JP2013537423A - 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 - Google Patents
低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 Download PDFInfo
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37455510P | 2010-08-17 | 2010-08-17 | |
| US61/374,555 | 2010-08-17 | ||
| PCT/US2011/047512 WO2012024170A2 (en) | 2010-08-17 | 2011-08-12 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016238640A Division JP6529481B2 (ja) | 2010-08-17 | 2016-12-08 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537423A true JP2013537423A (ja) | 2013-10-03 |
| JP2013537423A5 JP2013537423A5 (enExample) | 2014-09-25 |
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524886A Withdrawn JP2013537423A (ja) | 2010-08-17 | 2011-08-12 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2016238640A Expired - Fee Related JP6529481B2 (ja) | 2010-08-17 | 2016-12-08 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2019091118A Expired - Fee Related JP6921144B2 (ja) | 2010-08-17 | 2019-05-14 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2021122646A Pending JP2021176318A (ja) | 2010-08-17 | 2021-07-27 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2023006010A Pending JP2023052480A (ja) | 2010-08-17 | 2023-01-18 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016238640A Expired - Fee Related JP6529481B2 (ja) | 2010-08-17 | 2016-12-08 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2019091118A Expired - Fee Related JP6921144B2 (ja) | 2010-08-17 | 2019-05-14 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2021122646A Pending JP2021176318A (ja) | 2010-08-17 | 2021-07-27 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| JP2023006010A Pending JP2023052480A (ja) | 2010-08-17 | 2023-01-18 | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
Country Status (14)
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|---|---|
| US (5) | US9029341B2 (enExample) |
| EP (3) | EP2606134B1 (enExample) |
| JP (5) | JP2013537423A (enExample) |
| KR (2) | KR102072631B1 (enExample) |
| CN (2) | CN103282497B (enExample) |
| AU (1) | AU2011292261B2 (enExample) |
| CA (1) | CA2807307C (enExample) |
| DK (1) | DK2606134T3 (enExample) |
| HR (1) | HRP20191232T1 (enExample) |
| HU (1) | HUE044815T2 (enExample) |
| LT (1) | LT2606134T (enExample) |
| RU (2) | RU2624045C2 (enExample) |
| SI (1) | SI2606134T1 (enExample) |
| WO (1) | WO2012024170A2 (enExample) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014500233A (ja) * | 2010-09-20 | 2014-01-09 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質 |
| JP2018520685A (ja) * | 2015-07-17 | 2018-08-02 | アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. | B型肝炎ウイルスに対する組成物および薬剤ならびにその使用 |
| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
| JP2019527694A (ja) * | 2016-08-04 | 2019-10-03 | アローヘッド ファーマシューティカルズ インコーポレイテッド | B型肝炎ウイルス感染のためのRNAi薬 |
| JP2021503941A (ja) * | 2017-12-01 | 2021-02-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
| JPWO2020100994A1 (ja) * | 2018-11-16 | 2021-09-30 | 公益財団法人東京都医学総合研究所 | B型肝炎ウイルスの複製阻害組成物 |
| US11534453B2 (en) | 2015-08-07 | 2022-12-27 | Arrowhead Pharmaceuticals, Inc. | RNAi therapy for hepatitis B virus infection |
| US11660347B2 (en) | 2017-12-01 | 2023-05-30 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing same, preparation method, and use thereof |
| JP2023538630A (ja) * | 2020-08-21 | 2023-09-08 | エフ. ホフマン-ラ ロシュ アーゲー | B型肝炎ウイルス感染症を処置するためのa1cf阻害剤の使用 |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| US12083142B2 (en) | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| US12428642B2 (en) | 2017-12-01 | 2025-09-30 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, preparation method and use thereof |
| US12497622B2 (en) | 2019-05-22 | 2025-12-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| US12496347B2 (en) | 2018-12-28 | 2025-12-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| US12540323B2 (en) | 2019-05-22 | 2026-02-03 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| US12577565B2 (en) | 2019-05-24 | 2026-03-17 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| KR20120095397A (ko) | 2009-10-16 | 2012-08-28 | 글락소 그룹 리미티드 | Hbv 안티센스 억제제 |
| JP2013537423A (ja) | 2010-08-17 | 2013-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害 |
| MX347253B (es) | 2011-04-21 | 2017-04-20 | Ionis Pharmaceuticals Inc | Modulación de la expresión del virus de hepatitis b (vhb). |
| SG194751A1 (en) * | 2011-06-30 | 2013-12-30 | Arrowhead Res Corp | Compositions and methods for inhibiting gene expression of hepatitis b virus |
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| GB201408623D0 (en) | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
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| JOP20200092A1 (ar) * | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| EA202191771A1 (ru) * | 2015-03-24 | 2022-01-31 | Элнилэм Фармасьютикалз, Инк. | КОМПОЗИЦИИ НА ОСНОВЕ RNAi ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| AU2016257150B2 (en) * | 2015-05-06 | 2022-03-31 | Benitec IP Holdings Inc. | Reagents for treatment of hepatitis B virus (HBV) infection and use thereof |
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| JP6986263B2 (ja) | 2015-11-09 | 2021-12-22 | ピューロテックバイオ株式会社 | 抗ウイルス薬 |
| US20190282604A1 (en) * | 2016-01-08 | 2019-09-19 | Arbutus Biopharma Corporation | Therapeutic compositions and methods for treating hepatitis b |
| TWI840950B (zh) | 2016-03-14 | 2024-05-01 | 瑞士商赫孚孟拉羅股份公司 | 用於降低pd-l1表現之寡核苷酸 |
| EP3472346B1 (en) | 2016-06-17 | 2023-01-18 | F. Hoffmann-La Roche AG | Papd5 and papd7 inhibitors for treating a hepatitis b infection |
| US20210290537A1 (en) * | 2016-12-08 | 2021-09-23 | Mallinckrodt Llc | Liposomal elinafide formulations and uses thereof |
| CN118384268A (zh) * | 2017-04-18 | 2024-07-26 | 阿尔尼拉姆医药品有限公司 | 具有乙肝病毒(hbv)感染的受试者的治疗方法 |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| TW202424191A (zh) | 2017-10-16 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | 用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子 |
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| JP2016121129A (ja) * | 2010-09-20 | 2016-07-07 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質 |
| JP2014500233A (ja) * | 2010-09-20 | 2014-01-09 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質 |
| JP2018520685A (ja) * | 2015-07-17 | 2018-08-02 | アークトゥラス・セラピューティクス・インコーポレイテッドArcturus Therapeutics,Inc. | B型肝炎ウイルスに対する組成物および薬剤ならびにその使用 |
| US11534453B2 (en) | 2015-08-07 | 2022-12-27 | Arrowhead Pharmaceuticals, Inc. | RNAi therapy for hepatitis B virus infection |
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| WO2018199338A1 (ja) * | 2017-04-27 | 2018-11-01 | 国立大学法人広島大学 | B型肝炎治療用核酸分子 |
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| JP2021503941A (ja) * | 2017-12-01 | 2021-02-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
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| JP7441174B2 (ja) | 2018-11-16 | 2024-02-29 | 公益財団法人東京都医学総合研究所 | B型肝炎ウイルスの複製阻害組成物 |
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