JPS5859994A - 組換えモノクローナル抗体 - Google Patents

組換えモノクローナル抗体

Info

Publication number
JPS5859994A
JPS5859994A JP57115320A JP11532082A JPS5859994A JP S5859994 A JPS5859994 A JP S5859994A JP 57115320 A JP57115320 A JP 57115320A JP 11532082 A JP11532082 A JP 11532082A JP S5859994 A JPS5859994 A JP S5859994A
Authority
JP
Japan
Prior art keywords
antibody
antigens
cells
antigen
produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57115320A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0367678B2 (cg-RX-API-DMAC10.html
Inventor
クリストフア−・エル・リ−デイング
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOODO OBU RIIJIENTSU UNIV OBU TEKISASU SYSTEM ZA
OBU TEKISASU SYSTEM ZA, University of
Original Assignee
BOODO OBU RIIJIENTSU UNIV OBU TEKISASU SYSTEM ZA
OBU TEKISASU SYSTEM ZA, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23068220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5859994(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BOODO OBU RIIJIENTSU UNIV OBU TEKISASU SYSTEM ZA, OBU TEKISASU SYSTEM ZA, University of filed Critical BOODO OBU RIIJIENTSU UNIV OBU TEKISASU SYSTEM ZA
Publication of JPS5859994A publication Critical patent/JPS5859994A/ja
Publication of JPH0367678B2 publication Critical patent/JPH0367678B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/819—Multifunctional antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP57115320A 1981-07-01 1982-07-01 組換えモノクローナル抗体 Granted JPS5859994A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/279,248 US4474893A (en) 1981-07-01 1981-07-01 Recombinant monoclonal antibodies
US279248 1981-07-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP3138042A Division JPH084496B2 (ja) 1981-07-01 1991-06-10 トリオーマ細胞およびその製造方法
JP3138041A Division JPH04228067A (ja) 1981-07-01 1991-06-10 クアドローマ細胞およびその製造方法

Publications (2)

Publication Number Publication Date
JPS5859994A true JPS5859994A (ja) 1983-04-09
JPH0367678B2 JPH0367678B2 (cg-RX-API-DMAC10.html) 1991-10-23

Family

ID=23068220

Family Applications (3)

Application Number Title Priority Date Filing Date
JP57115320A Granted JPS5859994A (ja) 1981-07-01 1982-07-01 組換えモノクローナル抗体
JP3138041A Granted JPH04228067A (ja) 1981-07-01 1991-06-10 クアドローマ細胞およびその製造方法
JP3138042A Expired - Lifetime JPH084496B2 (ja) 1981-07-01 1991-06-10 トリオーマ細胞およびその製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP3138041A Granted JPH04228067A (ja) 1981-07-01 1991-06-10 クアドローマ細胞およびその製造方法
JP3138042A Expired - Lifetime JPH084496B2 (ja) 1981-07-01 1991-06-10 トリオーマ細胞およびその製造方法

Country Status (6)

Country Link
US (1) US4474893A (cg-RX-API-DMAC10.html)
EP (1) EP0068763B2 (cg-RX-API-DMAC10.html)
JP (3) JPS5859994A (cg-RX-API-DMAC10.html)
AT (1) ATE26464T1 (cg-RX-API-DMAC10.html)
CA (1) CA1190873A (cg-RX-API-DMAC10.html)
DE (1) DE3276007D1 (cg-RX-API-DMAC10.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62244392A (ja) * 1986-04-15 1987-10-24 Snow Brand Milk Prod Co Ltd ハイブリド−マを用いて抗体を産生する方法
JPS6312276A (ja) * 1982-04-12 1988-01-19 ハイブリテツク　インコ−ポレ−テツド 二重特異性を有する抗体の製造方法
JPH02500321A (ja) * 1986-04-14 1990-02-08 ザ・ジェネラル・ホスピタル・コーポレーション ヘテロ二官能性抗体および利用方法
JPH0690753A (ja) * 1982-01-22 1994-04-05 Sandoz Ag ハイブリドーマセルラインの製造法
JPH0690786A (ja) * 1981-12-21 1994-04-05 Boston Biomedical Res Inst Inc 複特異性抗体決定子

Families Citing this family (661)

* Cited by examiner, † Cited by third party
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US4401764A (en) * 1980-02-07 1983-08-30 Technicon Instruments Corporation Immunoassays employing labeled reagent and a conjugate having two binding sites
US4714681A (en) * 1981-07-01 1987-12-22 The Board Of Reagents, The University Of Texas System Cancer Center Quadroma cells and trioma cells and methods for the production of same
JP3177776B2 (ja) * 1988-09-27 2001-06-18 武田薬品工業株式会社 ハイブリッドモノクローナル抗体，抗体産生ポリドーマおよび抗体含有薬剤
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
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US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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US4777245A (en) * 1984-01-06 1988-10-11 Genelabs Incorporated Non-human primate monoclonal antibodies and methods
US4634666A (en) * 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
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US4649106A (en) * 1984-06-01 1987-03-10 Dana-Farber Cancer Institute, Inc. Distinguishing subsets of human cells
US4722892A (en) * 1984-08-31 1988-02-02 Meares Claude F Monoclonal antibodies against metal chelates
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US4818679A (en) * 1985-02-19 1989-04-04 The Trustees Of Columbia University In The City Of New York Method for recovering mutant cells
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US4831122A (en) * 1986-01-09 1989-05-16 Regents Of The University Of Minnesota Radioimmunotoxins
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US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US5853988A (en) * 1986-08-11 1998-12-29 Massachusetts Eye And Ear Infirmary Diagnosis of retinoblastoma
US7223842B1 (en) 1986-08-11 2007-05-29 Massachusetts Eye And Ear Infirmary Detection of proteins whose absence is associated with a neoplasm
US7384735B1 (en) 1986-08-11 2008-06-10 Massachusetts Eye And Ear Infirmary Retinoblastoma nucleic acids
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US4874693A (en) * 1986-10-10 1989-10-17 Mark Bogart Method for assessing placental dysfunction
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US5567584A (en) * 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
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US5316932A (en) * 1989-03-24 1994-05-31 Duke University Homogeneous denatured human 06-guanine alkyltransferase prepared by immunoaffinity chromatography using monoclonal antibody specific for enzyme
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JPH084496B2 (ja) 1996-01-24
EP0068763A2 (en) 1983-01-05
DE3276007D1 (en) 1987-05-14
ATE26464T1 (de) 1987-04-15
CA1190873A (en) 1985-07-23
EP0068763A3 (en) 1983-06-08
JPH0367678B2 (cg-RX-API-DMAC10.html) 1991-10-23
JPH04228067A (ja) 1992-08-18
JPH0565155B2 (cg-RX-API-DMAC10.html) 1993-09-17
EP0068763B1 (en) 1987-04-08
US4474893A (en) 1984-10-02
EP0068763B2 (en) 1993-04-21
JPH04228068A (ja) 1992-08-18

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