PL1622912T3 - 2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2A - Google Patents
2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2AInfo
- Publication number
- PL1622912T3 PL1622912T3 PL04760128T PL04760128T PL1622912T3 PL 1622912 T3 PL1622912 T3 PL 1622912T3 PL 04760128 T PL04760128 T PL 04760128T PL 04760128 T PL04760128 T PL 04760128T PL 1622912 T3 PL1622912 T3 PL 1622912T3
- Authority
- PL
- Poland
- Prior art keywords
- triazolo
- pyrazolo
- alkynyl
- alkenyl
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46484003P | 2003-04-23 | 2003-04-23 | |
EP04760128A EP1622912B1 (en) | 2003-04-23 | 2004-04-21 | 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e ] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists |
PCT/US2004/012471 WO2004094431A2 (en) | 2003-04-23 | 2004-04-21 | 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1622912T3 true PL1622912T3 (pl) | 2009-11-30 |
Family
ID=33310963
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04760128T PL1622912T3 (pl) | 2003-04-23 | 2004-04-21 | 2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2A |
PL378867A PL378867A1 (pl) | 2003-04-23 | 2004-04-21 | 2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D> |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL378867A PL378867A1 (pl) | 2003-04-23 | 2004-04-21 | 2-alkinylo- i 2-alkenylo-pirazolo- [4,3-e] -1,2,4-triazolo- [1,5-c]-pirymidynowi antagoniści receptora adenozynowego A <v>2a<D> |
Country Status (32)
Country | Link |
---|---|
US (2) | US6897217B2 (pl) |
EP (1) | EP1622912B1 (pl) |
JP (2) | JP4527712B2 (pl) |
KR (1) | KR100831107B1 (pl) |
CN (1) | CN100503609C (pl) |
AR (1) | AR044041A1 (pl) |
AT (1) | ATE432282T1 (pl) |
AU (1) | AU2004233334B2 (pl) |
BR (1) | BRPI0409787B8 (pl) |
CA (1) | CA2522813C (pl) |
CL (1) | CL2004000847A1 (pl) |
CO (1) | CO5700766A2 (pl) |
CY (1) | CY1109263T1 (pl) |
DE (1) | DE602004021250D1 (pl) |
DK (1) | DK1622912T3 (pl) |
EC (1) | ECSP056115A (pl) |
ES (1) | ES2326270T3 (pl) |
HK (1) | HK1085466A1 (pl) |
HR (1) | HRP20090394T1 (pl) |
IL (1) | IL171567A (pl) |
MX (1) | MXPA05011366A (pl) |
MY (1) | MY139344A (pl) |
NO (1) | NO332182B1 (pl) |
NZ (1) | NZ542823A (pl) |
PE (1) | PE20050141A1 (pl) |
PL (2) | PL1622912T3 (pl) |
PT (1) | PT1622912E (pl) |
RU (1) | RU2373210C2 (pl) |
SI (1) | SI1622912T1 (pl) |
TW (2) | TWI355381B (pl) |
WO (1) | WO2004094431A2 (pl) |
ZA (1) | ZA200508489B (pl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7313588B1 (en) * | 2000-07-13 | 2007-12-25 | Biap Systems, Inc. | Locally executing software agent for retrieving remote content and method for creation and use of the agent |
MXPA04005209A (es) * | 2001-11-30 | 2004-08-19 | Schering Corp | Antagonistas del receptor de adenosina a2a. |
EP2269596A3 (en) | 2002-12-19 | 2011-09-14 | Schering Corporation | Use of adenosine A2a receptor antagonists for the treatment of extrapyramidal syndrome and other movement disorders |
US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
RU2373210C2 (ru) * | 2003-04-23 | 2009-11-20 | Шеринг Корпорейшн | 2-АЛКИНИЛ- И 2-АЛКЕНИЛ-ПИРАЗОЛ-[4,3-e]-1, 2, 4-ТРИАЗОЛО-[1,5-c]-ПИРИМИДИНОВЫЕ АНТАГОНИСТЫ A2A РЕЦЕПТОРА АДЕНОЗИНА |
DE602005020127D1 (de) * | 2004-04-21 | 2010-05-06 | Schering Corp | Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
EP2258372B8 (en) * | 2005-06-07 | 2012-12-19 | Kyowa Hakko Kirin Co., Ltd. | A2A antagonists for use in the treatment of motor disorders |
EP1934227B1 (en) * | 2005-09-19 | 2011-12-21 | Schering Corporation | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
PE20070521A1 (es) * | 2005-09-23 | 2007-07-13 | Schering Corp | 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a |
ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
US7723343B2 (en) * | 2007-03-30 | 2010-05-25 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2A receptor antagonists |
CA2717172A1 (en) * | 2008-03-04 | 2009-09-11 | Schering Corporation | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists |
US8512594B2 (en) * | 2008-08-25 | 2013-08-20 | Air Products And Chemicals, Inc. | Curing agent of N,N′-dimethyl-meta-xylylenediamine and multifunctional amin(s) |
US8501997B2 (en) * | 2008-08-25 | 2013-08-06 | Air Products And Chemicals, Inc. | Curing agent for low temperature cure applications |
ES2487616T3 (es) | 2009-03-10 | 2014-08-22 | Takeda Pharmaceutical Company Limited | Derivados de benzofurano |
WO2011017299A2 (en) * | 2009-08-07 | 2011-02-10 | Schering Corporation | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE |
US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
JP6298765B2 (ja) * | 2011-12-27 | 2018-03-20 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 脳卒中の治療または予防に使用されるするためのフェニルカルバメート化合物 |
WO2014101120A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
PT2970255T (pt) * | 2013-03-14 | 2017-09-05 | Galapagos Nv | Compostos e as suas composições farmacêuticas para o tratamento de doenças inflamatórias |
EP3723754A4 (en) | 2017-12-13 | 2021-05-19 | Merck Sharp & Dohme Corp. | IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES |
WO2021011670A1 (en) * | 2019-07-17 | 2021-01-21 | Teon Therapeutics, Inc. | Adenosine a2a receptor antagonists and uses thereof |
CN115160120A (zh) * | 2022-08-02 | 2022-10-11 | 乐威医药(江苏)股份有限公司 | 一种多烷氧基芳香酮的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US785906A (en) * | 1904-12-06 | 1905-03-28 | Albert P Mcbride | Casing packer and shoe for gas or oil wells. |
IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
AU7237294A (en) | 1993-07-27 | 1995-02-28 | Kyowa Hakko Kogyo Co. Ltd. | Remedy for parkinson's disease |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
DE19826843A1 (de) * | 1998-06-16 | 1999-12-23 | Boehringer Ingelheim Pharma | Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
PT1283839E (pt) * | 2000-05-26 | 2005-08-31 | Schering Corp | Antagonistas do receptor a2a da adenosina |
GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
CN1491227A (zh) * | 2001-02-05 | 2004-04-21 | 株式会社大V制药工厂 | 三唑并喹唑啉和吡唑并三唑并嘧啶衍生物、医药组合物、腺苷 a 3受体亲和剂、降眼压剂、预防和治疗青光眼的制剂及降低眼压的方法 |
JP4545437B2 (ja) | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンa2a受容体アンタゴニストとしてのイミダゾ(4,3−e)−1,2,4−トリアゾロ(1,5−c)ピリミジン |
EP2269596A3 (en) * | 2002-12-19 | 2011-09-14 | Schering Corporation | Use of adenosine A2a receptor antagonists for the treatment of extrapyramidal syndrome and other movement disorders |
RU2373210C2 (ru) * | 2003-04-23 | 2009-11-20 | Шеринг Корпорейшн | 2-АЛКИНИЛ- И 2-АЛКЕНИЛ-ПИРАЗОЛ-[4,3-e]-1, 2, 4-ТРИАЗОЛО-[1,5-c]-ПИРИМИДИНОВЫЕ АНТАГОНИСТЫ A2A РЕЦЕПТОРА АДЕНОЗИНА |
-
2004
- 2004-04-21 RU RU2005136166/04A patent/RU2373210C2/ru not_active IP Right Cessation
- 2004-04-21 AU AU2004233334A patent/AU2004233334B2/en not_active Ceased
- 2004-04-21 CL CL200400847A patent/CL2004000847A1/es unknown
- 2004-04-21 EP EP04760128A patent/EP1622912B1/en not_active Expired - Lifetime
- 2004-04-21 DE DE602004021250T patent/DE602004021250D1/de not_active Expired - Lifetime
- 2004-04-21 PE PE2004000392A patent/PE20050141A1/es not_active Application Discontinuation
- 2004-04-21 TW TW093111142A patent/TWI355381B/zh not_active IP Right Cessation
- 2004-04-21 KR KR1020057019891A patent/KR100831107B1/ko active IP Right Grant
- 2004-04-21 WO PCT/US2004/012471 patent/WO2004094431A2/en active Application Filing
- 2004-04-21 AT AT04760128T patent/ATE432282T1/de active
- 2004-04-21 CA CA002522813A patent/CA2522813C/en not_active Expired - Fee Related
- 2004-04-21 ES ES04760128T patent/ES2326270T3/es not_active Expired - Lifetime
- 2004-04-21 NZ NZ542823A patent/NZ542823A/en not_active IP Right Cessation
- 2004-04-21 TW TW100131963A patent/TWI375677B/zh not_active IP Right Cessation
- 2004-04-21 PT PT04760128T patent/PT1622912E/pt unknown
- 2004-04-21 AR ARP040101344A patent/AR044041A1/es not_active Application Discontinuation
- 2004-04-21 SI SI200431189T patent/SI1622912T1/sl unknown
- 2004-04-21 JP JP2006501291A patent/JP4527712B2/ja not_active Expired - Fee Related
- 2004-04-21 MY MYPI20041463A patent/MY139344A/en unknown
- 2004-04-21 PL PL04760128T patent/PL1622912T3/pl unknown
- 2004-04-21 CN CNB2004800107535A patent/CN100503609C/zh not_active Expired - Fee Related
- 2004-04-21 BR BRPI0409787-4 patent/BRPI0409787B8/pt not_active IP Right Cessation
- 2004-04-21 US US10/829,416 patent/US6897217B2/en not_active Expired - Lifetime
- 2004-04-21 PL PL378867A patent/PL378867A1/pl unknown
- 2004-04-21 MX MXPA05011366A patent/MXPA05011366A/es active IP Right Grant
- 2004-04-21 DK DK04760128T patent/DK1622912T3/da active
-
2005
- 2005-05-23 US US11/135,261 patent/US7368449B2/en not_active Expired - Lifetime
- 2005-10-19 ZA ZA200508489A patent/ZA200508489B/en unknown
- 2005-10-21 CO CO05107374A patent/CO5700766A2/es active IP Right Grant
- 2005-10-21 EC EC2005006115A patent/ECSP056115A/es unknown
- 2005-10-26 IL IL171567A patent/IL171567A/en active IP Right Grant
- 2005-11-22 NO NO20055510A patent/NO332182B1/no not_active IP Right Cessation
-
2006
- 2006-03-21 HK HK06103531.4A patent/HK1085466A1/xx not_active IP Right Cessation
-
2009
- 2009-07-10 HR HR20090394T patent/HRP20090394T1/xx unknown
- 2009-08-04 CY CY20091100821T patent/CY1109263T1/el unknown
- 2009-11-04 JP JP2009253549A patent/JP2010059178A/ja not_active Withdrawn
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