ATE46512T1 - Verfahren zur synthese von pyridoimidazorifamycin. - Google Patents
Verfahren zur synthese von pyridoimidazorifamycin.Info
- Publication number
- ATE46512T1 ATE46512T1 AT85104790T AT85104790T ATE46512T1 AT E46512 T1 ATE46512 T1 AT E46512T1 AT 85104790 T AT85104790 T AT 85104790T AT 85104790 T AT85104790 T AT 85104790T AT E46512 T1 ATE46512 T1 AT E46512T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridoimidazorifamycin
- synthesis
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03463/84A IT1199374B (it) | 1984-05-15 | 1984-05-15 | Processo per la preparazione di pirido-imidazo-rifamicine |
EP85104790A EP0161534B1 (de) | 1984-05-15 | 1985-04-19 | Verfahren zur Synthese von Pyridoimidazorifamycin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE46512T1 true ATE46512T1 (de) | 1989-10-15 |
Family
ID=11107845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85104790T ATE46512T1 (de) | 1984-05-15 | 1985-04-19 | Verfahren zur synthese von pyridoimidazorifamycin. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4557866A (de) |
EP (1) | EP0161534B1 (de) |
JP (1) | JPS60252483A (de) |
AR (1) | AR241913A1 (de) |
AT (1) | ATE46512T1 (de) |
AU (1) | AU568934B2 (de) |
CA (1) | CA1215708A (de) |
DE (1) | DE3573120D1 (de) |
DK (1) | DK162647C (de) |
ES (1) | ES8603489A1 (de) |
FI (1) | FI81101C (de) |
GR (1) | GR851144B (de) |
IE (1) | IE58392B1 (de) |
IT (1) | IT1199374B (de) |
NO (1) | NO164242C (de) |
PH (1) | PH22007A (de) |
PT (1) | PT80446B (de) |
ZA (1) | ZA852971B (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
AU2002364162A1 (en) * | 2001-12-13 | 2003-06-30 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
US7923553B2 (en) | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
ES2522895T3 (es) * | 2005-03-03 | 2014-11-19 | Alfa Wassermann S.P.A. | Nuevas formas polimorfas de rifaximina, procedimientos para su producción y uso de las mismas en preparados medicinales |
ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
ES2747259T3 (es) | 2006-03-09 | 2020-03-10 | Salix Pharmaceuticals Inc | Preparación anti-disfunción rectal de rifaximina |
AU2007281413B2 (en) | 2006-08-02 | 2013-10-31 | Christopher Jahraus | Compositions and methods for the treatment of radiation proctosigmoiditis |
ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
NZ575550A (en) * | 2006-09-22 | 2011-12-22 | Cipla Ltd | Rifaximin |
US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
US8486956B2 (en) | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
MY158257A (en) | 2008-02-25 | 2016-09-30 | Salix Pharmaceuticals Ltd | Forms of rifaximin and uses thereof |
DK2252148T3 (da) | 2008-02-26 | 2019-05-06 | Salix Pharmaceuticals Ltd | Fremgangsmåder til behandling af irritabel tarmsyndrom |
US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
WO2009137672A1 (en) | 2008-05-07 | 2009-11-12 | Salix Pharmaceuticals, Ltd. | Methods of treating bowel disease by administering a bowel cleanser and an antibiotic |
CN101585843B (zh) * | 2008-05-21 | 2011-07-06 | 重庆赛诺生物药业股份有限公司 | 一种利福昔明的制备工艺 |
PL2350096T3 (pl) | 2008-10-02 | 2020-06-29 | Salix Pharmaceuticals, Ltd. | Sposoby leczenia encefalopatii wątrobowej |
US7928115B2 (en) * | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
KR101906177B1 (ko) | 2008-12-10 | 2018-10-10 | 시플라 리미티드 | 리팍시민 복합체 |
IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
CN102548408A (zh) | 2009-06-02 | 2012-07-04 | 萨利克斯药品有限公司 | 治疗肝性脑病的方法 |
EP2475392A4 (de) | 2009-09-13 | 2013-01-09 | Salix Pharmaceuticals Ltd | Verfahren zur behandlung des reizdarmsyndroms |
JP2013511570A (ja) | 2009-11-23 | 2013-04-04 | シプラ・リミテッド | 局所用泡沫組成物 |
EP2401282B2 (de) | 2009-12-28 | 2017-01-04 | Silvio Massimo Lavagna | Verfahren zur herstellung von amorphem rifaximin |
WO2011103246A1 (en) | 2010-02-18 | 2011-08-25 | Salix Pharmaceuticals, Ltd. | Methods for treating infection |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
WO2011156897A2 (en) * | 2010-06-16 | 2011-12-22 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
SI2593463T1 (sl) | 2010-07-12 | 2020-10-30 | Salix Pharmaceuticals, Inc. | Formulacije rifaksimina in njihove uporabe |
WO2012035544A2 (en) | 2010-09-13 | 2012-03-22 | Sequent Scientific Ltd. | A novel polymorphic form of rifaximin and process for its preparation |
AU2012214239B2 (en) | 2011-02-11 | 2016-06-30 | Salix Pharmaceuticals, Ltd. | Forms of Rifaximin and uses thereof |
EP2705042A1 (de) | 2011-05-02 | 2014-03-12 | Ranbaxy Laboratories Limited | Rifaximin-dimethylformamid-solvat |
WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
US20130184302A1 (en) | 2011-11-02 | 2013-07-18 | Enoch Bortey | Methods for treating irritable bowel syndrome (ibs) and infections |
WO2013185211A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
US20160038468A1 (en) | 2013-03-15 | 2016-02-11 | Alfa Wassermann S.P.A. | Rifaximin for use in the treating of vaginal infections |
WO2014140995A2 (en) | 2013-03-15 | 2014-09-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
CN105324109A (zh) | 2013-04-12 | 2016-02-10 | 意大利阿尔法韦士曼制药公司 | Nsaid施用和相关的组合物、方法和系统 |
US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
ITMI20131307A1 (it) | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
CN103509038B (zh) * | 2013-09-30 | 2016-01-20 | 浙江思贤制药有限公司 | 一种新晶型利福昔明ζ及其制备方法 |
EP2927235B1 (de) | 2014-03-31 | 2017-02-08 | Euticals S.P.A. | Polymorphe Mischung von Rifaximin und ihre Verwendung zur Herstellung fester Formulierungen |
EP3140313B1 (de) | 2014-05-04 | 2020-02-26 | Salix Pharmaceuticals, Inc. | Ibs-mikrobiota und verwendungen davon |
ES2810010T3 (es) | 2014-05-12 | 2021-03-08 | Alfasigma Spa | Preparación y uso de la forma cristalina tau de rifaximina solvatada con DEGME |
EP2982764A1 (de) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identifizierung von Vaginalbakterien |
US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
EP4137132A1 (de) | 2016-09-30 | 2023-02-22 | Salix Pharmaceuticals, Inc. | Feste dispersionsformen von rifaximin |
EP3645539B1 (de) * | 2017-06-26 | 2021-04-07 | Biofer S.p.A. | Pyrido-imidazo-rifamycinderivate als antibakterielle mittel |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1154655B (it) * | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
-
1984
- 1984-05-15 IT IT03463/84A patent/IT1199374B/it active
-
1985
- 1985-04-19 DE DE8585104790T patent/DE3573120D1/de not_active Expired
- 1985-04-19 AT AT85104790T patent/ATE46512T1/de not_active IP Right Cessation
- 1985-04-19 EP EP85104790A patent/EP0161534B1/de not_active Expired
- 1985-04-19 ZA ZA852971A patent/ZA852971B/xx unknown
- 1985-04-25 PH PH32186A patent/PH22007A/en unknown
- 1985-04-26 US US06/727,521 patent/US4557866A/en not_active Expired - Lifetime
- 1985-04-29 CA CA000480321A patent/CA1215708A/en not_active Expired
- 1985-05-13 PT PT80446A patent/PT80446B/pt unknown
- 1985-05-13 GR GR851144A patent/GR851144B/el unknown
- 1985-05-14 ES ES543115A patent/ES8603489A1/es not_active Expired
- 1985-05-14 NO NO851921A patent/NO164242C/no not_active IP Right Cessation
- 1985-05-14 FI FI851907A patent/FI81101C/fi not_active IP Right Cessation
- 1985-05-14 IE IE119185A patent/IE58392B1/en not_active IP Right Cessation
- 1985-05-14 JP JP60102528A patent/JPS60252483A/ja active Granted
- 1985-05-14 DK DK214685A patent/DK162647C/da not_active IP Right Cessation
- 1985-05-15 AR AR85300385A patent/AR241913A1/es active
- 1985-05-15 AU AU42515/85A patent/AU568934B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
PT80446A (en) | 1985-06-01 |
AU568934B2 (en) | 1988-01-14 |
JPS60252483A (ja) | 1985-12-13 |
NO164242B (no) | 1990-06-05 |
FI81101C (fi) | 1990-09-10 |
EP0161534A3 (en) | 1987-03-04 |
IT1199374B (it) | 1988-12-30 |
US4557866A (en) | 1985-12-10 |
DK162647B (da) | 1991-11-25 |
ES543115A0 (es) | 1986-01-01 |
DK214685A (da) | 1985-11-16 |
FI851907A0 (fi) | 1985-05-14 |
IE58392B1 (en) | 1993-09-08 |
ES8603489A1 (es) | 1986-01-01 |
CA1215708A (en) | 1986-12-23 |
DE3573120D1 (en) | 1989-10-26 |
FI851907L (fi) | 1985-11-16 |
ZA852971B (en) | 1985-12-24 |
PH22007A (en) | 1988-05-02 |
NO164242C (no) | 1990-09-12 |
PT80446B (pt) | 1987-11-11 |
AU4251585A (en) | 1985-11-21 |
JPH0469634B2 (de) | 1992-11-06 |
IE851191L (en) | 1985-11-15 |
NO851921L (no) | 1985-11-18 |
FI81101B (fi) | 1990-05-31 |
GR851144B (de) | 1985-11-25 |
EP0161534B1 (de) | 1989-09-20 |
AR241913A1 (es) | 1993-01-29 |
IT8403463A0 (it) | 1984-05-15 |
EP0161534A2 (de) | 1985-11-21 |
DK162647C (da) | 1992-04-13 |
DK214685D0 (da) | 1985-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEFA | Change of the company name | ||
EELA | Cancelled due to lapse of time |