ATE330956T1 - Bizyklisch substituierte 4- aminopyridopyrimidinderivate - Google Patents

Bizyklisch substituierte 4- aminopyridopyrimidinderivate

Info

Publication number
ATE330956T1
ATE330956T1 AT02252428T AT02252428T ATE330956T1 AT E330956 T1 ATE330956 T1 AT E330956T1 AT 02252428 T AT02252428 T AT 02252428T AT 02252428 T AT02252428 T AT 02252428T AT E330956 T1 ATE330956 T1 AT E330956T1
Authority
AT
Austria
Prior art keywords
substituted
bizyclic
aminopyridopyrimidine
derivatives
compounds
Prior art date
Application number
AT02252428T
Other languages
English (en)
Inventor
Samit Kumar Bhattacharya
John Charles Kath
Joel Morris
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE330956T1 publication Critical patent/ATE330956T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02252428T 2001-04-13 2002-04-03 Bizyklisch substituierte 4- aminopyridopyrimidinderivate ATE330956T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28391001P 2001-04-13 2001-04-13

Publications (1)

Publication Number Publication Date
ATE330956T1 true ATE330956T1 (de) 2006-07-15

Family

ID=23088090

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02252428T ATE330956T1 (de) 2001-04-13 2002-04-03 Bizyklisch substituierte 4- aminopyridopyrimidinderivate

Country Status (9)

Country Link
US (1) US6927220B2 (de)
EP (1) EP1249451B1 (de)
JP (1) JP4028278B2 (de)
AT (1) ATE330956T1 (de)
BR (1) BR0201286A (de)
CA (1) CA2381513C (de)
DE (1) DE60212487T2 (de)
ES (1) ES2263743T3 (de)
MX (1) MXPA02003796A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1636195A1 (de) * 2003-05-27 2006-03-22 Pfizer Products Inc. Chinazoline und pyrido[3,4-d]pyrimidine als rezeptor tyrosin kinase inhibitoren
UA96745C2 (en) * 2005-11-22 2011-12-12 Кудос Фармасьютикалз Лимитед PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2150115B1 (de) * 2007-05-23 2013-09-18 Merck Sharp & Dohme Corp. Cyclopropylpyrrolidinorexin-rezeptorantagonisten
EP2638036B1 (de) * 2010-11-09 2017-08-16 Betta Pharmaceuticals Co., Ltd. Verbindung zur erhöhung der kinaseaktivität und ihre verwendung
AU2020435503A1 (en) * 2020-03-13 2022-10-20 F. Hoffmann-La Roche Ag ErbB receptor inhibitors as anti-tumor agents
BR112023021111A2 (pt) 2021-04-13 2023-12-19 Nuvalent Inc Composto, composição farmacêutica, método de tratamento de câncer, método para inibir seletivamente her2, método de regulação de um nível de her2, método para aumentar um nível de her2, método de diminuição da fosforilação de her2
WO2022266458A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 6-heterocycloalkyl-quinazoline derivatives and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884418B1 (en) * 1989-08-04 2005-04-26 Berlex Laboratories, Inc. Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
EP0831829B1 (de) * 1995-06-07 2003-08-20 Pfizer Inc. Heterocyclische kondensierte pyrimidin-derivate
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
DK0892789T4 (da) 1996-04-12 2010-04-06 Warner Lambert Co Irreversible inhibitorer af tyrosin kinaser
HRP970371A2 (en) * 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
PL331154A1 (en) 1996-07-13 1999-06-21 Glaxo Group Ltd Bicyclic heteroaromatic compounds as inhibitors of proteinous tyrosine kinase
HUP0100287A3 (en) * 1997-11-11 2003-04-28 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
GB2345486A (en) 1999-01-11 2000-07-12 Glaxo Group Ltd Heteroaromatic protein tyrosine kinase inhibitors
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
US6297238B1 (en) * 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
EP1192151B1 (de) 1999-07-09 2007-11-07 Glaxo Group Limited Anilinochinazoline als protein-tyrosin-kinasehemmer
US20050038047A1 (en) * 2003-08-14 2005-02-17 Edwards Paul John Azaquinazoline derivatives

Also Published As

Publication number Publication date
EP1249451A3 (de) 2003-03-12
DE60212487T2 (de) 2006-12-21
DE60212487D1 (de) 2006-08-03
MXPA02003796A (es) 2002-11-07
EP1249451A2 (de) 2002-10-16
JP2002322178A (ja) 2002-11-08
ES2263743T3 (es) 2006-12-16
US6927220B2 (en) 2005-08-09
JP4028278B2 (ja) 2007-12-26
US20030045535A1 (en) 2003-03-06
CA2381513A1 (en) 2002-10-13
EP1249451B1 (de) 2006-06-21
CA2381513C (en) 2006-01-10
BR0201286A (pt) 2003-03-11

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties