JP2010512160A5 - - Google Patents
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- Publication number
- JP2010512160A5 JP2010512160A5 JP2009540888A JP2009540888A JP2010512160A5 JP 2010512160 A5 JP2010512160 A5 JP 2010512160A5 JP 2009540888 A JP2009540888 A JP 2009540888A JP 2009540888 A JP2009540888 A JP 2009540888A JP 2010512160 A5 JP2010512160 A5 JP 2010512160A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- host cell
- protein
- library
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 101000081248 MUC3A Proteins 0.000 claims 2
- 102000037240 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000021340 human MUC3A protein Human genes 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
Claims (10)
- 配列番号７６の核酸によりコードされる改変ヒトＭＵＣ３タンパク質。
- 配列番号７６の核酸によりコードされる改変ヒトＭＵＣ３タンパク質とアンカー部分とが結合したタンパク質。
- アンカー部分が、グリコシル−ホスファチジル−イノシトール（ＧＰＩ）ペプチドアンカーである、請求項２に記載のタンパク質。
- 配列番号７６の核酸を含有する宿主細胞。
- 宿主細胞が酵母細胞である、請求項４に記載の宿主細胞。
- ストーク部分として配列番号７６の核酸によりコードされるポリペプチドの配列を含む融合タンパク質を複数含むライブラリー。
- ライブラリーが酵母細胞を用いたものである、請求項６に記載のライブラリー。
- 配列番号７６の核酸を含むベクター。
- 配列番号７６の核酸を宿主細胞にて発現させることにより、配列番号７６の核酸によりコードされるポリペプチドの配列を含む融合タンパク質を産生する方法。
- 宿主細胞が酵母細胞である、請求項９に記載の産生方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93495106P | 2006-12-12 | 2006-12-12 | |
| US60/934,951 | 2006-12-12 | ||
| PCT/IB2007/003908 WO2008072075A2 (en) | 2006-12-12 | 2007-12-07 | Transferrin fusion protein libraries |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512160A JP2010512160A (ja) | 2010-04-22 |
| JP2010512160A5 true JP2010512160A5 (ja) | 2012-08-30 |
| JP5492563B2 JP5492563B2 (ja) | 2014-05-14 |
Family
ID=39362844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540888A Expired - Fee Related JP5492563B2 (ja) | 2006-12-12 | 2007-12-07 | トランスフェリン融合タンパク質ライブラリー |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8822639B2 (ja) |
| EP (2) | EP2114999A2 (ja) |
| JP (1) | JP5492563B2 (ja) |
| KR (1) | KR20090098880A (ja) |
| CN (1) | CN101622274A (ja) |
| AU (1) | AU2007331195A1 (ja) |
| CA (1) | CA2673085C (ja) |
| ES (1) | ES2535358T3 (ja) |
| IL (1) | IL198815A0 (ja) |
| MX (1) | MX2009006398A (ja) |
| NO (1) | NO20092591L (ja) |
| WO (1) | WO2008072075A2 (ja) |
| ZA (1) | ZA200904757B (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8401798B2 (en) * | 2008-06-06 | 2013-03-19 | Dna Twopointo, Inc. | Systems and methods for constructing frequency lookup tables for expression systems |
| AU2010306940A1 (en) | 2009-10-12 | 2012-06-07 | Smith, Larry | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| CN102258767B (zh) * | 2010-05-24 | 2013-05-15 | 黄敏铨 | 促进伤口愈合的组合物 |
| US20130251740A1 (en) * | 2010-10-26 | 2013-09-26 | Rockefeller University (The) | Immunogenic agents |
| EP2670421B1 (en) * | 2011-02-02 | 2017-12-06 | Medipost Co., Ltd. | Use of icam-1 for prevention or treatment of neurological diseases |
| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| WO2013184938A2 (en) | 2012-06-08 | 2013-12-12 | Alkermes. Inc. | Fusion polypeptides comprising mucin-domain polypeptide linkers |
| EP2929351B1 (en) * | 2012-12-10 | 2019-10-09 | The University of Queensland | Cell-free biofragment compositions and related systems, devices, and methods |
| US10829771B2 (en) * | 2014-11-10 | 2020-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for expressing polypeptides on the surface of cells |
| WO2017170418A1 (ja) * | 2016-03-30 | 2017-10-05 | 株式会社カネカ | エンドヌクレアーゼ活性を有するポリペプチド及びその製造方法 |
| BR112019003622A2 (pt) * | 2016-08-25 | 2019-05-21 | Jcr Pharmaceuticals Co., Ltd. | método para produção de uma proteína de fusão. |
| WO2020127983A1 (en) * | 2018-12-21 | 2020-06-25 | Vib Vzw | Fusion proteins comprising a cytokine and scaffold protein |
| CN113045670B (zh) * | 2019-12-27 | 2022-11-01 | 华南农业大学 | 一种可溶性鸡α干扰素融合蛋白及其生产方法与应用 |
| WO2023114912A2 (en) * | 2021-12-16 | 2023-06-22 | Thomas Jefferson University | A therapeutic against crimean-congo hemorrhagic fever virus |
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| US4782137A (en) | 1984-01-24 | 1988-11-01 | Immunex Corporation | Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same |
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| AU600885B2 (en) | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
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| US5026651A (en) | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
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| US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
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| US5347849A (en) | 1990-08-30 | 1994-09-20 | Tanknology Corporation International | Water sensor that detects tank or vessel leakage |
| US5986067A (en) | 1991-02-08 | 1999-11-16 | The University Of Vermont And State Agricultural College | Recombinant transferrins, transferrin half-molecules and mutants thereof |
| CA2122717C (en) | 1991-11-08 | 2003-07-15 | David C. Anderson | Hemoglobins as drug delivery agents |
| ATE183515T1 (de) | 1992-07-20 | 1999-09-15 | Univ Duke | Zusammensetzungen die die hiv replikation inhibieren |
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| WO1994018221A1 (en) * | 1993-02-02 | 1994-08-18 | The Scripps Research Institute | Methods for producing polypeptide binding sites |
| ZA94916B (en) | 1993-02-10 | 1995-08-10 | Unilever Plc | Immobilized proteins with specific binding capacities and their use in processes and products |
| WO1994017810A1 (en) | 1993-02-12 | 1994-08-18 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
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| WO2006049983A2 (en) | 2004-10-27 | 2006-05-11 | Biorexis Pharmaceutical Corporation | Peptide yy modified transferrin fusion proteins |
| JP2008531059A (ja) | 2005-03-04 | 2008-08-14 | バイオレクシス ファーマシューティカル コーポレーション | 改変トランスフェリン融合タンパク質 |
| US20090275481A1 (en) | 2005-06-17 | 2009-11-05 | Pfizer, Inc. | Anchored Transferrin Fusion Protein Libraries |
| KR101193722B1 (ko) | 2006-07-24 | 2013-01-11 | 바이오렉시스 파마슈티칼 코포레이션 | 엑센딘 융합 단백질 |
-
2007
- 2007-12-07 CA CA2673085A patent/CA2673085C/en not_active Expired - Fee Related
- 2007-12-07 MX MX2009006398A patent/MX2009006398A/es unknown
- 2007-12-07 EP EP07859040A patent/EP2114999A2/en active Pending
- 2007-12-07 KR KR1020097014465A patent/KR20090098880A/ko not_active Application Discontinuation
- 2007-12-07 JP JP2009540888A patent/JP5492563B2/ja not_active Expired - Fee Related
- 2007-12-07 WO PCT/IB2007/003908 patent/WO2008072075A2/en active Application Filing
- 2007-12-07 ES ES12157790.2T patent/ES2535358T3/es active Active
- 2007-12-07 AU AU2007331195A patent/AU2007331195A1/en not_active Abandoned
- 2007-12-07 CN CN200780050623A patent/CN101622274A/zh active Pending
- 2007-12-07 EP EP12157790.2A patent/EP2479189B1/en not_active Not-in-force
- 2007-12-07 US US12/517,855 patent/US8822639B2/en not_active Expired - Fee Related
-
2009
- 2009-05-19 IL IL198815A patent/IL198815A0/en unknown
- 2009-07-07 NO NO20092591A patent/NO20092591L/no not_active Application Discontinuation
- 2009-07-07 ZA ZA200904757A patent/ZA200904757B/xx unknown
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