HK1179953A1 - 吡咯並嘧啶化合物及其用途 - Google Patents

吡咯並嘧啶化合物及其用途

Info

Publication number
HK1179953A1
HK1179953A1 HK13107097.2A HK13107097A HK1179953A1 HK 1179953 A1 HK1179953 A1 HK 1179953A1 HK 13107097 A HK13107097 A HK 13107097A HK 1179953 A1 HK1179953 A1 HK 1179953A1
Authority
HK
Hong Kong
Prior art keywords
pyrrolopyrimidine compounds
pyrrolopyrimidine
compounds
Prior art date
Application number
HK13107097.2A
Other languages
English (en)
Inventor
Wei-Guo Su
Wei Deng
Jinshui Li
Jianguo Ji
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2010/076187 external-priority patent/WO2012022045A1/en
Priority claimed from CN201010257786.7A external-priority patent/CN102372717B/zh
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of HK1179953A1 publication Critical patent/HK1179953A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
HK13107097.2A 2010-08-20 2013-06-18 吡咯並嘧啶化合物及其用途 HK1179953A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2010/076187 WO2012022045A1 (en) 2010-08-20 2010-08-20 Pyrrolopyrimidine compounds and uses thereof
CN201010257786.7A CN102372717B (zh) 2010-08-20 2010-08-20 吡咯并嘧啶类化合物及其用途
PCT/CN2011/078575 WO2012022265A1 (en) 2010-08-20 2011-08-18 Pyrrolopyrimidine compounds and uses thereof

Publications (1)

Publication Number Publication Date
HK1179953A1 true HK1179953A1 (zh) 2013-10-11

Family

ID=45604781

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13107097.2A HK1179953A1 (zh) 2010-08-20 2013-06-18 吡咯並嘧啶化合物及其用途

Country Status (14)

Country Link
US (3) US9346810B2 (zh)
EP (1) EP2606051B1 (zh)
JP (1) JP5749341B2 (zh)
KR (1) KR101541086B1 (zh)
CN (1) CN103119045B (zh)
AU (1) AU2011291185C1 (zh)
BR (1) BR112013003864B1 (zh)
CA (1) CA2808543C (zh)
HK (1) HK1179953A1 (zh)
MX (1) MX2013001970A (zh)
NZ (1) NZ606751A (zh)
RU (1) RU2563644C2 (zh)
SG (1) SG187742A1 (zh)
WO (1) WO2012022265A1 (zh)

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JP6919977B2 (ja) 2016-03-16 2021-08-18 クラ オンコロジー，インク． メニン−ｍｌｌの置換された阻害剤及びその使用方法
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SG10201912372XA (en) 2016-12-09 2020-02-27 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
EP3601249A4 (en) 2017-03-24 2020-12-16 Kura Oncology, Inc. METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA
WO2018189335A1 (en) 2017-04-13 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
WO2018226976A1 (en) 2017-06-08 2018-12-13 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
JP7216705B2 (ja) 2017-07-28 2023-02-02 ニンバス ラクシュミ， インコーポレイテッド Ｔｙｋ２阻害剤およびその使用方法
CN109422751B (zh) * 2017-09-03 2022-04-22 上海美志医药科技有限公司 一类具有降解酪氨酸蛋白激酶jak3活性的化合物
US11649251B2 (en) 2017-09-20 2023-05-16 Kura Oncology, Inc. Substituted inhibitors of menin-MLL and methods of use
NZ762985A (en) 2017-09-22 2024-03-22 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
HUE061607T2 (hu) 2017-10-18 2023-07-28 Jubilant Epipad LLC Imidazopiridin vegyületek mint PAD inhibitorok
CN111386265A (zh) 2017-11-06 2020-07-07 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
EP3704120B1 (en) 2017-11-24 2024-03-06 Jubilant Episcribe LLC Heterocyclic compounds as prmt5 inhibitors
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PE20211389A1 (es) 2018-06-13 2021-07-27 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y su uso como agentes terapeuticos
PE20211066A1 (es) 2018-08-31 2021-06-09 Xenon Pharmaceuticals Inc Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos
JP7383012B2 (ja) * 2018-08-31 2023-11-17 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN113194956A (zh) 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 用于癌症治疗的cxcr7抑制剂
CN110538183B (zh) * 2019-10-09 2021-05-04 吉林大学 一种预防和治疗小儿湿疹的组合物及其制备方法
WO2022194782A1 (en) * 2021-03-15 2022-09-22 Chiesi Farmaceutici S.P.A. Heterocyclic derivatives as janus kinase inhibitors
JP7023026B1 (ja) 2021-05-18 2022-02-21 株式会社アイビー化粧品 Ｊａｋ阻害剤
WO2022242768A1 (zh) * 2021-05-21 2022-11-24 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物的应用
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Also Published As

Publication number Publication date
JP5749341B2 (ja) 2015-07-15
BR112013003864B1 (pt) 2021-08-31
US20160228443A1 (en) 2016-08-11
JP2013537542A (ja) 2013-10-03
US10111875B2 (en) 2018-10-30
US20190060319A1 (en) 2019-02-28
RU2013104520A (ru) 2014-09-27
NZ606751A (en) 2015-04-24
KR20130045398A (ko) 2013-05-03
WO2012022265A1 (en) 2012-02-23
CA2808543C (en) 2016-01-26
CA2808543A1 (en) 2012-02-23
SG187742A1 (en) 2013-03-28
EP2606051A4 (en) 2014-03-05
US10369153B2 (en) 2019-08-06
AU2011291185B2 (en) 2014-11-27
AU2011291185A1 (en) 2013-02-28
CN103119045A (zh) 2013-05-22
CN103119045B (zh) 2016-02-17
US20130210831A1 (en) 2013-08-15
AU2011291185C1 (en) 2015-04-16
EP2606051A1 (en) 2013-06-26
MX2013001970A (es) 2013-08-09
KR101541086B1 (ko) 2015-08-03
BR112013003864A2 (pt) 2016-07-05
EP2606051B1 (en) 2016-10-05
US9346810B2 (en) 2016-05-24
RU2563644C2 (ru) 2015-09-20

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220818