BR112013003864A2 - compostos de pirrolpirimidina e usos dos mesmos - Google Patents

compostos de pirrolpirimidina e usos dos mesmos

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Publication number
BR112013003864A2
BR112013003864A2 BR112013003864A BR112013003864A BR112013003864A2 BR 112013003864 A2 BR112013003864 A2 BR 112013003864A2 BR 112013003864 A BR112013003864 A BR 112013003864A BR 112013003864 A BR112013003864 A BR 112013003864A BR 112013003864 A2 BR112013003864 A2 BR 112013003864A2
Authority
BR
Brazil
Prior art keywords
pyrrolpyrimidine
compounds
diseases
relates
disorders
Prior art date
Application number
BR112013003864A
Other languages
English (en)
Other versions
BR112013003864B1 (pt
Inventor
Jianguo Ji
Jinshui Li
Wei Deng
Wei-Guo Su
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201010257786.7A external-priority patent/CN102372717B/zh
Priority claimed from PCT/CN2010/076187 external-priority patent/WO2012022045A1/en
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of BR112013003864A2 publication Critical patent/BR112013003864A2/pt
Publication of BR112013003864B1 publication Critical patent/BR112013003864B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

compostos de pirrolpirimidina e usos dos mesmos. a presente invenção refere-se a compostos de pirrolpirimidina da fórmula i capazes de inibir as quinases jak, em que r~1 ~, r~2 ~ e m são definidos na descrição. a invenção refere-se ainda às composições farmacêuticas contendo esses compostos de pirrolpirimidina, e o uso desses compostos de pirrolpirimidina no tratamento de distúrbios ou doenças, tais como doenças inflamatórias e câncer.
BR112013003864-0A 2010-08-20 2011-08-18 Compostos de pirrolpirimidina, composição e uso dos mesmos BR112013003864B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201010257786.7A CN102372717B (zh) 2010-08-20 2010-08-20 吡咯并嘧啶类化合物及其用途
CN2010102577867 2010-08-20
CNPCTCN2010076187 2010-08-20
PCT/CN2010/076187 WO2012022045A1 (en) 2010-08-20 2010-08-20 Pyrrolopyrimidine compounds and uses thereof
PCT/CN2011/078575 WO2012022265A1 (en) 2010-08-20 2011-08-18 Pyrrolopyrimidine compounds and uses thereof

Publications (2)

Publication Number Publication Date
BR112013003864A2 true BR112013003864A2 (pt) 2016-07-05
BR112013003864B1 BR112013003864B1 (pt) 2021-08-31

Family

ID=45604781

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013003864-0A BR112013003864B1 (pt) 2010-08-20 2011-08-18 Compostos de pirrolpirimidina, composição e uso dos mesmos

Country Status (14)

Country Link
US (3) US9346810B2 (pt)
EP (1) EP2606051B1 (pt)
JP (1) JP5749341B2 (pt)
KR (1) KR101541086B1 (pt)
CN (1) CN103119045B (pt)
AU (1) AU2011291185C1 (pt)
BR (1) BR112013003864B1 (pt)
CA (1) CA2808543C (pt)
HK (1) HK1179953A1 (pt)
MX (1) MX2013001970A (pt)
NZ (1) NZ606751A (pt)
RU (1) RU2563644C2 (pt)
SG (1) SG187742A1 (pt)
WO (1) WO2012022265A1 (pt)

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CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物
CN112262142B (zh) 2018-06-13 2023-11-14 泽农医药公司 苯磺酰胺化合物及其作为治疗剂的用途
CN112638879A (zh) 2018-08-31 2021-04-09 泽农医药公司 杂芳基取代的磺酰胺化合物及其作为治疗剂的用途
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Also Published As

Publication number Publication date
US20190060319A1 (en) 2019-02-28
EP2606051B1 (en) 2016-10-05
HK1179953A1 (zh) 2013-10-11
JP2013537542A (ja) 2013-10-03
JP5749341B2 (ja) 2015-07-15
EP2606051A4 (en) 2014-03-05
KR20130045398A (ko) 2013-05-03
CA2808543C (en) 2016-01-26
MX2013001970A (es) 2013-08-09
AU2011291185C1 (en) 2015-04-16
EP2606051A1 (en) 2013-06-26
US20130210831A1 (en) 2013-08-15
CA2808543A1 (en) 2012-02-23
WO2012022265A1 (en) 2012-02-23
US10369153B2 (en) 2019-08-06
US20160228443A1 (en) 2016-08-11
CN103119045B (zh) 2016-02-17
AU2011291185A1 (en) 2013-02-28
NZ606751A (en) 2015-04-24
SG187742A1 (en) 2013-03-28
US10111875B2 (en) 2018-10-30
RU2563644C2 (ru) 2015-09-20
KR101541086B1 (ko) 2015-08-03
RU2013104520A (ru) 2014-09-27
CN103119045A (zh) 2013-05-22
US9346810B2 (en) 2016-05-24
BR112013003864B1 (pt) 2021-08-31
AU2011291185B2 (en) 2014-11-27

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