DK0592434T3 - Forbedret fremgangsmåde til syntese af oligomerer - Google Patents

Forbedret fremgangsmåde til syntese af oligomerer

Info

Publication number
DK0592434T3
DK0592434T3 DK91919675T DK91919675T DK0592434T3 DK 0592434 T3 DK0592434 T3 DK 0592434T3 DK 91919675 T DK91919675 T DK 91919675T DK 91919675 T DK91919675 T DK 91919675T DK 0592434 T3 DK0592434 T3 DK 0592434T3
Authority
DK
Denmark
Prior art keywords
oligomers
synthesis
improved method
methods
result
Prior art date
Application number
DK91919675T
Other languages
English (en)
Inventor
Robert E Klem
Timothy A Riley
William B Marvin
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Application granted granted Critical
Publication of DK0592434T3 publication Critical patent/DK0592434T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91919675T 1990-10-26 1991-10-21 Forbedret fremgangsmåde til syntese af oligomerer DK0592434T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60579090A 1990-10-26 1990-10-26
PCT/US1991/007630 WO1992007864A1 (en) 1990-10-26 1991-10-21 Improved process for the synthesis of oligomers

Publications (1)

Publication Number Publication Date
DK0592434T3 true DK0592434T3 (da) 1999-06-21

Family

ID=24425218

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91919675T DK0592434T3 (da) 1990-10-26 1991-10-21 Forbedret fremgangsmåde til syntese af oligomerer

Country Status (14)

Country Link
US (1) US5726300A (da)
EP (1) EP0592434B1 (da)
JP (1) JPH06509542A (da)
AT (1) ATE171947T1 (da)
AU (1) AU669103B2 (da)
CA (1) CA2094803A1 (da)
DE (1) DE69130331T2 (da)
DK (1) DK0592434T3 (da)
ES (1) ES2124231T3 (da)
IE (1) IE913761A1 (da)
IL (1) IL99844A (da)
NZ (1) NZ240325A (da)
TW (1) TW216423B (da)
WO (1) WO1992007864A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3250093A (en) 1991-12-12 1993-07-19 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
DE69432635D1 (de) * 1993-07-19 2003-06-12 Gen Probe Inc Oligonukleotide mit wirkung gegen den menschlichen immunodefiziens-virus
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
ATE194391T1 (de) * 1995-01-19 2000-07-15 Gen Probe Inc Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
SI2757091T1 (en) 2008-04-01 2018-01-31 Biosearch Technologies, Inc. Stabilized nucleic acid black gas-fluorofor probe
US10913767B2 (en) * 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
CN104736551B (zh) * 2012-08-15 2017-07-28 Ionis制药公司 使用改进的封端方案制备寡聚化合物的方法
EP3140286B1 (en) 2014-05-09 2018-12-26 Biosearch Technologies, Inc. Cosmic quenchers
WO2016160646A1 (en) * 2015-04-02 2016-10-06 Merck Sharp & Dohme Corp. Process for making phosphoramidate protected nucleoside compounds
SG11201708480YA (en) 2015-04-15 2017-12-28 Biosearch Tech Inc Dual quencher probes
US20200165599A1 (en) 2017-05-11 2020-05-28 Gen-Probe Incorporated Compositions and Methods for Isolating Target Nucleic Acids
CN114728263A (zh) 2019-11-14 2022-07-08 简·探针公司 用于捕获靶核酸的组合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides

Also Published As

Publication number Publication date
NZ240325A (en) 1993-06-25
EP0592434A4 (en) 1996-04-24
WO1992007864A1 (en) 1992-05-14
ES2124231T3 (es) 1999-02-01
EP0592434B1 (en) 1998-10-07
JPH06509542A (ja) 1994-10-27
IE913761A1 (en) 1992-05-22
CA2094803A1 (en) 1992-04-27
US5726300A (en) 1998-03-10
DE69130331D1 (de) 1998-11-12
DE69130331T2 (de) 1999-03-04
AU8875391A (en) 1992-05-26
ATE171947T1 (de) 1998-10-15
EP0592434A1 (en) 1994-04-20
IL99844A (en) 1995-07-31
TW216423B (da) 1993-11-21
AU669103B2 (en) 1996-05-30

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