KR102072631B1 - 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제 - Google Patents

짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제 Download PDF

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KR102072631B1
KR102072631B1 KR1020137006656A KR20137006656A KR102072631B1 KR 102072631 B1 KR102072631 B1 KR 102072631B1 KR 1020137006656 A KR1020137006656 A KR 1020137006656A KR 20137006656 A KR20137006656 A KR 20137006656A KR 102072631 B1 KR102072631 B1 KR 102072631B1
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sina
nucleotides
nucleic acid
hbv
molecules
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KR20130137156A (ko
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스티브 바츠
덩컨 브라운
마이클 로빈손
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시르나 쎄러퓨틱스 인코퍼레이티드
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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KR1020137006656A 2010-08-17 2011-08-12 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제 Expired - Fee Related KR102072631B1 (ko)

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KR1020207002596A KR102413007B1 (ko) 2010-08-17 2011-08-12 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제

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Application Number Priority Date Filing Date Title
US37455510P 2010-08-17 2010-08-17
US61/374,555 2010-08-17
PCT/US2011/047512 WO2012024170A2 (en) 2010-08-17 2011-08-12 RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

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KR1020207002596A Division KR102413007B1 (ko) 2010-08-17 2011-08-12 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제

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KR102072631B1 true KR102072631B1 (ko) 2020-02-03

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KR1020207002596A Active KR102413007B1 (ko) 2010-08-17 2011-08-12 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제

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US (5) US9029341B2 (enExample)
EP (3) EP3587574B1 (enExample)
JP (5) JP2013537423A (enExample)
KR (2) KR102072631B1 (enExample)
CN (2) CN103282497B (enExample)
AU (1) AU2011292261B2 (enExample)
CA (1) CA2807307C (enExample)
DK (1) DK2606134T3 (enExample)
HR (1) HRP20191232T1 (enExample)
HU (1) HUE044815T2 (enExample)
LT (1) LT2606134T (enExample)
RU (2) RU2624045C2 (enExample)
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WO2022131883A1 (ko) * 2020-12-18 2022-06-23 올릭스 주식회사 HBV 발현을 억제하는 RNAi 제제 및 이의 용도

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