|
DE3177215D1
(de)
*
|
1980-02-29 |
1990-10-25 |
University Patents Inc |
Verfahren zur herstellung von modifizierten anorganischen polymeren.
|
|
US6692941B1
(en)
*
|
1980-08-26 |
2004-02-17 |
The Regents Of The University Of California |
Bovine growth hormone
|
|
US7101981B1
(en)
|
1980-08-26 |
2006-09-05 |
Regents Of The University Of California |
Bovine growth hormone recombinantly produced in E. coli
|
|
US4973679A
(en)
*
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
JPS58109498A
(ja)
*
|
1981-08-24 |
1983-06-29 |
Agency Of Ind Science & Technol |
オリゴリボヌクレオチド
|
|
EP0090789A1
(en)
*
|
1982-03-26 |
1983-10-05 |
Monsanto Company |
Chemical DNA synthesis
|
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
|
WO1984001394A1
(fr)
*
|
1982-09-30 |
1984-04-12 |
Iro Ab |
Dispositif de stockage, debitage et mesure de fil
|
|
US5198540A
(en)
*
|
1982-10-28 |
1993-03-30 |
Hubert Koster |
Process for the preparation of oligonucleotides in solution
|
|
DE3239887A1
(de)
*
|
1982-10-28 |
1984-05-03 |
Hubert Prof. Dr. 2000 Hamburg Köster |
Verfahren zur herstellung von oligonucleotiden
|
|
FR2544720B1
(fr)
*
|
1983-04-19 |
1987-11-27 |
California Inst Of Techn |
Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
|
|
WO1984004749A1
(en)
*
|
1983-06-01 |
1984-12-06 |
Beckman Instruments Inc |
Novel preparation of nucleoside phosphoramidite intermediates
|
|
USRE34069E
(en)
*
|
1983-08-18 |
1992-09-15 |
Biosyntech Gmbh |
Process for the preparation of oligonucleotides
|
|
DE3329892A1
(de)
*
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
DE3332068A1
(de)
*
|
1983-09-06 |
1985-03-21 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
|
|
US5166330A
(en)
*
|
1983-09-06 |
1992-11-24 |
Hoechst Aktiengesellschaft |
Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
|
|
CA1244786A
(en)
*
|
1983-12-20 |
1988-11-15 |
Lloyd M. Smith |
Synthesis of amino-derivitized oligonucleotides
|
|
US5118800A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5118802A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
US5015733A
(en)
*
|
1983-12-20 |
1991-05-14 |
California Institute Of Technology |
Nucleosides possessing blocked aliphatic amino groups
|
|
USRE43096E1
(en)
|
1984-01-16 |
2012-01-10 |
California Institute Of Technology |
Tagged extendable primers and extension products
|
|
US5821058A
(en)
*
|
1984-01-16 |
1998-10-13 |
California Institute Of Technology |
Automated DNA sequencing technique
|
|
US5367066A
(en)
*
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
JPS61112093A
(ja)
*
|
1984-11-05 |
1986-05-30 |
Wakunaga Seiyaku Kk |
ヌクレオチド誘導体
|
|
FR2575751B1
(fr)
*
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
DE3507881A1
(de)
*
|
1985-03-06 |
1986-09-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren und mittel zur phosphorylierung
|
|
US5332845A
(en)
*
|
1985-03-28 |
1994-07-26 |
Chiron Corporation |
Phosphorylating reagents
|
|
US5252760A
(en)
*
|
1985-03-28 |
1993-10-12 |
Chiron Corporation |
Method of using colored phosphorylating reagents
|
|
EP0222889B1
(en)
*
|
1985-05-15 |
1993-10-27 |
Amoco Corporation |
Cytidine analogs
|
|
US4751177A
(en)
*
|
1985-06-13 |
1988-06-14 |
Amgen |
Methods and kits for performing nucleic acid hybridization assays
|
|
US4797355A
(en)
*
|
1985-06-13 |
1989-01-10 |
Amgen Inc. |
Methods for attaching polynucleotides to supports
|
|
US4739044A
(en)
*
|
1985-06-13 |
1988-04-19 |
Amgen |
Method for derivitization of polynucleotides
|
|
WO1986007362A1
(en)
*
|
1985-06-14 |
1986-12-18 |
University Patents, Inc. |
Method for synthesizing deoxyoligonucleotides
|
|
US4757141A
(en)
*
|
1985-08-26 |
1988-07-12 |
Applied Biosystems, Incorporated |
Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
|
|
EP0216357A3
(en)
*
|
1985-09-25 |
1988-08-31 |
Nippon Zeon Co., Ltd. |
Phosphoramidite compounds and process for production thereof
|
|
US4808708A
(en)
*
|
1985-11-02 |
1989-02-28 |
Toagosei Chemical Industry Co., Ltd. |
Phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides and their uses
|
|
US4855225A
(en)
*
|
1986-02-07 |
1989-08-08 |
Applied Biosystems, Inc. |
Method of detecting electrophoretically separated oligonucleotides
|
|
US5242823A
(en)
*
|
1986-03-07 |
1993-09-07 |
International Genetic Engineering, Inc. |
Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen
|
|
DE3788914T2
(de)
*
|
1986-09-08 |
1994-08-25 |
Ajinomoto Kk |
Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
|
|
WO1988003149A1
(fr)
*
|
1986-10-30 |
1988-05-05 |
Daicel Chemical Industries, Ltd. |
Procede de synthese d'oligonucleotides et composes servant a former des groupes protecteurs a poids moleculaire eleve
|
|
US5071974A
(en)
*
|
1986-10-31 |
1991-12-10 |
Amoco Corporation |
Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
|
|
US4923901A
(en)
*
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US6031091A
(en)
*
|
1987-09-21 |
2000-02-29 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
|
US5585481A
(en)
*
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US4965349A
(en)
*
|
1987-12-24 |
1990-10-23 |
Applied Biosystems, Inc. |
Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
|
|
WO1989009780A1
(en)
*
|
1988-04-15 |
1989-10-19 |
Chemical Industry Institute Of Toxicology |
Site-specific tritium-labeled oligodeoxynucleotides
|
|
US5218103A
(en)
*
|
1988-05-26 |
1993-06-08 |
University Patents, Inc. |
Nucleoside thiophosphoramidites
|
|
US5602244A
(en)
*
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5750666A
(en)
*
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
IL90359A0
(en)
*
|
1988-05-26 |
1989-12-15 |
University Patents Inc |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production
|
|
US5278302A
(en)
*
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
US5216141A
(en)
*
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
JPH0291088A
(ja)
*
|
1988-09-29 |
1990-03-30 |
Central Glass Co Ltd |
ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
CA2028153A1
(en)
*
|
1989-02-24 |
1990-08-25 |
Steven S. Smith |
Heterologous block oligomers
|
|
AU5418290A
(en)
*
|
1989-03-31 |
1990-11-05 |
University Patents Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US6254861B1
(en)
|
1989-05-23 |
2001-07-03 |
Chandra Choudhury |
Hematopoietic growth factor derived from T lymphocytes
|
|
DE3916871A1
(de)
*
|
1989-05-24 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
|
|
GR890100349A
(el)
*
|
1989-05-26 |
1994-03-31 |
University Patents Inc |
Ενώσεις νουκλεοσιδίων & πολυνουκλεοτιδίων, θειοφωσφοραμιδίων & φωσφοροδιθειικών εστέρων & μέθοδοι.
|
|
US5256775A
(en)
*
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
KR920701230A
(ko)
*
|
1989-06-05 |
1992-08-11 |
원본미기재 |
엑소뉴클레아제-내성 올리고뉴클레오티드 및 그 제조방법
|
|
US5204455A
(en)
*
|
1989-06-15 |
1993-04-20 |
Froehler Brian C |
Monomethoxytrityl protected oligonucleotides bound to a solid support
|
|
US6300486B1
(en)
|
1989-06-15 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US5164491A
(en)
*
|
1989-06-15 |
1992-11-17 |
Gilead Sciences |
Large scale synthesis of oligonucleotides and their associated analogs
|
|
US7049102B1
(en)
|
1989-09-22 |
2006-05-23 |
Board Of Trustees Of Leland Stanford University |
Multi-gene expression profile
|
|
US5545522A
(en)
|
1989-09-22 |
1996-08-13 |
Van Gelder; Russell N. |
Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
|
|
US5003097A
(en)
*
|
1989-10-02 |
1991-03-26 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the sulfurization of phosphorous groups in compounds
|
|
AU6603690A
(en)
*
|
1989-10-05 |
1991-04-28 |
University Patents Inc. |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
|
|
US5914396A
(en)
*
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
EP0463712A3
(en)
|
1990-06-27 |
1992-04-08 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
|
US5316908A
(en)
*
|
1990-07-13 |
1994-05-31 |
Life Technologies, Inc. |
Size markers for electrophoretic analysis of DNA
|
|
ATE171947T1
(de)
*
|
1990-10-26 |
1998-10-15 |
Genta Inc |
Verbessertes verfahren zur synthese von oligomeren
|
|
US6605712B1
(en)
*
|
1990-12-20 |
2003-08-12 |
Arch Development Corporation |
Gene transcription and ionizing radiation: methods and compositions
|
|
US5594121A
(en)
*
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US5556961A
(en)
*
|
1991-11-15 |
1996-09-17 |
Foote; Robert S. |
Nucleosides with 5'-O-photolabile protecting groups
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
TW393513B
(en)
*
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
AU3222793A
(en)
*
|
1991-11-26 |
1993-06-28 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
AU3250093A
(en)
|
1991-12-12 |
1993-07-19 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
US5644048A
(en)
*
|
1992-01-10 |
1997-07-01 |
Isis Pharmaceuticals, Inc. |
Process for preparing phosphorothioate oligonucleotides
|
|
CA2129105A1
(en)
*
|
1992-02-12 |
1993-08-19 |
Michael J. Conrad |
Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
|
|
US5652099A
(en)
*
|
1992-02-12 |
1997-07-29 |
Conrad; Michael J. |
Probes comprising fluorescent nucleosides and uses thereof
|
|
US5428148A
(en)
*
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
|
US5348868A
(en)
*
|
1992-04-24 |
1994-09-20 |
Beckman Instruments, Inc. |
Methods and reagents for cleaving and deprotecting oligonucleotides
|
|
US5616700A
(en)
*
|
1992-04-24 |
1997-04-01 |
Beckman Instruments, Inc. |
Processes for synthesizing nucleotides and modified nucleotides using N.sub.
|
|
US5583211A
(en)
*
|
1992-10-29 |
1996-12-10 |
Beckman Instruments, Inc. |
Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
|
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US5428149A
(en)
*
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
|
HUT74597A
(en)
|
1993-06-23 |
1997-01-28 |
Genesys Pharma Inc |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
|
US5623068A
(en)
*
|
1994-03-07 |
1997-04-22 |
Beckman Instruments, Inc. |
Synthesis of DNA using substituted phenylacetyl-protected nucleotides
|
|
US6639061B1
(en)
|
1999-07-07 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate oligomers and related compounds
|
|
US5510476A
(en)
*
|
1994-07-07 |
1996-04-23 |
Isis Pharmaceuticals, Inc. |
Carbocation scavenging during oligonucleotide synthesis
|
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
|
US5703223A
(en)
*
|
1994-09-02 |
1997-12-30 |
Thomas Jefferson University |
Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
|
|
US6558633B1
(en)
|
1994-09-21 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Chemical reaction apparatus and methods
|
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
US5717085A
(en)
*
|
1994-11-23 |
1998-02-10 |
Terrapin Technologies, Inc. |
Process for preparing codon amidites
|
|
US5908926A
(en)
*
|
1995-03-16 |
1999-06-01 |
Duke University |
5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
|
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
|
US6531589B1
(en)
*
|
1995-06-01 |
2003-03-11 |
Hybridon, Inc. |
Base protecting groups and synthons for oligonucleotide synthesis
|
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
|
US6111095A
(en)
*
|
1995-06-07 |
2000-08-29 |
Merck & Co., Inc. |
Capped synthetic RNA, analogs, and aptamers
|
|
CA2222581C
(en)
|
1995-06-07 |
2004-05-11 |
Lynx Therapeutics, Inc. |
Oligonucleotide tags for sorting and identification
|
|
US5889136A
(en)
*
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
EP0863910A1
(en)
|
1995-10-19 |
1998-09-16 |
NeXstar Pharmaceuticals, Inc. |
Method for solution phase synthesis of oligonucleotides
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US6476216B1
(en)
*
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US6160109A
(en)
*
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
|
US20030119724A1
(en)
*
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
|
US5808035A
(en)
*
|
1995-12-08 |
1998-09-15 |
Usher; David A. |
Protected nucleoside and method for its synthesis
|
|
US5736626A
(en)
|
1996-01-29 |
1998-04-07 |
The Perkin-Elmer Corporation |
Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
|
|
EP0932698A1
(en)
*
|
1996-03-26 |
1999-08-04 |
Lynx Therapeutics, Inc. |
Oligonucleotide treatments and compositions for human melanoma
|
|
US5959100A
(en)
*
|
1996-03-27 |
1999-09-28 |
Nexstar Pharmaceuticals, Inc. |
Pyrimidine nucleosides as therapeutic and diagnostic agents
|
|
US6020481A
(en)
*
|
1996-04-01 |
2000-02-01 |
The Perkin-Elmer Corporation |
Asymmetric benzoxanthene dyes
|
|
US5852168A
(en)
*
|
1996-04-30 |
1998-12-22 |
Regents Of The University Of Minesota |
Sulfurization of phosphorus-containing compounds
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6060240A
(en)
*
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
|
US6103891A
(en)
*
|
1996-12-27 |
2000-08-15 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US5955600A
(en)
*
|
1996-12-27 |
1999-09-21 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
|
US6172217B1
(en)
|
1996-12-27 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Method of synthesizing phosphorothioate oligonucleotides
|
|
US5902881A
(en)
|
1997-03-03 |
1999-05-11 |
Isis Pharmaceuticals, Inc. |
Reagent useful for synthesizing sulfurized oligonucleotide analogs
|
|
US5760209A
(en)
*
|
1997-03-03 |
1998-06-02 |
Isis Pharmaceuticals, Inc. |
Protecting group for synthesizing oligonucleotide analogs
|
|
US6265193B1
(en)
*
|
1997-03-12 |
2001-07-24 |
Pe Corporation (Ny) |
DNA polymerases having improved labeled nucleotide incorporation properties
|
|
WO1998044156A1
(en)
*
|
1997-03-27 |
1998-10-08 |
Life Technologies, Inc. |
Nucleic acid ladders
|
|
WO1999003872A1
(en)
|
1997-07-15 |
1999-01-28 |
Life Technologies, Inc. |
Nucleic acid ladders
|
|
US6008379A
(en)
|
1997-10-01 |
1999-12-28 |
The Perkin-Elmer Corporation |
Aromatic-substituted xanthene dyes
|
|
US5936087A
(en)
|
1997-11-25 |
1999-08-10 |
The Perkin-Elmer Corporation |
Dibenzorhodamine dyes
|
|
US6583168B1
(en)
|
1997-11-25 |
2003-06-24 |
Applera Corporation |
Sulfonated diarylrhodamine dyes
|
|
US6441150B1
(en)
*
|
1997-12-16 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
|
|
US7427678B2
(en)
*
|
1998-01-08 |
2008-09-23 |
Sigma-Aldrich Co. |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
|
|
EP1714699B1
(en)
*
|
1998-01-12 |
2010-08-18 |
Massachusetts Institute of Technology |
System for analyzing a plurality of samples
|
|
US6893877B2
(en)
|
1998-01-12 |
2005-05-17 |
Massachusetts Institute Of Technology |
Methods for screening substances in a microwell array
|
|
US6426185B1
(en)
|
1998-01-16 |
2002-07-30 |
Large Scale Biology Corporation |
Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
|
|
US20030027173A1
(en)
*
|
1998-01-16 |
2003-02-06 |
Della-Cioppa Guy |
Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
|
|
US6303848B1
(en)
|
1998-01-16 |
2001-10-16 |
Large Scale Biology Corporation |
Method for conferring herbicide, pest, or disease resistance in plant hosts
|
|
US20020164585A1
(en)
*
|
1998-01-16 |
2002-11-07 |
Sean Chapman |
Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
|
|
US6080868A
(en)
|
1998-01-23 |
2000-06-27 |
The Perkin-Elmer Corporation |
Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6020475A
(en)
*
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US7273933B1
(en)
|
1998-02-26 |
2007-09-25 |
Isis Pharmaceuticals, Inc. |
Methods for synthesis of oligonucleotides
|
|
US6111086A
(en)
*
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
US6531590B1
(en)
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
|
US6590092B1
(en)
*
|
1998-05-19 |
2003-07-08 |
Nam Q. Ngo |
Process for preparing a “universal support” and the reagents used for generating such support
|
|
US6274725B1
(en)
|
1998-06-02 |
2001-08-14 |
Isis Pharmaceuticals, Inc. |
Activators for oligonucleotide synthesis
|
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
|
US6919437B1
(en)
|
1998-06-11 |
2005-07-19 |
Isis Pharmaceuticals, Inc. |
Synthetic methods and intermediates for triester oligonucleotides
|
|
US6270730B1
(en)
|
1998-06-16 |
2001-08-07 |
Northwest Engineering Inc. |
Multi-well rotary synthesizer
|
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
|
US6326478B1
(en)
|
1998-07-08 |
2001-12-04 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6124484A
(en)
|
1998-07-17 |
2000-09-26 |
Isis Pharmaceuticals, Inc. |
Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
|
|
US6271042B1
(en)
*
|
1998-08-26 |
2001-08-07 |
Alpha Innotech Corporation |
Biochip detection system
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
|
US6153411A
(en)
*
|
1998-10-30 |
2000-11-28 |
American Water Works Company, Inc. |
Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
|
|
US6169177B1
(en)
|
1998-11-06 |
2001-01-02 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomeric compounds
|
|
WO2000036151A1
(en)
|
1998-12-14 |
2000-06-22 |
Li-Cor, Inc. |
A heterogeneous assay for pyrophosphate detection
|
|
US6380378B1
(en)
|
1998-12-24 |
2002-04-30 |
Toagosei Company, Ltd. |
Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
|
|
US6432642B1
(en)
*
|
1999-01-15 |
2002-08-13 |
Pe Corporation (Ny) |
Binary probe and clamp composition and methods for a target hybridization detection
|
|
US6465628B1
(en)
*
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
US20040082774A1
(en)
*
|
1999-03-16 |
2004-04-29 |
Guzaev Andrei P. |
Novel phosphate and thiophosphate protecting groups
|
|
US6121437A
(en)
*
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6399765B1
(en)
*
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
|
MXPA01009361A
(es)
*
|
1999-03-19 |
2002-06-04 |
Genencor Int |
Placa de pruebas de multiples agujeros pasantes para filtracion de alto rendimiento.
|
|
AU2998800A
(en)
|
1999-03-24 |
2000-10-09 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
|
US6221635B1
(en)
|
1999-05-06 |
2001-04-24 |
The Wistar Institute |
Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
|
|
US6610842B1
(en)
|
1999-05-06 |
2003-08-26 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomers using phosphoramidite compositions
|
|
CA2375060A1
(en)
*
|
1999-05-24 |
2000-11-30 |
Life Technologies Corporation |
Method for deblocking of labeled oligonucleotides
|
|
US20070059752A1
(en)
*
|
1999-06-09 |
2007-03-15 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
|
US7183405B2
(en)
|
1999-06-25 |
2007-02-27 |
Syn Gen, Inc. |
Compositions and methods for labeling oligonucleotides
|
|
US6750357B1
(en)
|
1999-06-25 |
2004-06-15 |
Syngen, Inc. |
Rhodamine-based fluorophores useful as labeling reagents
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US6346423B1
(en)
|
1999-07-16 |
2002-02-12 |
Agilent Technologies, Inc. |
Methods and compositions for producing biopolymeric arrays
|
|
US6306599B1
(en)
|
1999-07-16 |
2001-10-23 |
Agilent Technologies Inc. |
Biopolymer arrays and their fabrication
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US6114518A
(en)
*
|
1999-09-30 |
2000-09-05 |
Becton, Dickinson And Company |
Synthesis and use of labelled phosphoramidite compositions
|
|
AU7855900A
(en)
|
1999-10-04 |
2001-05-10 |
University Of Medicine And Dentistry Of New Jersey |
Methods for identifying rna binding compounds
|
|
US6451998B1
(en)
|
1999-10-18 |
2002-09-17 |
Agilent Technologies, Inc. |
Capping and de-capping during oligonucleotide synthesis
|
|
JP2003517589A
(ja)
*
|
1999-11-02 |
2003-05-27 |
セリーヌ フー, |
分子マイクロアレイならびにその生産および使用のための方法
|
|
US6361958B1
(en)
|
1999-11-12 |
2002-03-26 |
Motorola, Inc. |
Biochannel assay for hybridization with biomaterial
|
|
US6875619B2
(en)
|
1999-11-12 |
2005-04-05 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
CA2392218A1
(en)
*
|
1999-11-17 |
2001-05-25 |
Jiuping Ji |
Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
|
|
US6716994B1
(en)
*
|
2000-01-04 |
2004-04-06 |
Applera Corporation |
Mobility-Modifying Cyanine Dyes
|
|
US20020151040A1
(en)
|
2000-02-18 |
2002-10-17 |
Matthew O' Keefe |
Apparatus and methods for parallel processing of microvolume liquid reactions
|
|
US20010055765A1
(en)
|
2000-02-18 |
2001-12-27 |
O'keefe Matthew |
Apparatus and methods for parallel processing of micro-volume liquid reactions
|
|
US7019129B1
(en)
|
2000-05-09 |
2006-03-28 |
Biosearch Technologies, Inc. |
Dark quenchers for donor-acceptor energy transfer
|
|
EP1313880A2
(en)
*
|
2000-05-30 |
2003-05-28 |
PE Corporation (NY) |
Methods for detecting target nucleic acids using coupled ligation and amplification
|
|
US6887664B2
(en)
|
2000-06-06 |
2005-05-03 |
Applera Corporation |
Asynchronous primed PCR
|
|
US6936702B2
(en)
*
|
2000-06-07 |
2005-08-30 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
|
US6869764B2
(en)
|
2000-06-07 |
2005-03-22 |
L--Cor, Inc. |
Nucleic acid sequencing using charge-switch nucleotides
|
|
JP2004516810A
(ja)
|
2000-06-07 |
2004-06-10 |
リ−コール インコーポレーティッド |
電荷スイッチヌクレオチド
|
|
US7135565B2
(en)
*
|
2000-07-28 |
2006-11-14 |
Agilent Technologies, Inc. |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
|
|
ATE432994T1
(de)
|
2000-09-26 |
2009-06-15 |
Boston Probes Inc |
Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
|
|
AU1312502A
(en)
*
|
2000-10-11 |
2002-04-22 |
Pe Corp Ny |
Fluorescent nucleobase conjugates having anionic linkers
|
|
US6693187B1
(en)
*
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
|
CA2428155A1
(en)
*
|
2000-11-09 |
2002-05-16 |
Invitrogen Corporation |
Method for removing a universal linker from an oligonucleotide
|
|
US6906182B2
(en)
|
2000-12-01 |
2005-06-14 |
Cell Works Therapeutics, Inc. |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
|
|
US6794141B2
(en)
|
2000-12-22 |
2004-09-21 |
Arcturus Bioscience, Inc. |
Nucleic acid amplification
|
|
US6825338B2
(en)
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
|
US8034791B2
(en)
|
2001-04-06 |
2011-10-11 |
The University Of Chicago |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
|
|
US20040242523A1
(en)
*
|
2003-03-06 |
2004-12-02 |
Ana-Farber Cancer Institue And The Univiersity Of Chicago |
Chemo-inducible cancer gene therapy
|
|
ES2380007T3
(es)
*
|
2001-04-06 |
2012-05-07 |
The University Of Chicago |
Inducción por agentes quimioterapéuticos de la actividad del promotor Egr-1 en la terapia génica
|
|
US20050221304A1
(en)
*
|
2001-04-11 |
2005-10-06 |
Charlie Xiang |
Modified random primers for probe labeling
|
|
US20030170675A1
(en)
*
|
2001-04-11 |
2003-09-11 |
The Gov't Of The U.S Of America As Represented By The Secretary Of The Dept. Of Health & Human Serv. |
Methods of manipulating nucleic acids
|
|
CA2381367A1
(en)
|
2001-04-12 |
2002-10-12 |
Hironori Komatsu |
Method for purifying 5'-protected 2'-deoxypurine nucleosides
|
|
US6867050B2
(en)
*
|
2001-05-16 |
2005-03-15 |
Academia Sinica |
Apparatus and methods for chemical synthesis
|
|
US20050009101A1
(en)
*
|
2001-05-17 |
2005-01-13 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
|
PL373962A1
(en)
*
|
2001-05-21 |
2005-09-19 |
Aclara Biosciences, Inc. |
Methods and compositions for analyzing proteins
|
|
US7300922B2
(en)
|
2001-05-25 |
2007-11-27 |
Duke University |
Modulators of pharmacological agents
|
|
ATE490267T1
(de)
*
|
2001-06-05 |
2010-12-15 |
Curevac Gmbh |
Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen
|
|
US7118907B2
(en)
*
|
2001-06-06 |
2006-10-10 |
Li-Cor, Inc. |
Single molecule detection systems and methods
|
|
AU2002322351A1
(en)
*
|
2001-06-28 |
2003-03-03 |
Ia, Inc. |
Fiber-optic sensor array
|
|
US7153954B2
(en)
|
2001-07-12 |
2006-12-26 |
Santaris Pharma A/S |
Method for preparation of LNA phosphoramidites
|
|
JP3935487B2
(ja)
*
|
2001-07-16 |
2007-06-20 |
フーベルト・ケスター |
捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
|
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
|
US20050042629A1
(en)
|
2002-09-13 |
2005-02-24 |
Applera Corporation |
Thermus scotoductus nucleic acid polymerases
|
|
US7052877B2
(en)
|
2001-11-30 |
2006-05-30 |
Applera Corporation |
Thermus brockianus nucleic acid polymerases
|
|
WO2003048179A2
(en)
*
|
2001-12-03 |
2003-06-12 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
|
GB0200526D0
(en)
*
|
2002-01-11 |
2002-02-27 |
Science And Technology The |
Methods
|
|
AU2003210629A1
(en)
*
|
2002-01-23 |
2003-09-02 |
Proligo, Llc |
Methods for the integrated synthesis and purification of oligonucleotides
|
|
EP2213737B1
(en)
|
2002-02-01 |
2012-11-07 |
Life Technologies Corporation |
Double-stranded oligonucleotides
|
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
EP1502102B1
(en)
*
|
2002-03-11 |
2009-01-14 |
caprotec bioanalytics GmbH |
Compounds and methods for analyzing the proteome
|
|
EP1485503A4
(en)
*
|
2002-03-15 |
2005-12-28 |
Arcturus Bioscience Inc |
IMPROVED NUCLEIC ACID AMPLIFICATION
|
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
|
DE60326228D1
(de)
|
2002-05-08 |
2009-04-02 |
Panasonic Corp |
Biomolekulares substrat und testvorrichtung
|
|
AU2003249681A1
(en)
*
|
2002-05-31 |
2003-12-19 |
Diversa Corporation |
Multiplexed systems for nucleic acid sequencing
|
|
CN100424091C
(zh)
|
2002-06-05 |
2008-10-08 |
三井化学株式会社 |
保护化2’-脱氧胞苷类的精制法
|
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
US7504215B2
(en)
|
2002-07-12 |
2009-03-17 |
Affymetrix, Inc. |
Nucleic acid labeling methods
|
|
EP1386925A1
(en)
*
|
2002-07-31 |
2004-02-04 |
Girindus AG |
Method for preparing oligonucleotides
|
|
US8277753B2
(en)
|
2002-08-23 |
2012-10-02 |
Life Technologies Corporation |
Microfluidic transfer pin
|
|
US20040137469A1
(en)
*
|
2002-09-08 |
2004-07-15 |
Casale Ralph A |
Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
|
|
US20040235005A1
(en)
*
|
2002-10-23 |
2004-11-25 |
Ernest Friedlander |
Methods and composition for detecting targets
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
JPWO2004052908A1
(ja)
*
|
2002-12-09 |
2006-04-13 |
三井化学株式会社 |
フォスフォロアミダイトの製造方法
|
|
GB0229423D0
(en)
*
|
2002-12-18 |
2003-01-22 |
Avecia Ltd |
Process
|
|
EP1608952B1
(en)
|
2002-12-20 |
2016-08-10 |
Life Technologies Corporation |
Assay apparatus and method using microfluidic arrays
|
|
EP1585755B1
(en)
*
|
2002-12-31 |
2015-08-05 |
Sigma-Aldrich Co. LLC |
Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
|
|
EP2259068B1
(en)
*
|
2003-01-16 |
2013-08-14 |
caprotec bioanalytics GmbH |
Capture compounds and methods for analyzing the proteome
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
JP3936300B2
(ja)
*
|
2003-02-28 |
2007-06-27 |
独立行政法人科学技術振興機構 |
新規なグアノシン誘導体及びその用途
|
|
WO2004087884A2
(en)
|
2003-03-27 |
2004-10-14 |
Ptc Therapeutics, Inc |
TARGETING ENZYMES OF THE tRNA SPLICING PATHWAY FOR IDENTIFICATION OF ANTI-FUNGAL AND/OR ANTI-PROLIFERATIVE MOLECULES
|
|
WO2004087069A2
(en)
|
2003-03-27 |
2004-10-14 |
Ptc Therapeutics, Inc. |
METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-PROLIFERATIVE AGENTS
|
|
US7745116B2
(en)
*
|
2003-04-08 |
2010-06-29 |
Pacific Biosciences Of California, Inc. |
Composition and method for nucleic acid sequencing
|
|
US20070179100A1
(en)
*
|
2003-04-09 |
2007-08-02 |
Muthiah Manoharan |
Protected monomers
|
|
WO2004101582A2
(en)
*
|
2003-05-09 |
2004-11-25 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
|
EP1660512A4
(en)
|
2003-06-02 |
2009-12-23 |
Isis Pharmaceuticals Inc |
SYNTHESIS OF OLIGONUCLEOTIDES USING ALTERNATIVE SOLVENTS
|
|
WO2005001129A2
(en)
*
|
2003-06-06 |
2005-01-06 |
Applera Corporation |
Mobility cassettes
|
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
|
WO2005027625A2
(en)
*
|
2003-09-18 |
2005-03-31 |
Mayo Foundation For Medical Education And Research |
Transgenic tieg non-human animals
|
|
WO2005027962A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
ES2403937T3
(es)
|
2003-11-13 |
2013-05-22 |
Isis Pharmaceuticals, Inc. |
Derivados de 5,6-dihidroxi-isoindol como conectores para la síntesis de oligómeros en fase sólida
|
|
DE602004030041D1
(de)
|
2003-12-22 |
2010-12-23 |
Univ Pennsylvania |
Verfahren und zusammensetzungen zur identifikation von rna-bindenden proteinen
|
|
EP1706149A2
(en)
*
|
2004-01-15 |
2006-10-04 |
Alza Corporation |
Liposome composition for delivery of therapeutic agents
|
|
US7691316B2
(en)
*
|
2004-02-12 |
2010-04-06 |
Chemistry & Technology For Genes, Inc. |
Devices and methods for the synthesis of nucleic acids
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
WO2005089945A1
(en)
|
2004-03-12 |
2005-09-29 |
Biotrove, Inc. |
Nanoliter array loading
|
|
PL1745062T3
(pl)
|
2004-04-22 |
2014-10-31 |
Regado Biosciences Inc |
Ulepszone modulatory czynników krzepnięcia
|
|
JP4592060B2
(ja)
*
|
2004-04-26 |
2010-12-01 |
キヤノン株式会社 |
Pcr増幅反応装置、ならびに、該装置を利用するpcr増幅反応方法
|
|
IL162276A0
(en)
*
|
2004-06-01 |
2005-11-20 |
Hadasit Med Res Service |
Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US12070731B2
(en)
|
2004-08-04 |
2024-08-27 |
Life Technologies Corporation |
Methods and systems for aligning dispensing arrays with microfluidic sample arrays
|
|
US20060105453A1
(en)
|
2004-09-09 |
2006-05-18 |
Brenan Colin J |
Coating process for microfluidic sample arrays
|
|
WO2006023880A2
(en)
|
2004-08-23 |
2006-03-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
DE102004042546A1
(de)
*
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
CN101258220A
(zh)
|
2004-09-16 |
2008-09-03 |
阿普里拉股份有限公司 |
荧光染料化合物,共轭物及其应用
|
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
US9809824B2
(en)
*
|
2004-12-13 |
2017-11-07 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
WO2006076650A2
(en)
*
|
2005-01-12 |
2006-07-20 |
Applera Corporation |
Compositions, methods, and kits for selective amplification of nucleic acids
|
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
|
CN101193905B
(zh)
|
2005-02-11 |
2014-06-25 |
纪念斯隆-凯特林癌症中心 |
用于检测抗药egfr突变体的方法和组合物
|
|
DE102005023170A1
(de)
|
2005-05-19 |
2006-11-23 |
Curevac Gmbh |
Optimierte Formulierung für mRNA
|
|
US7741471B2
(en)
|
2005-05-26 |
2010-06-22 |
Eragen Biosciences, Inc. |
Reagents for the improved synthesis of isoguanosine containing oligonucleotides
|
|
JP2009501024A
(ja)
*
|
2005-07-12 |
2009-01-15 |
テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション |
癌の診断及び治療における遺伝的及びエピジェネティックな変化
|
|
US7892795B2
(en)
|
2005-08-02 |
2011-02-22 |
Focus Diagnostics, Inc. |
Methods and compositions for detecting BK virus
|
|
US20070202515A1
(en)
*
|
2005-10-12 |
2007-08-30 |
Pathologica, Llc. |
Promac signature application
|
|
US20090075273A1
(en)
*
|
2005-11-14 |
2009-03-19 |
Siemens Healthcare Diagnostics Inc. |
Planar Waveguide Detection Chips and Chambers for Performing Multiple PCR Assays
|
|
US7579459B2
(en)
*
|
2005-12-12 |
2009-08-25 |
Ngo Nam Q |
Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
JP5342881B2
(ja)
|
2006-01-27 |
2013-11-13 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
6−修飾された二環式核酸類似体
|
|
WO2007095155A2
(en)
|
2006-02-13 |
2007-08-23 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Primers and probes for detection and discrimination of types and subtypes of influenza viruses
|
|
CA2647260A1
(en)
*
|
2006-03-24 |
2007-11-08 |
Archemix Corp. |
Solid support reagents for synthesis
|
|
EP2023940B1
(en)
|
2006-05-05 |
2011-06-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
US20080009007A1
(en)
*
|
2006-06-16 |
2008-01-10 |
Pacific Biosciences Of California, Inc. |
Controlled initiation of primer extension
|
|
EP3796002B1
(en)
|
2006-07-14 |
2023-11-22 |
The Regents of The University of California |
Cancer biomarkers and methods of use thereof
|
|
AU2007280690C1
(en)
|
2006-07-31 |
2012-08-23 |
Curevac Gmbh |
Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant
|
|
DE102006035618A1
(de)
*
|
2006-07-31 |
2008-02-07 |
Curevac Gmbh |
Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
|
|
US8138330B2
(en)
*
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US7947447B2
(en)
|
2007-01-16 |
2011-05-24 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
WO2008141248A2
(en)
|
2007-05-10 |
2008-11-20 |
Agilent Technologies, Inc. |
Thiocarbon-protecting groups for rna synthesis
|
|
MX2009012635A
(es)
*
|
2007-05-23 |
2012-09-13 |
Mannkind Corp |
Vectores multicistronicos y metodos para su diseño.
|
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
ES2959127T3
(es)
|
2007-06-19 |
2024-02-20 |
Hoffmann La Roche |
Secuenciación de ácidos nucleicos de alto rendimiento por expansión
|
|
CA2692579C
(en)
|
2007-07-05 |
2016-05-03 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
US8404830B2
(en)
*
|
2007-07-17 |
2013-03-26 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
WO2009023855A2
(en)
|
2007-08-15 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
DK2548962T3
(en)
|
2007-09-19 |
2016-04-11 |
Applied Biosystems Llc |
Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof
|
|
WO2009046738A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
|
|
EP3222290A1
(en)
|
2007-10-09 |
2017-09-27 |
CureVac AG |
Composition for treating prostate cancer (pca)
|
|
US7829735B2
(en)
*
|
2007-10-26 |
2010-11-09 |
Northwestern University |
Universal phosphoramidite for preparation of modified biomolecules and surfaces
|
|
TWI415858B
(zh)
*
|
2007-11-06 |
2013-11-21 |
Pharmaessentia Corp |
β-核苷之新穎合成技術
|
|
EP2176408B9
(en)
|
2008-01-31 |
2015-11-11 |
Curevac GmbH |
NUCLEIC ACIDS COMPRISING FORMULA (NuGiXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS
|
|
WO2009100320A2
(en)
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
US10131904B2
(en)
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
DK2285819T3
(da)
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
|
US8273534B2
(en)
|
2008-05-14 |
2012-09-25 |
Genomic Health, Inc. |
Predictors of patient response to treatment with EGF receptor inhibitors
|
|
WO2010005693A1
(en)
*
|
2008-06-23 |
2010-01-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cyclized ngr peptide compounds, compositions, and methods of their use
|
|
JP5438922B2
(ja)
*
|
2008-06-25 |
2014-03-12 |
日東電工株式会社 |
核酸の製造方法
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
CA2746527A1
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
US8604192B2
(en)
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
MX2011004097A
(es)
|
2008-10-15 |
2011-07-28 |
Isis Pharmaceuticals Inc |
Modulacion de la expresion del factor 11.
|
|
EP2358398A2
(en)
|
2008-10-24 |
2011-08-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
WO2010048549A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
RU2572826C2
(ru)
|
2008-12-02 |
2016-01-20 |
Чиралджен, Лтд. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
EP2389452A2
(en)
|
2009-01-21 |
2011-11-30 |
Vertex Pharmaceuticals Incorporated |
Methods for amplifying hepatitis c virus nucleic acids
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2010138926A1
(en)
|
2009-05-29 |
2010-12-02 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Nucleic acids for detection and discrimination of genotypes of chlamydophila psittaci
|
|
CA2767253A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc. |
Novel nucleic acid prodrugs and methods of use thereof
|
|
EP2278334A1
(en)
|
2009-07-22 |
2011-01-26 |
Etablissement Francais du Sang |
A membrane based microarray device for high-throughput multianalyte detection
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
|
EP2507381A4
(en)
|
2009-12-04 |
2016-07-20 |
Hoffmann La Roche |
MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
WO2011069528A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Lyophilization of nucleic acids in lactate-containing solutions
|
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
|
US10113206B2
(en)
|
2010-02-24 |
2018-10-30 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9080171B2
(en)
|
2010-03-24 |
2015-07-14 |
RXi Parmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
|
BR112012024049A2
(pt)
|
2010-03-24 |
2017-03-01 |
Rxi Pharmaceuticals Corp |
interferência de rna em indicações dérmicas e fibróticas
|
|
EP3345915B1
(en)
|
2010-04-12 |
2021-11-24 |
Somalogic, Inc. |
5-position modified pyrimidines and their use
|
|
WO2011139721A1
(en)
|
2010-04-27 |
2011-11-10 |
The Regents Of The University Of California |
Cancer biomarkers and methods of use thereof
|
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2580228B1
(en)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
BR112012030311A2
(pt)
|
2010-06-08 |
2017-01-24 |
Genentech Inc |
anticorpo
|
|
CA2801523C
(en)
|
2010-07-30 |
2021-08-03 |
Curevac Gmbh |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
JP5868324B2
(ja)
|
2010-09-24 |
2016-02-24 |
株式会社Wave Life Sciences Japan |
不斉補助基
|
|
RU2013120302A
(ru)
|
2010-10-01 |
2014-11-20 |
Модерна Терапьютикс, Инк. |
Сконструированные нуклеиновые кислоты и способы их применения
|
|
CA3077910A1
(en)
|
2010-11-17 |
2012-05-24 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
AR084358A1
(es)
|
2010-12-27 |
2013-05-08 |
Lilly Co Eli |
Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
|
|
AU2011352800B2
(en)
|
2010-12-27 |
2015-09-03 |
Elanco Us Inc. |
Bovine viral diarrhea virus type 1b vaccine compositions and methods
|
|
RU2639549C2
(ru)
|
2010-12-30 |
2017-12-21 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Молекулы нуклеиновых кислот, которые придают устойчивость к насекомым-вредителям отряда жесткокрылых
|
|
AU2011351946B2
(en)
|
2010-12-30 |
2017-05-18 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the vacuolar ATPase C subunit and confer resistance to coleopteran pests
|
|
UY33853A
(es)
|
2010-12-30 |
2012-07-31 |
Dow Agrosciences Llc |
?moléculas de ácido nucleico que se dirigen a la subunidad h de la atpasa vacuolar y confieren resistencia a plagas de coleópteros?.
|
|
RU2013135491A
(ru)
|
2010-12-30 |
2015-02-10 |
Дау Агросайенсиз Ллс |
Молекулы нуклеиновых кислот, которые нацелены на малый gtp-связывающий белок rho1 и сообщают устойчивость к вредителям отряда жесткокрылых
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
ES2537189T3
(es)
|
2011-05-24 |
2015-06-03 |
Elitech Holding B.V. |
Detección de estafilococos áureos resistentes a la meticilina
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
BR112013032223A2
(pt)
|
2011-06-15 |
2016-12-20 |
Grifols Therapeutics Inc |
molécula de ácido nucleico isolada, e, composição
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
EP2736916B1
(en)
|
2011-07-26 |
2019-05-22 |
ELITechGroup, Inc. |
Minor groove binder phosphoramidites and methods of use
|
|
WO2013036332A2
(en)
|
2011-09-07 |
2013-03-14 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining hepatitis a virus
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
US9428813B2
(en)
|
2012-03-26 |
2016-08-30 |
The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services |
DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2844775B1
(en)
|
2012-05-02 |
2018-07-18 |
Ibis Biosciences, Inc. |
Dna sequencing
|
|
WO2013166303A1
(en)
|
2012-05-02 |
2013-11-07 |
Ibis Biosciences, Inc. |
Dna sequencing
|
|
US10458915B2
(en)
|
2012-05-18 |
2019-10-29 |
Pacific Biosciences Of California, Inc. |
Heteroarylcyanine dyes
|
|
US10245229B2
(en)
|
2012-06-08 |
2019-04-02 |
Translate Bio, Inc. |
Pulmonary delivery of mRNA to non-lung target cells
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. |
キラル制御
|
|
CN104684923B
(zh)
|
2012-07-13 |
2018-09-28 |
株式会社新日本科学 |
手性核酸佐剂
|
|
SG11201500239VA
(en)
|
2012-07-13 |
2015-03-30 |
Wave Life Sciences Japan |
Asymmetric auxiliary group
|
|
EP2885312B1
(en)
|
2012-08-15 |
2025-09-03 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
US9950001B2
(en)
|
2012-08-20 |
2018-04-24 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
JP6533896B2
(ja)
*
|
2012-09-04 |
2019-06-26 |
株式会社ダナフォーム |
化合物、核酸、標識物質および検出方法
|
|
MY167603A
(en)
|
2012-10-04 |
2018-09-20 |
The Board Of Trustees Of Leland Stanford Junior Univ |
Method and reagents for detection, quantitation, and serotyping of dengue viruses
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US20160046997A1
(en)
|
2012-10-18 |
2016-02-18 |
Oslo Universitetssykehus Hf |
Biomarkers for cervical cancer
|
|
WO2014063051A2
(en)
|
2012-10-18 |
2014-04-24 |
Idexx Laboratories, Inc. |
Nucleic acid amplification controls and kits and methods of use thereof
|
|
WO2014081507A1
(en)
|
2012-11-26 |
2014-05-30 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
WO2014120861A2
(en)
|
2013-01-31 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
|
DK2970456T3
(da)
|
2013-03-14 |
2021-07-05 |
Translate Bio Inc |
Fremgangsmåder og sammensætninger til levering af mrna-kodede antistoffer
|
|
PL3467108T3
(pl)
|
2013-03-14 |
2024-09-30 |
Translate Bio, Inc. |
Sposoby oczyszczania informacyjnego rna
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
DK2991656T3
(da)
|
2013-05-01 |
2020-03-23 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
|
|
EP3004131B1
(en)
|
2013-06-05 |
2020-07-22 |
AM Chemicals Llc |
Phosphoramidite building blocks for sugar-conjugated oligonucleotides
|
|
US9069358B2
(en)
|
2013-06-24 |
2015-06-30 |
Biolytic Lab Performance, Inc. |
System for controlling and optimizing reactions in solid phase synthesis of small molecules
|
|
TWI707038B
(zh)
|
2013-08-05 |
2020-10-11 |
美商扭轉生物科技有限公司 |
重新合成之基因庫
|
|
BR112016003361A2
(pt)
|
2013-08-21 |
2017-11-21 |
Curevac Ag |
vacina do vírus sincicial respiratório (rsv)
|
|
EP3035955B1
(en)
|
2013-08-21 |
2019-09-11 |
CureVac AG |
Composition and vaccine for treating lung cancer
|
|
JP2016538829A
(ja)
|
2013-10-03 |
2016-12-15 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
低密度リポタンパク質受容体をコードするポリヌクレオチド
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
ES2707966T3
(es)
|
2013-10-22 |
2019-04-08 |
Translate Bio Inc |
Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
|
|
AU2014340149B2
(en)
|
2013-10-22 |
2020-12-24 |
Shire Human Genetic Therapies, Inc. |
CNS delivery of mRNA and uses thereof
|
|
MX2016005238A
(es)
|
2013-10-22 |
2016-08-12 |
Shire Human Genetic Therapies |
Formulaciones de lipidos para la administracion de acido ribonucleico mensajero.
|
|
EA034103B1
(ru)
|
2013-10-22 |
2019-12-27 |
Транслейт Био, Инк. |
СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
|
|
ES2806575T3
(es)
|
2013-11-01 |
2021-02-18 |
Curevac Ag |
ARN modificado con propiedades inmunoestimuladoras disminuidas
|
|
EP3068783B1
(en)
|
2013-11-15 |
2020-09-23 |
The Board of Trustees of the Leland Stanford Junior University |
Agonists of hypocretin receptor 2 for use for treating heart failure
|
|
BR112016010165A2
(pt)
|
2013-11-21 |
2017-12-05 |
Somalogic Inc |
composições de nucleotídeos modificados de citidina-5-carboxamida e métodos relacionados às mesmas
|
|
WO2015084897A2
(en)
|
2013-12-02 |
2015-06-11 |
Mirimmune, Llc |
Immunotherapy of cancer
|
|
BR102014031844A2
(pt)
|
2013-12-20 |
2015-10-06 |
Dow Agrosciences Llc |
ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
|
|
RU2016129435A
(ru)
|
2013-12-20 |
2018-01-25 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Молекулы нуклеиновой кислоты phkп ii-140, которые придают устойчивость к жестококрылым насекомым-вредителям
|
|
CA2927254C
(en)
|
2013-12-30 |
2023-10-24 |
Curevac Ag |
Artificial nucleic acid molecules
|
|
EP3495486B1
(en)
|
2013-12-30 |
2020-12-16 |
CureVac AG |
Artificial nucleic acid molecules
|
|
KR102399799B1
(ko)
|
2013-12-30 |
2022-05-18 |
큐어백 아게 |
인공 핵산 분자
|
|
WO2015108048A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
WO2015108047A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
|
JPWO2015108046A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
EP3119789B1
(en)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CN106103717A
(zh)
|
2014-03-19 |
2016-11-09 |
Ionis制药公司 |
用于调节共济失调蛋白2表达的组合物
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
US20170143848A1
(en)
|
2014-03-24 |
2017-05-25 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for the treatment of ocular diseases
|
|
RS60707B1
(sr)
|
2014-04-01 |
2020-09-30 |
Biogen Ma Inc |
Kompozicije za modulaciju ekspresije sod-1
|
|
CA2936286A1
(en)
|
2014-04-01 |
2015-10-08 |
Curevac Ag |
Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
PT3134506T
(pt)
|
2014-04-25 |
2019-10-31 |
Translate Bio Inc |
Métodos de purificação de rna mensageiro
|
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
|
DK3137476T3
(da)
|
2014-04-28 |
2019-11-18 |
Ionis Pharmaceuticals Inc |
Linker-modificerede oligomerforbindelser
|
|
KR102375480B1
(ko)
|
2014-04-30 |
2022-03-16 |
애질런트 테크놀로지스, 인크. |
인 보호기 및 이의 제조 방법 및 용도
|
|
SG11201608502TA
(en)
|
2014-05-01 |
2016-11-29 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating complement factor b expression
|
|
US10098959B2
(en)
|
2014-05-01 |
2018-10-16 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
AU2015255995B2
(en)
|
2014-05-07 |
2018-05-10 |
Dow Agrosciences Llc |
Dre4 nucleic acid molecules that confer resistance to coleopteran pests
|
|
WO2015175870A1
(en)
|
2014-05-16 |
2015-11-19 |
Life Technologies Corporation |
Carbopyronone compounds useful as diagnostic adjuvants
|
|
JP6557722B2
(ja)
|
2014-05-30 |
2019-08-07 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
核酸の送達のための生分解性脂質
|
|
US9802975B2
(en)
|
2014-06-10 |
2017-10-31 |
Agilent Technologies, Inc. |
Protecting groups for “Z nucleotide” and methods thereof
|
|
EP3160959B1
(en)
|
2014-06-24 |
2023-08-30 |
Translate Bio, Inc. |
Stereochemically enriched compositions for delivery of nucleic acids
|
|
BR112016030852A2
(pt)
|
2014-07-02 |
2018-01-16 |
Shire Human Genetic Therapies |
encapsulação de rna mensageiro
|
|
US10093967B2
(en)
|
2014-08-12 |
2018-10-09 |
The Regents Of The University Of Michigan |
Detection of nucleic acids
|
|
KR102506169B1
(ko)
|
2014-09-05 |
2023-03-08 |
피오 파마슈티칼스 코프. |
Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
|
|
MX2017003123A
(es)
|
2014-09-12 |
2017-05-12 |
Genentech Inc |
Anticuerpos y conjugados modificados geneticamente con cisteina.
|
|
BR112017004056A2
(pt)
|
2014-09-12 |
2017-12-05 |
Biogen Ma Inc |
composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
|
|
BR112017007923B1
(pt)
|
2014-10-17 |
2023-12-12 |
The Penn State Research Foundation |
Método para produzir manipulação genética mediada por reações multiplex com rna em uma célula receptora, construção de ácido nucleico,cassete de expressão, vetor, célula receptora e célula geneticamente modificada
|
|
WO2016090323A1
(en)
|
2014-12-05 |
2016-06-09 |
Prelude, Inc. |
Dcis recurrence and invasive breast cancer
|
|
WO2016090262A1
(en)
|
2014-12-05 |
2016-06-09 |
Shire Human Genetic Therapies, Inc. |
Messenger rna therapy for treatment of articular disease
|
|
WO2016094607A2
(en)
|
2014-12-12 |
2016-06-16 |
Elitechgroup B.V. |
Methods and compositions for detecting antibiotic resistant bacteria
|
|
EP3230467A1
(en)
|
2014-12-12 |
2017-10-18 |
ELITechGroup B.V. |
Methods and compositions for detecting antibiotic resistant bacteria
|
|
DE202015010000U1
(de)
|
2014-12-12 |
2023-07-03 |
CureVac SE |
Artifizielle Nukleinsäuremoleküle für eine verbesserte Proteinexpression
|
|
EP3037432B1
(en)
|
2014-12-22 |
2020-06-17 |
Dow AgroSciences LLC |
Nucampholin nucleic acid molecules to control coleopteran insect pests
|
|
KR102580696B1
(ko)
|
2014-12-30 |
2023-09-19 |
큐어백 에스이 |
신규 인공 핵산 분자
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
CA2975855C
(en)
|
2015-02-04 |
2025-09-23 |
Twist Bioscience Corporation |
SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS
|
|
WO2016126882A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
|
WO2016137923A1
(en)
|
2015-02-23 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
EP3067424A1
(en)
|
2015-03-13 |
2016-09-14 |
Dow AgroSciences LLC |
Rna polymerase i1 nucleic acid molecules to control insect pests
|
|
US10172924B2
(en)
|
2015-03-19 |
2019-01-08 |
Translate Bio, Inc. |
MRNA therapy for pompe disease
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US9981239B2
(en)
|
2015-04-21 |
2018-05-29 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
|
BR102016012010A2
(pt)
|
2015-05-29 |
2020-03-24 |
Dow Agrosciences Llc |
Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
|
|
GB201511470D0
(en)
|
2015-06-30 |
2015-08-12 |
Cellcall Kft |
HPV detection method
|
|
CN108135923B
(zh)
|
2015-07-06 |
2021-03-02 |
菲奥医药公司 |
靶向超氧化物歧化酶1(sod1)的核酸分子
|
|
US10808247B2
(en)
|
2015-07-06 |
2020-10-20 |
Phio Pharmaceuticals Corp. |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
CN108135921B
(zh)
|
2015-07-22 |
2023-10-17 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
JP6882782B2
(ja)
|
2015-08-04 |
2021-06-02 |
デューク ユニバーシティ |
遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
|
|
CA2992801A1
(en)
|
2015-08-28 |
2017-03-09 |
Curevac Ag |
Artificial nucleic acid molecules
|
|
KR20180050411A
(ko)
|
2015-09-18 |
2018-05-14 |
트위스트 바이오사이언스 코포레이션 |
올리고핵산 변이체 라이브러리 및 그의 합성
|
|
KR102794025B1
(ko)
|
2015-09-22 |
2025-04-09 |
트위스트 바이오사이언스 코포레이션 |
핵산 합성을 위한 가요성 기판
|
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
|
WO2017070151A1
(en)
|
2015-10-19 |
2017-04-27 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
|
|
EP3374504B1
(en)
|
2015-11-09 |
2025-03-19 |
CureVac SE |
Optimized nucleic acid molecules
|
|
CN115920796A
(zh)
|
2015-12-01 |
2023-04-07 |
特韦斯特生物科学公司 |
功能化表面及其制备
|
|
US11058709B1
(en)
|
2015-12-04 |
2021-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
JPWO2017111137A1
(ja)
|
2015-12-22 |
2018-10-18 |
味の素株式会社 |
オリゴヌクレオチドの製造方法
|
|
US20190002887A1
(en)
|
2015-12-31 |
2019-01-03 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
WO2017177169A1
(en)
|
2016-04-08 |
2017-10-12 |
Rana Therapeutics, Inc. |
Multimeric coding nucleic acid and uses thereof
|
|
EP3443123B1
(en)
|
2016-04-11 |
2021-08-11 |
Board of Regents, The University of Texas System |
Methods and compositions for detecting single t cell receptor affinity and sequence
|
|
WO2017210476A1
(en)
|
2016-06-01 |
2017-12-07 |
Duke University |
Nonfouling biosensors
|
|
CA3027312A1
(en)
|
2016-06-13 |
2017-12-21 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
|
EP3471781A4
(en)
|
2016-06-17 |
2020-05-06 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF GYS1 EXPRESSION
|
|
IL291323B2
(en)
|
2016-07-15 |
2023-09-01 |
Am Chemicals Llc |
Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
|
|
US11046776B2
(en)
|
2016-08-05 |
2021-06-29 |
Genentech, Inc. |
Multivalent and multiepitopic antibodies having agonistic activity and methods of use
|
|
JP2019532027A
(ja)
|
2016-08-17 |
2019-11-07 |
ソルスティス バイオロジクス,リミティッド |
ポリヌクレオチド構築物
|
|
US10907156B2
(en)
|
2016-08-19 |
2021-02-02 |
Fundación Para La Investigación Biomédica Del Hospital Univ. Ramón Y Cajal |
MiR-127 agents for use in the treatment of renal fibrosis
|
|
JP6854340B2
(ja)
|
2016-08-22 |
2021-04-07 |
ツイスト バイオサイエンス コーポレーション |
デノボ合成された核酸ライブラリ
|
|
US10417457B2
(en)
|
2016-09-21 |
2019-09-17 |
Twist Bioscience Corporation |
Nucleic acid based data storage
|
|
EP3515928B1
(en)
|
2016-09-23 |
2026-01-28 |
Duke University |
Unstructured non-repetitive polypeptides having lcst behavior
|
|
EP3522898A4
(en)
|
2016-10-06 |
2020-05-27 |
Ionis Pharmaceuticals, Inc. |
METHOD FOR CONJUGATING OLIGOMERIC COMPOUNDS
|
|
MA46761A
(fr)
|
2016-11-10 |
2019-09-18 |
Translate Bio Inc |
Administration sous-cutanée d'arn messager
|
|
WO2018089237A1
(en)
|
2016-11-10 |
2018-05-17 |
Dow Agrosciences Llc |
Cytochrome b (cytb) nucleic acid molecules that control pathogens
|
|
MX2019005470A
(es)
|
2016-11-10 |
2019-11-21 |
Translate Bio Inc |
Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm.
|
|
WO2018089801A1
(en)
|
2016-11-10 |
2018-05-17 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
WO2018102745A1
(en)
|
2016-12-02 |
2018-06-07 |
Cold Spring Harbor Laboratory |
Modulation of lnc05 expression
|
|
KR102514213B1
(ko)
|
2016-12-16 |
2023-03-27 |
트위스트 바이오사이언스 코포레이션 |
면역 시냅스의 변이체 라이브러리 및 그의 합성
|
|
EP3342780A1
(en)
|
2016-12-30 |
2018-07-04 |
Dow AgroSciences LLC |
Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
|
|
WO2018132732A1
(en)
|
2017-01-12 |
2018-07-19 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
CN110892485B
(zh)
|
2017-02-22 |
2024-03-22 |
特韦斯特生物科学公司 |
基于核酸的数据存储
|
|
WO2018157133A1
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
EP3585892B8
(en)
|
2017-02-27 |
2022-07-13 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
MA47824A
(fr)
|
2017-03-07 |
2020-01-15 |
Translate Bio Inc |
Administration polyanionique d'acides nucléiques
|
|
AU2018231211A1
(en)
|
2017-03-08 |
2019-10-03 |
The Regents Of The University Of Michigan |
Analyte detection
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
WO2018170169A1
(en)
|
2017-03-15 |
2018-09-20 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
|
WO2018195355A1
(en)
|
2017-04-19 |
2018-10-25 |
Rxi Pharmaceuticals Corporation |
Topical delivery of nucleic acid compounds
|
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
MX2019013752A
(es)
|
2017-05-16 |
2020-07-20 |
Translate Bio Inc |
Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones.
|
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
|
EP4047039A1
(en)
|
2017-06-12 |
2022-08-24 |
Translate Bio, Inc. |
Poly(phosphoesters) for delivery of nucleic acids
|
|
US10696965B2
(en)
|
2017-06-12 |
2020-06-30 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
|
EP3641834B1
(en)
|
2017-06-19 |
2023-10-04 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of friedreich's ataxia
|
|
WO2019006455A1
(en)
|
2017-06-30 |
2019-01-03 |
Solstice Biologics, Ltd. |
AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
|
|
WO2019006374A1
(en)
|
2017-06-30 |
2019-01-03 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
|
|
US11197884B2
(en)
|
2017-08-18 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
CN111566125A
(zh)
|
2017-09-11 |
2020-08-21 |
特韦斯特生物科学公司 |
Gpcr结合蛋白及其合成
|
|
CA3075532A1
(en)
|
2017-09-15 |
2019-03-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Multiplex production and barcoding of genetically engineered cells
|
|
CN111565834B
(zh)
|
2017-10-20 |
2022-08-26 |
特韦斯特生物科学公司 |
用于多核苷酸合成的加热的纳米孔
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
EP3727428A1
(en)
|
2017-12-20 |
2020-10-28 |
Translate Bio, Inc. |
Improved composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
US11459564B2
(en)
|
2017-12-21 |
2022-10-04 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
KR102804057B1
(ko)
|
2018-01-04 |
2025-05-07 |
트위스트 바이오사이언스 코포레이션 |
Dna 기반 디지털 정보 저장
|
|
BR112020014425A2
(pt)
|
2018-01-15 |
2020-12-29 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de dnm2
|
|
US12296018B2
(en)
|
2018-01-26 |
2025-05-13 |
Duke University |
Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
|
|
WO2019152802A1
(en)
|
2018-02-02 |
2019-08-08 |
Translate Bio, Inc. |
Cationic polymers
|
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
|
CA3094020A1
(en)
|
2018-04-11 |
2019-10-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
US11613554B2
(en)
|
2018-04-13 |
2023-03-28 |
Bristol-Myers Squibb Company |
Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds
|
|
EP3788343B1
(en)
|
2018-04-30 |
2024-03-27 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
US11866788B2
(en)
|
2018-05-08 |
2024-01-09 |
Sanford Burnham Prebys Medical Discovery Institute |
Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
|
|
SG11202010215TA
(en)
|
2018-05-09 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn3 expression
|
|
JP7438135B2
(ja)
|
2018-05-09 |
2024-02-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Fxiの発現を低下させるための化合物及び方法
|
|
US20210220449A1
(en)
|
2018-05-15 |
2021-07-22 |
Translate Bio, Inc. |
Subcutaneous Delivery of Messenger RNA
|
|
JP7384832B2
(ja)
|
2018-05-16 |
2023-11-21 |
トランスレイト バイオ, インコーポレイテッド |
リボースカチオン性脂質
|
|
CA3100739A1
(en)
|
2018-05-18 |
2019-11-21 |
Twist Bioscience Corporation |
Polynucleotides, reagents, and methods for nucleic acid hybridization
|
|
CN112437767B
(zh)
|
2018-05-24 |
2023-10-27 |
川斯勒佰尔公司 |
硫酯阳离子脂质
|
|
JP7463006B2
(ja)
|
2018-05-30 |
2024-04-08 |
トランスレイト バイオ, インコーポレイテッド |
ステロイド性部分を含むカチオン性脂質
|
|
CA3101484A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
|
WO2019232095A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Vitamin cationic lipids
|
|
CA3101454A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Messenger rna vaccines and uses thereof
|
|
US11384376B2
(en)
|
2018-05-31 |
2022-07-12 |
Roche Molecular Systems, Inc. |
Reagents and methods for post-synthetic modification of nucleic acids
|
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
WO2020001793A1
(en)
|
2018-06-29 |
2020-01-02 |
Eberhard-Karls-Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
EP3823725A4
(en)
|
2018-07-17 |
2023-05-10 |
Aronora, Inc. |
METHODS FOR SAFELY REDUCING THROMBOPOIETIN
|
|
KR20210056331A
(ko)
|
2018-07-23 |
2021-05-18 |
트랜슬레이트 바이오 인코포레이티드 |
전령 rna의 건조 분말 제형
|
|
BR112021000308A2
(pt)
|
2018-07-25 |
2021-04-13 |
Ionis Pharmaceuticals, Inc. |
Compostos e métodos para redução da expressão de atxn2
|
|
EP3829622A4
(en)
|
2018-08-02 |
2022-05-11 |
Duke University |
DOUBLE AGONIST FUSION PROTEINS
|
|
CA3108544A1
(en)
|
2018-08-24 |
2020-02-27 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
KR20210091120A
(ko)
|
2018-08-29 |
2021-07-21 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정
|
|
WO2020051541A1
(en)
|
2018-09-07 |
2020-03-12 |
Duke University |
Nanoparticulate drug delivery systems
|
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
|
WO2020056338A1
(en)
|
2018-09-14 |
2020-03-19 |
Prelude Corporation |
Method of selection for treatment of subjects at risk of invasive breast cancer
|
|
CA3112837A1
(en)
|
2018-10-19 |
2020-04-23 |
Translate Bio, Inc. |
Pumpless encapsulation of messenger rna
|
|
KR20210089648A
(ko)
|
2018-11-08 |
2021-07-16 |
트랜슬레이트 바이오 인코포레이티드 |
메신저 rna 정제를 위한 방법 및 조성물
|
|
WO2020097511A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
|
WO2020097379A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
EP3877444A1
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
Multi-peg lipid compounds
|
|
MX2021005482A
(es)
|
2018-11-09 |
2021-09-08 |
Translate Bio Inc |
Lípidos de 2,5-dioxopiperazina con porciones éster, tioéster, disulfuro y anhidrido intercaladas.
|
|
AU2019378763B2
(en)
|
2018-11-12 |
2025-06-26 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
BR112021008967A2
(pt)
|
2018-11-15 |
2021-08-17 |
Ionis Pharmaceuticals, Inc. |
moduladores da expressão de irf5
|
|
WO2020106903A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Cationic lipid compounds and compositions thereof for use in the delivery of messenger rna
|
|
MX2021005969A
(es)
|
2018-11-21 |
2021-09-14 |
Translate Bio Inc |
Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado.
|
|
SG11202103794QA
(en)
|
2018-11-21 |
2021-05-28 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing prion expression
|
|
US12357959B2
(en)
|
2018-12-26 |
2025-07-15 |
Twist Bioscience Corporation |
Highly accurate de novo polynucleotide synthesis
|
|
JP2022516356A
(ja)
|
2019-01-07 |
2022-02-25 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全症の治療のための組成物および方法
|
|
SG11202107399WA
(en)
|
2019-01-31 |
2021-08-30 |
Ionis Pharmaceuticals Inc |
Modulators of yap1 expression
|
|
EP3921411A4
(en)
|
2019-02-08 |
2023-03-08 |
The Board of Trustees of the Leland Stanford Junior University |
MANUFACTURE AND TRACKING OF GM CELLS WITH COMBINATORY GENETIC MODIFICATIONS
|
|
CN113766930B
(zh)
|
2019-02-26 |
2025-07-22 |
特韦斯特生物科学公司 |
Glp1受体的变异核酸文库
|
|
CA3131691A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for antibody optimization
|
|
TW202540426A
(zh)
|
2019-02-27 |
2025-10-16 |
美商Ionis製藥公司 |
Malat1表現之調節劑
|
|
FI3947684T3
(fi)
|
2019-03-29 |
2025-05-27 |
Ionis Pharmaceuticals Inc |
Yhdisteitä ja menetelmiä ube3a-ats:n moduloimiseksi
|
|
WO2020214946A1
(en)
|
2019-04-18 |
2020-10-22 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
WO2020219427A1
(en)
|
2019-04-22 |
2020-10-29 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
BR112021022909A2
(pt)
|
2019-05-14 |
2022-01-25 |
Translate Bio Inc |
Processo aprimorado de preparação de nanopartículas lipídicas carregadas com mrna
|
|
AU2020275885B2
(en)
|
2019-05-15 |
2026-02-05 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
US20220226244A1
(en)
|
2019-05-31 |
2022-07-21 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
EP3986858A1
(en)
|
2019-06-21 |
2022-04-27 |
Translate Bio, Inc. |
Tricine and citric acid lipids
|
|
AU2020298294A1
(en)
|
2019-06-21 |
2022-02-17 |
Twist Bioscience Corporation |
Barcode-based nucleic acid sequence assembly
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
US20230181483A1
(en)
|
2019-07-08 |
2023-06-15 |
Translate Bio, Inc. |
Improved mrna-loaded lipid nanoparticles and processes of making the same
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
EP4003311A1
(en)
|
2019-07-23 |
2022-06-01 |
Translate Bio, Inc. |
Stable compositions of mrna-loaded lipid nanoparticles and processes of making
|
|
EP3956450B1
(en)
|
2019-07-26 |
2025-08-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
|
IL290078B2
(en)
|
2019-07-30 |
2025-09-01 |
Translate Bio Inc |
Treatment of cystic fibrosis by administering mRNA encoding CFTR in the form of a fine spray
|
|
EP4013767A4
(en)
|
2019-08-15 |
2023-10-25 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds and uses thereof
|
|
EP4031253B1
(en)
|
2019-09-19 |
2025-11-05 |
Sanford Burnham Prebys Medical Discovery Institute |
Methods and compositions for treating myc-driven cancers
|
|
JP2022548309A
(ja)
|
2019-09-23 |
2022-11-17 |
ツイスト バイオサイエンス コーポレーション |
Crth2のバリアント核酸ライブラリー
|
|
WO2021061842A1
(en)
|
2019-09-23 |
2021-04-01 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for single domain antibodies
|
|
IL293670A
(en)
|
2019-12-09 |
2022-08-01 |
Twist Bioscience Corp |
Variable nucleic acid libraries for adenosine receptors
|
|
US20230051811A1
(en)
|
2019-12-20 |
2023-02-16 |
Translate Bio, Inc |
Rectal delivery of messenger rna
|
|
US12053551B2
(en)
|
2019-12-20 |
2024-08-06 |
Translate Bio, Inc. |
Process of preparing mRNA-loaded lipid nanoparticles
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
CA3170319A1
(en)
|
2020-02-10 |
2021-08-19 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
JP7744354B2
(ja)
|
2020-02-25 |
2025-09-25 |
トランスレイト バイオ, インコーポレイテッド |
Mrna担持脂質ナノ粒子を調製する改善された方法
|
|
CR20220485A
(es)
|
2020-02-28 |
2022-11-10 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
|
WO2021202694A1
(en)
|
2020-04-01 |
2021-10-07 |
Translate Bio, Inc. |
Phenolic acid lipid based cationic lipids
|
|
CA3174286A1
(en)
|
2020-04-02 |
2021-10-07 |
Robert PLACE |
Targeted inhibition using engineered oligonucleotides
|
|
MX2022013707A
(es)
|
2020-05-01 |
2022-12-07 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular atxn1.
|
|
WO2021226463A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
WO2021231697A1
(en)
|
2020-05-14 |
2021-11-18 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
WO2021231901A1
(en)
|
2020-05-15 |
2021-11-18 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
US12188060B2
(en)
|
2020-05-15 |
2025-01-07 |
Crispr Therapeutics Ag |
Messenger RNA encoding Cas9 for use in genome-editing systems
|
|
BR112022024206A2
(pt)
|
2020-06-29 |
2023-01-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para modular plp1
|
|
WO2022006527A1
(en)
|
2020-07-02 |
2022-01-06 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
AU2021315992A1
(en)
|
2020-07-28 |
2023-02-09 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing app expression
|
|
IL300258A
(en)
|
2020-08-07 |
2023-03-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating SCN2A
|
|
CA3193347A1
(en)
|
2020-09-23 |
2022-03-31 |
Saswata KARMAKAR |
Piperazine-based cationic lipids
|
|
MX2023003345A
(es)
|
2020-09-23 |
2023-07-24 |
Translate Bio Inc |
Lípidos catiónicos basados en tes.
|
|
WO2022072836A2
(en)
|
2020-10-01 |
2022-04-07 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
CN116546976A
(zh)
|
2020-10-06 |
2023-08-04 |
翻译生物公司 |
脂质纳米颗粒的改进工艺和配制
|
|
WO2022078569A1
(en)
|
2020-10-12 |
2022-04-21 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for rna editing
|
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
|
KR20230087536A
(ko)
|
2020-10-12 |
2023-06-16 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 프로세스
|
|
WO2022099003A1
(en)
|
2020-11-06 |
2022-05-12 |
Sanofi |
Lipid nanoparticles for delivering mrna vaccines
|
|
EP4136092B1
(en)
|
2020-11-18 |
2024-07-31 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
|
JP2023554346A
(ja)
|
2020-12-18 |
2023-12-27 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
第xii因子を調節するための化合物及び方法
|
|
WO2022178438A1
(en)
|
2021-02-22 |
2022-08-25 |
Duke University |
Non-immunogenic poegma-aptamer conjugates
|
|
WO2022183015A1
(en)
|
2021-02-26 |
2022-09-01 |
The Regents Of The University Of California |
Assembled three-dimensional cultures of human neurons and glia and their use
|
|
TW202309002A
(zh)
|
2021-04-15 |
2023-03-01 |
美商轉譯生技公司 |
基於「古德」緩衝液的陽離子脂質
|
|
US20220364078A1
(en)
|
2021-05-14 |
2022-11-17 |
Crispr Therapeutics Ag |
Mrna large scale synthesis and purification
|
|
WO2022256303A1
(en)
|
2021-05-31 |
2022-12-08 |
Genscript Usa Inc. |
Electrografted films for dna synthesis
|
|
WO2022261075A1
(en)
|
2021-06-07 |
2022-12-15 |
The Board Of Trustees Of The University Of Illinois |
Photoactivatable gasdermin proteins
|
|
KR20240022610A
(ko)
|
2021-06-18 |
2024-02-20 |
사노피 |
다가 인플루엔자 백신
|
|
KR20240023602A
(ko)
|
2021-06-18 |
2024-02-22 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Ifnar1 발현을 감소시키기 위한 화합물 및 방법
|
|
EP4370678A2
(en)
|
2021-07-14 |
2024-05-22 |
Mirecule, Inc. |
Oligonucleotides and compositions thereof for neuromuscular disorders
|
|
AU2022336615A1
(en)
|
2021-09-02 |
2024-04-11 |
Sanofi Pasteur Inc. |
Compositions and methods for rna affinity purification
|
|
EP4395933A1
(en)
|
2021-09-03 |
2024-07-10 |
Elegen Corporation |
Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
|
|
AU2022359812A1
(en)
|
2021-10-05 |
2024-05-16 |
Sanofi Pasteur Inc. |
METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME
|
|
EP4413149A1
(en)
|
2021-10-05 |
2024-08-14 |
Microsoft Technology Licensing, LLC |
Regulation of dna synthesis by nucleotides linked to protecting groups
|
|
US20250230511A1
(en)
|
2021-10-29 |
2025-07-17 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
|
MX2024005462A
(es)
|
2021-11-05 |
2024-05-22 |
Sanofi Sa |
Vacuna de arn del virus respiratorio sincitial.
|
|
JP2024545572A
(ja)
|
2021-11-10 |
2024-12-10 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全の治療のための組成物及び方法
|
|
AU2022399571A1
(en)
|
2021-11-30 |
2024-07-11 |
Sanofi Pasteur Inc. |
Human metapneumovirus vaccines
|
|
WO2023111262A1
(en)
|
2021-12-17 |
2023-06-22 |
Sanofi |
Lyme disease rna vaccine
|
|
CN118829624A
(zh)
|
2022-01-17 |
2024-10-22 |
赛诺菲 |
脂质化合物及其用途
|
|
TW202345835A
(zh)
|
2022-03-16 |
2023-12-01 |
美商轉譯生技公司 |
非對稱的基於哌嗪之陽離子脂質
|
|
JP2025510288A
(ja)
|
2022-03-28 |
2025-04-14 |
エフ. ホフマン-ラ ロシュ アーゲー |
異性体的に純粋なポリオール系ホスホロアミダイトの合成
|
|
CN121318878A
(zh)
|
2022-04-13 |
2026-01-13 |
赛诺菲 |
基于“古德”缓冲液的阳离子脂质
|
|
WO2023214082A2
(en)
|
2022-05-06 |
2023-11-09 |
Sanofi |
Signal sequences for nucleic acid vaccines
|
|
EP4539858A1
(en)
|
2022-06-17 |
2025-04-23 |
Sanofi Pasteur Inc. |
Compositions and methods for circular rna affinity purification
|
|
CN119487130A
(zh)
|
2022-06-28 |
2025-02-18 |
豪夫迈·罗氏有限公司 |
具有大斯托克斯位移的荧光染料
|
|
TW202424185A
(zh)
|
2022-07-29 |
2024-06-16 |
法商賽諾菲公司 |
無乙醇之mRNA純化方法
|
|
EP4577236A1
(en)
|
2022-08-22 |
2025-07-02 |
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. |
Vaccines against coronaviruses
|
|
JP2025532127A
(ja)
|
2022-09-23 |
2025-09-29 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Mecp2発現を低減する化合物及び方法
|
|
EP4360657A1
(en)
|
2022-10-28 |
2024-05-01 |
Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal |
Mir-326 for the treatment of cancer
|
|
CN120112645A
(zh)
|
2022-11-04 |
2025-06-06 |
赛诺菲巴斯德有限公司 |
用于信使rna加尾的方法
|
|
WO2024094881A1
(en)
|
2022-11-04 |
2024-05-10 |
Sanofi |
Respiratory syncytial virus rna vaccination
|
|
WO2024099575A1
(en)
|
2022-11-11 |
2024-05-16 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for site-directed editing of a target rna
|
|
EP4622630A1
(en)
|
2022-11-21 |
2025-10-01 |
Translate Bio, Inc. |
Compositions of dry powder formulations of messenger rna and methods of use thereof
|
|
CN120659802A
(zh)
|
2022-12-15 |
2025-09-16 |
赛诺菲巴斯德有限公司 |
mRNA重组加帽酶
|
|
CN120641393A
(zh)
|
2022-12-22 |
2025-09-12 |
赛诺菲巴斯德有限公司 |
双酯和酰胺阳离子脂质
|
|
CN120418451A
(zh)
|
2023-01-06 |
2025-08-01 |
Dna斯克瑞普特公司 |
用于获得正确组装核酸的方法
|
|
GB202300915D0
(en)
|
2023-01-20 |
2023-03-08 |
Sisaf Ltd |
mRNA COMPOSITIONS
|
|
AR132053A1
(es)
|
2023-03-02 |
2025-05-21 |
Sanofi Pasteur |
Composiciones para su uso en el tratamiento de clamidia
|
|
EP4666070A2
(en)
|
2023-03-31 |
2025-12-24 |
The Regents of University of California |
Induced pluripotent stem cell model of fibrous dysplasia/mccune-albright syndrome and methods of use
|
|
CN120957707A
(zh)
|
2023-04-17 |
2025-11-14 |
赛诺菲巴斯德有限公司 |
可复溶干粉配制品及其使用方法
|
|
WO2024228121A1
(en)
|
2023-05-02 |
2024-11-07 |
The University Of Tokyo |
Long interspersed nuclear element r2 for target-specific gene delivery
|
|
US12502424B2
(en)
|
2023-05-05 |
2025-12-23 |
Sanofi Pasteur Inc. |
Compositions for use in treatment of acne
|
|
US20250009865A1
(en)
|
2023-05-10 |
2025-01-09 |
Sanofi |
Combination respiratory mrna vaccines
|
|
CN121464146A
(zh)
|
2023-06-12 |
2026-02-03 |
赛诺菲 |
具有芳香族头基团的基于固醇的阳离子脂质
|
|
WO2024256457A1
(en)
|
2023-06-12 |
2024-12-19 |
Sanofi |
Tricine and citric acid-based cationic lipids with aromatic head groups
|
|
MX2025015001A
(es)
|
2023-06-12 |
2026-02-03 |
Sanofi Sa |
Lipidos cationicos basados en tricina y acido citrico
|
|
CN121712487A
(zh)
|
2023-06-28 |
2026-03-20 |
赛诺菲巴斯德有限公司 |
脂质纳米颗粒配制品中的固醇类似物
|
|
AU2024306474A1
(en)
|
2023-06-28 |
2026-02-12 |
Sanofi Pasteur Inc. |
Helper lipids for nucleic acid delivery
|
|
AR133127A1
(es)
|
2023-06-28 |
2025-08-27 |
Sanofi Sa |
Lípidos ionizables a base de dianhidrohexitol para el suministro de ácidos nucleicos
|
|
IL325951A
(en)
|
2023-07-19 |
2026-03-01 |
Sanofi Sa |
Antigenic structures of PORPHYROMONAS GINGIVALIS
|
|
US20250090650A1
(en)
|
2023-09-06 |
2025-03-20 |
Sanofi |
Modified influenza b hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2025061967A1
(en)
|
2023-09-20 |
2025-03-27 |
Sanofi |
"good" buffer-based cationic lipids for nucleic acid delivery
|
|
WO2025085519A1
(en)
|
2023-10-16 |
2025-04-24 |
Typewriter Therapeutics, Inc. |
R2 retrotransposons for gene writing
|
|
AU2024363859A1
(en)
|
2023-10-18 |
2026-04-09 |
Amgen Inc. |
Evaluation of mrna transcript levels using ddpcr for early pool and single-cell clone assessment in cell line development
|
|
EP4553174A1
(en)
|
2023-11-08 |
2025-05-14 |
Consejo Superior De Investigaciones Científicas |
Methods to determine the thymic function by droplet digital pcr system
|
|
WO2025134071A1
(en)
|
2023-12-22 |
2025-06-26 |
Sanofi |
Malic and glutaric acid based ionizable lipids
|
|
WO2025141521A1
(en)
|
2023-12-29 |
2025-07-03 |
Sanofi |
Lipids having dendritic moieties
|
|
WO2025163146A1
(en)
|
2024-01-31 |
2025-08-07 |
Sanofi |
Methods for ethanol-free mrna purification
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025210592A1
(en)
|
2024-04-05 |
2025-10-09 |
Sanofi Pasteur Inc. |
Muscle cell lnp-mrna quality control assays
|
|
WO2025217194A1
(en)
|
2024-04-09 |
2025-10-16 |
Typewriter Therapeutics, Inc. |
Repeat dosing of retrotransposons
|
|
WO2025250906A1
(en)
|
2024-05-30 |
2025-12-04 |
Aera Therapeutics, Inc. |
Process for preparation of targeted lipid nanoparticles
|
|
WO2026006524A2
(en)
|
2024-06-26 |
2026-01-02 |
Sanofi Pasteur Inc. |
Bis-ester and amide cationic lipids
|
|
WO2026003373A1
(en)
|
2024-06-28 |
2026-01-02 |
Sanofi |
Phenolic acid lipid based cationic lipids
|
|
WO2026008743A1
(en)
|
2024-07-02 |
2026-01-08 |
Sanofi Pasteur Inc. |
Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid
|
|
WO2026027730A1
(en)
|
2024-07-31 |
2026-02-05 |
Sanofi |
Modified h5 influenza hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2026033123A1
(en)
|
2024-08-08 |
2026-02-12 |
Sanofi Pasteur Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
WO2026053147A1
(en)
|
2024-09-05 |
2026-03-12 |
Sanofi Pasteur Inc. |
Helper lipids and lnp compositions comprising same
|
|
WO2026052773A1
(en)
|
2024-09-06 |
2026-03-12 |
Sanofi |
Modified influenza a hemagglutinin polypeptides and nucleic acids and uses thereof
|
|
WO2026052826A1
(en)
|
2024-09-09 |
2026-03-12 |
Roche Diagnostics Gmbh |
Methods for producing fluorescent dyes
|