BR112013019354A2 - derivados de (1,2,4)triazolo[4,3-a]quinoxalina como inibidores de fosfodiesterases - Google Patents

derivados de (1,2,4)triazolo[4,3-a]quinoxalina como inibidores de fosfodiesterases

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Publication number
BR112013019354A2
BR112013019354A2 BR112013019354A BR112013019354A BR112013019354A2 BR 112013019354 A2 BR112013019354 A2 BR 112013019354A2 BR 112013019354 A BR112013019354 A BR 112013019354A BR 112013019354 A BR112013019354 A BR 112013019354A BR 112013019354 A2 BR112013019354 A2 BR 112013019354A2
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BR
Brazil
Prior art keywords
triazolo
quinoxaline derivatives
phosphodiesterase inhibitors
phosphodiesterase
inhibitors
Prior art date
Application number
BR112013019354A
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English (en)
Inventor
Langen Barbara
Grunwald Christian
Stange Hans
Lankau Hans-Joachim
Höfgen Norbert
Dost Rita
Egerland Ute
Original Assignee
Boehringer Ingelheim Int
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Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112013019354A2 publication Critical patent/BR112013019354A2/pt

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

derivados de (1,2,4)triazolo[4,3-a]quinoxalina como inibidores de fosfodiesterases a presente invenção refere-se a derivados de (1,2,4)triazolo[4,3-a]quinoxalina da fórmula (i) que são inbidores da fosfodiesterase 2 e/ou 10, úteis no tratamento de doenças do sistema nervoso central.
BR112013019354A 2011-01-31 2012-01-31 derivados de (1,2,4)triazolo[4,3-a]quinoxalina como inibidores de fosfodiesterases BR112013019354A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437848P 2011-01-31 2011-01-31
PCT/EP2012/051546 WO2012104293A1 (en) 2011-01-31 2012-01-31 (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases

Publications (1)

Publication Number Publication Date
BR112013019354A2 true BR112013019354A2 (pt) 2019-09-24

Family

ID=45833359

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013019354A BR112013019354A2 (pt) 2011-01-31 2012-01-31 derivados de (1,2,4)triazolo[4,3-a]quinoxalina como inibidores de fosfodiesterases

Country Status (24)

Country Link
US (1) US9540379B2 (pt)
EP (1) EP2670754B1 (pt)
JP (1) JP6027547B2 (pt)
KR (1) KR20140019342A (pt)
CN (1) CN103459395A (pt)
AR (1) AR085099A1 (pt)
AU (1) AU2012213471B2 (pt)
BR (1) BR112013019354A2 (pt)
CA (1) CA2824929A1 (pt)
CL (1) CL2013002003A1 (pt)
CO (1) CO6811848A2 (pt)
EA (1) EA023792B1 (pt)
EC (1) ECSP13012824A (pt)
GE (1) GEP20156333B (pt)
IL (1) IL226826A (pt)
MA (1) MA34844B1 (pt)
MX (1) MX2013008667A (pt)
PE (1) PE20141023A1 (pt)
SG (1) SG192210A1 (pt)
TN (1) TN2013000325A1 (pt)
TW (1) TWI535718B (pt)
UA (1) UA111963C2 (pt)
UY (1) UY33888A (pt)
WO (1) WO2012104293A1 (pt)

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WO2013034758A1 (en) 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
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