BR112015015468B8 - Composto, e, composição farmacêutica - Google Patents

Composto, e, composição farmacêutica

Info

Publication number
BR112015015468B8
BR112015015468B8 BR112015015468A BR112015015468A BR112015015468B8 BR 112015015468 B8 BR112015015468 B8 BR 112015015468B8 BR 112015015468 A BR112015015468 A BR 112015015468A BR 112015015468 A BR112015015468 A BR 112015015468A BR 112015015468 B8 BR112015015468 B8 BR 112015015468B8
Authority
BR
Brazil
Prior art keywords
compound
compounds
pharmaceutical composition
receptor antagonists
pharmaceutical compositions
Prior art date
Application number
BR112015015468A
Other languages
English (en)
Other versions
BR112015015468B1 (pt
BR112015015468A2 (pt
Inventor
Boyce Christopher
Huang Xianhai
Ali Amjad
Man-Chu Lo Michael
Lim YeonHee
Stamford Andrew
Kuang Rongze
Tempest Paul
Yu Younong
J Henderson Timothy
Kim Jae-Hun
Ting Pauline
Zheng Junying
Metzger Edward
Zorn Nicolas
Xiao Dong
V Gallo Gioconda
Won Walter
Wu Heping
Deng Qiaolin
Original Assignee
Merck Sharp & Dohme
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme
Publication of BR112015015468A2 publication Critical patent/BR112015015468A2/pt
Publication of BR112015015468B1 publication Critical patent/BR112015015468B1/pt
Publication of BR112015015468B8 publication Critical patent/BR112015015468B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

COMPOSTO, E, COMPOSIÇÃO FARMACÊUTICA. São descritos compostos da Fórmula G1 (estruturalmente representados): onde "RG3", "Rd1" a "Rd4", "n", "m", "p", "W", "X", "Y" e "Z" são aqui definidos, compostos estes que são antagonistas do receptor de A2A. Também são aqui descritos os usos dos compostos aqui descritos como antagonistas do receptor de A2a no tratamento ou prevenção potenciais de distúrbios e doenças neurológicas em que os receptores de A2A estão envolvidos. Também são aqui descritas composições farmacêuticas compreendendo estes compostos e usos destas composições farmacêuticas.
BR112015015468A 2012-12-28 2013-12-20 Composto, e, composição farmacêutica BR112015015468B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/087865 2012-12-28
PCT/CN2012/087865 WO2014101120A1 (en) 2012-12-28 2012-12-28 Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
PCT/CN2013/076853 WO2014101373A1 (en) 2012-12-28 2013-06-06 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds for treatment of central nervous system disorder
CNPCT/CN2013/076853 2013-06-06
PCT/US2013/076781 WO2014105666A1 (en) 2012-12-28 2013-12-20 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties

Publications (3)

Publication Number Publication Date
BR112015015468A2 BR112015015468A2 (pt) 2017-07-11
BR112015015468B1 BR112015015468B1 (pt) 2021-10-26
BR112015015468B8 true BR112015015468B8 (pt) 2023-04-25

Family

ID=51019745

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015015468A BR112015015468B8 (pt) 2012-12-28 2013-12-20 Composto, e, composição farmacêutica

Country Status (22)

Country Link
US (2) US9708347B2 (pt)
EP (1) EP2945632B1 (pt)
JP (1) JP6306049B2 (pt)
KR (1) KR102165113B1 (pt)
AU (1) AU2013370977B2 (pt)
BR (1) BR112015015468B8 (pt)
CA (1) CA2896056C (pt)
CY (1) CY1120258T1 (pt)
DK (1) DK2945632T3 (pt)
ES (1) ES2667477T3 (pt)
HR (1) HRP20180678T1 (pt)
HU (1) HUE037950T2 (pt)
LT (1) LT2945632T (pt)
ME (1) ME03034B (pt)
MX (1) MX370017B (pt)
NO (1) NO2945632T3 (pt)
PL (1) PL2945632T3 (pt)
PT (1) PT2945632T (pt)
RS (1) RS57162B1 (pt)
RU (2) RU2018136104A (pt)
SI (1) SI2945632T1 (pt)
WO (3) WO2014101120A1 (pt)

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US10568882B2 (en) 2015-08-21 2020-02-25 Srx Cardio, Llc Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators and their use
WO2017034990A1 (en) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity
EP3394061B1 (en) 2015-12-23 2020-03-11 Merck Sharp & Dohme Corp. 6,7-dihydro-5h-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017107087A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017147328A1 (en) 2016-02-23 2017-08-31 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
CN108884061B (zh) 2017-01-13 2021-11-16 江苏恒瑞医药股份有限公司 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
CN110382499B (zh) 2017-02-27 2023-01-03 贝达药业股份有限公司 Fgfr抑制剂及其应用
WO2018166493A1 (zh) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
RU2748993C1 (ru) * 2017-09-28 2021-06-02 СиСТОУН ФАРМАСЬЮТИКАЛС (СУЧЖОУ) КО., ЛТД. Производное с конденсированным кольцом в качестве ингибитора рецептора a2a
EP3723754A4 (en) 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
JP2021512959A (ja) 2018-02-06 2021-05-20 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Ｊｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． ピラゾロ［１，５−ａ］［１，３，５］トリアジン−２−アミン誘導体、その製造法、およびその医薬用途
MA54298A (fr) 2018-11-30 2022-03-09 Merck Sharp & Dohme Dérivés amino triazolo quinazoline 9-substitués utiles en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
EP3785734B1 (en) 2019-03-26 2023-04-12 Novel Pharma Inc. Long-acting fatty acid-binding gnrh derivative and pharmaceutical composition comprising same
TW202142538A (zh) 2020-02-07 2021-11-16 美商迦舒布魯姆生物有限公司 雜環ｇｌｐ－１促效劑
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers

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Also Published As

Publication number Publication date
DK2945632T3 (en) 2018-05-22
RS57162B1 (sr) 2018-07-31
BR112015015468B1 (pt) 2021-10-26
KR102165113B1 (ko) 2020-10-13
US20170197991A1 (en) 2017-07-13
CA2896056A1 (en) 2014-07-03
MX370017B (es) 2019-11-28
EP2945632A4 (en) 2016-09-14
KR20150100879A (ko) 2015-09-02
US20150361098A1 (en) 2015-12-17
RU2015131148A (ru) 2017-02-03
US10011615B2 (en) 2018-07-03
EP2945632A1 (en) 2015-11-25
BR112015015468A2 (pt) 2017-07-11
SI2945632T1 (en) 2018-05-31
CY1120258T1 (el) 2019-07-10
WO2014101373A1 (en) 2014-07-03
ES2667477T3 (es) 2018-05-11
NO2945632T3 (pt) 2018-08-04
LT2945632T (lt) 2018-05-25
RU2671628C2 (ru) 2018-11-06
JP6306049B2 (ja) 2018-04-04
ME03034B (me) 2018-10-20
MX2015008481A (es) 2015-09-23
CA2896056C (en) 2020-11-10
AU2013370977A1 (en) 2015-07-09
HRP20180678T1 (hr) 2018-06-01
WO2014101120A1 (en) 2014-07-03
AU2013370977B2 (en) 2017-12-14
PT2945632T (pt) 2018-05-22
US9708347B2 (en) 2017-07-18
PL2945632T3 (pl) 2018-07-31
EP2945632B1 (en) 2018-03-07
RU2018136104A3 (pt) 2022-04-05
JP2016504363A (ja) 2016-02-12
RU2018136104A (ru) 2018-11-21
WO2014105666A1 (en) 2014-07-03
HUE037950T2 (hu) 2018-09-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2013, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: MERCK SHARP AND DOHME LLC (US)