IT1154655B - Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica - Google Patents

Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Info

Publication number
IT1154655B
IT1154655B IT03429/80A IT342980A IT1154655B IT 1154655 B IT1154655 B IT 1154655B IT 03429/80 A IT03429/80 A IT 03429/80A IT 342980 A IT342980 A IT 342980A IT 1154655 B IT1154655 B IT 1154655B
Authority
IT
Italy
Prior art keywords
imidazo
preparation
antibacterial action
rifamycin derivatives
action substance
Prior art date
Application number
IT03429/80A
Other languages
English (en)
Other versions
IT8003429A0 (it
Inventor
Egidio Marchi
Lauretta Montecchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of IT8003429A0 publication Critical patent/IT8003429A0/it
Priority to IT03429/80A priority Critical patent/IT1154655B/it
Priority to US06/262,123 priority patent/US4341785A/en
Priority to NLAANVRAGE8102290,A priority patent/NL187022C/xx
Priority to AU70655/81A priority patent/AU537093B2/en
Priority to AT0222781A priority patent/AT373599B/de
Priority to GR65010A priority patent/GR75640B/el
Priority to PT73064A priority patent/PT73064B/pt
Priority to EG280/81A priority patent/EG14891A/xx
Priority to PH25656A priority patent/PH17207A/en
Priority to LU83376A priority patent/LU83376A1/fr
Priority to FR8110058A priority patent/FR2482967A1/fr
Priority to DK224781A priority patent/DK157876C/da
Priority to ES502906A priority patent/ES502906A0/es
Priority to BE2/59169A priority patent/BE888895A/fr
Priority to FI811565A priority patent/FI69467C/fi
Priority to ZA00813430A priority patent/ZA813430B/xx
Priority to IE1139/81A priority patent/IE51204B1/en
Priority to CA000378015A priority patent/CA1142518A/en
Priority to NO811731A priority patent/NO155622C/no
Priority to SE8103216A priority patent/SE453089B/sv
Priority to JP7787781A priority patent/JPS5711987A/ja
Priority to GB8115790A priority patent/GB2079270B/en
Priority to AR285424A priority patent/AR226212A1/es
Priority to CH3381/81A priority patent/CH648037A5/de
Priority to DE19813120460 priority patent/DE3120460A1/de
Priority to PH26842A priority patent/PH18704A/en
Application granted granted Critical
Publication of IT1154655B publication Critical patent/IT1154655B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT03429/80A 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica IT1154655B (it)

Priority Applications (26)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica
US06/262,123 US4341785A (en) 1980-05-22 1981-05-11 Imidazo-rifamycin derivatives with antibacterial utility
NLAANVRAGE8102290,A NL187022C (nl) 1980-05-22 1981-05-11 Rifamycine derivaten met anti-bacteriele werking, en dergelijke derivaten bevattend farmaceutisch preparaat.
AU70655/81A AU537093B2 (en) 1980-05-22 1981-05-18 New imidazo-rifamycin derivatives with antibacterial utility
AT0222781A AT373599B (de) 1980-05-22 1981-05-19 Verfahren zur herstellung neuer rifamycinderivate
GR65010A GR75640B (it) 1980-05-22 1981-05-20
PT73064A PT73064B (en) 1980-05-22 1981-05-20 New imidazo-rifamycin derivatives with anti-bacterial utility
EG280/81A EG14891A (en) 1980-05-22 1981-05-20 A process for preparation of derivatives of imiadozo-new rifamicyn have process antibacterial utility
PH25656A PH17207A (en) 1980-05-22 1981-05-20 New imidazo-rifamycin derivatives with antibacterial utility
LU83376A LU83376A1 (fr) 1980-05-22 1981-05-20 Nouveaux derives d'imidazo-rifamycine a activite antibacterienne
FR8110058A FR2482967A1 (fr) 1980-05-22 1981-05-20 Nouveaux derives de l'imidazo-rifamycine, leur procede de preparation et leur application en therapeutique
ES502906A ES502906A0 (es) 1980-05-22 1981-05-21 Un procedimiento para la preparacion de nuevos derivados de imidazo-rifamicina
DK224781A DK157876C (da) 1980-05-22 1981-05-21 Analogifremgangsmaade til fremstilling af imidazo-rifamycin-derivater
BE2/59169A BE888895A (fr) 1980-05-22 1981-05-21 Nouveaux derives d'imidazo-rifamycine a activite antibacterienne
FI811565A FI69467C (fi) 1980-05-22 1981-05-21 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara pyrido- och isokinolin(1',2':1,2)imidazo(5,4-c)rifamycin soch sv-derivat
ZA00813430A ZA813430B (en) 1980-05-22 1981-05-21 New imidazo-rifamycin derivatives with antibacterial utility
IE1139/81A IE51204B1 (en) 1980-05-22 1981-05-21 Imidazo-rifamycin derivatives
CA000378015A CA1142518A (en) 1980-05-22 1981-05-21 Imidazo-rifamycin derivatives with antibacterial utility
NO811731A NO155622C (no) 1980-05-22 1981-05-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrido- og isokinolin (1[,2[:1,2) imidazo (5,4-c) rifamycin sv og s derivater.
SE8103216A SE453089B (sv) 1980-05-22 1981-05-21 Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition
JP7787781A JPS5711987A (en) 1980-05-22 1981-05-22 Novel imidazo-rifamycin derivative
GB8115790A GB2079270B (en) 1980-05-22 1981-05-22 Imidazo-rifamycin derivatives
AR285424A AR226212A1 (es) 1980-05-22 1981-05-22 Procedimiento para preparar nuevos derivados de imidazo rifamicina
CH3381/81A CH648037A5 (de) 1980-05-22 1981-05-22 Imidazo-rifamycin-derivate mit antibakterieller wirksamkeit.
DE19813120460 DE3120460A1 (de) 1980-05-22 1981-05-22 Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
PH26842A PH18704A (en) 1980-05-22 1982-02-09 Method of treatment using inidazo-rifamycin derivatives with antibacterial utility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
IT8003429A0 IT8003429A0 (it) 1980-05-22
IT1154655B true IT1154655B (it) 1987-01-21

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Country Status (25)

Country Link
US (1) US4341785A (it)
JP (1) JPS5711987A (it)
AR (1) AR226212A1 (it)
AT (1) AT373599B (it)
AU (1) AU537093B2 (it)
BE (1) BE888895A (it)
CA (1) CA1142518A (it)
CH (1) CH648037A5 (it)
DE (1) DE3120460A1 (it)
DK (1) DK157876C (it)
EG (1) EG14891A (it)
ES (1) ES502906A0 (it)
FI (1) FI69467C (it)
FR (1) FR2482967A1 (it)
GB (1) GB2079270B (it)
GR (1) GR75640B (it)
IE (1) IE51204B1 (it)
IT (1) IT1154655B (it)
LU (1) LU83376A1 (it)
NL (1) NL187022C (it)
NO (1) NO155622C (it)
PH (2) PH17207A (it)
PT (1) PT73064B (it)
SE (1) SE453089B (it)
ZA (1) ZA813430B (it)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094737A2 (en) 2005-03-07 2006-09-14 Alfa Wassermann S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin
WO2007103448A2 (en) 2006-03-09 2007-09-13 Salix Pharmaceuticals, Inc. Rifaximin anti-rectal dysfunction preparation
WO2008016708A2 (en) 2006-08-02 2008-02-07 Salix Pharmaceuticals, Inc. Methods for treatment of radiation enteritis
EP2011486A1 (en) 2007-07-06 2009-01-07 Lupin Ltd. Pharmaceutical compositions of rifaximin
WO2009108814A1 (en) 2008-02-26 2009-09-03 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
WO2009108730A2 (en) 2008-02-25 2009-09-03 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
WO2009137672A1 (en) 2008-05-07 2009-11-12 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
WO2010040020A1 (en) 2008-10-02 2010-04-08 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
EP2208730A1 (en) 2003-11-07 2010-07-21 ALFA WASSERMANN S.p.A. Polymorphic forms of rifaximin, processes for their production and use thereof in medicinal preparations
WO2011051971A2 (en) 2009-10-27 2011-05-05 Lupin Limited Solid dispersion of rifaximin
WO2011061519A2 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
WO2011080691A1 (en) 2009-12-28 2011-07-07 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
MD4081G2 (ro) * 2005-03-03 2011-07-31 Alfa Wassermann S.P.A. Forme polimorfe de rifaximină, procedee de obţinere şi utilizare a acestora în calitate de preparate medicamentoase cu activitate antibiotică
WO2011103120A1 (en) 2010-02-19 2011-08-25 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
WO2011107970A2 (en) 2010-03-05 2011-09-09 Alfa Wassermann S.P.A. Rifaximin powder, process for preparing the same and controlled release compositions containing said rifaximin useful for obtaining a long-lasting effect.
WO2011110930A2 (en) 2010-03-10 2011-09-15 Lupin Limited Rifaximin ready-to-use suspension
WO2012009388A1 (en) 2010-07-12 2012-01-19 Salix Pharmaceuticals, Ltd Formulations of rifaximin and uses thereof
WO2012109605A2 (en) 2011-02-11 2012-08-16 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
WO2013017928A1 (en) 2011-07-29 2013-02-07 Alfa Wassermann S.P.A. Pharmaceutical compositions comprising rifaximin, processes for their preparation and their use in the treatment of vaginal infections
US8383151B2 (en) 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
WO2013067394A1 (en) 2011-11-02 2013-05-10 Salix Pharmaceuticals, Ltd Methods for treating irritable bowel syndrome (ibs) and infections
WO2014006576A1 (en) 2012-07-06 2014-01-09 Alfa Wassermann S.P.A. Pharmaceutical compositions comprising rifaximin and amino acids, preparation method and use thereof
WO2014140995A2 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Method for diagnosing vaginal infections
WO2014140988A1 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections.
WO2014167533A1 (en) 2013-04-12 2014-10-16 Alfa Wassermann S.P.A. Nsaid administration and related compositions, methods and systems.
WO2015171493A1 (en) 2014-05-04 2015-11-12 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
WO2015173697A1 (en) 2014-05-12 2015-11-19 Alfa Wassermann S.P.A. New solvated crystal form of rifaximin, production, compositions and uses thereof
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
EP3650022A1 (en) 2010-02-18 2020-05-13 Salix Pharmaceuticals, Ltd. Methods for treating rifampin resistant clostridium difficilis infections
EP3964066A1 (en) 2009-06-02 2022-03-09 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy

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IT1199374B (it) 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
DE69829905T2 (de) * 1997-02-28 2006-03-09 Kaneka Corp. Heilmittel für durch Helicobacter verursachte Krankheit
WO2003045319A2 (en) * 2001-11-21 2003-06-05 Activbiotics, Inc. Targeted therapeutics and uses thereof
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
WO2004041240A1 (en) * 2002-11-05 2004-05-21 Piero Chiarelli Controlled and continued delivery of rifaximin and/or other substances
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
BRPI0614758A2 (pt) 2005-08-11 2011-04-12 Targanta Therapeutics Inc rifamicinas fosfonadas e usos destas para a prevenção e tratamento de infecções na articulação e osso
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
KR101667534B1 (ko) * 2006-09-22 2016-10-19 씨아이피엘에이 엘티디. 리팍시민
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
RU2011116400A (ru) 2008-09-26 2012-11-10 Аска Фармасьютикал Ко., Лтд. (Jp) Средство для предотвращения и/или лечения функционального расстройства желудочно-кишечного тракта
CA2745980C (en) 2008-12-10 2017-10-31 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
RU2582940C2 (ru) 2009-09-13 2016-04-27 Саликс Фармасьютикалз, Лтд. Способы лечения синдрома раздраженного кишечника (срк)
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
EP2705042A1 (en) 2011-05-02 2014-03-12 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
CA2861104A1 (en) * 2012-01-25 2013-08-01 Salix Pharmaceuticals, Ltd. Rifaximin derivative and uses thereof
WO2014091432A1 (en) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Pharmaceutical compositions of rifaximin
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
KR20240124428A (ko) 2016-09-30 2024-08-16 샐릭스 파마슈티컬스 인코포레이티드 리팍시민의 고체 분산물 형태
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EP2210893A1 (en) 2003-11-07 2010-07-28 ALFA WASSERMANN S.p.A. Polymorphous forms of rifaximin as antibiotics
EP2208730A1 (en) 2003-11-07 2010-07-21 ALFA WASSERMANN S.p.A. Polymorphic forms of rifaximin, processes for their production and use thereof in medicinal preparations
US9271968B2 (en) 2005-03-03 2016-03-01 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US8518949B2 (en) 2005-03-03 2013-08-27 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
MD4081G2 (ro) * 2005-03-03 2011-07-31 Alfa Wassermann S.P.A. Forme polimorfe de rifaximină, procedee de obţinere şi utilizare a acestora în calitate de preparate medicamentoase cu activitate antibiotică
WO2006094737A2 (en) 2005-03-07 2006-09-14 Alfa Wassermann S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin
MD4180C1 (ro) * 2005-03-07 2013-03-31 Alfa Wassermann S.P.A. Procedeu de fabricare a compoziţiilor farmaceutice cu conţinut de rifaximină sub formă de microgranule gastrorezistente, compoziţii şi utilizarea lor în tratamentul afecţiunilor inflamatoare ale intestinelor
WO2007103448A2 (en) 2006-03-09 2007-09-13 Salix Pharmaceuticals, Inc. Rifaximin anti-rectal dysfunction preparation
WO2008016708A2 (en) 2006-08-02 2008-02-07 Salix Pharmaceuticals, Inc. Methods for treatment of radiation enteritis
EP2420226A1 (en) 2007-07-06 2012-02-22 Lupin Limited Pharmaceutical compositions of rifaximin
US8383151B2 (en) 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
EP2011486A1 (en) 2007-07-06 2009-01-07 Lupin Ltd. Pharmaceutical compositions of rifaximin
EP3714878A1 (en) 2007-07-06 2020-09-30 Lupin Limited Pharmaceutical compositions of rifaximin
EP2837378A1 (en) 2007-07-06 2015-02-18 Lupin Limited Pharmaceutical compositions of rifaximin
WO2009108730A2 (en) 2008-02-25 2009-09-03 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
EP3563850A1 (en) 2008-02-26 2019-11-06 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
WO2009108814A1 (en) 2008-02-26 2009-09-03 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
WO2009137672A1 (en) 2008-05-07 2009-11-12 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
WO2010040020A1 (en) 2008-10-02 2010-04-08 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
EP3628319A1 (en) 2008-10-02 2020-04-01 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy using rifaximin
EP4342465A2 (en) 2008-10-02 2024-03-27 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
EP3964066A1 (en) 2009-06-02 2022-03-09 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
WO2011051971A2 (en) 2009-10-27 2011-05-05 Lupin Limited Solid dispersion of rifaximin
WO2011061519A2 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
WO2011080691A1 (en) 2009-12-28 2011-07-07 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
EP3650022A1 (en) 2010-02-18 2020-05-13 Salix Pharmaceuticals, Ltd. Methods for treating rifampin resistant clostridium difficilis infections
WO2011103120A1 (en) 2010-02-19 2011-08-25 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
US9498442B2 (en) 2010-03-05 2016-11-22 Alfa Wassermann S.P.A. Rifaximin powder, process for preparing the same an controlled release compositions containing said rifaximin useful for obtaining a long-lasting effect
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FI69467C (fi) 1986-02-10
DE3120460A1 (de) 1982-03-11
IE811139L (en) 1981-11-22
PH17207A (en) 1984-06-19
NO155622C (no) 1987-04-29
ES8203388A1 (es) 1982-04-01
GB2079270B (en) 1984-01-18
FI811565L (fi) 1981-11-23
ZA813430B (en) 1982-06-30
FI69467B (fi) 1985-10-31
FR2482967B1 (it) 1985-03-29
IE51204B1 (en) 1986-10-29
AT373599B (de) 1984-02-10
DK157876B (da) 1990-02-26
ATA222781A (de) 1983-06-15
NL187022C (nl) 1991-05-01
AR226212A1 (es) 1982-06-15
NO155622B (no) 1987-01-19
CH648037A5 (de) 1985-02-28
AU7065581A (en) 1981-11-26
IT8003429A0 (it) 1980-05-22
AU537093B2 (en) 1984-06-07
DE3120460C2 (it) 1990-12-13
DK224781A (da) 1981-11-23
JPS5711987A (en) 1982-01-21
CA1142518A (en) 1983-03-08
NL8102290A (nl) 1981-12-16
LU83376A1 (fr) 1981-09-11
JPS6123192B2 (it) 1986-06-04
US4341785A (en) 1982-07-27
PH18704A (en) 1985-09-05
EG14891A (en) 1985-12-31
SE453089B (sv) 1988-01-11
DK157876C (da) 1990-07-30
ES502906A0 (es) 1982-04-01
GR75640B (it) 1984-08-02
NO811731L (no) 1981-11-23
FR2482967A1 (fr) 1981-11-27
PT73064A (en) 1981-06-01
PT73064B (en) 1982-07-05
SE8103216L (sv) 1981-11-23
BE888895A (fr) 1981-09-16
NL187022B (nl) 1990-12-03
GB2079270A (en) 1982-01-20

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