AR048617A1 - Antagonistas del receptor a2a de la adenosina con estructura de pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidina. - Google Patents
Antagonistas del receptor a2a de la adenosina con estructura de pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidina.Info
- Publication number
- AR048617A1 AR048617A1 ARP050101559A ARP050101559A AR048617A1 AR 048617 A1 AR048617 A1 AR 048617A1 AR P050101559 A ARP050101559 A AR P050101559A AR P050101559 A ARP050101559 A AR P050101559A AR 048617 A1 AR048617 A1 AR 048617A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydroxyalkyl
- group
- alkoxyalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se refiere a antagonistas del receptor A2A de la adenosina con estructura de pirazolo-[4,3-E]-1,2,4-triazolo-[1,5-C]-pirimidina, y composiciones farmacéuticas que los contienen y usos. Reivindicacion 1: Un compuesto que tiene la formula estructural (1) o una sal aceptable para uso farmacéutico del mismo, donde R es R6-fenilo, R6-furanilo, R6-tienilo, R6-piridilo, R6-piridilo N-oxido, R6-oxazolilo, R6-pirrolilo o cicloalquenilo; R1, R2, R3, R4 y R5 se seleccionan independientemente del grupo integrado por H, alquilo y alcoxialquilo; R6 es 1 a 3 sustituyentes independientemente seleccionados del grupo integrado por H, alquilo, -CF3, halogeno, -NO2, -CN, -NR7R8, alcoxi, alquiltio, alquilsulfinilo y alquilsulfonilo; R7 es H o alquilo; R8 es H, alquilo, alquilC(O)- o alquil-SO2-; Z es R9, R10-arilo o R9,R10-heteroarilo; R9 es alquenilo, hidroxialquilo, alcoxialquilo, alcoxi-alcoxi-alquilo-, (di-alcoxi)-alquilo, (hidroxi)-alcoxialquilo, R15-cicloalquilo, R15- cicloalquilalquilo, cicloalquil-oxi, cicloalquil-O-alcoxi, cianoalquilo, -C(O)R13, -N(R11)(R12), N(R11)(R12)-alquilo-, -C(O)N(R13)(R16), -alquilen-C(O)-N(R11)2, -C(O)-(R15-heterocicloalquilo), R15-heterocicloalquil-alquilo, R15-heterocicloalquil- alcoxi, R19-heteroarilo, CF3-alquilen-O-alquilo, CF3-hidroxialquilo, (CF3)(hidroxi)alcoxi, ciano-alcoxi, -alquilen-C(O)-O-alquilo, -SO2-N(alquilo)2, (cicloalquil)hidroxialquilo, (hidroxialquil)alcoxi, (dihidroxi)alquilo, (dihidroxi)alcoxi o - C(=NOR17)-CF3; R10 es 1 a 3 sustituyentes independientemente seleccionados del grupo integrado por H, alquilo, alquenilo, hidroxi, alcoxi, hidroxialquilo, hidroxialcoxi, alcoxialquilo, alcoxialcoxi, alcoxi-alcoxi-alquilo-, (di-alcoxi)-alquilo, (hidroxi)-alcoxialquilo, R15-cicloalquilo, R15-cicloalquilalquilo, cicloalquil-oxi, cicloalquil-O-alcoxi, alquil-SO2-, alquil-SO-, halo, -CN, cianoalquilo, -CHF2, -CF3, -OCHF2, -OCF3, -C(O)R13, -O-alquilen-C(O)OR13, -C(O)O-alquilo, -N(R11)(R12), N(R11)(R12)-alquilo, N(R11)(R12)-alcoxi, -C(O)N(R13)(R16), R19-heteroarilo, R15-heterocicloalquilo, R15-heterocicloalquil-alquilo, R15-heterocicloalquil-alcoxi, R15-heterocicloalquil-oxi, CF3-alquilen-O-alquilo, CF3-hidroxialquilo, (CF3)(hidroxi)alcoxi, ciano-alcoxi, -alquilen-C(O)-O-alquilo, -SO2-N(alquilo)2, (cicloalquil)hidroxialquilo, (hidroxialquil)alcoxi, (dihidroxi)alquilo, (dihidroxi)alcoxi, -C(=NOR17)-alquilo y -C(=NOR17)-CF3; o un grupo R9 y un grupo R10 en átomos de anillos de C adyacentes juntos forman -O-(CH2)2-O-, -CH2-O-(CH2)2-O-, -O-(CH2)2-, -(CH2)3-O-, -O-(CH2)3-O-, -(CH2)3- o -CH2-CH=CH-, done el anillo formado por los sustituyentes R9 y R10 y los átomos de C del anillo al cual están unidos están sustituidos con R16; o un grupo R9 y un grupo R10 en átomos de anillos de C adyacentes juntos forman -N(R11)-C(O)-O-, -N(R11)-C(O)-S- o -N(R12)-(CH2)2-; o un grupo R9 y un grupo R10 en átomos de anillos de C adyacentes juntos forman -(CH2)2CH(OR18)- , -CH2CH(OR18)CH2-, -(CH2)3CH(OR18)-, -(CH2)2CH(OR18)CH2-, -(CH2)2C(O)-, -CH2C(O)CH2-, -(CH2)3C(O)-, -(CH2)2C(O)CH2-, -O(CH2)2CH(OR18)- o -OCH2CH(OR18)CH2-, donde el anillo formado por los sustituyentes R9 y R10 y los átomos de C del anillo al cual están unidos está sustituido opcionalmente en un átomo de C con hidroxialquilo o alcoxialquilo; cada R11 se selecciona independientemente del grupo integrado por H y alquilo; cada R12 se selecciona independientemente del grupo integrado por H, alquilo, cicloalquilo, hidroxialquilo, alcoxialquilo, -C(O)-alquilo, -C(O)O-alquilo, (alcoxi)hidroxialquilo, alcoxialquil-C(O)-, -SO2alquilo, -alquilen-C(O)alquilo y -alquilen-C(O)O-alquilo; R13 es H, alquilo o -CF3, R15 es 1 a 3 sustituyentes independientemente seleccionados del grupo integrado por H, alquilo, -OH, alcoxi, alcoxialquilo e hidroxialquilo, o dos sustituyentes R15, tomados junto con el C al cual están unidos, forman un grupo -C(=O)-, R16 es H, alquilo, alcoxialquilo, OH o hidroxialquilo; R17 es H o alquilo; R18 es H o alquilo, y R19 es 1 o 2 sustituyentes independientemente seleccionados del grupo integrado por H, alquilo, hidroxialquilo, alcoxialquilo, -C(O)N(R11)(R12) y -N(R11)2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56391304P | 2004-04-21 | 2004-04-21 | |
US60996604P | 2004-09-15 | 2004-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048617A1 true AR048617A1 (es) | 2006-05-10 |
Family
ID=34966464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101559A AR048617A1 (es) | 2004-04-21 | 2005-04-20 | Antagonistas del receptor a2a de la adenosina con estructura de pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidina. |
Country Status (17)
Country | Link |
---|---|
US (1) | US7709492B2 (es) |
EP (1) | EP1745047B1 (es) |
JP (2) | JP2007533754A (es) |
KR (1) | KR20060135901A (es) |
AR (1) | AR048617A1 (es) |
AT (1) | ATE461932T1 (es) |
AU (1) | AU2005236059B2 (es) |
CA (1) | CA2563635A1 (es) |
DE (1) | DE602005020127D1 (es) |
ES (1) | ES2342082T3 (es) |
HK (1) | HK1095818A1 (es) |
IL (1) | IL178674A0 (es) |
MX (1) | MXPA06012231A (es) |
NZ (1) | NZ550591A (es) |
PE (1) | PE20060185A1 (es) |
TW (1) | TW200538118A (es) |
WO (1) | WO2005103055A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ522326A (en) * | 2000-05-26 | 2006-03-31 | Schering Corp | Adenosine A2A receptor antagonists |
US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
ES2328581T3 (es) | 2003-09-19 | 2009-11-16 | Janssen Pharmaceutica Nv | Acidos 4-((fhenoxialquil)tio)-fenoxiaceticos y analogos. |
MY147518A (en) | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
CN101084205A (zh) * | 2004-12-13 | 2007-12-05 | 艾尼纳制药公司 | 作为5ht2c受体调节剂以治疗与其相关病症的n-联芳基和n-芳基杂芳基哌嗪衍生物 |
CA2594987A1 (en) * | 2004-12-14 | 2006-06-22 | Shionogi & Co., Ltd. | Therapeutic agent for constipation |
JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
JP2009508871A (ja) * | 2005-09-19 | 2009-03-05 | シェーリング コーポレイション | アデノシンA2a受容体アンタゴニストとしての2−ヘテロアリール−ピラゾロ−[4,3−e]−1,2,4−トリアゾロ−[1,5−c]−ピリミジン |
PE20070521A1 (es) | 2005-09-23 | 2007-07-13 | Schering Corp | 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a |
PE20080188A1 (es) | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
US7723343B2 (en) * | 2007-03-30 | 2010-05-25 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2A receptor antagonists |
WO2009111449A1 (en) * | 2008-03-04 | 2009-09-11 | Schering Corporation | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists |
WO2010068756A2 (en) * | 2008-12-10 | 2010-06-17 | Thesis Chemistry, Llc | Process for manufacture of optically active 2-(acyloxymethyl)-1, 3 oxathiolanes |
TW201036614A (en) * | 2008-12-30 | 2010-10-16 | Arqule Inc | Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
US8431699B2 (en) * | 2009-02-27 | 2013-04-30 | Vertichem Corporation | Method for manufacture of 2-oxoimidazolidines |
ES2487616T3 (es) | 2009-03-10 | 2014-08-22 | Takeda Pharmaceutical Company Limited | Derivados de benzofurano |
TW201100427A (en) * | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted heterocyclic compounds |
TWI508960B (zh) * | 2009-10-08 | 2015-11-21 | Sanofi Aventis | 作為pgds抑制劑之苯基二唑衍生物 |
US9006177B2 (en) * | 2010-09-24 | 2015-04-14 | Advinus Therapeutics Limited | Fused tricyclic compounds as adenosine receptor antagonist |
WO2012135084A1 (en) * | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | METABOLITES OF 2-(FURAN-2-YL)-7-(2-(4-(4-(2-METHOXYETHOXY)PHENYL)PIPERAZIN-1-YL)ETHYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
EP2797880B1 (en) * | 2011-12-27 | 2017-03-01 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in preventing or treating epilepsy |
HUE059990T2 (hu) * | 2017-03-30 | 2023-01-28 | iTeos Belgium SA | 2-Oxo-tiazol-származékok A2A inhibitorként és a rákos megbetegedések kezelésében alkalmazható vegyületekként |
TWI801372B (zh) * | 2017-03-30 | 2023-05-11 | 比利時商艾特歐斯比利時有限公司 | 作為a2a抑制劑的硫胺甲酸酯衍生物以及用於癌症治療的方法 |
CN108218796A (zh) * | 2017-12-31 | 2018-06-29 | 佛山市赛维斯医药科技有限公司 | 含酰肼结构的化合物、制备方法及其用途 |
CN108191775A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 一种末端烯丙基丙酰肼结构化合物及其用途 |
CN108148004A (zh) * | 2017-12-31 | 2018-06-12 | 佛山市赛维斯医药科技有限公司 | 一种含丙酰肼和嘧啶结构的化合物、制备方法及其用途 |
CN107935953A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 含末端烯键和酰肼结构的comt抑制剂、制备方法及其用途 |
MX2020010618A (es) | 2018-04-08 | 2020-11-12 | Beigene Ltd | Derivados de pirazolotriazolopiriminina como antagonista del receptor a2a. |
CN110742893B (zh) * | 2018-07-23 | 2024-04-05 | 百济神州(北京)生物科技有限公司 | A2a受体拮抗剂治疗癌症的方法 |
US11376255B2 (en) | 2018-09-11 | 2022-07-05 | iTeos Belgium SA | Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents |
BE1026615B1 (fr) * | 2018-09-27 | 2020-07-06 | Iteos Therapeutics S A | Combinaison d’un inhibiteur du récepteur a2a et d'un agent anticancéreux |
EP4410375A2 (en) * | 2018-09-11 | 2024-08-07 | iTeos Belgium SA | Thiocarbamate derivatives as a2a inhibitors, pharmaceutical composition thereof and combinations with anticancer agents |
BE1026758B1 (fr) * | 2018-09-11 | 2020-06-09 | Iteos Therapeutics S A | Composition pharmaceutique comprenant des dérivés de thiocarbamate inhibiteurs d’a2a |
US11427594B2 (en) | 2018-09-27 | 2022-08-30 | iTeos Belgium SA | Non brain penetrant A2A inhibitors and methods for use in the treatment of cancers |
BE1026602B1 (fr) * | 2018-09-27 | 2020-06-18 | Iteos Therapeutics S A | Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers |
CR20210271A (es) | 2018-11-30 | 2021-07-14 | Merck Sharp & Dohme | Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso |
US20220235056A1 (en) * | 2019-05-03 | 2022-07-28 | Nektar Therapeutics | Adenosine 2 receptor antagonists |
US20230024108A1 (en) * | 2019-07-17 | 2023-01-26 | Teon Therapeutics, Inc. | Adenosine a2a receptor antagonists |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
DE69428977T2 (de) | 1993-07-27 | 2002-07-11 | Kyowa Hakko Kogyo Co., Ltd. | Arzneimittel gegen Parkinsonsche Krankheit |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
NZ522326A (en) | 2000-05-26 | 2006-03-31 | Schering Corp | Adenosine A2A receptor antagonists |
GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
JP4545437B2 (ja) | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンa2a受容体アンタゴニストとしてのイミダゾ(4,3−e)−1,2,4−トリアゾロ(1,5−c)ピリミジン |
DE60335294D1 (de) | 2002-12-19 | 2011-01-20 | Schering Corp | Dlung des extrapyramidalen syndroms |
DE602004021250D1 (de) * | 2003-04-23 | 2009-07-09 | Schering Corp | 2-alkinyl- und 2-alkenyl-pyrazolo-ä4,3-eü -1,2,4-triazolo-ä1,5-cü -pyrimidinadenosin a2a rezeptorantagonisten |
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2005
- 2005-04-19 AU AU2005236059A patent/AU2005236059B2/en not_active Ceased
- 2005-04-19 KR KR1020067021803A patent/KR20060135901A/ko not_active Application Discontinuation
- 2005-04-19 CA CA002563635A patent/CA2563635A1/en not_active Abandoned
- 2005-04-19 PE PE2005000428A patent/PE20060185A1/es not_active Application Discontinuation
- 2005-04-19 JP JP2007509594A patent/JP2007533754A/ja active Pending
- 2005-04-19 ES ES05737774T patent/ES2342082T3/es active Active
- 2005-04-19 NZ NZ550591A patent/NZ550591A/en unknown
- 2005-04-19 DE DE602005020127T patent/DE602005020127D1/de active Active
- 2005-04-19 US US11/108,916 patent/US7709492B2/en active Active
- 2005-04-19 MX MXPA06012231A patent/MXPA06012231A/es active IP Right Grant
- 2005-04-19 EP EP05737774A patent/EP1745047B1/en active Active
- 2005-04-19 TW TW094112339A patent/TW200538118A/zh unknown
- 2005-04-19 WO PCT/US2005/013454 patent/WO2005103055A1/en active Application Filing
- 2005-04-19 AT AT05737774T patent/ATE461932T1/de not_active IP Right Cessation
- 2005-04-20 AR ARP050101559A patent/AR048617A1/es not_active Application Discontinuation
-
2006
- 2006-10-17 IL IL178674A patent/IL178674A0/en unknown
-
2007
- 2007-03-19 HK HK07102948.2A patent/HK1095818A1/xx not_active IP Right Cessation
-
2008
- 2008-04-08 JP JP2008100773A patent/JP2008231111A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US7709492B2 (en) | 2010-05-04 |
NZ550591A (en) | 2010-10-29 |
WO2005103055A1 (en) | 2005-11-03 |
EP1745047A1 (en) | 2007-01-24 |
HK1095818A1 (en) | 2007-05-18 |
TW200538118A (en) | 2005-12-01 |
ES2342082T3 (es) | 2010-07-01 |
ATE461932T1 (de) | 2010-04-15 |
AU2005236059B2 (en) | 2009-01-15 |
JP2008231111A (ja) | 2008-10-02 |
CA2563635A1 (en) | 2005-11-03 |
KR20060135901A (ko) | 2006-12-29 |
IL178674A0 (en) | 2007-02-11 |
EP1745047B1 (en) | 2010-03-24 |
MXPA06012231A (es) | 2006-12-15 |
PE20060185A1 (es) | 2006-03-20 |
JP2007533754A (ja) | 2007-11-22 |
US20050239795A1 (en) | 2005-10-27 |
DE602005020127D1 (de) | 2010-05-06 |
AU2005236059A1 (en) | 2005-11-03 |
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