ATE402152T1 - Hiv-inhibierende1,2,4-triazine - Google Patents
Hiv-inhibierende1,2,4-triazineInfo
- Publication number
- ATE402152T1 ATE402152T1 AT04708367T AT04708367T ATE402152T1 AT E402152 T1 ATE402152 T1 AT E402152T1 AT 04708367 T AT04708367 T AT 04708367T AT 04708367 T AT04708367 T AT 04708367T AT E402152 T1 ATE402152 T1 AT E402152T1
- Authority
- AT
- Austria
- Prior art keywords
- hiv
- triazine
- inhibiting
- Prior art date
Links
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furnace Details (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0301289 | 2003-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402152T1 true ATE402152T1 (de) | 2008-08-15 |
Family
ID=32892827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04708367T ATE402152T1 (de) | 2003-02-07 | 2004-02-05 | Hiv-inhibierende1,2,4-triazine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7585861B2 (de) |
| EP (1) | EP1597242B1 (de) |
| JP (1) | JP4783725B2 (de) |
| KR (1) | KR20050105190A (de) |
| CN (2) | CN102503903A (de) |
| AP (1) | AP2005003365A0 (de) |
| AT (1) | ATE402152T1 (de) |
| AU (1) | AU2004213173B2 (de) |
| BR (1) | BRPI0407306A (de) |
| CA (1) | CA2513123C (de) |
| DE (1) | DE602004015254D1 (de) |
| EA (1) | EA010379B1 (de) |
| ES (1) | ES2311146T3 (de) |
| HR (1) | HRP20050690A2 (de) |
| IL (1) | IL170120A (de) |
| MX (1) | MXPA05008368A (de) |
| NO (1) | NO20054127L (de) |
| PL (1) | PL232814B1 (de) |
| WO (1) | WO2004074266A1 (de) |
| ZA (1) | ZA200506254B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2543376A1 (de) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazin Kinasehemmer |
| JP5031564B2 (ja) * | 2004-08-10 | 2012-09-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ抑制１，２，４−トリアジン−６−オン誘導体 |
| AU2005276974B2 (en) | 2004-08-25 | 2012-08-02 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| NZ567851A (en) | 2005-11-01 | 2011-09-30 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| JP2010518014A (ja) | 2007-01-31 | 2010-05-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用な２−アミノピリジン誘導体 |
| MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| EP2318407B1 (de) | 2008-07-23 | 2013-01-02 | Vertex Pharmaceuticals Incorporated | Pyrazolpyridine als kinaseinhibitoren |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| JP5631310B2 (ja) | 2008-07-23 | 2014-11-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 三環式ピラゾロピリジンキナーゼ阻害剤 |
| CA2732765A1 (en) * | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| WO2010129668A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| CN102869663A (zh) | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 吡唑并吡嗪激酶抑制剂 |
| US9067932B2 (en) | 2010-01-27 | 2015-06-30 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| MX2012008643A (es) | 2010-01-27 | 2013-02-26 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| WO2012060847A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| AU2018239542C1 (en) | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| WO2021071984A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| EP4076448A4 (de) | 2019-12-20 | 2024-03-27 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazole und verwendungen davon |
| CN111333543B (zh) * | 2020-04-17 | 2022-09-16 | 武汉工程大学 | 一种利匹韦林中间体的合成方法 |
| EP4333841A1 (de) | 2021-05-04 | 2024-03-13 | Tenaya Therapeutics, Inc. | 2-fluoralkyl-1,3,4-oxadiazol-5-yl-thiazol-, hdac6-inhibitoren zur verwendung bei der behandlung von stoffwechselerkrankungen und hfpef |
| CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
| CN117658936B (zh) * | 2023-11-30 | 2025-06-06 | 上海予君生物科技发展有限公司 | 一种3,5,6-三氯-[1,2,4]-三嗪的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| EP0862463A1 (de) | 1995-11-23 | 1998-09-09 | Janssen Pharmaceutica N.V. | Feste mischungen von cyclodextrinen, hergestellt durch schmelzextrusionsverfahren |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| BR9909168A (pt) | 1998-03-27 | 2000-12-05 | Lg Chemical Ltd | Derivados de ácido ascórbico polietoxilados como anti-oxidantes e processo para preparação dos mesmo |
| NZ506679A (en) * | 1998-03-27 | 2002-11-26 | Janssen Pharmaceutica Nv | HIV inhibiting pyrimidine derivatives |
| EP0945447A1 (de) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| AP1636A (en) * | 1998-11-10 | 2006-07-17 | Janssen Pharmaceutica Nv | 2.4-disubstituted triazine derivatives. |
| SK287269B6 (sk) | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom |
| JP5230050B2 (ja) | 2000-05-08 | 2013-07-10 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ複製阻害剤 |
| ES2290313T3 (es) * | 2001-03-15 | 2008-02-16 | Janssen Pharmaceutica N.V. | Derivados de pirazinona que inhiben el vih. |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
-
2004
- 2004-02-05 KR KR1020057013955A patent/KR20050105190A/ko not_active Withdrawn
- 2004-02-05 EA EA200501268A patent/EA010379B1/ru not_active IP Right Cessation
- 2004-02-05 US US10/544,584 patent/US7585861B2/en not_active Expired - Lifetime
- 2004-02-05 MX MXPA05008368A patent/MXPA05008368A/es active IP Right Grant
- 2004-02-05 CN CN201110305993XA patent/CN102503903A/zh active Pending
- 2004-02-05 DE DE602004015254T patent/DE602004015254D1/de not_active Expired - Lifetime
- 2004-02-05 ES ES04708367T patent/ES2311146T3/es not_active Expired - Lifetime
- 2004-02-05 AT AT04708367T patent/ATE402152T1/de not_active IP Right Cessation
- 2004-02-05 AP AP2005003365A patent/AP2005003365A0/xx unknown
- 2004-02-05 HR HR20050690A patent/HRP20050690A2/xx not_active Application Discontinuation
- 2004-02-05 EP EP04708367A patent/EP1597242B1/de not_active Expired - Lifetime
- 2004-02-05 AU AU2004213173A patent/AU2004213173B2/en not_active Ceased
- 2004-02-05 PL PL378107A patent/PL232814B1/pl unknown
- 2004-02-05 WO PCT/EP2004/050084 patent/WO2004074266A1/en not_active Ceased
- 2004-02-05 CN CNA2004800035861A patent/CN1747941A/zh active Pending
- 2004-02-05 JP JP2006502005A patent/JP4783725B2/ja not_active Expired - Fee Related
- 2004-02-05 BR BRPI0407306-1A patent/BRPI0407306A/pt not_active IP Right Cessation
- 2004-02-05 CA CA2513123A patent/CA2513123C/en not_active Expired - Fee Related
-
2005
- 2005-08-04 ZA ZA200506254A patent/ZA200506254B/en unknown
- 2005-08-04 IL IL170120A patent/IL170120A/en active IP Right Grant
- 2005-09-05 NO NO20054127A patent/NO20054127L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20054127L (no) | 2005-09-05 |
| EP1597242B1 (de) | 2008-07-23 |
| CA2513123C (en) | 2013-04-23 |
| ZA200506254B (en) | 2008-02-27 |
| CN1747941A (zh) | 2006-03-15 |
| ES2311146T3 (es) | 2009-02-01 |
| AP2005003365A0 (en) | 2005-09-30 |
| AU2004213173B2 (en) | 2010-07-29 |
| MXPA05008368A (es) | 2005-11-04 |
| EP1597242A1 (de) | 2005-11-23 |
| BRPI0407306A (pt) | 2006-02-21 |
| KR20050105190A (ko) | 2005-11-03 |
| PL378107A1 (pl) | 2006-03-06 |
| CN102503903A (zh) | 2012-06-20 |
| CA2513123A1 (en) | 2004-09-02 |
| JP4783725B2 (ja) | 2011-09-28 |
| WO2004074266A8 (en) | 2004-11-11 |
| AU2004213173A1 (en) | 2004-09-02 |
| EA010379B1 (ru) | 2008-08-29 |
| PL232814B1 (pl) | 2019-07-31 |
| HRP20050690A2 (en) | 2006-08-31 |
| JP2006516983A (ja) | 2006-07-13 |
| US7585861B2 (en) | 2009-09-08 |
| DE602004015254D1 (de) | 2008-09-04 |
| IL170120A (en) | 2013-04-30 |
| WO2004074266A1 (en) | 2004-09-02 |
| US20070037811A1 (en) | 2007-02-15 |
| EA200501268A1 (ru) | 2006-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |