EA201300871A1 - ПРОИЗВОДНЫЕ (1,2,4)ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗ - Google Patents

ПРОИЗВОДНЫЕ (1,2,4)ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗ

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Publication number
EA201300871A1
EA201300871A1 EA201300871A EA201300871A EA201300871A1 EA 201300871 A1 EA201300871 A1 EA 201300871A1 EA 201300871 A EA201300871 A EA 201300871A EA 201300871 A EA201300871 A EA 201300871A EA 201300871 A1 EA201300871 A1 EA 201300871A1
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EA
Eurasian Patent Office
Prior art keywords
triazolo
inhibitors
derivatives
phosphodyesteres
chinoxaline
Prior art date
Application number
EA201300871A
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English (en)
Other versions
EA023792B1 (ru
Inventor
Ханс-Йоахим Ланкау
Барбара Ланген
Кристиан Грунвальд
Норберт Хёфген
Ханс Штанге
Рита Дост
Уте Эгерланд
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201300871A1 publication Critical patent/EA201300871A1/ru
Publication of EA023792B1 publication Critical patent/EA023792B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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Abstract

В заявке описаны производные (1,2,4)триазоло[4,3-a]хиноксалина, которые являются ингибиторами фосфодиэстеразы 2 и/или 10, применимые для лечения заболеваний центральной нервной системы.
EA201300871A 2011-01-31 2012-01-31 ПРОИЗВОДНЫЕ (1,2,4)ТРИАЗОЛО[4,3-а]ХИНОКСАЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗ EA023792B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437848P 2011-01-31 2011-01-31
PCT/EP2012/051546 WO2012104293A1 (en) 2011-01-31 2012-01-31 (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases

Publications (2)

Publication Number Publication Date
EA201300871A1 true EA201300871A1 (ru) 2014-01-30
EA023792B1 EA023792B1 (ru) 2016-07-29

Family

ID=45833359

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EA201300871A EA023792B1 (ru) 2011-01-31 2012-01-31 ПРОИЗВОДНЫЕ (1,2,4)ТРИАЗОЛО[4,3-а]ХИНОКСАЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗ

Country Status (24)

Country Link
US (1) US9540379B2 (ru)
EP (1) EP2670754B1 (ru)
JP (1) JP6027547B2 (ru)
KR (1) KR20140019342A (ru)
CN (1) CN103459395A (ru)
AR (1) AR085099A1 (ru)
AU (1) AU2012213471B2 (ru)
BR (1) BR112013019354A2 (ru)
CA (1) CA2824929A1 (ru)
CL (1) CL2013002003A1 (ru)
CO (1) CO6811848A2 (ru)
EA (1) EA023792B1 (ru)
EC (1) ECSP13012824A (ru)
GE (1) GEP20156333B (ru)
IL (1) IL226826A (ru)
MA (1) MA34844B1 (ru)
MX (1) MX2013008667A (ru)
PE (1) PE20141023A1 (ru)
SG (1) SG192210A1 (ru)
TN (1) TN2013000325A1 (ru)
TW (1) TWI535718B (ru)
UA (1) UA111963C2 (ru)
UY (1) UY33888A (ru)
WO (1) WO2012104293A1 (ru)

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CN104411312B (zh) 2012-06-26 2018-03-06 詹森药业有限公司 包括pde2抑制剂例如1‑芳基‑4‑甲基‑[1,2,4]三唑[4,3‑a]‑喹喔啉化合物和pde10抑制剂的用于在治疗神经病学障碍或代谢障碍中使用的组合
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EP2670754A1 (en) 2013-12-11
SG192210A1 (en) 2013-09-30
AU2012213471B2 (en) 2016-07-14
AR085099A1 (es) 2013-09-11
MA34844B1 (fr) 2014-01-02
TWI535718B (zh) 2016-06-01
JP6027547B2 (ja) 2016-11-16
EP2670754B1 (en) 2017-05-24
TW201245198A (en) 2012-11-16
TN2013000325A1 (en) 2015-01-20
CO6811848A2 (es) 2013-12-16
UA111963C2 (uk) 2016-07-11
CN103459395A (zh) 2013-12-18
KR20140019342A (ko) 2014-02-14
PE20141023A1 (es) 2014-09-04
CA2824929A1 (en) 2012-08-09
WO2012104293A1 (en) 2012-08-09
CL2013002003A1 (es) 2013-12-06
ECSP13012824A (es) 2013-10-31
JP2014503576A (ja) 2014-02-13
NZ611630A (en) 2015-03-27
US20120302564A1 (en) 2012-11-29
IL226826A (en) 2016-10-31
BR112013019354A2 (pt) 2019-09-24
US9540379B2 (en) 2017-01-10
EA023792B1 (ru) 2016-07-29
MX2013008667A (es) 2013-10-01
UY33888A (es) 2012-08-31
GEP20156333B (en) 2015-07-27
AU2012213471A1 (en) 2013-07-04

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