DE602004015254D1 - Hiv-inhibierende1,2,4-triazine - Google Patents
Hiv-inhibierende1,2,4-triazineInfo
- Publication number
- DE602004015254D1 DE602004015254D1 DE602004015254T DE602004015254T DE602004015254D1 DE 602004015254 D1 DE602004015254 D1 DE 602004015254D1 DE 602004015254 T DE602004015254 T DE 602004015254T DE 602004015254 T DE602004015254 T DE 602004015254T DE 602004015254 D1 DE602004015254 D1 DE 602004015254D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- triazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0301289 | 2003-02-07 | ||
| PCT/EP2004/050084 WO2004074266A1 (en) | 2003-02-07 | 2004-02-05 | Hiv inhibiting 1,2,4-triazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004015254D1 true DE602004015254D1 (de) | 2008-09-04 |
Family
ID=32892827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004015254T Expired - Lifetime DE602004015254D1 (de) | 2003-02-07 | 2004-02-05 | Hiv-inhibierende1,2,4-triazine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7585861B2 (de) |
| EP (1) | EP1597242B1 (de) |
| JP (1) | JP4783725B2 (de) |
| KR (1) | KR20050105190A (de) |
| CN (2) | CN102503903A (de) |
| AP (1) | AP2005003365A0 (de) |
| AT (1) | ATE402152T1 (de) |
| AU (1) | AU2004213173B2 (de) |
| BR (1) | BRPI0407306A (de) |
| CA (1) | CA2513123C (de) |
| DE (1) | DE602004015254D1 (de) |
| EA (1) | EA010379B1 (de) |
| ES (1) | ES2311146T3 (de) |
| HR (1) | HRP20050690A2 (de) |
| IL (1) | IL170120A (de) |
| MX (1) | MXPA05008368A (de) |
| NO (1) | NO20054127L (de) |
| PL (1) | PL232814B1 (de) |
| WO (1) | WO2004074266A1 (de) |
| ZA (1) | ZA200506254B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005231507B2 (en) | 2004-04-08 | 2012-03-01 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| RU2401833C2 (ru) * | 2004-08-10 | 2010-10-20 | Янссен Фармацевтика Н.В. | Производные 1, 2, 4-триазин-6-она, ингибирующие вич |
| JP5275628B2 (ja) | 2004-08-25 | 2013-08-28 | ターゲジェン インコーポレーティッド | 複素環式化合物および使用方法 |
| MX2007003321A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| CN101083994A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途 |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| WO2006034315A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580845A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| DK1951684T3 (en) | 2005-11-01 | 2016-10-24 | Targegen Inc | BIARYLMETAPYRIMIDIN kinase inhibitors |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| MX2009008253A (es) * | 2007-01-31 | 2009-10-12 | Vertex Pharma | Derivados de 2-aminopiridina utiles como inhibidores de cinasa. |
| CA2723961C (en) | 2008-05-21 | 2017-03-21 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| JP5631310B2 (ja) | 2008-07-23 | 2014-11-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 三環式ピラゾロピリジンキナーゼ阻害剤 |
| AU2009274011B2 (en) | 2008-07-23 | 2014-12-18 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| MX2011001319A (es) | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
| CN102459259A (zh) | 2009-05-06 | 2012-05-16 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶类 |
| MX2012008644A (es) | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasa de pirazolopiridinas. |
| CN102869664A (zh) | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 吡唑并嘧啶类激酶抑制剂 |
| WO2011094288A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| WO2012060847A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| SG10202110874TA (en) | 2016-06-07 | 2021-11-29 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| EA201992253A1 (ru) | 2017-03-23 | 2020-03-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| WO2021071984A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| CN114980887A (zh) | 2019-12-20 | 2022-08-30 | 特纳亚治疗股份有限公司 | 氟代烷基-噁二唑及其用途 |
| CN111333543B (zh) * | 2020-04-17 | 2022-09-16 | 武汉工程大学 | 一种利匹韦林中间体的合成方法 |
| CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| HUP9900730A3 (en) | 1995-11-23 | 2001-04-28 | Janssen Pharmaceutica Nv | Solid mixtures of cyclodextrins prepared via melt-extrusion |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| JP3440263B2 (ja) | 1998-03-27 | 2003-08-25 | エルジー・ライフ・サイエンシーズ・リミテッド | 新規アスコルビン酸誘導体及びその調製方法 |
| EP0945447A1 (de) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| WO1999050250A1 (en) * | 1998-03-27 | 1999-10-07 | Janssen Pharmaceutica N.V. | Hiv inhibiting pyrimidine derivatives |
| OA11674A (en) * | 1998-11-10 | 2005-01-12 | Janssen Pharmaceutica Nv | HIV Replication inhibiting pyrimidines. |
| NZ510919A (en) * | 1998-11-10 | 2003-11-28 | Janssen Pharmaceutica Nv | 2,4-disubstituted triazine derivatives |
| ES2542326T3 (es) * | 2000-05-08 | 2015-08-04 | Janssen Pharmaceutica Nv | Inhibidores de la replicación del VIH |
| WO2002078708A1 (en) | 2001-03-15 | 2002-10-10 | Janssen Pharmaceutica N.V. | Hiv inhibiting pyrazinone derivatives |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
-
2004
- 2004-02-05 MX MXPA05008368A patent/MXPA05008368A/es active IP Right Grant
- 2004-02-05 AU AU2004213173A patent/AU2004213173B2/en not_active Ceased
- 2004-02-05 ES ES04708367T patent/ES2311146T3/es not_active Expired - Lifetime
- 2004-02-05 AP AP2005003365A patent/AP2005003365A0/xx unknown
- 2004-02-05 US US10/544,584 patent/US7585861B2/en active Active
- 2004-02-05 CN CN201110305993XA patent/CN102503903A/zh active Pending
- 2004-02-05 CA CA2513123A patent/CA2513123C/en not_active Expired - Fee Related
- 2004-02-05 DE DE602004015254T patent/DE602004015254D1/de not_active Expired - Lifetime
- 2004-02-05 JP JP2006502005A patent/JP4783725B2/ja not_active Expired - Fee Related
- 2004-02-05 AT AT04708367T patent/ATE402152T1/de not_active IP Right Cessation
- 2004-02-05 PL PL378107A patent/PL232814B1/pl unknown
- 2004-02-05 CN CNA2004800035861A patent/CN1747941A/zh active Pending
- 2004-02-05 WO PCT/EP2004/050084 patent/WO2004074266A1/en active IP Right Grant
- 2004-02-05 BR BRPI0407306-1A patent/BRPI0407306A/pt not_active IP Right Cessation
- 2004-02-05 EA EA200501268A patent/EA010379B1/ru not_active IP Right Cessation
- 2004-02-05 KR KR1020057013955A patent/KR20050105190A/ko not_active Application Discontinuation
- 2004-02-05 EP EP04708367A patent/EP1597242B1/de not_active Expired - Lifetime
-
2005
- 2005-08-01 HR HR20050690A patent/HRP20050690A2/xx not_active Application Discontinuation
- 2005-08-04 ZA ZA200506254A patent/ZA200506254B/en unknown
- 2005-08-04 IL IL170120A patent/IL170120A/en active IP Right Grant
- 2005-09-05 NO NO20054127A patent/NO20054127L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4783725B2 (ja) | 2011-09-28 |
| EP1597242B1 (de) | 2008-07-23 |
| EA010379B1 (ru) | 2008-08-29 |
| US20070037811A1 (en) | 2007-02-15 |
| CA2513123A1 (en) | 2004-09-02 |
| EA200501268A1 (ru) | 2006-02-24 |
| EP1597242A1 (de) | 2005-11-23 |
| CN1747941A (zh) | 2006-03-15 |
| NO20054127L (no) | 2005-09-05 |
| ATE402152T1 (de) | 2008-08-15 |
| ZA200506254B (en) | 2008-02-27 |
| KR20050105190A (ko) | 2005-11-03 |
| MXPA05008368A (es) | 2005-11-04 |
| HRP20050690A2 (en) | 2006-08-31 |
| WO2004074266A8 (en) | 2004-11-11 |
| US7585861B2 (en) | 2009-09-08 |
| JP2006516983A (ja) | 2006-07-13 |
| CN102503903A (zh) | 2012-06-20 |
| ES2311146T3 (es) | 2009-02-01 |
| CA2513123C (en) | 2013-04-23 |
| IL170120A (en) | 2013-04-30 |
| AP2005003365A0 (en) | 2005-09-30 |
| AU2004213173B2 (en) | 2010-07-29 |
| PL378107A1 (pl) | 2006-03-06 |
| WO2004074266A1 (en) | 2004-09-02 |
| PL232814B1 (pl) | 2019-07-31 |
| BRPI0407306A (pt) | 2006-02-21 |
| AU2004213173A1 (en) | 2004-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |