PE20211066A1 - Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos - Google Patents

Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos

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Publication number
PE20211066A1
PE20211066A1 PE2021000164A PE2021000164A PE20211066A1 PE 20211066 A1 PE20211066 A1 PE 20211066A1 PE 2021000164 A PE2021000164 A PE 2021000164A PE 2021000164 A PE2021000164 A PE 2021000164A PE 20211066 A1 PE20211066 A1 PE 20211066A1
Authority
PE
Peru
Prior art keywords
diyl
heteroaryl
therapeutic agents
thiophen
pyridine
Prior art date
Application number
PE2021000164A
Other languages
English (en)
Inventor
Thilo Focken
Jean-Christophe Andrez
Kristen Nicole Burford
Christoph Martin Dehnhardt
Michael Edward Grimwood
Qi Jia
Verner Alexander Lofstrand
Michael Scott Wilson
Alla Yurevna Zenova
Steven Sigmund Wesolowski
Shaoyi Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of PE20211066A1 publication Critical patent/PE20211066A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invencion esta dirigida a compuestos de bencenosulfonamida sustituidos con heteroarilo de formula (I), sus estereoisomeros, enantiomeros, tautomeros de los mismos o mezclas de los mismos; donde A es piridin-2,5 diil, tiofen-2,5 diil, imidazo[1,2-a]piridina-5,8-diil, tiofen-3,5 diil, entre otros; cada uno, sustituido independientemente con (R5)n o (R6)n; n es 1 o 2; R2 es N-heteroarilo de 5 o 6 miembros, cada uno opcionalmente sustituido; R3 y R4 son cada uno independientemente hidrogeno o alquilo; cada R5 y R6 es independientemente hidrogeno, alquilo, halo, haloalquilo, cicloalquilo opcionalmente sustituido, ciano o -OR7. Un compuesto seleccionado es (S)-5-cloro-6-((1-(5-cloro-2-fluorofenil)etil)amino)-N-(tiazol-4-il)piridina-3-sulfonamida. Tambien refiere a una composicion farmaceutica que los comprenden, siendo utiles para el tratamiento de enfermedades o afecciones asociadas con canales de sodio dependientes de voltaje, particularmente, con la actividad de NaV1.6, tales como epilepsia y/o trastornos de ataques epilepticos
PE2021000164A 2018-08-31 2019-08-29 Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos PE20211066A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862725956P 2018-08-31 2018-08-31
PCT/US2019/048917 WO2020047323A1 (en) 2018-08-31 2019-08-29 Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
PE20211066A1 true PE20211066A1 (es) 2021-06-09

Family

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Family Applications (1)

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PE2021000164A PE20211066A1 (es) 2018-08-31 2019-08-29 Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos

Country Status (25)

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US (2) US10981905B2 (es)
EP (1) EP3844150A1 (es)
JP (1) JP7450606B2 (es)
KR (1) KR20210054510A (es)
CN (1) CN112638879A (es)
AU (1) AU2019331005B2 (es)
BR (1) BR112021000209A2 (es)
CA (1) CA3110853A1 (es)
CL (1) CL2021000443A1 (es)
CO (1) CO2021001433A2 (es)
CR (1) CR20210099A (es)
DO (1) DOP2021000031A (es)
EA (1) EA202190395A1 (es)
EC (1) ECSP21013035A (es)
IL (1) IL279810A (es)
JO (1) JOP20200337A1 (es)
MA (1) MA53489A (es)
MX (1) MX2021001380A (es)
NI (1) NI202100013A (es)
PE (1) PE20211066A1 (es)
PH (1) PH12021550381A1 (es)
SG (1) SG11202100109TA (es)
TW (1) TW202115018A (es)
WO (1) WO2020047323A1 (es)
ZA (1) ZA202100593B (es)

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JP7450606B2 (ja) 2024-03-15
CR20210099A (es) 2021-06-24
US11639351B2 (en) 2023-05-02
AU2019331005B2 (en) 2024-03-28
US20200157089A1 (en) 2020-05-21
EA202190395A1 (ru) 2021-06-15
IL279810A (en) 2021-03-01
TW202115018A (zh) 2021-04-16
CL2021000443A1 (es) 2021-07-02
DOP2021000031A (es) 2021-03-31
EP3844150A1 (en) 2021-07-07
US20220348570A1 (en) 2022-11-03
AU2019331005A1 (en) 2021-02-18
MA53489A (fr) 2021-12-08
CA3110853A1 (en) 2020-03-05
CN112638879A (zh) 2021-04-09
ECSP21013035A (es) 2021-03-31
JP2021535134A (ja) 2021-12-16
SG11202100109TA (en) 2021-02-25
BR112021000209A2 (pt) 2021-08-24
NI202100013A (es) 2021-06-22
WO2020047323A1 (en) 2020-03-05
CO2021001433A2 (es) 2021-05-10
MX2021001380A (es) 2021-05-27
ZA202100593B (en) 2023-10-25
KR20210054510A (ko) 2021-05-13
US10981905B2 (en) 2021-04-20
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