DE69130331D1 - Verbessertes verfahren zur synthese von oligomeren - Google Patents

Verbessertes verfahren zur synthese von oligomeren

Info

Publication number
DE69130331D1
DE69130331D1 DE69130331T DE69130331T DE69130331D1 DE 69130331 D1 DE69130331 D1 DE 69130331D1 DE 69130331 T DE69130331 T DE 69130331T DE 69130331 T DE69130331 T DE 69130331T DE 69130331 D1 DE69130331 D1 DE 69130331D1
Authority
DE
Germany
Prior art keywords
oligomers
synthesis
improved method
methods
result
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69130331T
Other languages
English (en)
Other versions
DE69130331T2 (de
Inventor
Robert Klem
William Marvin
Timothy Riley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genta Inc
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Application granted granted Critical
Publication of DE69130331D1 publication Critical patent/DE69130331D1/de
Publication of DE69130331T2 publication Critical patent/DE69130331T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
DE69130331T 1990-10-26 1991-10-21 Verbessertes verfahren zur synthese von oligomeren Expired - Fee Related DE69130331T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60579090A 1990-10-26 1990-10-26
PCT/US1991/007630 WO1992007864A1 (en) 1990-10-26 1991-10-21 Improved process for the synthesis of oligomers

Publications (2)

Publication Number Publication Date
DE69130331D1 true DE69130331D1 (de) 1998-11-12
DE69130331T2 DE69130331T2 (de) 1999-03-04

Family

ID=24425218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130331T Expired - Fee Related DE69130331T2 (de) 1990-10-26 1991-10-21 Verbessertes verfahren zur synthese von oligomeren

Country Status (14)

Country Link
US (1) US5726300A (de)
EP (1) EP0592434B1 (de)
JP (1) JPH06509542A (de)
AT (1) ATE171947T1 (de)
AU (1) AU669103B2 (de)
CA (1) CA2094803A1 (de)
DE (1) DE69130331T2 (de)
DK (1) DK0592434T3 (de)
ES (1) ES2124231T3 (de)
IE (1) IE913761A1 (de)
IL (1) IL99844A (de)
NZ (1) NZ240325A (de)
TW (1) TW216423B (de)
WO (1) WO1992007864A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0616612A4 (de) 1991-12-12 1995-01-11 Gilead Sciences Inc Nukleasestabile und bindungsfähige oligomere und verfahren zu ihrer verwendung.
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
AU688364B2 (en) * 1993-07-19 1998-03-12 Gen-Probe Incorporated Oligonucleotides with activity against human immunodeficiency virus
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
ES2150103T3 (es) * 1995-01-19 2000-11-16 Gen Probe Inc Oligonucleotidos de amplificacion de acido nucleico y sondas para borrelia asociados con la enfermedad de lyme.
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5747252A (en) 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
LT2757091T (lt) 2008-04-01 2017-09-11 Biosearch Technologies, Inc. Stabilizuotos nukleorūgšties tamsūs kvenčerio-fluoroforo zondai
WO2011133876A2 (en) * 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
KR102237882B1 (ko) 2012-08-15 2021-04-07 아이오니스 파마수티컬즈, 인코포레이티드 변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
US10301310B2 (en) 2014-05-09 2019-05-28 Biosearch Technologies, Inc. Cosmic quenchers
US10618926B2 (en) 2015-04-02 2020-04-14 Merck Sharp & Dohme Process for making phosphoramidate protected nucleoside compounds
PT3283499T (pt) 2015-04-15 2022-08-23 Biosearch Tech Inc Sondas de extintor dual
US20200165599A1 (en) 2017-05-11 2020-05-28 Gen-Probe Incorporated Compositions and Methods for Isolating Target Nucleic Acids
EP4058187A1 (de) 2019-11-14 2022-09-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum einfangen von zielnukleinsäuren

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides

Also Published As

Publication number Publication date
EP0592434B1 (de) 1998-10-07
EP0592434A1 (de) 1994-04-20
IL99844A (en) 1995-07-31
IE913761A1 (en) 1992-05-22
US5726300A (en) 1998-03-10
ES2124231T3 (es) 1999-02-01
NZ240325A (en) 1993-06-25
CA2094803A1 (en) 1992-04-27
DE69130331T2 (de) 1999-03-04
EP0592434A4 (en) 1996-04-24
TW216423B (de) 1993-11-21
DK0592434T3 (da) 1999-06-21
AU8875391A (en) 1992-05-26
WO1992007864A1 (en) 1992-05-14
ATE171947T1 (de) 1998-10-15
AU669103B2 (en) 1996-05-30
JPH06509542A (ja) 1994-10-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee