ATE402152T1 - Hiv-inhibierende1,2,4-triazine - Google Patents
Hiv-inhibierende1,2,4-triazineInfo
- Publication number
- ATE402152T1 ATE402152T1 AT04708367T AT04708367T ATE402152T1 AT E402152 T1 ATE402152 T1 AT E402152T1 AT 04708367 T AT04708367 T AT 04708367T AT 04708367 T AT04708367 T AT 04708367T AT E402152 T1 ATE402152 T1 AT E402152T1
- Authority
- AT
- Austria
- Prior art keywords
- hiv
- triazine
- inhibiting
- Prior art date
Links
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furnace Details (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0301289 | 2003-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402152T1 true ATE402152T1 (de) | 2008-08-15 |
Family
ID=32892827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04708367T ATE402152T1 (de) | 2003-02-07 | 2004-02-05 | Hiv-inhibierende1,2,4-triazine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7585861B2 (de) |
| EP (1) | EP1597242B1 (de) |
| JP (1) | JP4783725B2 (de) |
| KR (1) | KR20050105190A (de) |
| CN (2) | CN102503903A (de) |
| AP (1) | AP2005003365A0 (de) |
| AT (1) | ATE402152T1 (de) |
| AU (1) | AU2004213173B2 (de) |
| BR (1) | BRPI0407306A (de) |
| CA (1) | CA2513123C (de) |
| DE (1) | DE602004015254D1 (de) |
| EA (1) | EA010379B1 (de) |
| ES (1) | ES2311146T3 (de) |
| HR (1) | HRP20050690A2 (de) |
| IL (1) | IL170120A (de) |
| MX (1) | MXPA05008368A (de) |
| NO (1) | NO20054127L (de) |
| PL (1) | PL232814B1 (de) |
| WO (1) | WO2004074266A1 (de) |
| ZA (1) | ZA200506254B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2543376A1 (de) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazin Kinasehemmer |
| JP5031564B2 (ja) * | 2004-08-10 | 2012-09-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ抑制１，２，４−トリアジン−６−オン誘導体 |
| MX2007002208A (es) | 2004-08-25 | 2007-05-08 | Targegen Inc | Compuestos hetrociclicos y metodos de uso. |
| CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
| AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| JP5149009B2 (ja) | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体 |
| EP1807085B1 (de) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034279A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| RU2589878C2 (ru) | 2005-11-01 | 2016-07-10 | Таргеджен, Инк. | Би-арил-мета-пиримидиновые ингибиторы киназ |
| EP2121613A2 (de) * | 2007-01-31 | 2009-11-25 | Vertex Pharmaceuticals, Inc. | 2-aminopyridinderivate als kinaseinhibitoren |
| WO2009143389A1 (en) | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| MX2011000839A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa. |
| AU2009274023A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| WO2010017350A1 (en) * | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| MX2011011653A (es) | 2009-05-06 | 2012-01-20 | Vertex Pharma | Pirazolopiridinas. |
| MX2012008641A (es) | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopirazinas. |
| MX2012008643A (es) | 2010-01-27 | 2013-02-26 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| CA2787315A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| KR102218333B1 (ko) | 2016-06-07 | 2021-02-22 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| HRP20241239T1 (hr) | 2017-03-23 | 2024-12-06 | Jacobio Pharmaceuticals Co., Ltd. | Novi heterociklički derivati korisni kao shp2 inhibitori |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| WO2021071984A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| PH12022551475A1 (en) | 2019-12-20 | 2023-11-29 | Tenaya Therapeutics Inc | Fluoroalkyl-oxadiazoles and uses thereof |
| CN111333543B (zh) * | 2020-04-17 | 2022-09-16 | 武汉工程大学 | 一种利匹韦林中间体的合成方法 |
| CA3216768A1 (en) | 2021-05-04 | 2022-11-10 | Jin Yang | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
| CN117658936B (zh) * | 2023-11-30 | 2025-06-06 | 上海予君生物科技发展有限公司 | 一种3,5,6-三氯-[1,2,4]-三嗪的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| TR199800729T2 (xx) | 1995-11-23 | 1998-07-21 | Janssen Pharmaceutica N.V. | Eritmeli ekstr�zyonla haz�rlanan siklodekstrin kat� kar���mlar�. |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| EP0945447A1 (de) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| BR9909168A (pt) | 1998-03-27 | 2000-12-05 | Lg Chemical Ltd | Derivados de ácido ascórbico polietoxilados como anti-oxidantes e processo para preparação dos mesmo |
| EE04850B1 (et) * | 1998-03-27 | 2007-06-15 | Janssen Pharmaceutica N.V. | Pürimidiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutamiseks HIV nakku |
| AU762523C (en) * | 1998-11-10 | 2004-02-12 | Janssen Pharmaceutica N.V. | HIV replication inhibiting pyrimidines |
| IL143024A0 (en) * | 1998-11-10 | 2002-04-21 | Janssen Pharmaceutica Nv | 2,4-disubstituted triazine derivatives |
| US7276510B2 (en) * | 2000-05-08 | 2007-10-02 | Janssen Pharmaceutica, Inc. | HIV replication inhibitors |
| ES2290313T3 (es) * | 2001-03-15 | 2008-02-16 | Janssen Pharmaceutica N.V. | Derivados de pirazinona que inhiben el vih. |
| JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
-
2004
- 2004-02-05 HR HR20050690A patent/HRP20050690A2/xx not_active Application Discontinuation
- 2004-02-05 MX MXPA05008368A patent/MXPA05008368A/es active IP Right Grant
- 2004-02-05 CN CN201110305993XA patent/CN102503903A/zh active Pending
- 2004-02-05 CN CNA2004800035861A patent/CN1747941A/zh active Pending
- 2004-02-05 PL PL378107A patent/PL232814B1/pl unknown
- 2004-02-05 AT AT04708367T patent/ATE402152T1/de not_active IP Right Cessation
- 2004-02-05 AP AP2005003365A patent/AP2005003365A0/xx unknown
- 2004-02-05 ES ES04708367T patent/ES2311146T3/es not_active Expired - Lifetime
- 2004-02-05 AU AU2004213173A patent/AU2004213173B2/en not_active Ceased
- 2004-02-05 BR BRPI0407306-1A patent/BRPI0407306A/pt not_active IP Right Cessation
- 2004-02-05 US US10/544,584 patent/US7585861B2/en not_active Expired - Lifetime
- 2004-02-05 EA EA200501268A patent/EA010379B1/ru not_active IP Right Cessation
- 2004-02-05 WO PCT/EP2004/050084 patent/WO2004074266A1/en not_active Ceased
- 2004-02-05 KR KR1020057013955A patent/KR20050105190A/ko not_active Withdrawn
- 2004-02-05 EP EP04708367A patent/EP1597242B1/de not_active Expired - Lifetime
- 2004-02-05 CA CA2513123A patent/CA2513123C/en not_active Expired - Fee Related
- 2004-02-05 JP JP2006502005A patent/JP4783725B2/ja not_active Expired - Fee Related
- 2004-02-05 DE DE602004015254T patent/DE602004015254D1/de not_active Expired - Lifetime
-
2005
- 2005-08-04 IL IL170120A patent/IL170120A/en active IP Right Grant
- 2005-08-04 ZA ZA200506254A patent/ZA200506254B/en unknown
- 2005-09-05 NO NO20054127A patent/NO20054127L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1597242B1 (de) | 2008-07-23 |
| HRP20050690A2 (en) | 2006-08-31 |
| ES2311146T3 (es) | 2009-02-01 |
| AP2005003365A0 (en) | 2005-09-30 |
| AU2004213173B2 (en) | 2010-07-29 |
| BRPI0407306A (pt) | 2006-02-21 |
| PL232814B1 (pl) | 2019-07-31 |
| EA010379B1 (ru) | 2008-08-29 |
| JP2006516983A (ja) | 2006-07-13 |
| PL378107A1 (pl) | 2006-03-06 |
| CN102503903A (zh) | 2012-06-20 |
| EP1597242A1 (de) | 2005-11-23 |
| WO2004074266A8 (en) | 2004-11-11 |
| MXPA05008368A (es) | 2005-11-04 |
| IL170120A (en) | 2013-04-30 |
| KR20050105190A (ko) | 2005-11-03 |
| NO20054127L (no) | 2005-09-05 |
| CA2513123C (en) | 2013-04-23 |
| US20070037811A1 (en) | 2007-02-15 |
| ZA200506254B (en) | 2008-02-27 |
| WO2004074266A1 (en) | 2004-09-02 |
| EA200501268A1 (ru) | 2006-02-24 |
| CN1747941A (zh) | 2006-03-15 |
| AU2004213173A1 (en) | 2004-09-02 |
| CA2513123A1 (en) | 2004-09-02 |
| JP4783725B2 (ja) | 2011-09-28 |
| DE602004015254D1 (de) | 2008-09-04 |
| US7585861B2 (en) | 2009-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |