JPWO2020072821A5 - - Google Patents

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JPWO2020072821A5
JPWO2020072821A5 JP2021517799A JP2021517799A JPWO2020072821A5 JP WO2020072821 A5 JPWO2020072821 A5 JP WO2020072821A5 JP 2021517799 A JP2021517799 A JP 2021517799A JP 2021517799 A JP2021517799 A JP 2021517799A JP WO2020072821 A5 JPWO2020072821 A5 JP WO2020072821A5
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JP
Japan
Prior art keywords
fusion protein
nucleic acid
heterodimeric
seq
expression vector
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2021517799A
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JP2022503959A (ja
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Priority claimed from PCT/US2019/054570 external-priority patent/WO2020072821A2/en
Publication of JP2022503959A publication Critical patent/JP2022503959A/ja
Publication of JPWO2020072821A5 publication Critical patent/JPWO2020072821A5/ja
Pending legal-status Critical Current

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Claims (5)

  1. ヘテロ二量体Fc融合タンパク質であって、
    a)配列番号382に示されるアミノ酸配列を含む第1の融合タンパク質と、
    b)配列番号404に示されるアミノ酸配列を含む第2の融合タンパク質と、を含み、
    前記第1の融合タンパク質が、配列番号382と比較してアミノ酸置換M428L/N434Sをさらに含み、前記第2の融合タンパク質が、配列番号404と比較してアミノ酸置換M428L/N424Sをさらに含み、付番がEU付番に従う、
    ヘテロ二量体Fc融合タンパク質。
  2. a)請求項1に記載の第1の融合タンパク質をコードする第1の核酸と、
    b)請求項1に記載の第2の融合タンパク質をコードする第2の核酸と、を含む、
    核酸組成物。
  3. a)請求項2に記載の第1の核酸を含む発現ベクターと、
    b)請求項2に記載の第2の核酸を含む発現ベクターと、を含む、
    発現ベクター組成物。
  4. 請求項3に記載の発現ベクター組成物を含む、宿主細胞。
  5. ヘテロ二量体Fc融合タンパク質を作製する方法であって、前記方法が、前記ヘテロ二量体Fc融合タンパク質が発現する条件下で請求項に記載の宿主細胞を培養することを含む、方法。
JP2021517799A 2018-10-03 2019-10-03 Il-12ヘテロ二量体fc-融合タンパク質 Pending JP2022503959A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862740813P 2018-10-03 2018-10-03
US62/740,813 2018-10-03
US201962810038P 2019-02-25 2019-02-25
US62/810,038 2019-02-25
US201962848512P 2019-05-15 2019-05-15
US62/848,512 2019-05-15
PCT/US2019/054570 WO2020072821A2 (en) 2018-10-03 2019-10-03 Il-12 heterodimeric fc-fusion proteins

Publications (2)

Publication Number Publication Date
JP2022503959A JP2022503959A (ja) 2022-01-12
JPWO2020072821A5 true JPWO2020072821A5 (ja) 2022-10-07

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JP2021517799A Pending JP2022503959A (ja) 2018-10-03 2019-10-03 Il-12ヘテロ二量体fc-融合タンパク質

Country Status (12)

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US (3) US11358999B2 (ja)
EP (1) EP3861016A2 (ja)
JP (1) JP2022503959A (ja)
KR (1) KR20210069641A (ja)
CN (1) CN113195523A (ja)
AU (1) AU2019355971A1 (ja)
CA (1) CA3115096A1 (ja)
IL (1) IL281962A (ja)
MA (1) MA53822A (ja)
MX (1) MX2021003765A (ja)
SG (1) SG11202103192RA (ja)
WO (1) WO2020072821A2 (ja)

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