MX369393B - Derivados de ftalazina. - Google Patents

Derivados de ftalazina.

Info

Publication number
MX369393B
MX369393B MX2015016760A MX2015016760A MX369393B MX 369393 B MX369393 B MX 369393B MX 2015016760 A MX2015016760 A MX 2015016760A MX 2015016760 A MX2015016760 A MX 2015016760A MX 369393 B MX369393 B MX 369393B
Authority
MX
Mexico
Prior art keywords
phthalazine derivatives
diseases
tankyrase
inflammation
inhibitors
Prior art date
Application number
MX2015016760A
Other languages
English (en)
Other versions
MX2015016760A (es
Inventor
Dorsch Dieter
Buchstaller Hans-Peter
Esdar Christina
Leuthner Birgitta
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2015016760A publication Critical patent/MX2015016760A/es
Publication of MX369393B publication Critical patent/MX369393B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Abstract

Los compuestos de la fórmula I en donde R1, X y n tienen los significados indicados en la reivindicación 1, son inhibidores de Tankirasa y se pueden emplear, inter alia, para el tratamiento de enfermedades tales como cáncer, enfermedades cardiovasculares, lesión del sistema nervioso central y diferentes formas de inflamación.
MX2015016760A 2013-06-24 2014-05-30 Derivados de ftalazina. MX369393B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003205 2013-06-24
PCT/EP2014/001467 WO2014206524A1 (en) 2013-06-24 2014-05-30 Phthalazine derivatives

Publications (2)

Publication Number Publication Date
MX2015016760A MX2015016760A (es) 2016-04-13
MX369393B true MX369393B (es) 2019-11-07

Family

ID=48698872

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016760A MX369393B (es) 2013-06-24 2014-05-30 Derivados de ftalazina.

Country Status (22)

Country Link
US (1) US9751842B2 (es)
EP (1) EP3013804B1 (es)
JP (1) JP6382964B2 (es)
KR (1) KR20160023854A (es)
CN (1) CN105339356B (es)
AR (1) AR096652A1 (es)
AU (1) AU2014301669B2 (es)
CA (1) CA2916557C (es)
DK (1) DK3013804T3 (es)
ES (1) ES2623704T3 (es)
HK (1) HK1221468A1 (es)
HR (1) HRP20170291T1 (es)
IL (1) IL243252A0 (es)
LT (1) LT3013804T (es)
MX (1) MX369393B (es)
PL (1) PL3013804T3 (es)
PT (1) PT3013804T (es)
RS (1) RS55943B1 (es)
RU (1) RU2663623C2 (es)
SG (1) SG11201510584WA (es)
SI (1) SI3013804T1 (es)
WO (1) WO2014206524A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466965A (en) 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
GB2384776C (en) * 2000-10-30 2006-02-03 Kudos Pharm Ltd Phthalazinone derivatives
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
EA014955B1 (ru) 2004-06-30 2011-04-29 Янссен Фармацевтика Н. В. Производные фталазина в качестве ингибиторов parp
CA2593005A1 (en) * 2005-01-03 2006-07-13 Myriad Genetics Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
JP2009286773A (ja) * 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類

Also Published As

Publication number Publication date
AR096652A1 (es) 2016-01-27
IL243252A0 (en) 2016-02-29
HRP20170291T1 (hr) 2017-04-21
US20160318876A1 (en) 2016-11-03
PT3013804T (pt) 2017-05-08
LT3013804T (lt) 2017-04-10
CN105339356B (zh) 2018-10-19
JP6382964B2 (ja) 2018-08-29
RU2016102057A (ru) 2017-07-28
AU2014301669A1 (en) 2016-02-11
WO2014206524A1 (en) 2014-12-31
MX2015016760A (es) 2016-04-13
SI3013804T1 (sl) 2017-05-31
RU2016102057A3 (es) 2018-03-16
CN105339356A (zh) 2016-02-17
HK1221468A1 (zh) 2017-06-02
EP3013804B1 (en) 2017-02-01
PL3013804T3 (pl) 2017-08-31
KR20160023854A (ko) 2016-03-03
DK3013804T3 (en) 2017-04-10
CA2916557C (en) 2021-08-03
CA2916557A1 (en) 2014-12-31
EP3013804A1 (en) 2016-05-04
RU2663623C2 (ru) 2018-08-07
AU2014301669B2 (en) 2018-03-01
SG11201510584WA (en) 2016-01-28
JP2016523272A (ja) 2016-08-08
RS55943B1 (sr) 2017-09-29
ES2623704T3 (es) 2017-07-12
US9751842B2 (en) 2017-09-05

Similar Documents

Publication Publication Date Title
MX362939B (es) Derivados de (aza-)isoquinolinona.
PH12014501829A1 (en) Bicyclic pyrazinone derivatives
MX357502B (es) Derivados de pirrolotriazinona.
MX2016001136A (es) Derivados de oxoquinazolinil-butanamida.
MX2020009780A (es) Compuestos de inhibidor de autotaxina.
MX362855B (es) Derivados de quinazolinona como inhidores poli (adp-ribosa) polimerasa (parp).
PH12014501581A1 (en) Tetrahydro-quinazolinone derivatives as tank and parp inhibitors
MX2016014436A (es) Derivados de heterociclil-butanamida.
MX2015017964A (es) Inhibidores de bromodominio.
MX2016002544A (es) Compuestos utiles como inmunomoduladores.
MX2016007801A (es) Pirimidopirimidinonas utiles como iniciadores de wee-1 cinasa.
PH12015502161A1 (en) Therapeutic compounds and compositions
MX2015014234A (es) Derivados 2-aminopirido-[4,3-d]pirimidin-5-ona y su uso como inhibidores de wee-1.
PH12016502291A1 (en) Indolizine derivatives as phosphoinositide 3-kinases inhibitors
MY181602A (en) Isochromene derivatives as phosphoinositide 3-kinases inhibitors
MX364859B (es) Derivados de imidazopirazinona.
MX2014012477A (es) Inhibidores pirrolopirazona de tanquirasa.
MX2016001134A (es) Derivados 1,3-disustituidos de ciclopentano.
MX2017013137A (es) Derivados de cromeno como inhibidores de las fosfoinositido-3-cina sas.
EA032271B9 (ru) Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний
MX2016001536A (es) Derivados de urea de piperidinas.
MX2018005515A (es) Derivados de 1,4-dicarbonil-piperidilo.
MX2015016760A (es) Derivados de ftalazina.
MX2016001934A (es) Derivados de ciclopentilamina 3-sustituidos.
PH12020500472A1 (en) Autotaxin inhibitor compounds

Legal Events

Date Code Title Description
FG Grant or registration