MX2014006015A - Derivados de 3-fenil-isoquinolin-1 (2h) -ona como inhibidores de parp-1. - Google Patents
Derivados de 3-fenil-isoquinolin-1 (2h) -ona como inhibidores de parp-1.Info
- Publication number
- MX2014006015A MX2014006015A MX2014006015A MX2014006015A MX2014006015A MX 2014006015 A MX2014006015 A MX 2014006015A MX 2014006015 A MX2014006015 A MX 2014006015A MX 2014006015 A MX2014006015 A MX 2014006015A MX 2014006015 A MX2014006015 A MX 2014006015A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- isoquinolin
- phenyl
- derivatives
- parp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan derivados de 3-fenil-isoquinolin-1(2H)-ona sustituidos que inhiben selectivamente la actividad de la poli (ADP-ribosa)polimerasa PARP-1 con respecto a la poli(ADP-ribosa)polimerasa PARP-2. Por tanto, los compuestos de la presente invención son útiles en el tratamiento de enfermedades tales como cáncer, enfermedades cardiovasculares, lesión del sistema nervioso central y diferentes formas de inflamación. La presente invención también proporciona procedimientos de preparación de estos compuestos, composiciones farmacéuticas que comprenden estos compuestos y procedimientos de tratamiento de enfermedades que utilizan composiciones farmacéuticas que comprenden estos compuestos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11190687 | 2011-11-25 | ||
EP12161489 | 2012-03-27 | ||
PCT/EP2012/073125 WO2013076090A1 (en) | 2011-11-25 | 2012-11-20 | 3-phenyl-isoquinolin-1(2h)-one derivatives as parp-1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014006015A true MX2014006015A (es) | 2014-06-04 |
Family
ID=47227787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006015A MX2014006015A (es) | 2011-11-25 | 2012-11-20 | Derivados de 3-fenil-isoquinolin-1 (2h) -ona como inhibidores de parp-1. |
Country Status (15)
Country | Link |
---|---|
US (1) | US9422243B2 (es) |
EP (1) | EP2788328B1 (es) |
JP (1) | JP6106182B2 (es) |
KR (1) | KR20140097457A (es) |
CN (1) | CN103946214B (es) |
AU (1) | AU2012342562B2 (es) |
BR (1) | BR112014012031A2 (es) |
CA (1) | CA2856759A1 (es) |
CL (1) | CL2014001323A1 (es) |
EA (1) | EA027800B1 (es) |
ES (1) | ES2676068T3 (es) |
HK (1) | HK1200166A1 (es) |
IN (1) | IN2014CN04671A (es) |
MX (1) | MX2014006015A (es) |
WO (1) | WO2013076090A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN2014MN01875A (es) | 2012-03-07 | 2015-07-03 | Cancer Res Inst Royal | |
EP3044221B1 (en) * | 2013-09-11 | 2018-02-21 | Institute of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
CN105917007A (zh) * | 2014-01-16 | 2016-08-31 | 克洛维斯肿瘤有限公司 | Parp抑制剂用以治疗显示杂合性丧失的乳腺癌或卵巢癌患者的用途 |
BR112018008630A2 (pt) | 2015-11-06 | 2018-10-30 | Neurocrine Biosciences Inc | derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida, seus usos, composição farmacêutica |
WO2023242302A1 (en) | 2022-06-15 | 2023-12-21 | Astrazeneca Ab | Combination therapy for treating cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2282410T3 (es) | 2001-05-08 | 2007-10-16 | Kudos Pharmaceuticals Limited | Derivados de isoquinolinona como inhibidores de parp. |
JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
US7425563B2 (en) * | 2002-07-24 | 2008-09-16 | Kyorin Pharmaceutical Co., Ltd. | 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative |
US8519136B2 (en) * | 2008-02-22 | 2013-08-27 | Msd K.K. | Aminopyridine derivatives having aurora a selective inhibitory action |
TWI499418B (zh) * | 2009-05-21 | 2015-09-11 | Nerviano Medical Sciences Srl | 異喹啉-1(2h)-酮衍生物 |
-
2012
- 2012-11-20 CA CA2856759A patent/CA2856759A1/en not_active Abandoned
- 2012-11-20 JP JP2014542801A patent/JP6106182B2/ja active Active
- 2012-11-20 AU AU2012342562A patent/AU2012342562B2/en not_active Ceased
- 2012-11-20 EA EA201491026A patent/EA027800B1/ru not_active IP Right Cessation
- 2012-11-20 ES ES12791464.6T patent/ES2676068T3/es active Active
- 2012-11-20 KR KR1020147017409A patent/KR20140097457A/ko not_active Application Discontinuation
- 2012-11-20 BR BR112014012031A patent/BR112014012031A2/pt not_active IP Right Cessation
- 2012-11-20 EP EP12791464.6A patent/EP2788328B1/en active Active
- 2012-11-20 WO PCT/EP2012/073125 patent/WO2013076090A1/en active Application Filing
- 2012-11-20 MX MX2014006015A patent/MX2014006015A/es unknown
- 2012-11-20 US US14/358,537 patent/US9422243B2/en active Active
- 2012-11-20 CN CN201280057586.4A patent/CN103946214B/zh active Active
- 2012-11-20 IN IN4671CHN2014 patent/IN2014CN04671A/en unknown
-
2014
- 2014-05-20 CL CL2014001323A patent/CL2014001323A1/es unknown
-
2015
- 2015-01-16 HK HK15100542.6A patent/HK1200166A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2788328A1 (en) | 2014-10-15 |
EA201491026A1 (ru) | 2014-11-28 |
EP2788328B1 (en) | 2018-01-31 |
CN103946214B (zh) | 2016-08-17 |
US9422243B2 (en) | 2016-08-23 |
US20140336192A1 (en) | 2014-11-13 |
EA027800B1 (ru) | 2017-09-29 |
CA2856759A1 (en) | 2013-05-30 |
CL2014001323A1 (es) | 2014-09-05 |
JP2014533709A (ja) | 2014-12-15 |
JP6106182B2 (ja) | 2017-03-29 |
AU2012342562A1 (en) | 2014-07-10 |
IN2014CN04671A (es) | 2015-09-18 |
BR112014012031A2 (pt) | 2017-05-30 |
HK1200166A1 (en) | 2015-07-31 |
AU2012342562B2 (en) | 2017-02-23 |
KR20140097457A (ko) | 2014-08-06 |
WO2013076090A1 (en) | 2013-05-30 |
CN103946214A (zh) | 2014-07-23 |
ES2676068T3 (es) | 2018-07-16 |
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