843 halogen group Chemical group 0.000 claims abstract description 17
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract description 16
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims abstract description 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 9
- 125000001246 bromo group Chemical group Br* 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract description 7
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 5
- 201000011510 cancer Diseases 0.000 claims abstract description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000001424 substituent group Chemical group 0.000 claims description 10
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 4
- XQPZOUAAXRXPAM-UHFFFAOYSA-N 5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3C4=CC(=CC=C4N=CN=3)C=3OC(C=O)=CC=3)=CC=2)Cl)=C1 XQPZOUAAXRXPAM-UHFFFAOYSA-N 0.000 claims description 3
- 125000005879 dioxolanyl group Chemical group 0.000 claims description 3
- YNPIJTZJPIIXEI-UHFFFAOYSA-N 5-[2-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3N=C4C=NC(=CC4=CN=3)C=3OC(C=O)=CC=3)=CC=2)Cl)=C1 YNPIJTZJPIIXEI-UHFFFAOYSA-N 0.000 claims description 2
- ASQPKYWSIJSYSQ-UHFFFAOYSA-N 5-[4-[3-fluoro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3C4=CC(=CC=C4N=CN=3)C=3OC(C=O)=CC=3)=CC=2)F)=C1 ASQPKYWSIJSYSQ-UHFFFAOYSA-N 0.000 claims description 2
- RSHUMBXTLYMGNO-UHFFFAOYSA-N 6-chloro-n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-7-fluoroquinazolin-4-amine Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3C4=CC(Cl)=C(F)C=C4N=CN=3)=CC=2)Cl)=C1 RSHUMBXTLYMGNO-UHFFFAOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- ZXWWVDAFBXIMTC-UHFFFAOYSA-N 5-[2-[3-bromo-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]furan-2-carbaldehyde Chemical compound FC=1C=C(COC2=C(C=C(C=C2)NC=2N=CC3=C(N=2)C=NC(=C3)C2=CC=C(O2)C=O)Br)C=CC=1 ZXWWVDAFBXIMTC-UHFFFAOYSA-N 0.000 claims 1
- NGZKIKQCAUGQCK-UHFFFAOYSA-N 5-[2-[3-fluoro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]furan-2-carbaldehyde Chemical compound FC=1C=C(COC2=C(C=C(C=C2)NC=2N=CC3=C(N=2)C=NC(=C3)C2=CC=C(O2)C=O)F)C=CC=1 NGZKIKQCAUGQCK-UHFFFAOYSA-N 0.000 claims 1
- LRRYDADCSUDXKL-UHFFFAOYSA-N 5-[4-[3-bromo-4-[(3-fluorophenyl)methoxy]phenyl]-7-fluoroquinazolin-6-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC(COC=2C(=CC(=CC=2)C=2C3=CC(=C(F)C=C3N=CN=2)C=2OC(C=O)=CC=2)Br)=C1 LRRYDADCSUDXKL-UHFFFAOYSA-N 0.000 claims 1
- DEECATMLEICPKT-UHFFFAOYSA-N 5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-7-fluoroquinazolin-6-yl]furan-2-carbaldehyde Chemical compound FC1=CC=CC(COC=2C(=CC(=CC=2)C=2C3=CC(=C(F)C=C3N=CN=2)C=2OC(C=O)=CC=2)Cl)=C1 DEECATMLEICPKT-UHFFFAOYSA-N 0.000 claims 1
- DINZEOMHTYMKJF-UHFFFAOYSA-N 6-chloro-7-fluoro-n-[3-fluoro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3C4=CC(Cl)=C(F)C=C4N=CN=3)=CC=2)F)=C1 DINZEOMHTYMKJF-UHFFFAOYSA-N 0.000 claims 1
- LPCDFUQIFYVPHL-UHFFFAOYSA-N n-[3-bromo-4-[(3-fluorophenyl)methoxy]phenyl]-6-chloro-7-fluoroquinazolin-4-amine Chemical compound FC1=CC=CC(COC=2C(=CC(NC=3C4=CC(Cl)=C(F)C=C4N=CN=3)=CC=2)Br)=C1 LPCDFUQIFYVPHL-UHFFFAOYSA-N 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 150000003557 thiazoles Chemical class 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 33
- 239000000203 mixture Substances 0.000 description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 13
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- 238000006243 chemical reaction Methods 0.000 description 11
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- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
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- 125000000217 alkyl group Chemical group 0.000 description 7
- 239000000047 product Substances 0.000 description 7
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
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- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
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- 201000004681 Psoriasis Diseases 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
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- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 4
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- BDAIUOPDSRAOKI-UHFFFAOYSA-N 4-chloro-6-iodoquinazoline Chemical compound C1=C(I)C=C2C(Cl)=NC=NC2=C1 BDAIUOPDSRAOKI-UHFFFAOYSA-N 0.000 description 3
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800569.7A GB9800569D0 (en) | 1998-01-12 | 1998-01-12 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1454907E true PT1454907E (pt) | 2009-02-18 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04076762T PT1454907E (pt) | 1998-01-12 | 1999-01-08 | Derivados de quinazolina e piridopirimidina |
| PT99902522T PT1047694E (pt) | 1998-01-12 | 1999-01-08 | Compostos heteroaromaticos biciclicos como inibidores da proteina tirosina quinase |
| PT04076761T PT1460072E (pt) | 1998-01-12 | 1999-01-08 | Composto biciclicos heteroaromaticos como inibidores de proteina tirosina quinase |
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| Application Number | Title | Priority Date | Filing Date |
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| PT99902522T PT1047694E (pt) | 1998-01-12 | 1999-01-08 | Compostos heteroaromaticos biciclicos como inibidores da proteina tirosina quinase |
| PT04076761T PT1460072E (pt) | 1998-01-12 | 1999-01-08 | Composto biciclicos heteroaromaticos como inibidores de proteina tirosina quinase |
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