BRPI1015135A2 - pirimidinonas como inibidores de pi3k - Google Patents

pirimidinonas como inibidores de pi3k

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Publication number
BRPI1015135A2
BRPI1015135A2 BRPI1015135A BRPI1015135A BRPI1015135A2 BR PI1015135 A2 BRPI1015135 A2 BR PI1015135A2 BR PI1015135 A BRPI1015135 A BR PI1015135A BR PI1015135 A BRPI1015135 A BR PI1015135A BR PI1015135 A2 BRPI1015135 A2 BR PI1015135A2
Authority
BR
Brazil
Prior art keywords
pyrimidinones
pi3k inhibitors
pi3ks
activity
diseases
Prior art date
Application number
BRPI1015135A
Other languages
English (en)
Inventor
P Combs Andrew
W Metcalf Brian
Li Yun-Long
Original Assignee
Incyte Corp
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1015135(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BRPI1015135A2 publication Critical patent/BRPI1015135A2/pt
Publication of BRPI1015135B1 publication Critical patent/BRPI1015135B1/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P11/16—Central respiratory analeptics
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pulmonology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"pirimidinonas inibidoras de pi3k composição compreendendo tais compostos, bem como usos dos mesmos". a presente invenção refere-se a pirimidinonas que modulam a atividade de fosfoinositídeo 3-cinases (pi3ks) e são úteis no tratamento de doenças relacionadas com a atividade de pi3ks incluindo, por exemplo, distúrbios inflamatórios, distúrbios imunobaseados, câncer, e outras doenças.
BRPI1015135-4A 2009-06-29 2010-06-28 Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos BRPI1015135B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22116009P 2009-06-29 2009-06-29
US61/221,160 2009-06-29
US25976509P 2009-11-10 2009-11-10
US61/259,765 2009-11-10
PCT/US2010/040150 WO2011008487A1 (en) 2009-06-29 2010-06-28 Pyrimidinones as pi3k inhibitors

Publications (2)

Publication Number Publication Date
BRPI1015135A2 true BRPI1015135A2 (pt) 2019-07-09
BRPI1015135B1 BRPI1015135B1 (pt) 2021-08-03

Family

ID=42575792

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015135-4A BRPI1015135B1 (pt) 2009-06-29 2010-06-28 Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos

Country Status (33)

Country Link
US (6) US8940752B2 (pt)
EP (2) EP2448938B9 (pt)
JP (2) JP5677425B2 (pt)
KR (1) KR101763656B1 (pt)
CN (2) CN102482278B (pt)
AR (1) AR077280A1 (pt)
AU (2) AU2010273816B2 (pt)
BR (1) BRPI1015135B1 (pt)
CA (1) CA2766100C (pt)
CL (1) CL2011003346A1 (pt)
CO (1) CO6440529A2 (pt)
CR (1) CR20110686A (pt)
DK (1) DK2448938T5 (pt)
EA (1) EA021595B1 (pt)
ES (1) ES2486715T3 (pt)
HK (1) HK1208224A1 (pt)
HR (1) HRP20140754T2 (pt)
IL (2) IL217044A (pt)
ME (1) ME01838B (pt)
MX (1) MX2011013816A (pt)
MY (1) MY162507A (pt)
NZ (1) NZ597050A (pt)
PE (1) PE20120493A1 (pt)
PH (1) PH12015501221A1 (pt)
PL (1) PL2448938T3 (pt)
PT (1) PT2448938E (pt)
RS (1) RS53494B9 (pt)
SG (1) SG177384A1 (pt)
SI (1) SI2448938T1 (pt)
SM (1) SMT201400116B (pt)
TW (2) TWI490219B (pt)
WO (1) WO2011008487A1 (pt)
ZA (1) ZA201109340B (pt)

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