DE602004021250D1 - 2-alkinyl- und 2-alkenyl-pyrazolo-ä4,3-eü -1,2,4-triazolo-ä1,5-cü -pyrimidinadenosin a2a rezeptorantagonisten - Google Patents

2-alkinyl- und 2-alkenyl-pyrazolo-ä4,3-eü -1,2,4-triazolo-ä1,5-cü -pyrimidinadenosin a2a rezeptorantagonisten

Info

Publication number
DE602004021250D1
DE602004021250D1 DE602004021250T DE602004021250T DE602004021250D1 DE 602004021250 D1 DE602004021250 D1 DE 602004021250D1 DE 602004021250 T DE602004021250 T DE 602004021250T DE 602004021250 T DE602004021250 T DE 602004021250T DE 602004021250 D1 DE602004021250 D1 DE 602004021250D1
Authority
DE
Germany
Prior art keywords
pyrimidinadenosine
alkinyl
triazolo
pyrazolo
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004021250T
Other languages
English (en)
Inventor
Bernard R Neustadt
Jinsong Hao
Hong Liu
Craig D Boyle
Samuel Chackalamannil
Unmesh G Shah
Andrew Stamford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE602004021250D1 publication Critical patent/DE602004021250D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE602004021250T 2003-04-23 2004-04-21 2-alkinyl- und 2-alkenyl-pyrazolo-ä4,3-eü -1,2,4-triazolo-ä1,5-cü -pyrimidinadenosin a2a rezeptorantagonisten Expired - Lifetime DE602004021250D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46484003P 2003-04-23 2003-04-23
PCT/US2004/012471 WO2004094431A2 (en) 2003-04-23 2004-04-21 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists

Publications (1)

Publication Number Publication Date
DE602004021250D1 true DE602004021250D1 (de) 2009-07-09

Family

ID=33310963

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004021250T Expired - Lifetime DE602004021250D1 (de) 2003-04-23 2004-04-21 2-alkinyl- und 2-alkenyl-pyrazolo-ä4,3-eü -1,2,4-triazolo-ä1,5-cü -pyrimidinadenosin a2a rezeptorantagonisten

Country Status (32)

Country Link
US (2) US6897217B2 (de)
EP (1) EP1622912B1 (de)
JP (2) JP4527712B2 (de)
KR (1) KR100831107B1 (de)
CN (1) CN100503609C (de)
AR (1) AR044041A1 (de)
AT (1) ATE432282T1 (de)
AU (1) AU2004233334B2 (de)
BR (1) BRPI0409787B8 (de)
CA (1) CA2522813C (de)
CL (1) CL2004000847A1 (de)
CO (1) CO5700766A2 (de)
CY (1) CY1109263T1 (de)
DE (1) DE602004021250D1 (de)
DK (1) DK1622912T3 (de)
EC (1) ECSP056115A (de)
ES (1) ES2326270T3 (de)
HK (1) HK1085466A1 (de)
HR (1) HRP20090394T1 (de)
IL (1) IL171567A (de)
MX (1) MXPA05011366A (de)
MY (1) MY139344A (de)
NO (1) NO332182B1 (de)
NZ (1) NZ542823A (de)
PE (1) PE20050141A1 (de)
PL (2) PL1622912T3 (de)
PT (1) PT1622912E (de)
RU (1) RU2373210C2 (de)
SI (1) SI1622912T1 (de)
TW (2) TWI355381B (de)
WO (1) WO2004094431A2 (de)
ZA (1) ZA200508489B (de)

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US7313588B1 (en) * 2000-07-13 2007-12-25 Biap Systems, Inc. Locally executing software agent for retrieving remote content and method for creation and use of the agent
MXPA04005209A (es) * 2001-11-30 2004-08-19 Schering Corp Antagonistas del receptor de adenosina a2a.
EP2269596A3 (de) 2002-12-19 2011-09-14 Schering Corporation Verwendungen von A2a-Rezeptor-Antagonisten zur Behandlung des extrapyramidalen Syndroms und weiteren Bewegungsstörungen
US20060128694A1 (en) * 2002-12-19 2006-06-15 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
RU2373210C2 (ru) * 2003-04-23 2009-11-20 Шеринг Корпорейшн 2-АЛКИНИЛ- И 2-АЛКЕНИЛ-ПИРАЗОЛ-[4,3-e]-1, 2, 4-ТРИАЗОЛО-[1,5-c]-ПИРИМИДИНОВЫЕ АНТАГОНИСТЫ A2A РЕЦЕПТОРА АДЕНОЗИНА
DE602005020127D1 (de) * 2004-04-21 2010-05-06 Schering Corp Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
EP2258372B8 (de) * 2005-06-07 2012-12-19 Kyowa Hakko Kirin Co., Ltd. A2A Antagonisten zur Behandlung von motorischen Störungen
EP1934227B1 (de) * 2005-09-19 2011-12-21 Schering Corporation 2-HETEROARYLPYRAZOLO[4,3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE ALS ANTAGONISTEN DES ADENOSIN-A2a-REZEPTORS
PE20070521A1 (es) * 2005-09-23 2007-07-13 Schering Corp 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US7723343B2 (en) * 2007-03-30 2010-05-25 King Pharmaceuticals Research And Development, Inc. Adenosine A2A receptor antagonists
CA2717172A1 (en) * 2008-03-04 2009-09-11 Schering Corporation 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists
US8512594B2 (en) * 2008-08-25 2013-08-20 Air Products And Chemicals, Inc. Curing agent of N,N′-dimethyl-meta-xylylenediamine and multifunctional amin(s)
US8501997B2 (en) * 2008-08-25 2013-08-06 Air Products And Chemicals, Inc. Curing agent for low temperature cure applications
ES2487616T3 (es) 2009-03-10 2014-08-22 Takeda Pharmaceutical Company Limited Derivados de benzofurano
WO2011017299A2 (en) * 2009-08-07 2011-02-10 Schering Corporation PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
JP6298765B2 (ja) * 2011-12-27 2018-03-20 バイオ−ファーム ソリューションズ カンパニー リミテッド 脳卒中の治療または予防に使用されるするためのフェニルカルバメート化合物
WO2014101120A1 (en) * 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
PT2970255T (pt) * 2013-03-14 2017-09-05 Galapagos Nv Compostos e as suas composições farmacêuticas para o tratamento de doenças inflamatórias
EP3723754A4 (de) 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. Imidazo[1,2-c]chinazolin-5-amin-verbindungen mit eigenschaften von a2a-antagonist
WO2021011670A1 (en) * 2019-07-17 2021-01-21 Teon Therapeutics, Inc. Adenosine a2a receptor antagonists and uses thereof
CN115160120A (zh) * 2022-08-02 2022-10-11 乐威医药（江苏）股份有限公司 一种多烷氧基芳香酮的合成方法

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US785906A (en) * 1904-12-06 1905-03-28 Albert P Mcbride Casing packer and shoe for gas or oil wells.
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
AU7237294A (en) 1993-07-27 1995-02-28 Kyowa Hakko Kogyo Co. Ltd. Remedy for parkinson's disease
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
DE19826843A1 (de) * 1998-06-16 1999-12-23 Boehringer Ingelheim Pharma Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT1283839E (pt) * 2000-05-26 2005-08-31 Schering Corp Antagonistas do receptor a2a da adenosina
GB0100624D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
CN1491227A (zh) * 2001-02-05 2004-04-21 株式会社大V制药工厂 三唑并喹唑啉和吡唑并三唑并嘧啶衍生物、医药组合物、腺苷 a 3受体亲和剂、降眼压剂、预防和治疗青光眼的制剂及降低眼压的方法
JP4545437B2 (ja) 2001-10-15 2010-09-15 シェーリング コーポレイション アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン
EP2269596A3 (de) * 2002-12-19 2011-09-14 Schering Corporation Verwendungen von A2a-Rezeptor-Antagonisten zur Behandlung des extrapyramidalen Syndroms und weiteren Bewegungsstörungen
RU2373210C2 (ru) * 2003-04-23 2009-11-20 Шеринг Корпорейшн 2-АЛКИНИЛ- И 2-АЛКЕНИЛ-ПИРАЗОЛ-[4,3-e]-1, 2, 4-ТРИАЗОЛО-[1,5-c]-ПИРИМИДИНОВЫЕ АНТАГОНИСТЫ A2A РЕЦЕПТОРА АДЕНОЗИНА

Also Published As

Publication number Publication date
PE20050141A1 (es) 2005-04-01
ATE432282T1 (de) 2009-06-15
JP4527712B2 (ja) 2010-08-18
EP1622912B1 (de) 2009-05-27
NO20055510D0 (no) 2005-11-22
TWI355381B (en) 2012-01-01
PL1622912T3 (pl) 2009-11-30
CN1777609A (zh) 2006-05-24
US7368449B2 (en) 2008-05-06
AR044041A1 (es) 2005-08-24
TW200427689A (en) 2004-12-16
BRPI0409787B8 (pt) 2021-05-25
HRP20090394T1 (en) 2009-08-31
DK1622912T3 (da) 2009-09-07
CY1109263T1 (el) 2014-07-02
CL2004000847A1 (es) 2005-03-11
KR20060005379A (ko) 2006-01-17
CN100503609C (zh) 2009-06-24
US20050222164A1 (en) 2005-10-06
ZA200508489B (en) 2007-04-25
KR100831107B1 (ko) 2008-05-20
NO332182B1 (no) 2012-07-23
RU2005136166A (ru) 2006-06-10
WO2004094431A3 (en) 2004-12-02
BRPI0409787A (pt) 2006-05-30
CA2522813C (en) 2009-09-08
US20040220194A1 (en) 2004-11-04
WO2004094431A2 (en) 2004-11-04
US6897217B2 (en) 2005-05-24
EP1622912A2 (de) 2006-02-08
CO5700766A2 (es) 2006-11-30
CA2522813A1 (en) 2004-11-04
MXPA05011366A (es) 2005-11-28
ES2326270T3 (es) 2009-10-06
MY139344A (en) 2009-09-30
NO20055510L (no) 2006-01-20
PT1622912E (pt) 2009-08-17
JP2006523619A (ja) 2006-10-19
BRPI0409787B1 (pt) 2018-08-21
PL378867A1 (pl) 2006-05-29
SI1622912T1 (sl) 2009-10-31
AU2004233334B2 (en) 2010-08-12
TW201144317A (en) 2011-12-16
IL171567A (en) 2013-01-31
HK1085466A1 (en) 2006-08-25
RU2373210C2 (ru) 2009-11-20
NZ542823A (en) 2009-03-31
ECSP056115A (es) 2006-03-01
TWI375677B (en) 2012-11-01
AU2004233334A1 (en) 2004-11-04
JP2010059178A (ja) 2010-03-18

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