ATE171947T1 - Verbessertes verfahren zur synthese von oligomeren - Google Patents

Verbessertes verfahren zur synthese von oligomeren

Info

Publication number
ATE171947T1
ATE171947T1 AT91919675T AT91919675T ATE171947T1 AT E171947 T1 ATE171947 T1 AT E171947T1 AT 91919675 T AT91919675 T AT 91919675T AT 91919675 T AT91919675 T AT 91919675T AT E171947 T1 ATE171947 T1 AT E171947T1
Authority
AT
Austria
Prior art keywords
oligomers
synthesis
improved method
methods
result
Prior art date
Application number
AT91919675T
Other languages
English (en)
Inventor
Robert E Klem
William B Marvin
Timothy A Riley
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Application granted granted Critical
Publication of ATE171947T1 publication Critical patent/ATE171947T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91919675T 1990-10-26 1991-10-21 Verbessertes verfahren zur synthese von oligomeren ATE171947T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60579090A 1990-10-26 1990-10-26

Publications (1)

Publication Number Publication Date
ATE171947T1 true ATE171947T1 (de) 1998-10-15

Family

ID=24425218

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91919675T ATE171947T1 (de) 1990-10-26 1991-10-21 Verbessertes verfahren zur synthese von oligomeren

Country Status (14)

Country Link
US (1) US5726300A (de)
EP (1) EP0592434B1 (de)
JP (1) JPH06509542A (de)
AT (1) ATE171947T1 (de)
AU (1) AU669103B2 (de)
CA (1) CA2094803A1 (de)
DE (1) DE69130331T2 (de)
DK (1) DK0592434T3 (de)
ES (1) ES2124231T3 (de)
IE (1) IE913761A1 (de)
IL (1) IL99844A (de)
NZ (1) NZ240325A (de)
TW (1) TW216423B (de)
WO (1) WO1992007864A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012135A1 (en) 1991-12-12 1993-06-24 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
CA2166889C (en) * 1993-07-19 2001-09-11 Todd C. Peterson Oligonucleotides with activity against human immunodeficiency virus
WO1995003427A2 (en) * 1993-07-19 1995-02-02 Gen-Probe Incorporated Oligonucleotide screening assay
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
ATE194391T1 (de) * 1995-01-19 2000-07-15 Gen Probe Inc Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
PL2757091T3 (pl) 2008-04-01 2017-10-31 Biosearch Tech Inc Stabilizowane ciemne wygaszające sondy fluoroforowe kwasu nukleinowego
US10913767B2 (en) * 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
CN104736551B (zh) * 2012-08-15 2017-07-28 Ionis制药公司 使用改进的封端方案制备寡聚化合物的方法
KR102360517B1 (ko) 2014-05-09 2022-02-09 바이오서치 테크날로지즈, 인크. 코스믹 소광제
US10618926B2 (en) 2015-04-02 2020-04-14 Merck Sharp & Dohme Process for making phosphoramidate protected nucleoside compounds
NZ737214A (en) 2015-04-15 2024-07-26 Biosearch Tech Inc Dual quencher probes
WO2018209068A1 (en) 2017-05-11 2018-11-15 Gen-Probe Incorporated Compositions and methods for isolating target nucleic acids
CN114728263A (zh) 2019-11-14 2022-07-08 简·探针公司 用于捕获靶核酸的组合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides

Also Published As

Publication number Publication date
NZ240325A (en) 1993-06-25
AU8875391A (en) 1992-05-26
IL99844A (en) 1995-07-31
AU669103B2 (en) 1996-05-30
DK0592434T3 (da) 1999-06-21
EP0592434A1 (de) 1994-04-20
EP0592434B1 (de) 1998-10-07
TW216423B (de) 1993-11-21
ES2124231T3 (es) 1999-02-01
DE69130331D1 (de) 1998-11-12
WO1992007864A1 (en) 1992-05-14
DE69130331T2 (de) 1999-03-04
CA2094803A1 (en) 1992-04-27
IE913761A1 (en) 1992-05-22
EP0592434A4 (en) 1996-04-24
US5726300A (en) 1998-03-10
JPH06509542A (ja) 1994-10-27

Similar Documents

Publication Publication Date Title
ATE171947T1 (de) Verbessertes verfahren zur synthese von oligomeren
ATA100687A (de) Verfahren zur herstellung von eisen
DE3578979D1 (de) Verfahren zur synthese von jodbenzol.
ATE266671T1 (de) Nukleinsäuresynthese unter verwendung von mittels licht abspaltbaren schutzgruppen
DE3784151D1 (de) Verfahren zur herstellung von alkylhalosilanen.
DE3878463D1 (de) Verfahren zur 9-alpha-dehalogenierung von 9-alpha-steroiden.
DE69403210D1 (de) Verfahren zur herstellung von n-acetylneuraminsäure
DE3674329D1 (de) Verfahren zur synthese von bornitrid des kubischen systems.
DE3776464D1 (de) Verfahren zur herstellung von maleimiden.
DE3780883D1 (de) Verfahren zur reinigung von tpa aus rohen praeparaten.
DE68914645D1 (de) Verfahren zur mikrobiologischen reinigung von wasser.
ATE174601T1 (de) Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
NZ307444A (en) Polyphenol oxidase genes from lettuce and banana
ATE321773T1 (de) Semisynthetisches verfahren zur herstellung von didemninanalogen
ATE278702T1 (de) Verfahren zur synthese von phosphorothioat- oligonukelotiden
DE69011719D1 (de) Verfahren zur Synthese von Acylamino-organosilicium-Verbindungen.
DE3767216D1 (de) Verfahren zur synthese von mono- oder dihydroxyfluoralkanen.
DE3776251D1 (de) Verfahren zur erzielung von hybridpflanzen von graminaceen.
EP0196223A3 (en) Dedicated ribosomes and their use in producing protein in cell culture
ATA279785A (de) Verfahren zur synthese von pyrido-imidazo-rifamycinen
ATE353368T1 (de) Verfahren zur herstellung verzweigtkettiger fettsäuren mittels genetisch modifizierter pflanzen
DE3767745D1 (de) Verfahren zur ph-pufferung.
DE3774222D1 (de) Verfahren zur herstellung von styroliertem hydrochinon.
DE3875602D1 (de) Verfahren zur hydratation von olefinen.
DE59206765D1 (de) Verfahren zur enzymatischen Synthese von 2-Desoxy-beta-D-galactosiden

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee