LT2757091T - Stabilizuotos nukleorūgšties tamsūs kvenčerio-fluoroforo zondai - Google Patents

Stabilizuotos nukleorūgšties tamsūs kvenčerio-fluoroforo zondai

Info

Publication number
LT2757091T
LT2757091T LTEP14152335.7T LT14152335T LT2757091T LT 2757091 T LT2757091 T LT 2757091T LT 14152335 T LT14152335 T LT 14152335T LT 2757091 T LT2757091 T LT 2757091T
Authority
LT
Lithuania
Prior art keywords
nucleic acid
dark quencher
stabilized nucleic
fluorophore probes
acid dark
Prior art date
Application number
LTEP14152335.7T
Other languages
English (en)
Inventor
Ronald M. Cook
Matt Lyttle
Original Assignee
Biosearch Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch Technologies, Inc. filed Critical Biosearch Technologies, Inc.
Publication of LT2757091T publication Critical patent/LT2757091T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B31/00—Disazo and polyazo dyes of the type A->B->C, A->B->C->D, or the like, prepared by diazotising and coupling
    • C09B31/02—Disazo dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
LTEP14152335.7T 2008-04-01 2009-04-01 Stabilizuotos nukleorūgšties tamsūs kvenčerio-fluoroforo zondai LT2757091T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4151508P 2008-04-01 2008-04-01

Publications (1)

Publication Number Publication Date
LT2757091T true LT2757091T (lt) 2017-09-11

Family

ID=41136104

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14152335.7T LT2757091T (lt) 2008-04-01 2009-04-01 Stabilizuotos nukleorūgšties tamsūs kvenčerio-fluoroforo zondai

Country Status (15)

Country Link
US (3) US8466266B2 (lt)
EP (2) EP2757091B1 (lt)
JP (1) JP5669721B2 (lt)
CN (1) CN102037144B (lt)
CA (1) CA2720511A1 (lt)
CY (1) CY1119237T1 (lt)
DK (1) DK2757091T3 (lt)
ES (1) ES2633786T3 (lt)
HR (1) HRP20171087T1 (lt)
LT (1) LT2757091T (lt)
MX (1) MX2010010881A (lt)
PL (1) PL2757091T3 (lt)
PT (1) PT2757091T (lt)
SI (1) SI2757091T1 (lt)
WO (1) WO2009124150A2 (lt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
PL2757091T3 (pl) * 2008-04-01 2017-10-31 Biosearch Tech Inc Stabilizowane ciemne wygaszające sondy fluoroforowe kwasu nukleinowego
EP2553123B1 (en) 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Methods for enhancing nucleic acid hybridization
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2012033848A1 (en) 2010-09-07 2012-03-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
SG11201508185YA (en) 2013-04-19 2015-11-27 Agency Science Tech & Res Tunable fluorescence using cleavable linkers
US9556475B2 (en) 2013-08-12 2017-01-31 Bio-Rad Laboratories, Inc. Amplification reporter with base-pairing oligomers
MY180166A (en) 2014-05-09 2020-11-24 Biosearch Tech Inc Cosmic quenchers
ES2924731T3 (es) * 2015-04-15 2022-10-10 Biosearch Tech Inc Sondas con extintor doble
WO2017048982A1 (en) * 2015-09-15 2017-03-23 Biosearch Technologies, Inc. Oligophosphate dark quenchers and uses
US10337051B2 (en) 2016-06-16 2019-07-02 The Regents Of The University Of California Methods and compositions for detecting a target RNA
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna
WO2018181428A1 (ja) 2017-03-29 2018-10-04 塩野義製薬株式会社 核酸医薬及び多分岐脂質の複合体
US11753681B2 (en) * 2017-11-03 2023-09-12 University Of Washington Digital nucleic acid amplification using encoded particles
KR102237237B1 (ko) * 2017-11-28 2021-04-07 에스에프씨 주식회사 소광자 및 이의 용도
EP3830301B1 (en) 2018-08-01 2024-05-22 Mammoth Biosciences, Inc. Programmable nuclease compositions and methods of use thereof
EP3931313A2 (en) 2019-01-04 2022-01-05 Mammoth Biosciences, Inc. Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
MX2021010559A (es) 2019-03-07 2021-12-15 Univ California Polipéptidos efectores de crispr-cas y métodos de uso de estos.
AU2021227185A1 (en) * 2020-02-24 2022-08-18 Integrated Dna Technologies, Inc. Oligonucleotide synthesis on solid support
WO2021240443A1 (en) 2020-05-27 2021-12-02 King Abdullah University Of Science And Technology Iscan: an rt-lamp-coupled crispr-cas module for rapid, sensitive detection of sars-cov-2
CN111647073B (zh) * 2020-07-03 2022-10-18 广东工业大学 一种荧光探针及其制备方法
CN112500714B (zh) * 2020-09-25 2021-10-22 四川大学 基于磷原子取代罗丹明衍生物骨架的染色试剂及其制备方法和应用
WO2023023673A2 (en) 2021-08-20 2023-02-23 Kasa Bio, L.L.C. Compositions and methods for multiplex detection of mirna and other polynucelotides
CN114295594B (zh) * 2021-12-06 2023-09-19 贵州理工学院 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器
US11834714B2 (en) 2021-12-20 2023-12-05 Enumerix, Inc. Detection and digital quantitation of multiple targets

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6003A (en) * 1849-01-09 Method of bending shelf from which iron tubes abe made
US2653109A (en) 1942-08-21 1953-09-22 Joseph L Switzer Light-responsive fluorescent media
US2554443A (en) 1947-11-13 1951-05-22 Gen Aniline & Film Corp Azo safranine leather dyestuffs
US2830943A (en) 1955-11-03 1958-04-15 Gen Electric Method for controlling the irradiation of polyethylene
US2945849A (en) 1957-03-04 1960-07-19 Bayer Ag Disazo compounds containing a quaternary ammonium group
US3121711A (en) 1960-05-27 1964-02-18 Du Pont Phenylphenazinium cationic dyes
US3369013A (en) 1965-07-12 1968-02-13 Eastman Kodak Co Disazo dyes
US3445452A (en) 1965-12-10 1969-05-20 Eastman Kodak Co Azobenzene-azo-aniline dyestuffs containing a pyrrolidinono,a piperidono or a phthalimidono group
FR1544951A (fr) 1966-11-21 1968-11-08 Inst Przemyslu Organiczego Procédé de préparation des colorants disazoïques
US3523936A (en) 1967-01-31 1970-08-11 Du Pont 2 - sulfonamido - 4 - (n,n - disubstituted amino)benzeneazo - 1,4 - naphthalene-or 1,4-benzene-azobenzene dyes
DE1930261C3 (de) 1969-06-13 1979-05-03 Bayer Ag, 5090 Leverkusen Disazofarbstoffe und ihre Verwendung zum Färben stickstoffhaltiger Fasermaterialien
DE2443119A1 (de) 1973-09-10 1975-03-13 Research Corp Selektive entfernung von albumin aus blutfluessigkeiten sowie substanzen zur durchfuehrung des verfahrens
US4069012A (en) 1974-03-26 1978-01-17 Cassella Farbwerke Mainkur Aktiengesellschaft Dyeing of polyester fabric with disazo dye
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4313872A (en) 1976-02-02 1982-02-02 Cassella Aktiengesellschaft Azo coupling in two-phase water-alcohol mixtures
DE2834054A1 (de) 1978-08-03 1980-02-21 Cassella Ag Wasserunloesliche disazofarbstoffe, ihre herstellung und verwendung
DE2840199A1 (de) 1978-09-15 1980-03-27 Cassella Ag Verfahren zum faerben und bedrucken von hochmolekularen polyestern und zellulosetriacetat
JPS5599967A (en) 1979-01-26 1980-07-30 Mitsubishi Chem Ind Ltd Disazo dye for cellulose-containing fibers
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4588517A (en) 1982-06-30 1986-05-13 Hitachi, Ltd. Liquid crystal composition
GB8314918D0 (en) 1983-05-31 1983-07-06 Vickers Plc Radiation sensitive compositions
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4623716A (en) 1984-11-01 1986-11-18 Usv Pharmaceutical Corp. Process for the preparation and purification of peptides
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4739044A (en) 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EG18377A (en) 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8629892D0 (en) 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US4888385A (en) 1987-04-30 1989-12-19 Millipore Corporation BOP reagent for solid phase peptide synthesis
US4965349A (en) 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
DE3803275A1 (de) 1988-02-04 1989-08-17 Dornier Medizintechnik Piezoelektrische stosswellenquelle
US4997928A (en) 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2006008C (en) 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
WO1990014353A1 (en) 1989-05-18 1990-11-29 Microprobe Corporation Crosslinking oligonucleotides
US5401847A (en) 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
CA2094803A1 (en) 1990-10-26 1992-04-27 Robert E. Klem Process for the synthesis of oligomers
US5384411A (en) 1991-06-20 1995-01-24 Hewlett-Packard Company Immobilization of PH-sensitive dyes to solid supports
JPH05142600A (ja) 1991-11-18 1993-06-11 Nippon Telegr & Teleph Corp <Ntt> 低屈折率光非線形高分子材料
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
US5348853A (en) 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
EP0601889A2 (en) 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
US5536820A (en) 1993-02-26 1996-07-16 E. I. Du Pont De Nemours And Company Avidin-binding azo reagents
JPH06258676A (ja) 1993-03-03 1994-09-16 Nippon Telegr & Teleph Corp <Ntt> ２次非線形光学材料
WO1995002848A1 (en) 1993-07-12 1995-01-26 Minnesota Mining And Manufacturing Company Multifunctional azo compounds and polymers derived therefrom for nonlinear optics
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US6291203B1 (en) 1995-11-13 2001-09-18 Molecular Probes, Inc. Cyanine dyes that stain cells and mitochondria
GB9523575D0 (en) 1995-11-17 1996-01-17 Zeneca Ltd Organic chemical compounds and processes
US5736626A (en) 1996-01-29 1998-04-07 The Perkin-Elmer Corporation Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
AU2735797A (en) 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
JP3898228B2 (ja) 1996-04-12 2007-03-28 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 検出プローブ、キット及びアッセイ
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US5874587A (en) 1996-06-25 1999-02-23 The Rockefeller University Imidazolium cations, processes for their preparation, and uses therefor
US6060242A (en) 1997-02-27 2000-05-09 Lorne Park Research, Inc. PNA diagnostic methods
US5942910A (en) 1997-08-28 1999-08-24 Texas Instruments Incorporated Method and circuit for providing accurate voltage sensing for a power transistor, or the like
AU743011B2 (en) 1997-09-12 2002-01-17 Phri Properties, Inc. Non-competitive co-amplification methods
US5935791A (en) 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6117986A (en) 1998-06-10 2000-09-12 Intergen Company, L.P. Pyrimidines linked to a quencher
KR100337169B1 (ko) 1998-07-20 2002-05-18 최중갑 복합염료 조성물을 이용한 폴리머 겔상의 ｄｎａ의 검출방법 및
US6037130A (en) 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6288221B1 (en) 1998-08-20 2001-09-11 Duke University Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
US6232075B1 (en) * 1998-12-14 2001-05-15 Li-Cor, Inc. Heterogeneous assay for pyrophosphate detection
IT1307864B1 (it) 1999-04-20 2001-11-19 Istituto Naz Per La Ricerca Su Metodo diagnostico per il riconoscimento di neoplasie umane attraversola determinazione dell'isoforma ctn-c della tn-c, frammenti di
US7160996B1 (en) * 1999-06-09 2007-01-09 Bioresearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
US20070059752A1 (en) 1999-06-09 2007-03-15 Biosearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
US6046049A (en) 1999-07-19 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of PI3 kinase p110 delta expression
ATE336591T1 (de) 1999-10-22 2006-09-15 New York Health Res Inst Nachweisverfahren für kurze sequenzvarianten
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US20040081959A9 (en) 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US7309573B2 (en) 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US20030082547A1 (en) * 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
AU2003213557A1 (en) 2002-02-27 2003-09-09 Biosource International Inc. Methods of using FET labeled oligonucleotides that include a 3' - 5' exonuclease resistant quencher domain and compositions for practicing the same
US6818420B2 (en) * 2002-02-27 2004-11-16 Biosource International, Inc. Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US7504495B2 (en) * 2003-11-20 2009-03-17 Exiqon A/S Quencher compositions comprising anthraquinone moieties
US7344701B2 (en) 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
US7705150B2 (en) 2004-02-04 2010-04-27 Biosearch Technologies, Inc. Cyanine dyes
WO2006002167A2 (en) * 2004-06-17 2006-01-05 University Of Florida Research Foudation, Inc. Multi-acceptor molecular probes and applications thereof
EP1816130A4 (en) * 2004-11-08 2012-04-25 Riken NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVE AND USE THEREOF
US20060178507A1 (en) 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
EP1844161A4 (en) * 2005-02-04 2010-10-27 Berry & Associates Inc DARK QUENCHERS, PROBES AND OTHER CONJUGATES WITH THEM AND THEIR USE
JP4344330B2 (ja) 2005-02-14 2009-10-14 富士通株式会社 ヌクレオチドオリゴマー、ヌクレオチドポリマー、機能性物質の構造決定方法および機能性物質の製造方法
CA2601554A1 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
PL2757091T3 (pl) 2008-04-01 2017-10-31 Biosearch Tech Inc Stabilizowane ciemne wygaszające sondy fluoroforowe kwasu nukleinowego
US9109321B2 (en) 2011-03-24 2015-08-18 General Electric Company Device and method for rinsing objects in an appliance
DE102012100056B3 (de) 2012-01-04 2013-04-18 Fujitsu Technology Solutions Intellectual Property Gmbh Gehäuse für ein Computersystem sowie Computersystem mit einem derartigen Gehäuse

Also Published As

Publication number Publication date
MX2010010881A (es) 2011-03-04
EP2268608A2 (en) 2011-01-05
PT2757091T (pt) 2017-07-24
CN102037144A (zh) 2011-04-27
US8674094B2 (en) 2014-03-18
EP2757091A1 (en) 2014-07-23
HRP20171087T1 (hr) 2017-10-06
CA2720511A1 (en) 2009-10-08
CN102037144B (zh) 2013-09-25
WO2009124150A2 (en) 2009-10-08
SI2757091T1 (en) 2018-01-31
US9803240B2 (en) 2017-10-31
CY1119237T1 (el) 2018-02-14
PL2757091T3 (pl) 2017-10-31
US8466266B2 (en) 2013-06-18
ES2633786T3 (es) 2017-09-25
WO2009124150A3 (en) 2009-12-30
JP5669721B2 (ja) 2015-02-12
DK2757091T3 (en) 2017-08-14
US20110282041A1 (en) 2011-11-17
EP2268608A4 (en) 2012-01-11
JP2011519356A (ja) 2011-07-07
US20140194611A1 (en) 2014-07-10
EP2757091B1 (en) 2017-06-28
US20090259030A1 (en) 2009-10-15

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