JP5677425B2 - Ｐｉ３ｋ阻害剤としてのピリミジノン - Google Patents

Ｐｉ３ｋ阻害剤としてのピリミジノン Download PDF

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JP5677425B2
JP5677425B2 JP2012518563A JP2012518563A JP5677425B2 JP 5677425 B2 JP5677425 B2 JP 5677425B2 JP 2012518563 A JP2012518563 A JP 2012518563A JP 2012518563 A JP2012518563 A JP 2012518563A JP 5677425 B2 JP5677425 B2 JP 5677425B2
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thiazolo
methyl
pyrimidin
ethyl
purin
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JP2012532131A (ja
JP2012532131A5 (https=
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ユン−ロン・リ
ブライアン・ダブリュー・メトカーフ
アンドリュー・ピー・クームズ
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012518563A 2009-06-29 2010-06-28 Ｐｉ３ｋ阻害剤としてのピリミジノン Expired - Fee Related JP5677425B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22116009P 2009-06-29 2009-06-29
US61/221,160 2009-06-29
US25976509P 2009-11-10 2009-11-10
US61/259,765 2009-11-10
PCT/US2010/040150 WO2011008487A1 (en) 2009-06-29 2010-06-28 Pyrimidinones as pi3k inhibitors

Related Child Applications (1)

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JP2014223540A Division JP2015042673A (ja) 2009-06-29 2014-10-31 Ｐｉ３ｋ阻害剤としてのピリミジノン

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JP2012532131A JP2012532131A (ja) 2012-12-13
JP2012532131A5 JP2012532131A5 (https=) 2013-08-15
JP5677425B2 true JP5677425B2 (ja) 2015-02-25

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JP2012518563A Expired - Fee Related JP5677425B2 (ja) 2009-06-29 2010-06-28 Ｐｉ３ｋ阻害剤としてのピリミジノン
JP2014223540A Pending JP2015042673A (ja) 2009-06-29 2014-10-31 Ｐｉ３ｋ阻害剤としてのピリミジノン

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US (6) US8940752B2 (https=)
EP (2) EP2448938B9 (https=)
JP (2) JP5677425B2 (https=)
KR (1) KR101763656B1 (https=)
CN (2) CN104945420A (https=)
AR (1) AR077280A1 (https=)
AU (2) AU2010273816B2 (https=)
BR (1) BRPI1015135B1 (https=)
CA (1) CA2766100C (https=)
CL (1) CL2011003346A1 (https=)
CO (1) CO6440529A2 (https=)
CR (1) CR20110686A (https=)
DK (1) DK2448938T5 (https=)
EA (1) EA021595B1 (https=)
ES (1) ES2486715T3 (https=)
HK (1) HK1208224A1 (https=)
HR (1) HRP20140754T2 (https=)
IL (2) IL217044A (https=)
ME (1) ME01838B (https=)
MX (1) MX2011013816A (https=)
MY (1) MY162507A (https=)
NZ (1) NZ597050A (https=)
PE (1) PE20120493A1 (https=)
PH (1) PH12015501221A1 (https=)
PL (1) PL2448938T3 (https=)
PT (1) PT2448938E (https=)
RS (1) RS53494B9 (https=)
SG (1) SG177384A1 (https=)
SI (1) SI2448938T1 (https=)
SM (1) SMT201400116B (https=)
TW (2) TW201602113A (https=)
WO (1) WO2011008487A1 (https=)
ZA (1) ZA201109340B (https=)

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SI2448938T1 (sl) 2014-08-29
BRPI1015135B1 (pt) 2021-08-03
US10829502B2 (en) 2020-11-10
WO2011008487A1 (en) 2011-01-20
BRPI1015135A2 (pt) 2019-07-09
ZA201109340B (en) 2022-03-30
DK2448938T3 (da) 2014-08-25
TW201602113A (zh) 2016-01-16
US9434746B2 (en) 2016-09-06
CN102482278B (zh) 2015-04-22
TW201113283A (en) 2011-04-16
CR20110686A (es) 2012-03-22
MY162507A (en) 2017-06-15

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