HRP20090394T1 - 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists - Google Patents
2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonistsInfo
- Publication number
- HRP20090394T1 HRP20090394T1 HR20090394T HRP20090394T HRP20090394T1 HR P20090394 T1 HRP20090394 T1 HR P20090394T1 HR 20090394 T HR20090394 T HR 20090394T HR P20090394 T HRP20090394 T HR P20090394T HR P20090394 T1 HRP20090394 T1 HR P20090394T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- alkoxy
- hydroxyalkyl
- alkoxyalkyl
- cycloalkyl
- Prior art date
Links
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 title 1
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- -1 -CHF2 Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46484003P | 2003-04-23 | 2003-04-23 | |
| PCT/US2004/012471 WO2004094431A2 (en) | 2003-04-23 | 2004-04-21 | 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090394T1 true HRP20090394T1 (en) | 2009-08-31 |
Family
ID=33310963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090394T HRP20090394T1 (en) | 2003-04-23 | 2009-07-10 | 2-alkynyl-and 2-alkenyl-pyrazolo- [4,3-e] -1,2,4-triazolo- [1,5-c] -pyrimidine adenosine a2a receptor antagonists |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6897217B2 (xx) |
| EP (1) | EP1622912B1 (xx) |
| JP (2) | JP4527712B2 (xx) |
| KR (1) | KR100831107B1 (xx) |
| CN (1) | CN100503609C (xx) |
| AR (1) | AR044041A1 (xx) |
| AT (1) | ATE432282T1 (xx) |
| AU (1) | AU2004233334B2 (xx) |
| BR (1) | BRPI0409787B8 (xx) |
| CA (1) | CA2522813C (xx) |
| CL (1) | CL2004000847A1 (xx) |
| CO (1) | CO5700766A2 (xx) |
| CY (1) | CY1109263T1 (xx) |
| DE (1) | DE602004021250D1 (xx) |
| DK (1) | DK1622912T3 (xx) |
| EC (1) | ECSP056115A (xx) |
| ES (1) | ES2326270T3 (xx) |
| HK (1) | HK1085466A1 (xx) |
| HR (1) | HRP20090394T1 (xx) |
| IL (1) | IL171567A (xx) |
| MX (1) | MXPA05011366A (xx) |
| MY (1) | MY139344A (xx) |
| NO (1) | NO332182B1 (xx) |
| NZ (1) | NZ542823A (xx) |
| PE (1) | PE20050141A1 (xx) |
| PL (2) | PL1622912T3 (xx) |
| PT (1) | PT1622912E (xx) |
| RU (1) | RU2373210C2 (xx) |
| SI (1) | SI1622912T1 (xx) |
| TW (2) | TWI355381B (xx) |
| WO (1) | WO2004094431A2 (xx) |
| ZA (1) | ZA200508489B (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7313588B1 (en) * | 2000-07-13 | 2007-12-25 | Biap Systems, Inc. | Locally executing software agent for retrieving remote content and method for creation and use of the agent |
| WO2003048165A1 (en) * | 2001-11-30 | 2003-06-12 | Schering Corporation | ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| JP2006514697A (ja) | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニストの使用 |
| CN100503609C (zh) * | 2003-04-23 | 2009-06-24 | 先灵公司 | 2-炔基-及2-链烯基-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]-嘧啶腺苷A2a受体拮抗剂 |
| WO2005103055A1 (en) * | 2004-04-21 | 2005-11-03 | Schering Corporation | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS |
| ATE556712T1 (de) * | 2005-06-07 | 2012-05-15 | Kyowa Hakko Kirin Co Ltd | A2a antagonisten zur behandlung von motorischen störungen |
| WO2007035542A1 (en) | 2005-09-19 | 2007-03-29 | Schering Corporation | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| AR056080A1 (es) * | 2005-09-23 | 2007-09-19 | Schering Corp | 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7691869B2 (en) | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| WO2009111449A1 (en) * | 2008-03-04 | 2009-09-11 | Schering Corporation | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists |
| US8512594B2 (en) * | 2008-08-25 | 2013-08-20 | Air Products And Chemicals, Inc. | Curing agent of N,N′-dimethyl-meta-xylylenediamine and multifunctional amin(s) |
| US8501997B2 (en) * | 2008-08-25 | 2013-08-06 | Air Products And Chemicals, Inc. | Curing agent for low temperature cure applications |
| ES2487616T3 (es) | 2009-03-10 | 2014-08-22 | Takeda Pharmaceutical Company Limited | Derivados de benzofurano |
| EP2462144B1 (en) * | 2009-08-07 | 2017-09-20 | Merck Sharp & Dohme Corp. | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| KR20140113918A (ko) * | 2011-12-27 | 2014-09-25 | (주)바이오팜솔루션즈 | 루게릭병의 치료 또는 예방에 사용되는 페닐카바메이트 화합물 |
| WO2014101120A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| ES2824723T3 (es) * | 2013-03-14 | 2021-05-13 | Galapagos Nv | Nuevos compuestos y composiciones farmacéuticas de los mismos para el tratamiento de trastornos inflamatorios |
| EP3723754A4 (en) | 2017-12-13 | 2021-05-19 | Merck Sharp & Dohme Corp. | IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES |
| JP2022540583A (ja) * | 2019-07-17 | 2022-09-16 | テオン セラピューティクス，インク． | アデノシンａ２ａ受容体アンタゴニスト及びその使用 |
| CN115160120B (zh) * | 2022-08-02 | 2024-08-27 | 乐威医药（江苏）股份有限公司 | 一种多烷氧基芳香酮的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US785906A (en) * | 1904-12-06 | 1905-03-28 | Albert P Mcbride | Casing packer and shoe for gas or oil wells. |
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ATE208199T1 (de) * | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| DE19826843A1 (de) * | 1998-06-16 | 1999-12-23 | Boehringer Ingelheim Pharma | Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| SK287748B6 (sk) * | 2000-05-26 | 2011-08-04 | Schering Corporation | Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| CA2437437A1 (en) * | 2001-02-05 | 2002-08-15 | Yasuhisa Kurogi | Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives, pharmaceutical, composition adenosine a3 receptor affinitive agent, intraocular-pressure reducing agent, pharmaceutical preparation for prevention and treatment of glaucoma, and intraocular-pressure reducing method |
| PE20030477A1 (es) | 2001-10-15 | 2003-06-06 | Schering Corp | ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a |
| JP2006514697A (ja) | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニストの使用 |
| CN100503609C (zh) * | 2003-04-23 | 2009-06-24 | 先灵公司 | 2-炔基-及2-链烯基-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]-嘧啶腺苷A2a受体拮抗剂 |
-
2004
- 2004-04-21 CN CNB2004800107535A patent/CN100503609C/zh not_active Expired - Fee Related
- 2004-04-21 WO PCT/US2004/012471 patent/WO2004094431A2/en active Application Filing
- 2004-04-21 CL CL200400847A patent/CL2004000847A1/es unknown
- 2004-04-21 TW TW093111142A patent/TWI355381B/zh not_active IP Right Cessation
- 2004-04-21 EP EP04760128A patent/EP1622912B1/en not_active Expired - Lifetime
- 2004-04-21 PL PL04760128T patent/PL1622912T3/pl unknown
- 2004-04-21 AR ARP040101344A patent/AR044041A1/es not_active Application Discontinuation
- 2004-04-21 CA CA002522813A patent/CA2522813C/en not_active Expired - Fee Related
- 2004-04-21 NZ NZ542823A patent/NZ542823A/en not_active IP Right Cessation
- 2004-04-21 AT AT04760128T patent/ATE432282T1/de active
- 2004-04-21 KR KR1020057019891A patent/KR100831107B1/ko active IP Right Grant
- 2004-04-21 AU AU2004233334A patent/AU2004233334B2/en not_active Ceased
- 2004-04-21 US US10/829,416 patent/US6897217B2/en not_active Expired - Lifetime
- 2004-04-21 MY MYPI20041463A patent/MY139344A/en unknown
- 2004-04-21 DK DK04760128T patent/DK1622912T3/da active
- 2004-04-21 SI SI200431189T patent/SI1622912T1/sl unknown
- 2004-04-21 PT PT04760128T patent/PT1622912E/pt unknown
- 2004-04-21 RU RU2005136166/04A patent/RU2373210C2/ru not_active IP Right Cessation
- 2004-04-21 BR BRPI0409787-4 patent/BRPI0409787B8/pt not_active IP Right Cessation
- 2004-04-21 ES ES04760128T patent/ES2326270T3/es not_active Expired - Lifetime
- 2004-04-21 PL PL378867A patent/PL378867A1/pl unknown
- 2004-04-21 JP JP2006501291A patent/JP4527712B2/ja not_active Expired - Fee Related
- 2004-04-21 TW TW100131963A patent/TWI375677B/zh not_active IP Right Cessation
- 2004-04-21 DE DE602004021250T patent/DE602004021250D1/de not_active Expired - Lifetime
- 2004-04-21 PE PE2004000392A patent/PE20050141A1/es not_active Application Discontinuation
- 2004-04-21 MX MXPA05011366A patent/MXPA05011366A/es active IP Right Grant
-
2005
- 2005-05-23 US US11/135,261 patent/US7368449B2/en not_active Expired - Lifetime
- 2005-10-19 ZA ZA200508489A patent/ZA200508489B/en unknown
- 2005-10-21 EC EC2005006115A patent/ECSP056115A/es unknown
- 2005-10-21 CO CO05107374A patent/CO5700766A2/es active IP Right Grant
- 2005-10-26 IL IL171567A patent/IL171567A/en active IP Right Grant
- 2005-11-22 NO NO20055510A patent/NO332182B1/no not_active IP Right Cessation
-
2006
- 2006-03-21 HK HK06103531.4A patent/HK1085466A1/xx not_active IP Right Cessation
-
2009
- 2009-07-10 HR HR20090394T patent/HRP20090394T1/xx unknown
- 2009-08-04 CY CY20091100821T patent/CY1109263T1/el unknown
- 2009-11-04 JP JP2009253549A patent/JP2010059178A/ja not_active Withdrawn
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