ATE46512T1 - Verfahren zur synthese von pyridoimidazorifamycin. - Google Patents
Verfahren zur synthese von pyridoimidazorifamycin.Info
- Publication number
- ATE46512T1 ATE46512T1 AT85104790T AT85104790T ATE46512T1 AT E46512 T1 ATE46512 T1 AT E46512T1 AT 85104790 T AT85104790 T AT 85104790T AT 85104790 T AT85104790 T AT 85104790T AT E46512 T1 ATE46512 T1 AT E46512T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridoimidazorifamycin
- synthesis
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03463/84A IT1199374B (it) | 1984-05-15 | 1984-05-15 | Processo per la preparazione di pirido-imidazo-rifamicine |
EP85104790A EP0161534B1 (de) | 1984-05-15 | 1985-04-19 | Verfahren zur Synthese von Pyridoimidazorifamycin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE46512T1 true ATE46512T1 (de) | 1989-10-15 |
Family
ID=11107845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85104790T ATE46512T1 (de) | 1984-05-15 | 1985-04-19 | Verfahren zur synthese von pyridoimidazorifamycin. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4557866A (de) |
EP (1) | EP0161534B1 (de) |
JP (1) | JPS60252483A (de) |
AR (1) | AR241913A1 (de) |
AT (1) | ATE46512T1 (de) |
AU (1) | AU568934B2 (de) |
CA (1) | CA1215708A (de) |
DE (1) | DE3573120D1 (de) |
DK (1) | DK162647C (de) |
ES (1) | ES8603489A1 (de) |
FI (1) | FI81101C (de) |
GR (1) | GR851144B (de) |
IE (1) | IE58392B1 (de) |
IT (1) | IT1199374B (de) |
NO (1) | NO164242C (de) |
PH (1) | PH22007A (de) |
PT (1) | PT80446B (de) |
ZA (1) | ZA852971B (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
AU2002364162A1 (en) * | 2001-12-13 | 2003-06-30 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
ITMI20032144A1 (it) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US7923553B2 (en) | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
ES2522895T3 (es) * | 2005-03-03 | 2014-11-19 | Alfa Wassermann S.P.A. | Nuevas formas polimorfas de rifaximina, procedimientos para su producción y uso de las mismas en preparados medicinales |
ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
MX2008011305A (es) | 2006-03-09 | 2009-02-10 | Salix Pharmaceuticals Inc | Preparacion anti-disfunsion rectal con rifaximina. |
WO2008016708A2 (en) | 2006-08-02 | 2008-02-07 | Salix Pharmaceuticals, Inc. | Methods for treatment of radiation enteritis |
ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
KR101667534B1 (ko) * | 2006-09-22 | 2016-10-19 | 씨아이피엘에이 엘티디. | 리팍시민 |
US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
US8486956B2 (en) | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
CN104650114A (zh) | 2008-02-25 | 2015-05-27 | 萨利克斯药品有限公司 | 利福昔明的多种形式及其用途 |
AU2009219240B2 (en) | 2008-02-26 | 2014-10-16 | Salix Pharmaceuticals, Ltd. | Methods for treating bowel diseases |
US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
DK2294012T3 (da) | 2008-05-07 | 2014-10-06 | Salix Pharmaceuticals Ltd | Administration af et tarmrensemiddel og et antibiotika til behandlingen af tarmsygdom |
CN101585843B (zh) * | 2008-05-21 | 2011-07-06 | 重庆赛诺生物药业股份有限公司 | 一种利福昔明的制备工艺 |
US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
BRPI0920465A2 (pt) | 2008-10-02 | 2018-03-20 | Salix Pharmaceuticals, Inc. | metodo de tratamento de encefalopatia hepática |
US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
WO2010067072A1 (en) | 2008-12-10 | 2010-06-17 | Cipla Limited | Rifaximin complexes |
IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
KR20120025578A (ko) | 2009-06-02 | 2012-03-15 | 샐릭스 파마슈티컬스 리미티드 | 간성 뇌병증의 치료방법 |
CN102596250A (zh) | 2009-09-13 | 2012-07-18 | 萨利克斯药品有限公司 | 治疗肠易激综合征(ibs)的方法 |
EP2503989A2 (de) | 2009-11-23 | 2012-10-03 | Cipla Limited | Topische schaumzusammensetzung |
US8952159B2 (en) | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
AU2011218129A1 (en) | 2010-02-18 | 2012-08-23 | Board Of Regents Of The University Of Texas System | Methods for treating infection |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
EP2582707A4 (de) * | 2010-06-16 | 2014-01-08 | Apotex Pharmachem Inc | Polymorphe formen von rifaximin |
CN103228662B (zh) | 2010-07-12 | 2016-08-10 | 萨利克斯药品有限公司 | 利福昔明的制剂及其用途 |
WO2012035544A2 (en) | 2010-09-13 | 2012-03-22 | Sequent Scientific Ltd. | A novel polymorphic form of rifaximin and process for its preparation |
US8735419B2 (en) | 2011-02-11 | 2014-05-27 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
AU2012251385A1 (en) | 2011-05-02 | 2013-11-21 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
EP2773205B1 (de) | 2011-11-02 | 2024-05-22 | Salix Pharmaceuticals, Inc. | Rifaximin zur behandlung von durchfall-reizdarmsyndrom |
CA2876737A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
US20160047819A1 (en) | 2013-03-15 | 2016-02-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
EP2968283A1 (de) | 2013-03-15 | 2016-01-20 | ALFA WASSERMANN S.p.A. | Rifaximin zur verwendung bei der behandlung von vaginalinfektionen |
PT2983647T (pt) | 2013-04-12 | 2020-11-09 | Alfasigma Spa | Administração de aine e composições, métodos e sistemas relacionados |
US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
ITMI20131307A1 (it) | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
CN103509038B (zh) * | 2013-09-30 | 2016-01-20 | 浙江思贤制药有限公司 | 一种新晶型利福昔明ζ及其制备方法 |
EP2927235B1 (de) | 2014-03-31 | 2017-02-08 | Euticals S.P.A. | Polymorphe Mischung von Rifaximin und ihre Verwendung zur Herstellung fester Formulierungen |
CA2947962C (en) | 2014-05-04 | 2024-01-16 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
WO2015173697A1 (en) | 2014-05-12 | 2015-11-19 | Alfa Wassermann S.P.A. | New solvated crystal form of rifaximin, production, compositions and uses thereof |
EP2982764A1 (de) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identifizierung von Vaginalbakterien |
US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
EP4137132A1 (de) | 2016-09-30 | 2023-02-22 | Salix Pharmaceuticals, Inc. | Feste dispersionsformen von rifaximin |
MX2019015681A (es) * | 2017-06-26 | 2020-02-26 | Biofer Spa | Derivados de pirido-imidazo rifamicina como agente antibacteriano. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1154655B (it) * | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
-
1984
- 1984-05-15 IT IT03463/84A patent/IT1199374B/it active
-
1985
- 1985-04-19 AT AT85104790T patent/ATE46512T1/de not_active IP Right Cessation
- 1985-04-19 EP EP85104790A patent/EP0161534B1/de not_active Expired
- 1985-04-19 DE DE8585104790T patent/DE3573120D1/de not_active Expired
- 1985-04-19 ZA ZA852971A patent/ZA852971B/xx unknown
- 1985-04-25 PH PH32186A patent/PH22007A/en unknown
- 1985-04-26 US US06/727,521 patent/US4557866A/en not_active Expired - Lifetime
- 1985-04-29 CA CA000480321A patent/CA1215708A/en not_active Expired
- 1985-05-13 PT PT80446A patent/PT80446B/pt unknown
- 1985-05-13 GR GR851144A patent/GR851144B/el unknown
- 1985-05-14 DK DK214685A patent/DK162647C/da not_active IP Right Cessation
- 1985-05-14 FI FI851907A patent/FI81101C/fi not_active IP Right Cessation
- 1985-05-14 ES ES543115A patent/ES8603489A1/es not_active Expired
- 1985-05-14 JP JP60102528A patent/JPS60252483A/ja active Granted
- 1985-05-14 IE IE119185A patent/IE58392B1/en not_active IP Right Cessation
- 1985-05-14 NO NO851921A patent/NO164242C/no not_active IP Right Cessation
- 1985-05-15 AR AR85300385A patent/AR241913A1/es active
- 1985-05-15 AU AU42515/85A patent/AU568934B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS60252483A (ja) | 1985-12-13 |
IE58392B1 (en) | 1993-09-08 |
AU568934B2 (en) | 1988-01-14 |
AU4251585A (en) | 1985-11-21 |
DK162647C (da) | 1992-04-13 |
NO164242C (no) | 1990-09-12 |
NO851921L (no) | 1985-11-18 |
FI81101C (fi) | 1990-09-10 |
PT80446B (pt) | 1987-11-11 |
US4557866A (en) | 1985-12-10 |
AR241913A1 (es) | 1993-01-29 |
NO164242B (no) | 1990-06-05 |
ES543115A0 (es) | 1986-01-01 |
JPH0469634B2 (de) | 1992-11-06 |
EP0161534A2 (de) | 1985-11-21 |
IT8403463A0 (it) | 1984-05-15 |
IE851191L (en) | 1985-11-15 |
ES8603489A1 (es) | 1986-01-01 |
FI851907A0 (fi) | 1985-05-14 |
DE3573120D1 (en) | 1989-10-26 |
PT80446A (en) | 1985-06-01 |
PH22007A (en) | 1988-05-02 |
EP0161534A3 (en) | 1987-03-04 |
DK162647B (da) | 1991-11-25 |
FI81101B (fi) | 1990-05-31 |
EP0161534B1 (de) | 1989-09-20 |
FI851907L (fi) | 1985-11-16 |
GR851144B (de) | 1985-11-25 |
CA1215708A (en) | 1986-12-23 |
DK214685D0 (da) | 1985-05-14 |
ZA852971B (en) | 1985-12-24 |
IT1199374B (it) | 1988-12-30 |
DK214685A (da) | 1985-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEFA | Change of the company name | ||
EELA | Cancelled due to lapse of time |